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Negative activation energy for homeothermy in thermogenic skunk cabbage

Research Project

Project/Area Number 16H05064
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionIwate University

Principal Investigator

Kikukatsu Ito  岩手大学, 農学部, 教授 (50232434)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords発熱植物 / 呼吸調節 / ザゼンソウ / 活性化エネルギー / 温度 / 恒温性 / メタボローム解析 / トランスクリプトーム解析 / レドックス制御 / 恒温植物 / 修正アレニウスモデル / 化学平衡 / 温度変化
Outline of Final Research Achievements

Homeothermy in animals involves a complex mechanism involving thermal receptors throughout the body and integration in the hypothalamus that controls shivering and nonshivering thermogenesis. The flowers of some ancient families of seed plants show a similar degree of physiological thermoregulation, but by a different mechanism. Here, we show that respiratory control in homeothermic spadices of skunk cabbage is achieved by rate-determining biochemical reactions in which the overall thermodynamic activation energy exhibits a negative value. We propose that a law of chemical equilibrium governs the homeothermic control in thermogenic skunk cabbage.

Academic Significance and Societal Importance of the Research Achievements

一般に植物は積極的な熱産生機構を持たず、その体温は外気温と共に変動するものと考えられているが、興味深いことに、我が国の寒冷地に自生し、早春に花を咲かせるザゼンソウは肉穂花序と呼ばれる花器が特異的に発熱し、その体温を23℃程度に維持できる恒温性を有している。本研究においては、ザゼンソウの体温制御が肉穂花序における代謝反応に関わる化学平衡の平衡点が温度により変動していることを世界ではじめて明らかにすることができた。本研究成果は、生物の表現型が化学平衡の平衡点の変化によって説明できることを意味しており、植物のみなならず、哺乳動物の恒温性の理解にも影響を与えるものである。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (26 results)

All 2018 2017 2016 Other

All Int'l Joint Research (5 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Int'l Joint Research] University of Adelaide(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Crete(ギリシャ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Sassex(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Adelaide(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Adelaide(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Thioredoxin o-mediated reduction of mitochondrial alternative oxidase in the thermogenic skunk cabbage Symplocarpus renifolius2018

    • Author(s)
      Umekawa Yui、Ito Kikukatsu
    • Journal Title

      The Journal of Biochemistry

      Volume: 165 Issue: 1 Pages: 57-65

    • DOI

      10.1093/jb/mvy082

    • NAID

      40021789431

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Data analytic study of the homothermal maintenance mechanism of <i>Skunk Cabbage</i>: Capturing pre-equilibrium characteristics using extended poisson model2018

    • Author(s)
      Kawasaki Shuji、Ito Kikukatsu
    • Journal Title

      Biophysics and Physicobiology

      Volume: 15 Issue: 0 Pages: 235-250

    • DOI

      10.2142/biophysico.15.0_235

    • NAID

      130007506150

    • ISSN
      2189-4779
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exogenous induction of thermogenesis in Arum concinnatum by salicylic acid2018

    • Author(s)
      Laina Danae、Oikonomou Ioanna、Koutroumpa Konstantina、Bariotakis Michael、Kotzabasis Kiriakos、Ito Kikukatsu、Seymour Roger S.、Pirintsos Stergios A.
    • Journal Title

      Functional Plant Biology

      Volume: 45 Issue: 12 Pages: 1195-1195

    • DOI

      10.1071/fp17247

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Respiration of thermogenic inflorescences of skunk cabbage Symplocarpus renifolius in heliox2018

    • Author(s)
      R.S. Seymour, K. Ito, Y. Umekawa
    • Journal Title

      Plant Cell Environ.

      Volume: 41 Issue: 2 Pages: 367-373

    • DOI

      10.1111/pce.13097

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ザゼンソウの恒温性を支配する負の活性化エネルギー2017

    • Author(s)
      梅川 結,伊藤 菊一
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 55 Issue: 8 Pages: 520-522

    • DOI

      10.1271/kagakutoseibutsu.55.520

    • NAID

      130007399716

    • ISSN
      0453-073X, 1883-6852
    • Year and Date
      2017-07-20
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The biochemical basis for thermoregulation in heat-producing flowers.2016

    • Author(s)
      Y. Umekawa, R.S. Seymour & K. Ito
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 24830-24830

    • DOI

      10.1038/srep24830

    • NAID

      120007179837

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 発熱植物ザゼンソウの肉穂花序におけるトランスクリプトーム解析2018

    • Author(s)
      谷本 悠,梅川 結,伊藤 菊一
    • Organizer
      日本生化学会東北支部 第84回例会・シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ザゼンソウの熱産生組織における遺伝子発現プロファイリング2018

    • Author(s)
      谷本 悠,梅川 結,伊藤 菊一
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ザゼンソウの熱産生組織で発現する複数のチオレドキシンレダクターゼ遺伝子2018

    • Author(s)
      樋口 リサ,梅川 結,伊藤 菊一
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ザゼンソウ発熱組織をターゲットとしたメタボローム解析2018

    • Author(s)
      梅川 結,高橋 秀行,伊藤 菊一
    • Organizer
      日本生化学会東北支部 第84回例会・シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Negative activation energies in homeothermic control in thermogenic plants.2018

    • Author(s)
      Kikukatsu Ito & Yui Umekawa
    • Organizer
      Cell Symposia: Multifaced Mitochondria
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発熱植物の恒温性メカニズムに関する研究2018

    • Author(s)
      梅川 結、伊藤 菊一
    • Organizer
      先進ゲノム支援研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Modified Arrhenius model reveals the biochemical basis for thermoregulation of skunk cabbage.2017

    • Author(s)
      Y. Umekawa & K. Ito
    • Organizer
      The Start of New Genomics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発熱植物ザゼンソウの熱産生に関わるミトコンドリア型チオレドキシンの同定2017

    • Author(s)
      梅川 結、伊藤 菊一
    • Organizer
      日本農芸化学会東北支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 恒温植物ザゼンソウの温度応答性呼吸調節メカニズムに関する研究2017

    • Author(s)
      梅川 結、伊藤 菊一
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Modified Arrhenius model reveals the biochemical basis for thermoregulation of skunk cabbage2017

    • Author(s)
      梅川 結、伊藤 菊一
    • Organizer
      The Start of New Genomics
    • Place of Presentation
      東京大学(東京都文京区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発熱植物ザゼンソウの不思議:植物の体温調節のしくみに学ぶ2017

    • Author(s)
      伊藤 菊一
    • Organizer
      平成28年度 岩手大学生産技術研究センター シンポジウム
    • Place of Presentation
      ホテルグランシェール花巻(岩手県花巻市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ザゼンソウの恒温性メカニズムにおけるAOXの酸化還元制御に関する研究2016

    • Author(s)
      梅川 結、伊藤 菊一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] The homeothermic control based on pre-equilibrium reaction in thermogenic skunk cabbage.2016

    • Author(s)
      Yui Umekawa, Kikukatsu Ito
    • Organizer
      Biochemistry 2016
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物の恒温性メカニズムを支配する負の活性化エネルギーに関する研究2016

    • Author(s)
      梅川 結、ロジャー セイモア、伊藤 菊一
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学 川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 植物の恒温性メカニズムを解き明かす2016

    • Author(s)
      伊藤 菊一
    • Organizer
      第24回山形分子生物学セミナー
    • Place of Presentation
      山形大学(山形県鶴岡市)
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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