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Elucidation of the signaling network controlling the crosstalk between plant immunity and environmental response

Research Project

Project/Area Number 16H05065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionNagoya University

Principal Investigator

Tada Yasuomi  名古屋大学, 遺伝子実験施設, 教授 (40552740)

Research Collaborator Tsukagoshi Hironaka  
Matsushita Tomonao  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords植物ホルモン / 発現制御 / 植物免疫 / 植物ホルモンシグナル / 転写制御因子 / サリチル酸 / ジャスモン酸
Outline of Final Research Achievements

The transcription library of Arabidopsis thaliana was screened to identify the regulators of immune cofactors NPR1 and JAZ proteins. We found that NPR1 and JAZ associate with TGA, WRKY, MYC, NAC, HSF transcription factors, and mediators involved in photoresponse, drought stress, cell cycle, and growth regulation. Furthermore, we have shown that NPR1 directly affects the transcriptomes of photomorphogenesis, drought stress, and wounding. The identification of hub mediators between plant immunity and environmental responses will contribute to unveiling the molecular network.

Academic Significance and Societal Importance of the Research Achievements

多様な情報伝達経路間の制御因子を特定することで、高度なネットワークを明らかにすることができる。これによって、trade-off等の農業利用上決して有利であるとは言えない形質に対して解決の糸口を与えることができる。例えば代替農薬により植物免疫が活性化すると、虫害応答が抑制され虫害が増大する等の問題が不可避であった。しかし、NPR1による虫害シグナルの抑制作用が明らかになったことで、本タンパク質を標的とした分子育種等により、免疫は活性化するが、虫害抵抗性には影響を与えない植物の育成が可能になると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] University of Edinburgh(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Duke University(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] In vitro Protein-DNA Binding Assay2019

    • Author(s)
      Nomoto Mika、Tada Yasuomi、Tsukagoshi Hironaka
    • Journal Title

      BIO-PROTOCOL

      Volume: 9 Issue: 3 Pages: 3-3

    • DOI

      10.21769/bioprotoc.3155

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-Free Protein Synthesis of Plant Transcription Factors2018

    • Author(s)
      Nomoto Mika、Tada Yasuomi
    • Journal Title

      Methods Mol Biol

      Volume: 1830 Pages: 337-349

    • DOI

      10.1007/978-1-4939-8657-6_20

    • ISBN
      9781493986569, 9781493986576
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] サリチル酸シグナルの転写制御因子であるNPR1はMYC転写因子のターンオーバーを制御することでジャスモン酸シグナルを抑制する2018

    • Author(s)
      野元美佳、板谷知健、鈴木孝征、塚越啓央、松下智直、時澤睦朋、山本義治、東山哲也、Steven H. Spoel、多田安臣
    • Organizer
      第82回日本植物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] サリチル酸生合成に関与する遺伝子発現制御機構の解析2018

    • Author(s)
      岡田絵美、板谷知健、野元美佳、多田安臣
    • Organizer
      「植物の成長可塑性を支える環境認識と記憶の自律分散型統御システム」第4回若手の会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SA応答性免疫機構を制御するphyB依存的なキナーゼの解析2018

    • Author(s)
      堀尾宗正、東井周、野元美佳、板谷知健、松下智直、多田安臣
    • Organizer
      平成30年度日本植物病理学会関西部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Crosstalk between environmental and immune signals2018

    • Author(s)
      野元美佳
    • Organizer
      Joint-degree symposium of Nagoya University and University of Edinburgh
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 植物ホルモンであるサリチル酸とジャスモン酸シグナルのクロストーク制御機構の解明2018

    • Author(s)
      野元美佳
    • Organizer
      埼玉大学生命科学系専攻セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 転写補助因子SNI1とNPR1によるWRKY転写因子を介したSA応答性遺伝子発現制御機構の解析2017

    • Author(s)
      清水琴恵・野元美佳・福井大和・板谷知健・森毅・時澤睦朋・山本義治・塚越啓央・多田安臣
    • Organizer
      平成29年度日本植物病理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The master transcription cofactor NPR1 represses transcription factors to up- and downregulate two immune signals dependent on transcriptional context2017

    • Author(s)
      Mika Nomoto, Tomotaka Itaya, Hironaka Tsukagoshi, Takamasa Suzuki, Michael J. Skelly, Tomonao Matsushita, Yoshiharu Y. Yamamoto, Tetsuya Higashiyama, Steven H. Spoel, and Yasuomi Tada
    • Organizer
      International Conference of Arabidopsis Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] phyシグナルが制御するSA応答性防御応答2017

    • Author(s)
      東井 周・野元美佳・板谷知健・塚越啓央・松下智直・多田安臣
    • Organizer
      平成29年度日本植物病理学会感染生理談話会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤色光シグナルが制御するSA応答性防御応答2017

    • Author(s)
      東井 周・野元美佳・板谷知健・塚越啓央・松下智直・多田安臣
    • Organizer
      平成29年度日本植物病理学会関西部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] phyシグナルが制御するSA応答性免疫機構2017

    • Author(s)
      東井周・堀尾宗正・野元美佳・板谷知健・塚越啓央・松下智直・多田安臣
    • Organizer
      第180回日本農芸化学会中部支部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transcription cofactors NPR1 and SNI1 antagonistically regulate SA signal through WRKY transcription factors2017

    • Author(s)
      Yamato Fukui, Mika Nomoto, Kotoe Shimizu, Tomotaka Itaya, Takamasa Suzuki, Hironaka Tsukagoshi, Tsuyoshi Mori, Mutsutomo Tokizawa, Yoshiharu Yamamoto, Tomonao Matsushita, Steven H. Spoel, Yasuomi Tada
    • Organizer
      新学術領域研究 環境記憶統合 第3回若手の回
    • Related Report
      2017 Annual Research Report
  • [Presentation] Salicylic acid-induced immune cofactor NPR1 directly represses MYC transcription activators in jasmonate signaling2017

    • Author(s)
      Mika Nomoto, Tomotaka Itaya, Hironaka Tsukagoshi, Takamasa Suzuki, Michael J. Skelly, Tomonao Matsushita, Yoshiharu Y. Yamamoto, Tetsuya Higashiyama, Steven H. Spoel, and Yasuomi Tada
    • Organizer
      新学術領域研究 環境記憶統合 第3回若手の回
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of SA/NPR1-dependent defense response regulated by phytochrome signaling2017

    • Author(s)
      Munemasa Horio, Amane Toui, Mika Nomoto, Tomotaka Itaya, Hironaka Tsukagoshi, Tomonao Matsushita, Yasuomi Tada
    • Organizer
      新学術領域研究 環境記憶統合 第3回若手の回
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comprehensive analysis of genes involved in salicylic acid biosynthesis in Arabidopsis thaliana2017

    • Author(s)
      Emi Okada, Mika Nomoto, Yasuomi Tada
    • Organizer
      新学術領域研究 環境記憶統合 第3回若手の回
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transcriptional context switches plant immune cofactors between activator and repressor behavior2016

    • Author(s)
      Mika Nomoto, Michael J. Skelly, Tomotaka Itaya, Hironaka Tsukagoshi, Tsuyoshi Mori, Takamasa Suzuki, Nodoka Oka, Tomonao Matsushita, Mutsutomo Tokizawa, Hitoshi Mori, Yoshiharu Y. Yamamoto, Tetsuya Higashiyama, Steven H. Spoel and Yasuomi Tada
    • Organizer
      Cold Spring Harbor Asia conference
    • Place of Presentation
      淡路島
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reciprocal regulation between salicylate- and jasmonate-responsive transcription factors in plant immunity2016

    • Author(s)
      野元美佳
    • Organizer
      新学術領域研究 環境記憶統合 第2回若手の回
    • Place of Presentation
      熱海
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 植物免疫系の制御因子であるNPR1とJAZが制御するERF1依存的な遺伝子発現機構の解析2016

    • Author(s)
      野元美佳・板谷知健・岡 和・鈴木孝征・森 毅・塚越啓央・松下智直・時澤睦朋・山本義治・東山哲也・Steven H. Spoel・多田安臣
    • Organizer
      日本植物学会第80会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Remarks] 名古屋大学遺伝子実験施設

    • URL

      https://www.gene.nagoya-u.ac.jp/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-06-09  

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