| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
We have developed an exceptionally chemoselective aerobic alcohol oxidation using AZADO/copper catalysis, which allows the presence of oxidation-labile functional groups, e.g. unprotected amino- and divalent sulfur groups. Based on the AZADO/copper system, a chirally modified AZADO has been designed to identify chemo- and enantioselective aerobic OKR of aliphatic secondary alcohols. We have also disclosed that Ln(OTf)3 enables catalytic intramolecular aminolysis of 3,4-epoxy-1-amines to give 2-substituted 3-hydroxypyrrolidines via unprecedented 5-endo-tet mode of cyclization.
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