| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Outline of Final Research Achievements |
We have studied on the total synthesis of natural products having intriguing nitrogen-containing macrocyclic structures and biological activities useful for drug discovery. As a result, we have achieved the formal synthesis of haliclonin A. In addition, we have developed a useful method for the preparation of the key precursor for the synthesis of marineosins A and B. We have also developed highly stereocontrolled routes to C4-C9 and C10-C21 fragments of thermolide family of natural products.
|
