| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
We have succeeded in creating a novel dianionic phase-transfer catalyst to bring strongly electrophilic dicationic fluorinating reagent, Selectfluor to the organic phase, and thus spontaneous racemic reaction is minimized to achieve chirality control of fluorofunctionalization of alkenes. Various allylic amides underwent fluorocyclization in a highly stereoselectivie manner to give drug-like heterocyclic compounds. Additionally, we developed direct Csp3-H fluorination of benzylic and aliphatic substrates under photo-irradiation.
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