Studies of modulation mechanisms of NF-kB signaling by novel cGMP pathway
| Project/Area Number |
16H05084
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | NF-kB / cGMP / 自然免疫 / NF-κB経路 / 薬学 / 遺伝学 / 免疫学 |
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| Outline of Final Research Achievements |
Innate immunity is involved in chronic inflammatory diseases, cancer metastasis, and lifestyle diseases by recognition of self-ligands. Therefore, understanding of regulation mechanisms of innate immune system is indispensable for understanding of these diseases and drug discovery. We have identified novel cGMP signaling pathway that modulates NF-κB pathway in innate immunity. In this study, we investigated modulation mechanisms of NF-κB signaling by novel cGMP pathway.
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| Academic Significance and Societal Importance of the Research Achievements |
自然免疫系が、病原体成分だけでなく、自己由来のリガンド（内因性リガンド）も認識することが明らかとなってきた。その際、病原体成分では強い反応が一過的に誘導されるのに対して、内因性リガンドでは弱い反応が持続的に誘導され、慢性炎症となる。したがって、このような自然免疫応答の違いが、どのようにして生じるのかを理解することが重要である。本研究により、自然免疫系の中心的なシグナル伝達であるNF-κB経路の調節機構が明らかとなり、自然免疫制御機構の理解に重要な進展が見られた。
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Report
(4 results)
Research Products
(16 results)
