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Studies of modulation mechanisms of NF-kB signaling by novel cGMP pathway

Research Project

Project/Area Number 16H05084
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTohoku University

Principal Investigator

Kurata Shoichiro  東北大学, 薬学研究科, 教授 (90221944)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
KeywordsNF-kB / cGMP / 自然免疫 / NF-κB経路 / 薬学 / 遺伝学 / 免疫学
Outline of Final Research Achievements

Innate immunity is involved in chronic inflammatory diseases, cancer metastasis, and lifestyle diseases by recognition of self-ligands. Therefore, understanding of regulation mechanisms of innate immune system is indispensable for understanding of these diseases and drug discovery. We have identified novel cGMP signaling pathway that modulates NF-κB pathway in innate immunity. In this study, we investigated modulation mechanisms of NF-κB signaling by novel cGMP pathway.

Academic Significance and Societal Importance of the Research Achievements

自然免疫系が、病原体成分だけでなく、自己由来のリガンド(内因性リガンド)も認識することが明らかとなってきた。その際、病原体成分では強い反応が一過的に誘導されるのに対して、内因性リガンドでは弱い反応が持続的に誘導され、慢性炎症となる。したがって、このような自然免疫応答の違いが、どのようにして生じるのかを理解することが重要である。本研究により、自然免疫系の中心的なシグナル伝達であるNF-κB経路の調節機構が明らかとなり、自然免疫制御機構の理解に重要な進展が見られた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (16 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Remarks (1 results)

  • [Int'l Joint Research] グラスゴー大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] グラスゴー大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Unexpected role of the IMD pathway in Drosophila gut defense against Staphylococcus aureus2018

    • Author(s)
      Hori A, Kurata S, Kuraishi T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 1 Pages: 395-400

    • DOI

      10.1016/j.bbrc.2017.11.004

    • NAID

      120006375092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel mode of induction of the humoral innate immune response in Drosophila larvae2017

    • Author(s)
      Hiroyuki Kenmoku, Aki Hori, Takayuki Kuraishi, and Shoichiro Kurata
    • Journal Title

      Disease Models & Mechanisms

      Volume: 10 Issue: 3 Pages: 271-281

    • DOI

      10.1242/dmm.027102

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subset of neurons controls the permeability of the peritrophic matrix and midgut structure in Drosophila adults.2016

    • Author(s)
      Hiroyuki Kenmoku, Hiroki Ishikawa, Manabu Ote, Takayuki Kuraishi, Shoichiro Kurata
    • Journal Title

      J. Exp. Biol.

      Volume: 219 Pages: 2331-2339

    • DOI

      10.1242/jeb.122960

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Neural control of host resistance to ingested bacteria in Drosophila2018

    • Author(s)
      Shoichiro Kurata
    • Organizer
      International Symposium for Infectious Diseases: Vector-borne Diseases
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intestinal autophagy suppresses unnecessary damage response induced by non-pathogenic enteric bacteria through Ref(2)P regulation.2018

    • Author(s)
      Hiroki Nagai, Hiroshi Tatara, Shoichiro Kurata, Tamaki Yano
    • Organizer
      13th Japanese Drosophila Research Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ腸管免疫の神経制御2018

    • Author(s)
      鈴木拓朗、石橋謙太朗、布施直之、倉田祥一朗
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ショウジョウバエを用いた自然免疫の記憶機構の解析2018

    • Author(s)
      岡森千咲、布施直之、倉田祥一朗
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neural control of gut homeostasiss in Drosophila immunity2017

    • Author(s)
      Shoichiro Kurata
    • Organizer
      The Tohoku Forum for Creativity Thematic Program 2017 New Horizons in Food Science via Agricultural Immunology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ショウジョウバエ自然免疫における細菌認識と感染防御2017

    • Author(s)
      倉田祥一朗
    • Organizer
      第70回日本細菌学会九州支部総会、第54回日本ウイルス学会九州支部総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neural control of gut homeostasiss in Drosophila immunity2017

    • Author(s)
      Shoichiro Kurata
    • Organizer
      The 2017 Japan-NIH Joint Symposium
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] E3 ubiquitin ligase Sherpa mediates Toll innate immune signaling in Drosophila2016

    • Author(s)
      Takayuki Kuraishi, Kanoh Hirotaka, Li-Li Tong, Shoichiro Kurata
    • Organizer
      57th Annual Drosophila Research Conference
    • Place of Presentation
      Florida, USA
    • Year and Date
      2016-07-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural control of gut homeostasiss in Drosophila immunity2016

    • Author(s)
      Shoichiro Kurata
    • Organizer
      The 2nd Asian Invertebrate Immunology Symposium
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 昆虫の自然免疫を支える異物パターン認識2016

    • Author(s)
      倉田祥一朗
    • Organizer
      日本比較免疫学会第28回学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院薬学研究科生命機能解析学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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