| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we examined the phenotypic analyses of KO mice of LysoPS receptors which was identified in our laboratory.Since LysoPS receptors are specifically expressed in immune cells such as T and B cells, we examined the antigen immune responses in the LysoPS receptor KO mice. In the antigen-immunized model, significant increase in the numbers of T cells and B cells was observed in KO mice, which revealed that LysoPS signal exerts an immunosuppressive function. In addition, we found that LysoPS was significantly increased in the situation where lymphocytes were activated. The information will help to understand the synthetic pathway of LysoPS in the future study.
|
