A novel immunomodulatory role of a lysophospholipid mediator, lysophosphatidylserine,, in lynphocytes.
| Project/Area Number |
16H05085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
AOKI JUNKEN 東北大学, 薬学研究科, 教授 (20250219)
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| Research Collaborator |
Ohwada Tomohiko , 教授
Yatomi Yutaka , 教授
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | リゾリン脂質 / 生理活性脂質 / GPCR / 抗原免疫 / B細胞 / リゾホスファチジルセリン / リンパ球 / 免疫 / 抗体 / セリン / ホスホリパーゼ / ノックアウトマウス |
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| Outline of Final Research Achievements |
In this study, we examined the phenotypic analyses of KO mice of LysoPS receptors which was identified in our laboratory.Since LysoPS receptors are specifically expressed in immune cells such as T and B cells, we examined the antigen immune responses in the LysoPS receptor KO mice. In the antigen-immunized model, significant increase in the numbers of T cells and B cells was observed in KO mice, which revealed that LysoPS signal exerts an immunosuppressive function. In addition, we found that LysoPS was significantly increased in the situation where lymphocytes were activated. The information will help to understand the synthetic pathway of LysoPS in the future study.
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| Academic Significance and Societal Importance of the Research Achievements |
GPCRは創薬の標的として有望である。本研究では、これまで未解明だった生理活性脂質リゾホスファチジルセリン（LysoPS）のGPCRを介する機能を世界に先駆けて明らかにすることができた。ホスファチジルセリン（PS）が免疫系に深く関与することは示唆されていたが、PSの一部はLysoPSに変換され機能することが想定される。本知見は、新規生理活性脂質の生体内機能を明らかにしたという、基礎的な貢献だけでなく、新規免疫抑制剤開発のための新たな分子標的を提供したという点においても、新規創薬を促進する極めて有用な情報となり得る。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites.2017
Author(s)
Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
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Journal Title
J. Lipid Res
Volume: 58
Issue: 4
Pages: 763-771
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction2016
Author(s)
Nagura, Y., Tsuno, NH., Kano, K., Inoue, A., Aoki, J., Hirowatari, Y., Kaneko, M., Kurano, M., Matsuhashi, M., Ohkawa, R., Tozuka, M., Yatomi, Y., and Okazaki, H.
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Journal Title
Transfus. Med.
Volume: 26
Issue: 5
Pages: 365-372
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine, an Emerging Lysophospholipid Mediator, Affords Compounds with Receptor Subtype Selectivity2016
Author(s)
Sejin Jung, Asuka Inoue, Sho Nakamura, Takayuki Kishi, Akiharu Uwamizu, Misa Sayama, Masaya Ikubo, Yuko Otani, Kuniyuki Kano, Kumiko Makide, Junken Aoki, Tomohiko Ohwada
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Journal Title
The Journal of Medicinal Chemistry
Volume: 59
Issue: 8
Pages: 3750-3776
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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