Manipulation of cellular function by forced ubiquitylation

• Project/Area Number: 16H05090
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: National Institute of Health Sciences
• Principal Investigator: NAITO MIKIHIKO 国立医薬品食品衛生研究所, 遺伝子医薬部, 部長 (00198011)
• Co-Investigator(Kenkyū-buntansha): 服部 隆行 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 (50377751)
• Research Collaborator: DEMIZU YOSUKE
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: ユビキチン / プロテアソーム / タンパク質分解 / プロテインノックダウン / SNIPER / エストロゲン受容体 / アンドロゲン受容体 / BCR-ABL / タンパク質 / Hisタグ / 蛋白質

Outline of Final Research Achievements

Based on our protein knockdown technology, we developed a number of Specific and Nongenetic IAP-dependent Protein Erasers (SNIPERs) that can induce the ubiquitylation and proteasomal degradation of estrogen receptor-alpha, androgen receptor, BCR-ABL, BRD4 and His-tagged proteins etc. We demonstrated that SNIPERs can target cytosolic, nuclear and membrane-anchored proteins for degradation, and clarified the degradation mechanism of target proteins and IAPs. We also showed that SNIPER against BCR-ABL protein can exhibit a potent anti-cancer effect even after the drug removal, which contrasts a kinase inhibitor whose anti-cancer effect diminished immediately after the drug removal. Protein degradation by SNIPERs can show pharmacologically different effects as compared with functional inhibitors.

Academic Significance and Societal Importance of the Research Achievements

SNIPER技術は研究代表者らが開発した独自技術であり、細胞内で標的タンパク質のユビキチン修飾が引き起こす直接的な影響を解析する事ができる。本研究で開発したSNIPER化合物を利用して学術的にも有意義な新しい知見が得られる可能性がある。またこの技術では任意の標的タンパク質を特異的に分解するSNIPER化合物を合理的に開発する事ができ、従来技術では阻害剤を開発する事が難しい標的タンパク質を狙って分解するSNIPERを開発する事も期待される。新しい創薬技術としても有望であり、社会的意義も高い。

Research Products

• [Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER) (2019)
  • Author(s): Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 67 Issue: 3 Pages: 203-209
  • DOI: 10.1248/cpb.c18-00567
  • NAID: 130007607114
  • ISSN: 0009-2363, 1347-5223
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein (2019)
  • Author(s): Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 67 Issue: 3 Pages: 165-172
  • DOI: 10.1248/cpb.c18-00703
  • NAID: 130007606378
  • ISSN: 0009-2363, 1347-5223
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SNIPERs - Hijacking IAP activity to induce protein degradation. (2019)
  • Author(s): Naito M, Ohoka N, Shibata N.
  • Journal Title: Drug Discovery Today: Technology Volume: 印刷中 Pages: 481-488
  • DOI: 10.1016/j.ddtec.2018.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase (2018)
  • Author(s): Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 13549-13549
  • DOI: 10.1038/s41598-018-31913-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation (2018)
  • Author(s): Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
  • Journal Title: Journal of Biological Chemistry Volume: 293 Issue: 18 Pages: 6776-6790
  • DOI: 10.1074/jbc.ra117.001091
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins (2018)
  • Author(s): K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
  • Journal Title: J Med Chem. Volume: 61 Issue: 2 Pages: 576-582
  • DOI: 10.1021/acs.jmedchem.7b00413
  • Peer Reviewed
• [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide (2017)
  • Author(s): T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Issue: 18 Pages: 4478-4481
  • DOI: 10.1016/j.bmcl.2017.08.001
  • Peer Reviewed
• [Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. (2017)
  • Author(s): Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
  • Journal Title: Cancer Sci Volume: 108 Issue: 5 Pages: 1032-1041
  • DOI: 10.1111/cas.13198
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH1 (2017)
  • Author(s): Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 22 Pages: 4985-4988
  • DOI: 10.1016/j.bmcl.2017.10.011
  • Peer Reviewed
• [Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands (2017)
  • Author(s): Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
  • Journal Title: Cancer Science Volume: 108 Issue: 8 Pages: 1657-1666
  • DOI: 10.1111/cas.13284
  • Peer Reviewed / Open Access
• [Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands (2017)
  • Author(s): Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
  • Journal Title: Journal of Medicinal Chemistry Volume: 61 Issue: 2 Pages: 543-575
  • DOI: 10.1021/acs.jmedchem.7b00168
  • Peer Reviewed
• [Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation (2017)
  • Author(s): Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 8 Issue: 10 Pages: 1042-1047
  • DOI: 10.1021/acsmedchemlett.7b00247
  • Peer Reviewed
• [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters. (2017)
  • Author(s): Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
  • Journal Title: Bioorg Med Chem. Volume: 25(6) Issue: 6 Pages: 1846-1851
  • DOI: 10.1016/j.bmc.2017.01.044
  • Peer Reviewed
• [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. (2017)
  • Author(s): Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
  • Journal Title: Mol pharmacol Volume: 91 Issue: 3 Pages: 159-166
  • DOI: 10.1124/mol.116.105569
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). (2017)
  • Author(s): Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
  • Journal Title: J Biol Chem Volume: 292 Issue: 11 Pages: 4556-4570
  • DOI: 10.1074/jbc.m116.768853
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells (2016)
  • Author(s): K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
  • Journal Title: Methods Mol. Biol. Volume: 1366 Pages: 549-560
  • DOI: 10.1007/978-1-4939-3127-9_42
  • ISBN: 9781493931262, 9781493931279
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy. (2016)
  • Author(s): Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
  • Journal Title: Curr Cancer Drug Targets Volume: 16 Pages: 136-146
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. (2016)
  • Author(s): Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
  • Journal Title: Bioorg Med Chem Lett Volume: 26 Issue: 20 Pages: 4865-4869
  • DOI: 10.1016/j.bmcl.2016.09.041
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook (2018)
  • Author(s): Mikihiko Naito
  • Organizer: EFMC-ISMC 2018
  • Int'l Joint Research / Invited
• [Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 第62回日本薬学会関東支部大会
  • Invited
• [Presentation] SNIPERによるプロテインノックダウン技術の開発 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 理研第４回DMP創薬ワークショップ
  • Invited
• [Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins (2018)
  • Author(s): Mikihiko Naito
  • Organizer: 薬物動態懇話会第41回年会
  • Invited
• [Presentation] キメラ型タンパク質分解薬SNIPERの開発 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 日本薬学会第139年会
  • Invited
• [Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 第91回日本内分泌学会学術総会
  • Invited
• [Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 日経バイオテクプロフェッショナルセミナー 低分子薬の新たなモダリティ：標的蛋白質分解誘導薬の最前線
  • Invited
• [Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発 (2018)
  • Author(s): 内藤幹彦
  • Organizer: 日本がん分子標的治療学会 鶴尾隆賞 受賞講演
  • Invited
• [Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases (2018)
  • Author(s): Mikihiko Naito
  • Organizer: 第41回日本分子生物学会年会
  • Invited
• [Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea (2018)
  • Author(s): Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
  • Organizer: 日本薬学会第139年会 国際創薬シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases (2018)
  • Author(s): Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity (2018)
  • Author(s): Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発 (2018)
  • Author(s): 大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
  • Organizer: 日本薬学会第139年会
• [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解 (2018)
  • Author(s): 内藤幹彦、大岡伸通、柴田識人、服部隆行
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands (2018)
  • Author(s): Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs. (2018)
  • Author(s): Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発 (2017)
  • Author(s): 大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-25
• [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発 (2017)
  • Author(s): 柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-25
• [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発 (2017)
  • Author(s): 沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-25
• [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases (2017)
  • Author(s): Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
  • Organizer: EMBO conference Ubiquitin and SUMO
  • Int'l Joint Research
• [Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases (2017)
  • Author(s): Mikihiko Naito
  • Organizer: 2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Degradation of oncogenic proteins by SNIPER compounds. (2017)
  • Author(s): Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発 (2017)
  • Author(s): 大岡伸通、柴田識人、服部隆行、内藤幹彦
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation (2017)
  • Author(s): Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析 (2017)
  • Author(s): 築茂由則、鈴木孝昌、内藤幹彦
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製 (2017)
  • Author(s): 鈴木孝昌、築茂由則、内藤幹彦、小原有弘
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン (2017)
  • Author(s): 大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
  • Organizer: 第21回日本がん分子標的治療学会 学術集会
• [Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases (2016)
  • Author(s): Mikihiko Naito
  • Organizer: The 21th 国際化学療法シンポジウム
  • Place of Presentation: 日本科学未来館（東京）
  • Year and Date: 2016-12-14
  • Int'l Joint Research / Invited
• [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用 (2016)
  • Author(s): 大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜国際会議場（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL (2016)
  • Author(s): Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜国際会議場（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価 (2016)
  • Author(s): 大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜国際会議場（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築 (2016)
  • Author(s): 服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-09-25
• [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン (2016)
  • Author(s): 大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立 (2016)
  • Author(s): 中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Presentation] 細胞内His タグタンパク質分解誘導剤の開発 (2016)
  • Author(s): 沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
  • Organizer: 第60回日本薬学会関東支部大会
  • Place of Presentation: 東京大学（東京）
• [Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発 (2016)
  • Author(s): 藤里卓磨、正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
  • Organizer: 第60回日本薬学会関東支部大会
  • Place of Presentation: 東京大学（東京）
• [Remarks]
  • URL: http://www.nihs.go.jp/mtgt/research.html
• [Remarks] 国立医薬品食品衛生研究所遺伝子医薬部 研究概要
  • URL: http://www.nihs.go.jp/mtgt/research.html