| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
In this project, we aimed to create the antigene method, which is an oligonucleotide therapeutic that acts directly on abnormal genes and specifically inhibits their expression. We succeeded in the chemical synthesis of an artificial nucleic acid capable of binding to a gene region that can not be bound by natural nucleic acid, and revealed that stable and selective triplex DNA formation can be formed. Furthermore, we also succeeded in developing a new nuclear delivery technology, and succeeded in effectively inhibiting gene expression by antigene oligonucleotides having the artificial nucleic acid.
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