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Expanded chemical properties of novel caged NOs and biological applications

Research Project

Project/Area Number 16H05103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionNagoya City University

Principal Investigator

Nakagawa Hidehiko  名古屋市立大学, 大学院薬学研究科, 教授 (80281674)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywordsケミカルバイオロジー / 光化学 / ケージド化合物 / 超音波 / 放射線
Outline of Final Research Achievements

Nitric oxide (NO) is an essential signal mediator, but it is unstable and not easy to handle. Caged compound is one of the useful compound category, and we have been developed caged NOs and the caged compounds of the species related to NO. In this project, we have developed novel caged NOs. One of them is a caged NO responding to yellowish-green light irradiation, which was found to be applicable to ex vivo experiments. The second is a nanoparticle version of caged NO. The third one is a version of caged NO responding to red light which was also applicable to ex vivo experiments.

Academic Significance and Societal Importance of the Research Achievements

本研究では種々のケージドNOの開発に成功し、実際に生物実験系で応用可能であることを示した。これらの化合物をさらに精査することで、NOの生理作用(血管拡張やがん細胞抑制)を利用した治療研究への応用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016 Other

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Structure-efficiency relationship of photoinduced electron transfer-triggered nitric oxide releasers.2019

    • Author(s)
      Ieda N, Oka Y, Yoshihara T, Tobita S, Sasamori T, Kawaguchi M, Nakagawa H
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 1430-1430

    • DOI

      10.1038/s41598-018-38252-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photo‐Controlled Release of Small Signaling Molecules to Induce Biological Responses2018

    • Author(s)
      Nakagawa Hidehiko
    • Journal Title

      The Chemical Record

      Volume: 18 Issue: 12 Pages: 1708-1716

    • DOI

      10.1002/tcr.201800035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets2017

    • Author(s)
      Sun Lue、Moritake Takashi、Ito Kazuya、Matsumoto Yoshitaka、Yasui Hironobu、Nakagawa Hidehiko、Hirayama Aki、Inanami Osamu、Tsuboi Koji
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 4 Pages: 1-24

    • DOI

      10.1371/journal.pone.0176162

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicolor protein FRET with tryptophan, selective coumarin-cysteine labeling, and genetic acridonylalanine encoding2017

    • Author(s)
      Ferrie John J.、Ieda Naoya、Haney Conor M.、Walters Christopher R.、Sungwienwong Itthipol、Yoon Jimin、Petersson E. James
    • Journal Title

      Chem. Commun.

      Volume: 53 Issue: 80 Pages: 11072-11075

    • DOI

      10.1039/c7cc05492k

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A yellowish-green-light-controllable nitric oxide donor based on N-nitrosoaminophenol applicable for photocontrolled vasolidation2017

    • Author(s)
      Okuno H, Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 15 Issue: 13 Pages: 2791-2796

    • DOI

      10.1039/c7ob00245a

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Photocontrol of NO, H<sub>2</sub>S, and HNO Release in Biological Systems by Using Specific Caged Compounds2016

    • Author(s)
      Hidehiko Nakagawa
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 9 Pages: 1249-1255

    • DOI

      10.1248/cpb.c16-00403

    • NAID

      130005261602

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser2016

    • Author(s)
      Yuji Hotta, Naoya Ieda, Ayako Fukumoto, Tomoya Kataoka, Yoshihiro Kawade, Yasuhiro Maeda, Hidehiko Nakagawa, and Kazunori Kimura
    • Journal Title

      Investig. Clin. Urol.

      Volume: 57 Issue: 3 Pages: 215-220

    • DOI

      10.4111/icu.2016.57.3.215

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] (7-Diethylaminocomarin-4-yl)methyl Ester of Suberoylanilide Hydroxamic Acid as a Caged Inhibitor for Photocontrol of Histone Deacetylase Activity2016

    • Author(s)
      Naoya Ieda, Sota Yamada, Mitsuyasu Kawaguchi, Naoki Miyata, and Hidehiko Nakagawa
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 24 Issue: 12 Pages: 2789-2793

    • DOI

      10.1016/j.bmc.2016.04.042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visible Light-Controlled Nitric Oxide Release from Hindered Nitrobenzene Derivatives for Specific Modulation of Mitochondrial Dynamics2016

    • Author(s)
      Kai Kitamura, Mitsuyasu Kawaguchi, Naoya Ieda, Naoki Miyata, and Hidehiko Nakagawa
    • Journal Title

      ACS Chem. Biol.

      Volume: 11 Issue: 5 Pages: 1271-1278

    • DOI

      10.1021/acschembio.5b00962

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional chemical donors for investigation of reactive sulfide species2016

    • Author(s)
      Hidehiko Nakagawa
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 147 Issue: 5 Pages: 294-298

    • DOI

      10.1254/fpj.147.294

    • NAID

      130005150961

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Photo-controllable nitric oxide releasers for manipulation of biological responses2018

    • Author(s)
      Hidehiko Nakagawa
    • Organizer
      16th Annual meeting of the Society for Free Radical Research India 2018
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Photo-controllable NO releasers and induction of biological responses2018

    • Author(s)
      Hidehiko Nakagawa
    • Organizer
      International symposium on caged compounds
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 特異的化学反応の発見から生物作用化合物の設計へ~光制御一酸化窒素投与剤の開発~2018

    • Author(s)
      中川秀彦
    • Organizer
      分子技術シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of Visible light-controllable NO donors and their biological applications2017

    • Author(s)
      ?ソNaoya Ieda, Hana Okuno, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan eighth International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photo-controllable Mitochondria-targeting Nitric Oxide Releasers and Modulation of Mitochondrial Dynamics2017

    • Author(s)
      Kai Kitamura, Mitsuyasu Kawaguchi, Naoya Ieda, Kauhiro Hishikawa, Takayoshi Suzuki, Naoki Miyata, Hidehiko Nakagawa
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan eighth International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photocontrollable hydrogen sulfide releaser with an acridone moiety2016

    • Author(s)
      Keisuke Shimoya, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
    • Organizer
      ACS National Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nitric oxide donor controllable with yellowish green light2016

    • Author(s)
      Hana Okuno, Naoya Ieda, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
    • Organizer
      ACS National Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photocontrolled release of NO and related species with small chemical tools2016

    • Author(s)
      Hidehiko Nakagawa
    • Organizer
      9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondria-Targeting Nitric Oxide Releasers Controllable with Visible Light and Manipulation of Mitochondrial Dynamics2016

    • Author(s)
      Kai Kitamura, Misuyasu Kawaguchi, Naoya Ieda, Kazuhiro Hishikawa, Takayoshi Suzuki, Naoki Miyata, Hidehiko Nakagawa
    • Organizer
      9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 薬化学|公立大学法人 名古屋市立大学 大学院薬学研究科・薬学部

    • URL

      https://www.nagoya-cu.ac.jp/phar/grad/soyaku/iyaku/yakka.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 薬化学分野 | 公立大学法人 名古屋市立大学大学院薬学研究科・薬学部

    • URL

      http://www.nagoya-cu.ac.jp/phar/grad/soyaku/iyaku/yakka.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 薬化学|公立大学法人 名古屋市立大学 大学院薬学研究科・薬学部

    • URL

      http://www.nagoya-cu.ac.jp/phar/grad/soyaku/iyaku/yakka.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ナノ粒子、水性分散液、一酸化窒素放出制御剤2019

    • Inventor(s)
      中川秀彦、家田直弥、川口充康
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-051163
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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