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Screening of molecular target for cancer therapy by using chemical genetics and functional genomics

Research Project

Project/Area Number 16H05105
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

DAN shingo  公益財団法人がん研究会, がん化学療法センター 分子薬理部, 部長 (70332202)

Co-Investigator(Kenkyū-buntansha) 田中 伯享  公益財団法人がん研究会, がん化学療法センター 分子薬理部, 研究員 (30815882)
大橋 愛美  公益財団法人がん研究会, がん化学療法センター 分子薬理部, 主任研究助手 (50727427)
赤塚 明宣  公益財団法人がん研究会, がん化学療法センター 分子薬理部, 研究員 (30649364)
Research Collaborator MATSUURA masaaki  
USHIJIMA masaru  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsケミカルジェネティクス / 機能ゲノミクス / がん脆弱性遺伝子 / 分子標的治療薬 / データベース / アンメットニーズ / 新規標的分子 / ケミカルバイオロジー / 分子標的 / がん依存性マップ / 脆弱性 / 合成致死 / 薬剤反応性 / インフォマティクス / 遺伝子異常
Outline of Final Research Achievements

The goal of the present study is to identify novel anticancer targets and develop targeted therapies to meet cancer unmet needs, such as the failure of existing chemotherapeutic drugs and targeted cancer drugs. In this study, taking advantage of our original JFCR39 panel consisting of 39 human cancer cell lines and the accompanying drug sensitivity database, we explored anticancer agents that showed strong anticancer effect to some of the 39 cell lines but did not affect the growth and survival of the rest of them. Using such anticancer agents, we established a unique methodology for identifying candidates for novel vulnerable genes and the drugs targeting them.

Academic Significance and Societal Importance of the Research Achievements

当部で開発されたJFCR39パネルは、種々の抗がん物質の同定や作用機序解析に使われてきた実績がある。特定のがん細胞に選択的な効果を示す薬剤をデータベースより抽出し、がんの脆弱性遺伝子探索のバイオプローブとして利用するストラテジーは独創的で、思いがけないがんの脆弱性が明らかになることが期待され、実際に見つかりつつある。ここで見出された化合物は脆弱性遺伝子を標的とするリード化合物ともなり、創薬的見地でも有利である。またアッセイ済みの薬剤として抗がん剤以外の医薬品も多数含まれており、ドラッグリポジショニングという観点からも興味深い。がんのアンメットニーズに応える新規治療法の開発へ応用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (47 results)

All 2019 2018 2017 2016 2009 Other

All Journal Article (19 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 19 results,  Open Access: 11 results,  Acknowledgement Compliant: 4 results) Presentation (26 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin2018

    • Author(s)
      Koutaro Hayakawa, Yusuke Hanaki, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie
    • Journal Title

      Heterocycles

      Volume: 97 Issue: 1 Pages: 478-492

    • DOI

      10.3987/com-18-s(t)37

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling2018

    • Author(s)
      Kawasaki Natsumi、Isogaya Kazunobu、Dan Shingo、Yamori Takao、Takano Hiroshi、Yao Ryoji、Morishita Yasuyuki、Taguchi Luna、Morikawa Masato、Heldin Carl-Henrik、Noda Tetsuo、Ehata Shogo、Miyazono Kohei、Koinuma Daizo
    • Journal Title

      Cell Discovery

      Volume: 4 Issue: 1 Pages: 1-16

    • DOI

      10.1038/s41421-017-0001-2

    • NAID

      120006902800

    • URL

      https://pure.teikyo.jp/en/publications/1ee5929f-9e7c-4d39-ad9e-8f2d6947ed29

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase2018

    • Author(s)
      Kitamura Kai、Itoh Hiroaki、Sakurai Kaori、Dan Shingo、Inoue Masayuki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Issue: 38 Pages: 12189-12199

    • DOI

      10.1021/jacs.8b07339

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines.2018

    • Author(s)
      Namatame N, Tamaki N, Yoshizawa Y, Okamura M, Nishimura Y, Yamazaki K, Tanaka M, Nakamura T, Semba K, Yamori T, Yaguchi SI, Dan S.
    • Journal Title

      Oncotarget.

      Volume: 9(80) Issue: 80 Pages: 35141-35161

    • DOI

      10.18632/oncotarget.26216

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.2018

    • Author(s)
      Hayakawa K, Hanaki Y, Tokuda H, Yanagita RC, Nakagawa Y, Okamura M, Dan S, Irie K.
    • Journal Title

      Heterocycles

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.2017

    • Author(s)
      Benabdi S, Peurois F, Nawrotek A, Chikireddy J, Caneque T, Yamori T, Shiina I, Ohashi Y, Dan S, Rodriguez R, Cherfils J, Zeghouf M.
    • Journal Title

      Biochemistry (Mosc)

      Volume: 56(38) Issue: 38 Pages: 5125-5133

    • DOI

      10.1021/acs.biochem.7b00706

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities2017

    • Author(s)
      Yusuke Hanaki, Masayuki Kikumori, Harukini Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie
    • Journal Title

      Molecules

      Volume: 22 Issue: 4 Pages: 631-631

    • DOI

      10.3390/molecules22040631

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines2017

    • Author(s)
      Takuya Matsumoto, Naoto Kojima, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 17 Pages: 2359-2366

    • DOI

      10.1016/j.tet.2017.03.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017

    • Author(s)
      Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori, and Shingo Dan
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 2 Pages: 1641-1655

    • DOI

      10.18632/oncotarget.22895

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I.2016

    • Author(s)
      Akatsuka A, Kojima N, Okamura M, Dan S, Yamori T.
    • Journal Title

      Pharmacol Res Perspect.

      Volume: 4(4) Issue: 4

    • DOI

      10.1002/prp2.246

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] M-COPA, a Golgi disruptor, inhibits cell surface expression of MET protein and exhibits antitumor activity against MET-addicted cancers.2016

    • Author(s)
      Ohashi Y, Okamura M, Hirosawa A, Akatsuka A, Shiina I, Yoshimatsu K, Yamori T, Dan S.
    • Journal Title

      Cancer Res

      Volume: in press Issue: 13 Pages: 3895-3903

    • DOI

      10.1158/0008-5472.can-15-2220

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.2016

    • Author(s)
      Hattori T, Watanabe-Takahashi M, Shiina I, Ohashi Y, Dan S, Nishikawa K, Yamori T, Naito M.
    • Journal Title

      Genes Cells.

      Volume: 21(8) Issue: 8 Pages: 901-906

    • DOI

      10.1111/gtc.12386

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model2016

    • Author(s)
      Matsumoto, Y., Tsujimoto, H., Ono, S., Shinomiya, N., Miyazaki, H., Hiraki, S., Takahata, R., Yoshida, K., Saitoh, D., Yamori, T., Yamamoto, J., and Hase, K.
    • Journal Title

      Annals of Surgical Oncology

      Volume: 23, Supplement 2 Issue: S2 Pages: 257-265

    • DOI

      10.1245/s10434-015-4466-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.2016

    • Author(s)
      Narita K, Matsuhara K, Itoh J, Akiyama Y, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 121 Pages: 592-609

    • DOI

      10.1016/j.ejmech.2016.05.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses.2016

    • Author(s)
      Okada M, Mei ZW, Hossain MI, Tominaga T, Takebayashi T, Murakami M, Yasuda M, Shigehiro T, Kasai T, Mizutani A, Murakami H, El Sayed Iel T, Dan S, Yamori T, Seno M, Inokuchi T.
    • Journal Title

      Med Chem Res.

      Volume: 25(5) Issue: 5 Pages: 879-892

    • DOI

      10.1007/s00044-016-1508-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription.2016

    • Author(s)
      Takemoto Y, Ito A, Niwa H, Okamura M, Fujiwara T, Hirano T, Handa N, Umehara T, Sonoda T, Ogawa K, Tariq M, Nishino N, Dan S, Kagechika H, Yamori T, Yokoyama S, Yoshida M.
    • Journal Title

      J. Med. Chem.

      Volume: 59 Issue: 8 Pages: 3650-3660

    • DOI

      10.1021/acs.jmedchem.5b01732

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition2016

    • Author(s)
      Shota Uesugi, Nozomi Fujisawa, Jun Yoshida, Mitsuru Watanabe, Shingo Dan, Takao Yamori, Yoshihito Shiono, Ken-ichi Kimura
    • Journal Title

      The Journal of Antibiotics

      Volume: 69 Issue: 3 Pages: 133-140

    • DOI

      10.1038/ja.2015.103

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer.2016

    • Author(s)
      Suenaga M, Mashima T, Kawata N, Wakatsuki T, Horiike Y, Matsusaka S, Dan S, Shinozaki E, Seimiya H, Mizunuma N, Yamaguchi K, Yamaguchi T.
    • Journal Title

      Oncotarget.

      Volume: 7(23) Issue: 23 Pages: 34811-34823

    • DOI

      10.18632/oncotarget.9187

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5''-epi-Spiruchostatin B, FK228(FR901228) and Preliminary Evaluation of Their Biological Activity2009

    • Author(s)
      Koichi Narita, Takuya Kikuchi, Kazuhiro Watanabe, Toshiya Takizawa, Takamasa Oguchi, Kyosuke Kudo, Keisuke Matsuhara, Hideki Abe, Takao Yamori, Minoru Yoshida, Tadashi Katoh
    • Journal Title

      Chem. Eur. J.

      Volume: 15巻 Issue: 42 Pages: 11174-11186

    • DOI

      10.1002/chem.200901552

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゲフィチニブ感受性を起点としたErbB4依存性肺がん細胞株及びその増殖阻害薬の同定2019

    • Author(s)
      田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
    • Organizer
      2018年度新学術領域研究学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of ERBB4 as an actionable target by using selective anticancer effect of EGFR family tyrosine kinase inhibitors2019

    • Author(s)
      田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
    • Organizer
      第11回(2019年)日米がん合同会議
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antitumor profile of a PI3K inhibitor ZSTK474 and conventional chemotherapeutic agents across a panel of human sarcoma cell lines2019

    • Author(s)
      玉城尚美、生田目奈知、吉澤雄也、岡村睦美、西村由美子、山崎佳波、矢口信一、旦慎吾
    • Organizer
      第11回(2019年)日米がん合同会議
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規ゴルジ体阻害剤M-COPAに対する獲得耐性機構の解析2018

    • Author(s)
      赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、旦慎吾
    • Organizer
      第22回日本がん分子標的治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ErbB4に依存した増殖を示す肺がん細胞株とその治療薬の同定2018

    • Author(s)
      田中伯享、大橋愛美、旦慎吾
    • Organizer
      第22回日本がん分子標的治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん分子標的治療の基本講座 セッション21 「in vitro data の読み方」2018

    • Author(s)
      旦慎吾
    • Organizer
      第22回日本がん分子標的治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] スフェロイド培養下におけるゴルジ体阻害阻害剤M-COPAによる抗がん効果2018

    • Author(s)
      大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] HER4依存性細胞株におけるHERファミリーチロシンキナーゼ阻害剤の抗がん効果2018

    • Author(s)
      田中伯享、山崎佳波、大橋愛美、西村由美子、旦慎吾
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PI3K阻害剤ZSTK474の滑膜肉腫に対する抗がん効果の検討2018

    • Author(s)
      玉城尚美、生田目奈知、岡村睦美、矢口信一、旦慎吾
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗白血病薬クラドリビンの上皮がん細胞に対する抗がん効果2018

    • Author(s)
      佐久間貴大、岩澤卓弥、田中伯享、赤塚明宣、山崎佳波、長原礼宗、旦慎吾
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規抗がん物質M-COPAの三次元培養下における抗がん効果2017

    • Author(s)
      筒井咲妃、大橋愛美、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規ゴルジ阻害剤M-COPAのEGFR-TKI耐性がんに対する抗がん効果2017

    • Author(s)
      大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第21回 日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規ゴルジ体阻害剤M-COPAが抗腫瘍効果を示すがん細胞の探索2017

    • Author(s)
      赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第21回 日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大腸がん細胞株のタンキラーゼ阻害剤感受性を予測するAPC変異2017

    • Author(s)
      田中伯享、馬島哲夫、旦慎吾、杉本芳一、清宮啓之
    • Organizer
      第21回 日本がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a unique anticancer drug lead, M-COPA, by using JFCR39 cancer cell line panel: its mode of action and antitumor profile.2017

    • Author(s)
      旦慎吾
    • Organizer
      JSPS China-Japan symposium on Molecular Cancer Therapy and Drug Development
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム“がん個別化医療の革新を目指す新規治療戦略:がんの脆弱性”講演テーマ「ユニークな抗がん物質の同定と作用メカニズム」 『ゴルジ体を標的としたユニークな抗がん物質M-COPAの同定とその抗がんメカニズム』2017

    • Author(s)
      旦慎吾
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新規ゴルジ阻害剤M-COPAのEGFR阻害剤耐性肺がんに対する抗がん効果2017

    • Author(s)
      大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] M-COPA, a new Golgi disruptor, inhibited growth of RTK-addicted human cancer cells2016

    • Author(s)
      大橋愛美、岡村睦美、方偲央、筒井咲妃、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
    • Organizer
      28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      ドイツ・ミュンヘン
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規ゴルジ体阻害剤M-COPAの受容体チロシンキナーゼにアディクトしたがんへの抗がん効果2016

    • Author(s)
      大橋愛美、岡村睦美、方偲央、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゴルジ阻害剤M-COPAのin vivo抗がん作用におけるERストレスシグナルの関与2016

    • Author(s)
      赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] PI3K阻害剤ZSTK474のユーイング肉腫細胞への抗がん効果の検討2016

    • Author(s)
      吉澤雄也、玉城尚美、生田目奈知、西村由美子、山崎佳波、岡村睦美、矢守隆夫、矢口信一、旦慎吾
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規ゴルジ体阻害剤M-COPAの細胞表面タンパク質発現に与える影響2016

    • Author(s)
      方偲央、大橋愛美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞に聞け!化合物が拓く生命科学の新境地2016

    • Author(s)
      旦慎吾
    • Organizer
      平成28年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム】」若手支援技術講習会
    • Place of Presentation
      蓼科
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規ゴルジ阻害剤M-COPAのRTK依存がんに対する抗がん効果2016

    • Author(s)
      大橋愛美、赤塚明宣、岡村睦美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第20回 日本がん分子標的治療学会
    • Place of Presentation
      別府
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規ゴルジ阻害剤M-COPAの抗がん作用メカニズムに対するERストレスの関与2016

    • Author(s)
      赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
    • Organizer
      第20回 日本がん分子標的治療学会
    • Place of Presentation
      別府
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞パネルを用いたユニークな抗がん物質の同定と作用メカニズム解析2016

    • Author(s)
      旦慎吾
    • Organizer
      早稲田大学 理工学部/大学院理工学研究科 講演会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 実験医学増刊・動き始めたがんゲノム医療「がんにおけるPI3K/Akt/mTOR経路の異常とそれを標的とした治療法の開発」2018

    • Author(s)
      旦慎吾
    • Publisher
      羊土社
    • ISBN
      9784758103732
    • Related Report
      2018 Annual Research Report
  • [Remarks] 分子薬理部|部門紹介|がん化学療法センター

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/molecular_pharmacology/index.html

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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