Investigation of mechanisms enabling mammalian hibernation
| Project/Area Number |
16H05127
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
|---|
| Research Institution | Hokkaido University (2017-2018)
The University of Tokyo (2016) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Keywords | 冬眠 / 代謝 / 細胞死耐性 / 細胞死 / 低体温 |
|---|
| Outline of Final Research Achievements |
Hibernation is a strategy that enables long-term survival at hypothermia by systemic metabolic suppression under extreme environments such as cold, dryness, and starvation. Mechanisms for this remarkable "hibernation tolerance" granted to hibernating animal is, however, poorly understood yet, whereas it is suggested that the hibernation tolerance is partly induced from the pre-hibernation period to the hibernation period. In this study, we attempted to elucidate the mechanism of hibernation tolerance in a model hibernating animal, Syrian hamsters. By profiling basal body temperature and global gene expression at different timepoints, we found that changes in basal body temperature and white adipose tissue remodeling take place prior to hibernation in Syrian hamsters.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により、シリアンハムスターは冬眠前に全身リモデリングを行うことが明らかになった。特に白色脂肪組織においては、脂質の異化能と同化能の同時亢進が生じ、また褐色脂肪細胞様の細胞も生じてくることが明らかとなった。これら変化の分子機構をさらに追求することにより、餌の枯渇する長期間の冬を貯蔵脂肪で乗り切るという冬眠の脂質代謝制御戦略が明らかになるだけでなく、ヒトの肥満や糖尿病などの、生活習慣病への新たな治療の糸口が見えてくると期待される。
|
Report
(4 results)
Research Products
(33 results)
-
-
-
-
-
[Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017
Author(s)
Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
-
Journal Title
J Cell Sci
Volume: 130
Issue: 20
Pages: 3568-3577
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator2016
Author(s)
Chayama, Y., Ando, L., Tamura, Y., Miura, M., Yamaguchi, Y.
-
Journal Title
Royal Society Open Science, 2016, DOI: 10.1098/rsos.160002
Volume: 3
Issue: 4
Pages: 160002-160002
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Investigation of mechanisms for skeletal muscle maintenance during hibernation season in a mammalian hibernator, Syrian golden hamster.2017
Author(s)
Yamaguchi, Y., Fujimoto, T., Ando, L., Chayama, Y., Anegawa, D., Taii,H., Tamura,Y., Shigenobu,S., Miura, M.
Organizer
第94回日本生理学会
Place of Presentation
アクトシティ浜松（静岡、浜松）
Year and Date
2017-03-28
Related Report
-
-
-
-
-
-
-
-
[Presentation] Evidence for systemic remodeling prior to hibernation in the Syrian hamster (Mesocricetus auratus),2016
Author(s)
Yamaguchi, Y., Chayama, Y., Ando, L., Anegawa, D., Shigenobu, S., Fujimoto, T., Taii, H., Tamura, Y., Miura, M.
Organizer
15th International Hibernation Symposium
Place of Presentation
Las Vegas, USA.
Year and Date
2016-08-01
Related Report
Int'l Joint Research
-
[Presentation] Molecular remodeling of inguinal adipose tissue precedes hibernation period in Syrian golden hamster2016
Author(s)
Chayama, Y., Ando, L., Shigenobu, S., Tamura, Y., Miura, M., Yamaguchi, Y.
Organizer
15th International Hibernation Symposium
Place of Presentation
Las Vegas, USA.
Year and Date
2016-08-01
Related Report
Int'l Joint Research
-
[Presentation] Investigation of mechanisms for the resistance to ischemia-reperfusion stress during hibernation period in Syrian hamsters2016
Author(s)
Anegawa, D., Chayama, Y., Ando, L., Shigenobu, S., Miura, M. Yamaguchi, Y.
Organizer
15th International Hibernation Symposium
Place of Presentation
Las Vegas, USA.
Year and Date
2016-08-01
Related Report
Int'l Joint Research
-
[Presentation] Pre-hibernation remodeling accompanies decreases in body temperature and body weight in a facultative mammalian hibernator, Syrian hamster2016
Author(s)
Yamaguchi, Y., Chayama, Y., Ando, L., Tamura, Y., Miura, M
Organizer
第39回日本神経科学大会
Place of Presentation
パシフィコ横浜（神奈川、横浜）
Year and Date
2016-07-20
Related Report
-
[Presentation] Evidence for systemic remodeling prior to hibernation in the Syrian hamster (Mesocricetus auratus)2016
Author(s)
Yamaguchi, Y., Chayama, Y., Ando, L., Shigenobu, S., Anegawa, D., Fujimoto, T., Tamura, Y., Miura, M
Organizer
Evolution of Seasonal Timer, NIBB conference
Place of Presentation
Okazaki, Japan.
Year and Date
2016-04-22
Related Report
Int'l Joint Research
-
