| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Hibernation is a strategy that enables long-term survival at hypothermia by systemic metabolic suppression under extreme environments such as cold, dryness, and starvation. Mechanisms for this remarkable "hibernation tolerance" granted to hibernating animal is, however, poorly understood yet, whereas it is suggested that the hibernation tolerance is partly induced from the pre-hibernation period to the hibernation period. In this study, we attempted to elucidate the mechanism of hibernation tolerance in a model hibernating animal, Syrian hamsters. By profiling basal body temperature and global gene expression at different timepoints, we found that changes in basal body temperature and white adipose tissue remodeling take place prior to hibernation in Syrian hamsters.
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