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Investigation of mechanisms enabling mammalian hibernation

Research Project

Project/Area Number 16H05127
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionHokkaido University (2017-2018)
The University of Tokyo (2016)

Principal Investigator

Yamaguchi Yoshifumi  北海道大学, 低温科学研究所, 教授 (10447443)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords冬眠 / 代謝 / 細胞死耐性 / 細胞死 / 低体温
Outline of Final Research Achievements

Hibernation is a strategy that enables long-term survival at hypothermia by systemic metabolic suppression under extreme environments such as cold, dryness, and starvation. Mechanisms for this remarkable "hibernation tolerance" granted to hibernating animal is, however, poorly understood yet, whereas it is suggested that the hibernation tolerance is partly induced from the pre-hibernation period to the hibernation period. In this study, we attempted to elucidate the mechanism of hibernation tolerance in a model hibernating animal, Syrian hamsters. By profiling basal body temperature and global gene expression at different timepoints, we found that changes in basal body temperature and white adipose tissue remodeling take place prior to hibernation in Syrian hamsters.

Academic Significance and Societal Importance of the Research Achievements

本研究により、シリアンハムスターは冬眠前に全身リモデリングを行うことが明らかになった。特に白色脂肪組織においては、脂質の異化能と同化能の同時亢進が生じ、また褐色脂肪細胞様の細胞も生じてくることが明らかとなった。これら変化の分子機構をさらに追求することにより、餌の枯渇する長期間の冬を貯蔵脂肪で乗り切るという冬眠の脂質代謝制御戦略が明らかになるだけでなく、ヒトの肥満や糖尿病などの、生活習慣病への新たな治療の糸口が見えてくると期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016 Other

All Journal Article (7 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (25 results) (of which Int'l Joint Research: 13 results,  Invited: 8 results) Remarks (1 results)

  • [Journal Article] Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator2019

    • Author(s)
      Chayama Yuichi、Ando Lisa、Sato Yuya、Shigenobu Shuji、Anegawa Daisuke、Fujimoto Takayuki、Taii Hiroki、Tamura Yutaka、Miura Masayuki、Yamaguchi Yoshifumi
    • Journal Title

      Frontiers in Physiology

      Volume: 9 Pages: 1973-1973

    • DOI

      10.3389/fphys.2018.01973

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 冬眠する哺乳類が示す虚血再灌流傷害耐性2019

    • Author(s)
      姉川大輔,三浦正幸,山口良文
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 71 Pages: 170-176

    • NAID

      40021798120

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 哺乳類の冬眠を可能とする低体温耐性機構2018

    • Author(s)
      姉川大輔,三浦正幸,山口良文
    • Journal Title

      月刊「細胞」8月号

      Volume: 50

    • Related Report
      2018 Annual Research Report
  • [Journal Article] What enables hibernation? ~ insights from a mammalian hibernator, Syrian hamster2018

    • Author(s)
      山口良文
    • Journal Title

      岡山実験動物研究会報

      Volume: 34

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017

    • Author(s)
      Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
    • Journal Title

      J Cell Sci

      Volume: 130 Issue: 20 Pages: 3568-3577

    • DOI

      10.1242/jcs.200519

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural tube closure and embryonic metabolism2017

    • Author(s)
      Yamaguchi Yoshifumi、Miyazawa Hidenobu、Miura Masayuki
    • Journal Title

      Congenital Anomalies

      Volume: 57 Issue: 5 Pages: 134-137

    • DOI

      10.1111/cga.12219

    • NAID

      130008142315

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator2016

    • Author(s)
      Chayama, Y., Ando, L., Tamura, Y., Miura, M., Yamaguchi, Y.
    • Journal Title

      Royal Society Open Science, 2016, DOI: 10.1098/rsos.160002

      Volume: 3 Issue: 4 Pages: 160002-160002

    • DOI

      10.1098/rsos.160002

    • NAID

      120007007804

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Systemic body remodeling preceding hibernation in a mammalian hibernator, Syrian hamster2019

    • Author(s)
      Yoshifumi Yamaguchi
    • Organizer
      9th Fereration of te Asian and Oceanian Physiological Societies confress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シリアンハムスターの冬眠生活環と連動した遺伝子発現変化2018

    • Author(s)
      Yoshifumi Yamaguchi
    • Organizer
      第41回 日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 冬眠する哺乳類シリアンハムスターの細胞自律的な低温耐性2018

    • Author(s)
      姉川大輔、茶山由一、安藤理沙、泰井宙輝、重信秀治、佐藤佑哉1、三浦 正幸、山口良文
    • Organizer
      第41回 日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 哺乳類冬眠動物が冬眠期に骨格筋量を制御するメカニズムの解析2018

    • Author(s)
      佐藤佑哉、藤本貴之、茶山 由一、安藤理沙、姉川大輔、齊木選射、嘉糠洋陸、三浦正幸、山口 良文
    • Organizer
      第41回 日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Skeletal muscle atrophy before hibernation and recovery after hibernation in a mammalian hibernator, Syrian hamster.2018

    • Author(s)
      Yoshifumi Yamaguchi
    • Organizer
      Europhysiology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 冬眠する哺乳類に学ぶ、長期寒冷下での白色脂肪と骨格筋の可逆的リモデリング2018

    • Author(s)
      山口良文
    • Organizer
      アディポサイエンス研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 冬眠動物が有する低体温耐性機構の解明にむけて2018

    • Author(s)
      山口良文
    • Organizer
      第二回冬眠休眠研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 冬眠する哺乳類シリアンハムスターを用いた冬眠能の解析2018

    • Author(s)
      山口良文
    • Organizer
      モロシヌス研究会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Elucidating the roles and regulation of cell death in mammalian development and physiology2018

    • Author(s)
      Yoshifumi Yamaguchi
    • Organizer
      Australia-Japan Meeting on Cell Death
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 哺乳類の冬眠を可能とする生体状態とは?2018

    • Author(s)
      山口良文
    • Organizer
      生理研研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 冬眠する哺乳類シリアンハムスターの冬眠時における骨格筋繊維タイプシフト2018

    • Author(s)
      山口良文、藤本貴之、佐藤佑哉、安藤理沙、茶山由一、姉川大輔、泰井宙輝、重信秀治、三浦正幸
    • Organizer
      第95回日本生理学会年会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Understanding seasonal body remodeling in mammalian hibernation2018

    • Author(s)
      Yoshifumi Yamaguchi
    • Organizer
      KEY-FORUM: The 3rd International Symposium on Stem Cell Traits and Developmental Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Investigation of mechanisms for skeletal muscle maintenance during hibernation season in a mammalian hibernator, Syrian golden hamster.2017

    • Author(s)
      Yamaguchi, Y., Fujimoto, T., Ando, L., Chayama, Y., Anegawa, D., Taii,H., Tamura,Y., Shigenobu,S., Miura, M.
    • Organizer
      第94回日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡、浜松)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] シリアンハムスターが冬眠期に示す骨格筋変化の解明2017

    • Author(s)
      山口良文
    • Organizer
      第12回環境生理プレコングレス
    • Place of Presentation
      アクトシティ浜松(静岡、浜松)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 哺乳類の冬眠を可能とする全身性代謝変化の分子基盤2017

    • Author(s)
      山口良文
    • Organizer
      ConBio 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カスパーゼ1活性の可視化から明らかになったインフラマソーム活性化様式2017

    • Author(s)
      山口良文、劉ティン、三浦正幸
    • Organizer
      日本病態プロテアーゼ研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 哺乳類冬眠動物が有する低体温耐性のメカニズムの解析2017

    • Author(s)
      姉川大輔、茶山由一、泰井宙輝、安藤理沙、藤本貴之、佐藤佑哉、重信秀治、三浦正幸、山口良文
    • Organizer
      第26回日本Cell Death学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 哺乳類の代謝が全身性に変わる二つの局面~「胚発生」と「冬眠」2017

    • Author(s)
      山口良文
    • Organizer
      がんと代謝研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 哺乳類の冬眠~季節環境に応じた全身性の代謝抑制と体温制御2016

    • Author(s)
      山口良文
    • Organizer
      第1回Biothermology Workshop - 生命システムの熱科学 -
    • Place of Presentation
      基礎生物学研究所(愛知、岡崎)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 冬眠する哺乳類シリアンハムスターに学ぶ、冬眠可能な生体状態とは?2016

    • Author(s)
      山口良文
    • Organizer
      第1回オモロイ生き物研究会
    • Place of Presentation
      定山渓ホテル(北海道、札幌)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Evidence for systemic remodeling prior to hibernation in the Syrian hamster (Mesocricetus auratus),2016

    • Author(s)
      Yamaguchi, Y., Chayama, Y., Ando, L., Anegawa, D., Shigenobu, S., Fujimoto, T., Taii, H., Tamura, Y., Miura, M.
    • Organizer
      15th International Hibernation Symposium
    • Place of Presentation
      Las Vegas, USA.
    • Year and Date
      2016-08-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular remodeling of inguinal adipose tissue precedes hibernation period in Syrian golden hamster2016

    • Author(s)
      Chayama, Y., Ando, L., Shigenobu, S., Tamura, Y., Miura, M., Yamaguchi, Y.
    • Organizer
      15th International Hibernation Symposium
    • Place of Presentation
      Las Vegas, USA.
    • Year and Date
      2016-08-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of mechanisms for the resistance to ischemia-reperfusion stress during hibernation period in Syrian hamsters2016

    • Author(s)
      Anegawa, D., Chayama, Y., Ando, L., Shigenobu, S., Miura, M. Yamaguchi, Y.
    • Organizer
      15th International Hibernation Symposium
    • Place of Presentation
      Las Vegas, USA.
    • Year and Date
      2016-08-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pre-hibernation remodeling accompanies decreases in body temperature and body weight in a facultative mammalian hibernator, Syrian hamster2016

    • Author(s)
      Yamaguchi, Y., Chayama, Y., Ando, L., Tamura, Y., Miura, M
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Evidence for systemic remodeling prior to hibernation in the Syrian hamster (Mesocricetus auratus)2016

    • Author(s)
      Yamaguchi, Y., Chayama, Y., Ando, L., Shigenobu, S., Anegawa, D., Fujimoto, T., Tamura, Y., Miura, M
    • Organizer
      Evolution of Seasonal Timer, NIBB conference
    • Place of Presentation
      Okazaki, Japan.
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 冬眠ハムスターの白色脂肪組織に冬支度の秘密をみる ~肥満や生活習慣病予防へも新たな視座~

    • URL

      https://www.hokudai.ac.jp/news/190129_pr.pdf

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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