| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Social stress often induces emotional alterations such as depression, and can be a risk factor for mental illness. However, the mechanism remains elusive. Using a mouse model of social defeat stress, here we found that single stress exposure induces dendritic hypertrophy of prefrontal neurons associated with stress resilience through dopamine D1 receptor, whereas repeated stress exposure activates prefrontal microglia through innate immune receptors TLR2/4 and consequently leads to dendritic atrophy of prefrontal neurons and depression-like behavior.
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