| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
We identified the actin-binding protein cortactin as a substrate of protein tyrosine phosphatase σ (PTPRσ). PTPRσ was activated by chondroitin sulfate and dephosphorylated cortactin. As a consequence, the autophagy flux was disrupted at the step of autophagosome-lysosome fusion. In addition, we succeeded in comprehensive screening of PTPRσ substrates.
Our study provided solid evidence of the direct relationship between PTPR and autophagy. Considering that autophagy dysfunction is involved in various disorders such as neurodegenerative diseases, our results may influence a broad spectrum of research fields.
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