| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Wnt signaling has multi-functionality and controls cell proliferation, differentiation, and death in a context-depemndent manner. In this study, we explored and analyzed the molecular basis underlying the Wnt signaling multi-functionality.
First, we discovered that abnormal cells with defective Wnt signaling are sensed and then killed by neighboring normal cells, by using zebrafish imaging analyses. We also found that this abnormal cell killing is essential for robust embryogenesis.
Second, by collaboration, we identified new regulators supporting the Wnt signaling multi-functionality.
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