Mechanism of differentiation of fetal Leydig cells by active and suppressive types of nuclear receptors
| Project/Area Number |
16H05142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
Inoue Miki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 胎仔精巣 / ライディッヒ細胞 / Ad4BP / Tmsb10 / DHH / ステロイド / 代謝 / 核内受容体 / 精巣 / 細胞分化 / 遺伝子 / 転写因子 |
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| Outline of Final Research Achievements |
Differentiation of Leydig cells that produce testosterone (androgen) in the testis is regulated by transcription factors such as Ad4BP/SF-1 and growth factors such as DHH. However, the mechanisms for Leydig cell differentiation by these factors remains unclear. In the present study, we newly identified Tmsb10 by a single cell transcriptome study. This factor was demonstrated to work in the process of Leydig cell differentiation from DHH stimulation to enhanced expression of Ad4BP.
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| Academic Significance and Societal Importance of the Research Achievements |
ライディッヒ細胞の分化に不可欠な転写因子や細胞増殖因子は知られていたが、これらの知見は遺伝子ノックアウトの解析から得られた成果であった。そのため、これらの因子がどのようなメカニズムでライディッヒ細胞を分化させるかは不明であった。本研究は、この点に踏み込むことでライディッヒ細胞の分化メカニズムの理解へ向けた成果となった。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids2018
Author(s)
Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa & Ken-ichirou Morohashi
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Journal Title
Communications Biology
Volume: 1
Issue: 1
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PKA signalling drives zonal conversion within adult adrenocortical lineage in a sexually dimorphic manner2018
Author(s)
Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaelle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Veronique Ducros, Anne-Marie Lefrancois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-ichirou Morohashi, David Breault, Pierre Val, Antoine Martinez
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Journal Title
JCI insight
Volume: 3
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth2017
Author(s)
Syu JS, Baba T, Huang JY, Ogawa H, Hsieh CH, Hu JX, Chen TY, Lin TC, Tsuchiya M, Morohashi K, Huang BM, Lu FI
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 240-240
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.2017
Author(s)
Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanal Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 41912-41912
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 核内受容体Ad4BP/SF-1によるステロイドホルモン産生の統括的制御2017
Author(s)
馬場崇, 大竹博之, 井上実紀, 佐藤哲也, 石原康宏, 宮林香奈子, 嶋雄一, 山崎岳, 須山幹太, Choi Man-Ho, 大川恭行, 諸橋憲一郎
Organizer
第21回日本生殖内分泌学会学術集会
Place of Presentation
大阪
Related Report
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