| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Differentiation of Leydig cells that produce testosterone (androgen) in the testis is regulated by transcription factors such as Ad4BP/SF-1 and growth factors such as DHH. However, the mechanisms for Leydig cell differentiation by these factors remains unclear. In the present study, we newly identified Tmsb10 by a single cell transcriptome study. This factor was demonstrated to work in the process of Leydig cell differentiation from DHH stimulation to enhanced expression of Ad4BP.
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