| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
The mechanism of regulation of putative transporter SIDT2 in RNautophagy was clarified. In addition, We found that the cytoplasmic domain of SIDT2 binds directly to HTT mRNA, the causative gene of Huntington's disease, via the arginine rich motif, and that the binding is polyQ-dependent, and that HTT mRNA is degraded as a substrate of RNautophagy. We performed a detailed analysis of SIDT2 KO mice and searched for SIDT2 mutations in human disease families, and clarified the pathology caused by SIDT2 dysfunction.
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