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Application of anti-claudin-4 antibody to anti-cancer therapy

Research Project

Project/Area Number 16H05164
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNara Medical University

Principal Investigator

Kuniyasu Hiroki  奈良県立医科大学, 医学部, 教授 (00253055)

Co-Investigator(Kenkyū-buntansha) 北台 靖彦  県立広島大学, 人間文化学部, 教授 (10304437)
大森 斉  奈良県立医科大学, 医学部, 研究員 (80213875)
千原 良友  奈良県立医科大学, 医学部附属病院, 研究員 (40405395)
佐々木 隆光  福岡大学, 医学部, 講師 (00382284)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsクローディン / タイトジャンクション / 抗癌剤 / 分子標的薬 / がん微小環境 / 細菌 / 上皮間葉移行 / 幹細胞性 / クローディン4 / YAP / Hippo / CPE / clostridium perfringens / 抗がん剤併用療法 / 抗がん剤耐性 / 抗がん剤副作用 / ミトコンドリア / タンネリング / ナノチューブ / 薬剤耐性 / 抗Claudin抗体 / 化学療法増感 / Claudinシグナル / 副作用 / 間葉系幹細胞 / 細胞間相互作用 / 癌転移 / ヘテロスフェア / claudin / 抗体療法 / tight junction / 抗がん剤増感 / 抗クローディン4抗体 / 胃癌 / ピロリ菌感染
Outline of Final Research Achievements

In in vitro and in vivo examinations using the anti-Claudin-4 antibody, 4D3 established in this study, the combination of 4D3 and an anticancer drug shows a synergistic effect in gastric cancer, colon cancer, pancreatic cancer, and breast cancer. 4D3 also enhanced the antitumoral effct of antibody drugs such as cetuximab. In addition, the combined use of 4D3 reduced the dosge while maintaining the effect of FOLFIRINOX, thus reducing the side effects. 4D3 affected the tumor microenvironment to provide decrease stemness and alteration in tumor-infiltrating immune cells. Furthermore, the role of non-tight junction claudin-4 in promoting cancer malignancy was clarified.

Academic Significance and Societal Importance of the Research Achievements

Claudin-4標的化のがん治療における有効性を種々のがんにおいて示すことができた。この知見から、現行の化学療法を抗claudin-4抗体を併用することによりその有効性を高め、副作用を軽減することが可能であることが明らかとなった。このことは、がん治療の可能性を拡張する意義がある。また、Claudin-4のtight junction以外での役割、とくにとの相互作用によるYAP活性化に関与することを明らかにし、claudin-4の新規な機能の発見につながった。このように、本研究は、学術的・社会的意義の高い研究と見なされる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (75 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (37 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 37 results,  Open Access: 28 results,  Acknowledgement Compliant: 6 results) Presentation (30 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (3 results) Remarks (2 results)

  • [Int'l Joint Research] Nantong University(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 南通大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Nantong University(China)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Targeting claudin‐4 enhances chemosensitivity in breast cancer2020

    • Author(s)
      Luo Yi、Kishi Shingo、Sasaki Takamitsu、Ohmori Hitoshi、Fujiwara‐Tani Rina、Mori Shiori、Goto Kei、Nishiguchi Yukiko、Mori Takuya、Kawahara Isao、Kondoh Masuo、Kuniyasu Hiroki
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 5 Pages: 1840-1850

    • DOI

      10.1111/cas.14361

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer2019

    • Author(s)
      Nishiguchi Yukiko、Oue Naohide、Fujiwara-Tani Rina、Sasaki Takamitsu、Ohmori Hitoshi、Kishi Shingo、Mori Shiori、Mori Takuya、Ikeda Naoya、Matsumoto Sohei、Wakatsuki Kohei、Luo Yi、Yasui Wataru、Sho Masayuki、Kuniyasu Hiroki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 1 Pages: 254-254

    • DOI

      10.3390/ijms21010254

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle2019

    • Author(s)
      Kawahara Isao、Goto Kei、Kodama Kenji、Luo Yi、Fujiwara-Tani Rina、Mori Takuya、Miyagawa Yoshihiro、Tanaka Hirokazu、Kodama Hiroyuki、Hosoito Nobuyoshi、Taniguchi Yukinori、Kuniyasu Hiroki
    • Journal Title

      Pathobiology

      Volume: 86 Issue: 5-6 Pages: 254-262

    • DOI

      10.1159/000501524

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of Parameters for Cancer-Induced Sarcopenia in Patients Autopsied after Death from Colorectal Cancer2019

    • Author(s)
      Ohmori Hitoshi、Kawahara Isao、Mori Takuya、Nukaga Shota、Luo Yi、Kishi Shingo、Fujiwara-Tani Rina?、Mori Shiori、Goto Kei、Sasaki Takamitsu、Kuniyasu Hiroki
    • Journal Title

      Pathobiology

      Volume: 86 Issue: 5-6 Pages: 306-314

    • DOI

      10.1159/000503037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas2019

    • Author(s)
      Sasaki Takamitsu、Fujiwara‐Tani Rina、Kishi Shingo、Mori Shiori、Luo Yi、Ohmori Hitoshi、Kawahara Isao、Goto Kei、Nishiguchi Yukiko、Mori Takuya、Sho Masayuki、Kondo Masuo、Kuniyasu Hiroki
    • Journal Title

      Cancer Medicine

      Volume: 8 Issue: 15 Pages: 6700-6708

    • DOI

      10.1002/cam4.2547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Giving combined medium‐chain fatty acids and glucose protects against cancer‐associated skeletal muscle atrophy2019

    • Author(s)
      Mori Takuya、Ohmori Hitoshi、Luo Yi、Mori Shiori、Miyagawa Yoshihiro、Nukaga Shota、Goto Kei、Fujiwara‐Tani Rina、Kishi Shingo、Sasaki Takamitsu、Fujii Kiyomu、Kawahara Isao、Kuniyasu Hiroki
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 10 Pages: 3391-3399

    • DOI

      10.1111/cas.14170

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concurrent Expression of CD47 and CD44 in Colorectal Cancer Promotes Malignancy2019

    • Author(s)
      Fujiwara-Tani Rina、Sasaki Takamitsu、Ohmori Hitoshi、Luo Yi、Goto Kei、Nishiguchi Yukiko、Mori Shiori、Nakashima Chie、Mori Takuya、Miyagawa Yoshihiro、Kawahara Isao、Fujii Kiyomu、Kishi Shingo、Tatsumoto Naokuni、Kuniyasu Hiroki
    • Journal Title

      Pathobiology

      Volume: 86 Issue: 4 Pages: 182-189

    • DOI

      10.1159/000496027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer2019

    • Author(s)
      Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 22 Pages: 2189-2202

    • DOI

      10.18632/oncotarget.26758

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy2019

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    • Journal Title

      Pathobiology

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.2019

    • Author(s)
      Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
    • Journal Title

      Pathobiology

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intermittent calorie restriction enhances epithelial- mesenchymal transition through alteration of energy metabolism in a mouse tumor model.2018

    • Author(s)
      Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
    • Journal Title

      Int J Oncol

      Volume: 52 Pages: 413-423

    • DOI

      10.3892/ijo.2017.4229

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma2018

    • Author(s)
      Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 6 Pages: 2036-2045

    • DOI

      10.1111/cas.13594

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma2018

    • Author(s)
      Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
    • Journal Title

      Histopathol

      Volume: 70 Pages: 539-548

    • DOI

      10.1016/j.ejps.2018.02.016

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pro-metastatic signaling of elaidic acid, a trans fatty acid, is associated with lipid rafts.2018

    • Author(s)
      Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Nakashima C, Sasaki T, Kuniyasu H
    • Journal Title

      Oncol Lett

      Volume: 15 Pages: 4423-4426

    • DOI

      10.3892/ol.2018.7817

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma2018

    • Author(s)
      10.1136/jclinpath-2017-204770
    • Journal Title

      J Clin Pathol

      Volume: 71 Issue: 5 Pages: 436-41

    • DOI

      10.1136/jclinpath-2017-204770

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer.2018

    • Author(s)
      Nakashima C, Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H*
    • Journal Title

      Oncol Lett

      Volume: 15 Pages: 8641-8646

    • DOI

      10.3892/ol.2018.8383

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma2018

    • Author(s)
      Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 144 Issue: 5 Pages: 875-882

    • DOI

      10.1007/s00432-018-2612-x

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells2018

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 10 Pages: 10-10

    • DOI

      10.3390/ijms19102907

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma2018

    • Author(s)
      Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
    • Journal Title

      Oncotarget 9(93): , 2018

      Volume: 9 Issue: 93 Pages: 36561-36574

    • DOI

      10.18632/oncotarget.26337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium2018

    • Author(s)
      Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
    • Journal Title

      Lipids in Health and Disease

      Volume: 17 Issue: 1 Pages: 258-258

    • DOI

      10.1186/s12944-018-0908-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer2018

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H*
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 100 Pages: 37367-37378

    • DOI

      10.18632/oncotarget.26427

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.2017

    • Author(s)
      Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
    • Journal Title

      Histopathol

      Volume: in press Issue: 4 Pages: 539-48

    • DOI

      10.1111/his.13097

    • Related Report
      2018 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.2017

    • Author(s)
      Hashimoto Y, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
    • Journal Title

      Ann NY Acad Sci

      Volume: 1397 Issue: 1 Pages: 5-16

    • DOI

      10.1111/nyas.13337

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.2017

    • Author(s)
      Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
    • Journal Title

      Int J Oncol

      Volume: 50 Issue: 1 Pages: 85-92

    • DOI

      10.3892/ijo.2016.3797

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells2017

    • Author(s)
      Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
    • Journal Title

      Pathobiol

      Volume: in press Issue: 3 Pages: 144-151

    • DOI

      10.1159/000449205

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.2017

    • Author(s)
      Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H*.
    • Journal Title

      Oncol Lett

      Volume: 14 Issue: 1 Pages: 681-686

    • DOI

      10.3892/ol.2017.6190

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.2017

    • Author(s)
      Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      World J Gastroentrol

      Volume: 23 Issue: 9 Pages: 1586-1593

    • DOI

      10.3748/wjg.v23.i9.1586

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.2017

    • Author(s)
      Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Oncol Lett

      Volume: 14 Issue: 1 Pages: 673-680

    • DOI

      10.3892/ol.2017.6195

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model2017

    • Author(s)
      Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
    • Journal Title

      Pathobiol

      Volume: in press Issue: 5 Pages: 237-242

    • DOI

      10.1159/000471854

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.2017

    • Author(s)
      Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
    • Journal Title

      J Pathol

      Volume: 243 Issue: 1 Pages: 100-110

    • DOI

      10.1002/path.4931

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of 5-HT4-receptors facilitates neurogenesis from transplanted neural stem cells in the anastomotic ileum.2016

    • Author(s)
      Goto K, Kawahara I, Inada H, Misawa H, Kuniyasu H, Nabekura J, Takaki M.
    • Journal Title

      J Physiol Sci,

      Volume: 66 Issue: 1 Pages: 67-76

    • DOI

      10.1007/s12576-015-0396-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MicroRNA-203 Suppresses Invasion and Epithelial-mesenchymal Transition Induction via Targeting NUAK1 and SNAI2 in Head and Neck Cancer2016

    • Author(s)
      Obayashi, M., Yoshida, M., Tsunematsu, T., Ogawa, I., Sasahira, T., Kuniyasu, H., Imoto, I., Abiko, Y., Xu, D., Fukunaga, S., Tahara, H., Kudo, Y., Nagao, T., Takata, T.
    • Journal Title

      Oncotarget

      Volume: 6972 Issue: 7 Pages: 8223-39

    • DOI

      10.18632/oncotarget.6972

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression.2016

    • Author(s)
      Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Katrin BA, Kuniyasu H.
    • Journal Title

      Oncotarget

      Volume: vol.7 Issue: 18 Pages: 26751-64

    • DOI

      10.18632/oncotarget.8495

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.2016

    • Author(s)
      Sasahira T, Kirita T, Nishiguchi Y, Kurihara M, Nakashima C, Bosserhoff AK, Kuniyasu H.
    • Journal Title

      Oncotarget

      Volume: May 16 Issue: 21 Pages: 1-16

    • DOI

      10.18632/oncotarget.9082

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma.2016

    • Author(s)
      Sasahira T, Kurihara M, Nishiguchi Y, Fujiwara R, Kirita T; Kuniyasu H
    • Journal Title

      Virchow Arch

      Volume: 469 Issue: 2 Pages: 163-172

    • DOI

      10.1007/s00428-016-1955-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration.2016

    • Author(s)
      Sasahira T, Kurihara M, Nakashima C, Kirita T, Kuniyasu H
    • Journal Title

      Br J Cancer

      Volume: 115 Issue: 1 Pages: 52-58

    • DOI

      10.1038/bjc.2016.167

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody.2016

    • Author(s)
      Hashimoto Y, Kawahigashi Y, Hata T, Li X, Watari A, Tada M, Ishii-Watabe A, Okada Y, Doi T, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
    • Journal Title

      Pharmacol Res Perspect

      Volume: 4 Issue: 5

    • DOI

      10.1002/prp2.266

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells2019

    • Author(s)
      Kishi S, Honoki K, Tsukamoto S, Fujii H, Kondo Y, Tanaka Y, Kuniyasu H
    • Organizer
      American Association for Cancer Research Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proof of concept for claudin-2-directed cancer therapy by using a monoclonal antibody that recognizes the extracellular loop domain of claudin-22019

    • Author(s)
      Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Tachibana K, Kondoh M
    • Organizer
      2019 Controlled Release Society Annual Meeting & Exposition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells2019

    • Author(s)
      Kishi S, Honoki K, Shiori M, Tsukamoto S, Fujii H, Kondoh Y, Tanaka Y, Kuniyasu H
    • Organizer
      ASUKA symposium 2019: A new phase of Regenerative Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 5-Aminolevulinic acid は ミトコンドリア関連活性酸素種およびアポトーシスを介してヒト前立腺癌に放射線増感効果をもたらす2019

    • Author(s)
      尾張拓也、三宅牧人、田中宣道、中井 靖、穴井 智、仲川嘉紀、國安弘基、藤本清秀
    • Organizer
      第35回前立腺シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Linoleic acid-related signal pathway associated with dormant stemness2019

    • Author(s)
      Ogata R, Mori S, Fujiwara-Tani R, Kishi S, Kuniyasu H
    • Organizer
      78th Annual Meeting of Japanese Association for Cancer
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of energy metabolism and malignant phenotype in cancer cells2019

    • Author(s)
      Mori S, Kishi S, Fujiwara-Tani R, Miyagawa Y, Mori T, Luo Y, Sasaki T, Honoki K, Kuniyasu H
    • Organizer
      78th Annual Meeting of Japanese Association for Cancer
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells2019

    • Author(s)
      Kishi S, Honoki K, Tsukamoto S, Fujii H, Kondo Y, Tanaka Y, Kuniyasu H
    • Organizer
      American Association for Cancer Research Annual Meeting 2019, Atlanta, 2019.3.29-4.3
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗 claudin-4 抗体のがん治療への応用2018

    • Author(s)
      國安弘基、西口由希子、谷 里奈、岸 真五、近藤昌夫
    • Organizer
      第107回日本病理学会総会、ワークショップ:多機能な細胞接着分子が関わるがんの理解 - 診断・治療への応用をめざして、札幌市、2018.6.21-23
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がんのエネルギー代謝―がん悪性形質との関連2018

    • Author(s)
      國安弘基、森汐莉、谷里奈、岸真吾、西口由希子、森拓也、宮川良博、後藤桂、川原勲、大森斉
    • Organizer
      第29回日本消化器癌発生学会、シンポジウム:がんメタボローム-マルチオミクスによる複雑性の統一-、東京都、2018.11.16-17
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pterostilbene (3',5'-dimethoxyresveratrol) inhibits cell growth and augments the efficacy of doxorubicin through stem cell phenotype suppression in osteosarcoma cells in vitro2017

    • Author(s)
      Kishi S, Honoki K, Fujii H, Kondo Y, Tsukamoto S, Kido A, Tsujiuchi T, Tanaka Y, Kuniyasu H
    • Organizer
      AACR Advances in Sarcomas: From Basic Science to Clinical Translation
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2017-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of anti-claudin-4 antibody on chemotherapeutic sensitivity in gastric cancer2017

    • Author(s)
      Nishiguchi Y, Luo Y, Fujiwara-Tani R, Sasahira T, Kondo M, Sho M, Kuniyasu H
    • Organizer
      12th International Gastric Cancer Congress
    • Place of Presentation
      Beijing, China
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胃癌における抗Claudin-4抗体の化学療法感受性への影響2017

    • Author(s)
      西口由希子、羅 奕、藤原里奈、笹平智則、近藤昌夫、中島祥介、國安弘基
    • Organizer
      第89回日本胃癌学会
    • Place of Presentation
      広島市
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effect of anti-claudin-4 antibody on chemotherapeutic sensitivity in gastric cancer2017

    • Author(s)
      Nishiguchi Y, Luo Y, Fujiwara-Tani R, Sasahira T, Kondo M, Sho M, Kuniyasu H
    • Organizer
      12th International Gastric Cancer Congress, Beijing, China,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pterostilbene (3',5'-dimethoxyresveratrol) inhibits cell growth and augments the efficacy of doxorubicin through stem cell phenotype suppression in osteosarcoma cells in vitro2017

    • Author(s)
      Kishi S, Honoki K, Fujii H, Kondo Y, Tsukamoto S, Kido A, Tsujiuchi T, Tanaka Y, Kuniyasu H
    • Organizer
      AACR Advances in Sarcomas: From Basic Science to Clinical Translation, Philadelphia, USA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胃癌における抗Claudin-4抗体の化学療法感受性への影響2017

    • Author(s)
      西口由希子、羅 奕、藤原里奈、笹平智則、近藤昌夫、中島祥介、國安弘基
    • Organizer
      第89回日本胃癌学会、広島
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胃癌における抗Claudin-4抗体の化学療法感受性への影響2017

    • Author(s)
      西口由希子、羅 奕、谷 里奈、笹平智則、近藤昌夫、庄 雅之、國安弘基
    • Organizer
      第106回日本病理学会総会、東京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大腸癌細胞のEMT形質獲得における間葉系幹細胞の役割2017

    • Author(s)
      國安弘基、谷 里奈、羅 奕、岸 真五、佐々木隆光、大森 斉
    • Organizer
      第106回日本病理学会総会、東京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胃癌における抗Claudin-4抗体の化学療法感受性への影響2017

    • Author(s)
      西口由希子、谷 里奈、近藤昌夫、庄 雅夫、國安弘基
    • Organizer
      第72回日本消化器外科学会、金沢市
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大腸癌細胞のEMT形質獲得における間葉系幹細胞の役割2017

    • Author(s)
      國安弘基、谷 里奈、羅 奕、大森 斉、佐々木隆光
    • Organizer
      第26回日本癌転移学会、大阪市
    • Related Report
      2017 Annual Research Report
  • [Presentation] The effect of anti-claudin-4 (CL-4) antibody on chemotherapeutic sensitivity in gastric cancer2017

    • Author(s)
      Nishiguchi Y, Fujiwara-Tani R, Kishi S, Sasaki T, Sasahira T, Kondo M, Sho M, Kuniyasu H
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer, Yokohama
    • Related Report
      2017 Annual Research Report
  • [Presentation] A role of mesenchymal stem cells of acquisition of EMT phenotype in colon cancer cells2017

    • Author(s)
      Kuniyasu H, Fujiwara-Tani R, Yi Luo, Nishiguchi Y, Kishi S, Kondo M, Sasaki T
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer, Yokohama, 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Enhancement of antitumoral effect of molecular-targeting antibody by anti-claudin-4 antibody.2016

    • Author(s)
      Kuniyasu H, Luo Y, Sasaki T, Chihara Y, Fujiwara R, Nishiguchi Y, Hashimoto Y, Kondo M
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Targeting distant metastasis of colorectal cancer with a combination of anti-claudin-4 antibody .2016

    • Author(s)
      Fujiwara R, Luo Y, Sasaki T, Nishiguchi Y, Ohmori H, Hashimoto Y, Kondo M, Kuniayasu H
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸腺腫におけるtight junctionタンパクのEMT形質獲得への関与2016

    • Author(s)
      藤原里奈、西口由希子、羅 奕、佐々木隆光、大森 斉、國安弘基
    • Organizer
      第27回日本消化器癌発生学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗claudin-4抗体と抗体分子治療薬の併用による効果促進2016

    • Author(s)
      國安弘基、羅 奕,、西口由希子,、藤原里奈、佐々木隆光、近藤昌夫
    • Organizer
      第25回日本癌転移学会
    • Place of Presentation
      米子市
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗claudin-4抗体の併用による抗体分子治療薬の効果促進2016

    • Author(s)
      國安弘基、羅 奕、桑田真臣、佐々木隆光、千原良友、藤井 澄、大森 斉
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃癌における抗Claudin-4抗体の化学療法感受性への影響2016

    • Author(s)
      西口由希子、羅 奕、谷 里奈、笹平智則、近藤昌夫、庄 雅之、國安弘基
    • Organizer
      第106回日本病理学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2016-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌細胞のEMT形質獲得における間葉系幹細胞の役割2016

    • Author(s)
      國安弘基、谷 里奈、羅 奕、岸 真五、佐々木隆光、大森 斉
    • Organizer
      第106回日本病理学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2016-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer.2016

    • Author(s)
      Kuwada M, Chihara Y, Luo Y, Sasaki T, Fujimoto K, Kondoh M, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protumoral role of trans fatty acid2016

    • Author(s)
      Ohmori H, Kuwai T, Kitadai Y, Fujii K, Fujiwara R, Nishiguchi Y, Sasahira T, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] Encyclopedia of Cancer2017

    • Author(s)
      Kuniyasu H
    • Total Pages
      4895
    • Publisher
      Springer&Verlag, Berlin
    • ISBN
      9783662468746
    • Related Report
      2017 Annual Research Report
  • [Book] Role of CD10 in the metastasis of colorectal cancer to the liver.2016

    • Author(s)
      Kuniyasu H, Fujii K, Ohmori H, Fujiwara-Tani R, Luo Y, Sasaki T
    • Total Pages
      189
    • Publisher
      Research Media
    • Related Report
      2016 Annual Research Report
  • [Book] Significance of anti-CLDN4 extracellular domain antibody in cancer treatment.2016

    • Author(s)
      Fujiwara-Tani R, Ohmori H, Fujii K, Sasaki T, Luo Y, Kuniyasu H
    • Total Pages
      189
    • Publisher
      Research Media
    • Related Report
      2016 Annual Research Report
  • [Remarks] 奈良県立医科大学分子病理学HP

    • URL

      http://www.naramed-u.ac.jp/~molepath/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 奈良県立医科大学分子病理学講座

    • URL

      http://www.naramed-u.ac.jp/~molepath/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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