| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
In this study, to understand the molecular mechanism underlying NASH, we employed genetically obese melanocortin-4 receptor-deficient mice, which sequentially developed simple steatosis, NASH, and hepatocellular carcinoma (HCC) when they were fed a Western diet. We also develop novel accelerated animal models which exhibited NASH and HCC in the short-term. Using these animal models, we identified a unique histological structure termed “crown-like structure”, in which macrophages aggregated around dead hepatocytes, thereby accelerating tissue remodeling during the disease progression from simple steatosis to NASH. Our data suggest that CLS is useful to examine the molecular mechanisms how certain drugs ameliorated NASH.
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