| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
By systematically elucidating the molecular mechanism in determining the undifferentiated maintenance of MSC and determining the direction of differentiation in this study, the mechanism to control the undifferentiated maintenance of stem cells / progenitor cells / mature cells and the directionality of differentiation is inscribed. An attempt was made to understand both in vivo and in vitro. As a result, FZD5 suppresses cellular senescence by activating the non-classical pathway by forced expression and knockdown of FZD5 and Notch2, and that Notch2 is upregulated under hypoxic conditions and induces cell proliferation It became clear. Furthermore, we generated a reporter transgenic mouse using MSC specific gene expression regulatory region and clarified that its expression is localized to undifferentiated MSC.
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