Study of tuberculosis latency and development of anti-tuberculosis strategy by keeping latent state
| Project/Area Number |
16H05187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
阿戸 学 国立感染症研究所, ハンセン病研究センター 感染制御部, 部長 (20392318)
田村 敏生 国立感染症研究所, ハンセン病研究センター 感染制御部, 室長 (40291306)
西山 晃史 新潟大学, 医歯学系, 講師 (80452069)
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| Research Collaborator |
Mekura Ryoji
Ozeki Yuriko
Katahira Masato
Yamaguchi Takehiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 結核 / ハンセン病 / 非結核性抗酸菌症 / 潜在性結核 / LTBI / 天然変性蛋白質 / ヒストン様蛋白質 / 潜伏感染 / 休眠 / 発症 / 抗酸菌 / 無症候感染 / ワクチン / 潜在性 / 潜伏 / パーシスター |
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| Outline of Final Research Achievements |
Tuberculosis is a serious health threat that kills more than 1.5 million people annually. Mycobacterium tuberculosis, an etiologic agent of tuberculosis, persistently infects one third of the human population, and 5 to 10% of them develops tuberculosis. Accordingly, prevention of the progression from latent tuberculosis is an efficient for tuberculosis control. At the latent stage M. tuberculosis is under dormant state where growth has ceased. Here we showed importance of suppression of energy production and fatty acid synthesis of mycobacteria for long term survival of mycobacterial after entering stationary phases. Our data provided reasonable basis of establishing a new control strategy against tuberculosis by deterring the disease onset.
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| Academic Significance and Societal Importance of the Research Achievements |
細菌は無限増殖細胞であるがゆえに、その長生きについての研究は少ない。一方で、抗酸菌は分裂を停止して休眠し長期間生存する。この特徴は、抗酸菌症の経過を特徴づけている。抗酸菌の長寿の機構を、特徴的な休眠の鍵分子を足ががりとして解析した結果、霊長類の長寿とも共有するメカニズム、すなわち増殖抑制、低代謝、ラジカル抵抗性、の重要性を明かにした。本研究は、細菌から霊長類まで、真核生物に普遍的な長期生存のメカニズムが、細菌細胞でも共有されることを示した。本成果は、我々の長寿のヒントも啓示し、また難治性抗酸菌症の発生母体である無症候感染の縮小を図る革新的な制御法開発に貢献する。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages.2018
Author(s)
Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka EA, Yamaguchi T, Osada-Oka M, Ono K, Oda T, Mwende F, Kaneko Y, Matsumoto M, Kaneko S, Ichinose Y, Njenga SM, Hamano S, Matsumoto S.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 6736-6736
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Longgitudial evaluation of humoral immunity and bacterial and clinical parameters reveals that antige-specific antibodies suppress inflammatory responses in active tuberculosis.2018
Author(s)
Niki M, Yoshiyama T, Miyamoto Y, Okamura M. Niki M, Oinuma K, Kaneko Y, Matsumoto S, Sasaki Y, Ogata H, Goto H, Kudoh S, and Hoshino Y.
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Journal Title
Related Report
Open Access
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[Journal Article] Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions.2017
Author(s)
Enany, S., Y. Yoshida, Y. Tateishi, Y. Ozeki, A. Nishiyama, A. Savitskaya, T. Yamaguchi, Y. Ohara, T. Yamamoto, M. Ato, and S. Matsumoto.
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Journal Title
Scientific reports
Volume: -
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Long term survival and organization of the genome by the intrinsically disordered histone-like protein in mycobacteria and its application to the diagnosis of asymptomatic tuberculosis.2019
Author(s)
Anna Savitskaya, Shymaa Enany, Yukiko Ohara, Akihito Nishiyama, Yuriko Ozeki, Takehiro Yamaguchi, Tsukasa Mashima, Yoshitaka Tateishi, Masaaki Nameta, Yutaka Yoshida, Shaban A. Kaboso, Haruka Kobayashi, Manabu Ato, Seigo Kitada, Ryoji Maekura, Olga V. Peryanova, Masato Katahira, and Sohkichi Matsumoto
Organizer
日米医学協力計画 抗酸菌症部会
Related Report
Int'l Joint Research / Invited
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[Presentation] Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions.2018
Author(s)
Shymaa Enany, Yutaka Yoshida, Yoshitaka Tateishi, Yuriko Ozeki, Akihito Nishiyama, Anna Savitskaya, Takehiro Yamaguchi, Yukiko Ohara, Tadashi Yamamoto, Manabu Ato, and Sohkichi Matsumoto,
Organizer
US-Japan Cooperative Medical Science Program, 52nd Mycobacteria Panel Meeting,
Related Report
Int'l Joint Research
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[Presentation] A new screen for tuberculosis drug candidates utilizing a luciferase-expressing recombinant Mycobacterium bovis Bacillus Calmette-Gueren2018
Author(s)
Yuriko Ozeki, Masayuki Igarashi, Matsumi Doe, Aki Tamaru, Naoko Kinoshita, Yoshitoshi Ogura, Tomotada Iwamoto, Ryuichi Sawa, Maya Umekita, Shymaa Enany, Yukiko Nishiuchi, Mayuko Osada-Oka, Tetsuya Hayashi, Mamiko Niki1,Yoshitaka Tateishi, Masaki Hatano, and Sohkichi Matsumoto.
Organizer
US-Japan Cooperative Medical Science Program, 52nd Mycobacteria Panel Meeting,
Related Report
Int'l Joint Research
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[Presentation] The effects of booster vaccine composed of MDP1 and G9.1 against tuberculosis in cynomogus monkeys.2018
Author(s)
Daisuke Hayashi, Jun-ichi Maeyama, Toshiko Yamamoto, Toshio Yamazaki, Tetsu Mukai, Toshiki Tamura, Sachi Okabayashi, Fumiko Suzuki, Yuriko Ozeki, Akira Yokoyama, Yuriko Suzaki, Yasushi Ami, Yoshitaka Goto, Sumiko Iho, Sohkichi Matsumoto and Saburo Yamamoto.
Organizer
US-Japan Cooperative Medical Science Program, 52nd Mycobacteria Panel Meeting,
Related Report
Int'l Joint Research
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