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Mechanisms for development of diseases by H. pylori virulence factor complex

Research Project

Project/Area Number 16H05191
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionOita University

Principal Investigator

YAMAOKA YOSHIO  大分大学, 医学部, 教授 (00544248)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywordsピロリ菌 / 外膜タンパク / タンパク質複合体 / 病原因子 / 炎症 / 抗体測定 / オルガノイド / ヘリコバクター・ピロリ / 感染症 / 癌 / 微生物
Outline of Final Research Achievements

We succeeded to construct recombinant proteins of the whole length of OipA and CagA, the important virulence factors of Helicobacter pylori. Using mass spectrometry analyses, our results first suggested that OipA forms multimeric complex within the membrane region of H. pylori, or forms complex with other factors such as CagA. Furthermore, we established the most reliable system in Japan to measure anti-CagA antibody in serum samples. In addition, we succeeded to construct an ex-vivo model of human stomach, gastric epithelial organoid monolayers (gastric monolayers). Using this novel model, we expect to promote our research field on searching the interaction between H. pylori and gastric mucosa.

Academic Significance and Societal Importance of the Research Achievements

今回、我々が作成した血清中のCagA抗体を測定する系では、日本人由来のピロリ菌を材料としており、欧米のピロリ菌を用いている市販キットに比べて、正確性が高く、今後の汎用が期待される。また、今までは、ピロリ菌と胃粘膜との相互関係を調べるのに、胃がん細胞株が用いられていたが、2次元ガストロイドという新しい系を確立したことで、今後の基礎研究の飛躍的な発展が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (163 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (18 results) Journal Article (84 results) (of which Int'l Joint Research: 50 results,  Peer Reviewed: 62 results,  Open Access: 46 results,  Acknowledgement Compliant: 11 results) Presentation (50 results) (of which Int'l Joint Research: 32 results,  Invited: 34 results) Book (4 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] ベイラー医科大学/ヒューストン大学ガルベストン校(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 108病院/チョーライ病院/ハノイ医科大学(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ブータン王立医科大学(ブータン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] キンシャサ大学/ムブジマイ大学/国立バイオ医学研究所(コンゴ民主共和国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベンダ大学(南アフリカ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学/テキサス大学ガルベストン校/フレッド・ハッチンソン癌研究センター(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] インドネシア大学/アイルランガ大学/ムハンマディア大学(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] モンゴル国立医科学大学/ウランバートル第3病院/モンゴル国立がん研究所(モンゴル)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チュラロンコン大学/タマサート大学/マエソット病院(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チョーライ病院/108病院/ハノイ医科大学(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学/テキサス大学ガルベストン校(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] インドネシア大学/アイルランガ大学/ムハンマディア大学(インドネシア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] モンゴル国立医科学大学/ウランバートル第3病院/モンゴル国立がん研究所(モンゴル)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] チュラロンコン大学/タマサート大学/マエソット病院(タイ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] チョーライ病院/108病院/ハノイ医科大学(ベトナム)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Role of Vonoprazan in Helicobacter pylori Eradication Therapy in Japan2019

    • Author(s)
      Sugimoto Mitsushige、Yamaoka Yoshio
    • Journal Title

      Frontiers in Pharmacology

      Volume: 9 Pages: 1560-1560

    • DOI

      10.3389/fphar.2018.01560

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <p>Alternative eradication regimens for <em>Helicobacter pylori</em> infection in Indonesian regions with high metronidazole and levofloxacin resistance</p>2019

    • Author(s)
      Miftahussurur Muhammad、Waskito Langgeng Agung、Syam Ari Fahrial、Nusi Iswan Abbas、Siregar Gontar、Richardo Marselino、Bakry Achmad Fuad、Rezkitha Yudith Annisa Ayu、Wibawa I Dewa Nyoman、Yamaoka Yoshio
    • Journal Title

      Infection and Drug Resistance

      Volume: Volume 12 Pages: 345-358

    • DOI

      10.2147/idr.s187063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effective therapeutic regimens in two South Asian countries with high resistance to major Helicobacter pylori antibiotics2019

    • Author(s)
      Miftahussurur Muhammad、Aftab Hafeza、Shrestha Pradeep Krishna、Sharma Rabi Prakash、Subsomwong Phawinee、Waskito Langgeng Agung、Doohan Dalla、Fauzia Kartika Afrida、Yamaoka Yoshio
    • Journal Title

      Antimicrobial Resistance & Infection Control

      Volume: 8 Issue: 1 Pages: 40-40

    • DOI

      10.1186/s13756-019-0482-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Five alternative Helicobacter pylori antibiotics to counter high levofloxacin and metronidazole resistance in the Dominican Republic2019

    • Author(s)
      Miftahussurur Muhammad、Cruz Modesto、Doohan Dalla、Subsomwong Phawinee、Abreu Jos? A. Jim?nez、Hosking Celso、Waskito Langgeng Agung、Yamaoka Yoshio
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: e0213868-e0213868

    • DOI

      10.1371/journal.pone.0213868

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aggregatibacter actinomycetemcomitans infection causes DNA double-strand breaks in host cells2018

    • Author(s)
      Teshima Rie、Hanada Katsuhiro、Akada Junko、Kawano Kenji、Yamaoka Yoshio
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 4 Pages: 264-273

    • DOI

      10.1111/gtc.12570

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prevalence of Helicobacter pylori infection and other risk factors among Mongolian dyspeptic patients who have a high incidence and mortality rate of gastric cancer2018

    • Author(s)
      Khasag Oyuntsetseg、Boldbaatar Gantuya、Tegshee Tserentogtoh、Duger Davaadorj、Dashdorj Azzaya、Uchida Tomohisa、Matsuhisa Takeshi、Yamaoka Yoshio
    • Journal Title

      Gut Pathogens

      Volume: 10 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s13099-018-0240-2

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distribution and clinical associations of integrating conjugative elements and cag pathogenicity islands of Helicobacter pylori in Indonesia2018

    • Author(s)
      Waskito Langgeng Agung、Miftahussurur Muhammad、Lusida Maria Inge、Syam Ari Fahrial、Suzuki Rumiko、Subsomwong Phawinee、Uchida Tomohisa、Hamdan Muhammad、Nasronudin、Yamaoka Yoshio
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 6073-6073

    • DOI

      10.1038/s41598-018-24406-y

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epidemiology of Helicobacter pylori and CagA-Positive Infections and Global Variations in Gastric Cancer2018

    • Author(s)
      Park Jin、Forman David、Waskito Langgeng、Yamaoka Yoshio、Crabtree Jean
    • Journal Title

      Toxins

      Volume: 10 Issue: 4 Pages: 163-163

    • DOI

      10.3390/toxins10040163

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence and Pattern of Antibiotic Resistant Strains of Helicobacter Pylori Infection in ASEAN2018

    • Author(s)
      Vilaichone RK, Quach DT, Yamaoka Y, Sugano K, Mahachai V
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 19 Pages: 1411-1413

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Helicobacter pylori and its CagA subtypes in gastric cancer and duodenal ulcer at an Austrian tertiary referral center over 25 years2018

    • Author(s)
      Kamogawa-Schifter Yumiko、Yamaoka Yoshio、Uchida Tomohisa、Beer Andrea、Tribl Barbara、Scheiger-Hekele Maximilian、Trauner Michael、Dolak Werner
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: e0197695-e0197695

    • DOI

      10.1371/journal.pone.0197695

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic diversity and functional analysis of oipA gene in association with other virulence factors among Helicobacter pylori isolates from Iranian patients with different gastric diseases2018

    • Author(s)
      Farzi Nastaran、Yadegar Abbas、Aghdaei Hamid Asadzadeh、Yamaoka Yoshio、Zali Mohammad Reza
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 60 Pages: 26-34

    • DOI

      10.1016/j.meegid.2018.02.017

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic populations and virulence factors of Helicobacter pylori2018

    • Author(s)
      Kabamba Evariste Tshibangu、Tuan Vo Phuoc、Yamaoka Yoshio
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 60 Pages: 109-116

    • DOI

      10.1016/j.meegid.2018.02.022

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Call for shift in Helicobacter pylori treatment2018

    • Author(s)
      Talebi Bezmin Abadi Amin、Yamaoka Yoshio
    • Journal Title

      European Journal of Gastroenterology & Hepatology

      Volume: 30 Issue: 6 Pages: 687-687

    • DOI

      10.1097/meg.0000000000001096

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Current understanding and management of Helicobacter pylori infection: an updated appraisal2018

    • Author(s)
      Ansari Shamshul、Yamaoka Yoshio
    • Journal Title

      F1000Research

      Volume: 7 Pages: 721-721

    • DOI

      10.12688/f1000research.14149.1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How to eliminate gastric cancer-related death worldwide?2018

    • Author(s)
      Yamaoka Yoshio
    • Journal Title

      Nature Reviews Clinical Oncology

      Volume: 15 Issue: 7 Pages: 407-408

    • DOI

      10.1038/s41571-018-0029-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of lyophilized, Kefir-fermented milk on constipation among persons with mental and physical disabilities2018

    • Author(s)
      Maki Rumiko、Matsukawa Mayumi、Matsuduka Atsuko、Hashinaga Masahiko、Anai Hirofumi、Yamaoka Yoshio、Hanada Katsuhiro、Fujii Chieko
    • Journal Title

      Japan Journal of Nursing Science

      Volume: 15 Issue: 3 Pages: 218-225

    • DOI

      10.1111/jjns.12189

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-proliferation effect of blue light-emitting diodes against antibiotic-resistant Helicobacter pylori2018

    • Author(s)
      Ma Jianwei、Hiratsuka Takahiro、Etoh Tsuyoshi、Akada Junko、Fujishima Hajime、Shiraishi Norio、Yamaoka Yoshio、Inomata Masafumi
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: なし Issue: 8 Pages: 1492-1499

    • DOI

      10.1111/jgh.14066

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New observations regarding Helicobacter pylori and gastric cancer in Mongolia2018

    • Author(s)
      Gantuya Boldbaatar、Bolor Dashdorj、Oyuntsetseg Khasag、Erdene-Ochir Yansan、Sanduijav Ruvjir、Davaadorj Duger、Tserentogtokh Tegshee、Azzaya Dashdorj、Uchida Tomohisa、Matsuhisa Takeshi、Yamaoka Yoshio
    • Journal Title

      Helicobacter

      Volume: 23 Issue: 4

    • DOI

      10.1111/hel.12491

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity2018

    • Author(s)
      Ansari Shamshul、Gantuya Boldbaatar、Tuan Vo、Yamaoka Yoshio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 8 Pages: 2424-2424

    • DOI

      10.3390/ijms19082424

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicobacter pylori therapy and clinical perspective2018

    • Author(s)
      Talebi Bezmin Abadi A, Yamaoka Y
    • Journal Title

      J Glob Antimicrob Resist

      Volume: S2213 Pages: 30057-2

    • DOI

      10.1016/j.jgar.2018.03.005

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathogenesis of Helicobacter pylori infection2018

    • Author(s)
      Waskito Langgeng Agung、Salama Nina R.、Yamaoka Yoshio
    • Journal Title

      Helicobacter

      Volume: 23 Issue: Suppl 1

    • DOI

      10.1111/hel.12516

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence2018

    • Author(s)
      Miftahussurur Muhammad、Doohan Dalla、Nusi Iswan Abbas、Adi Pangestu、Rezkitha Yudith Annisa Ayu、Waskito Langgeng Agung、Fauzia Kartika Afrida、Bramantoro Taufan、Maimunah Ummi、Thamrin Husin、Masithah Safitri Indah、Sukadiono Sukadiono、Uchida Tomohisa、Lusida Maria Inge、Yamaoka Yoshio
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0205644-e0205644

    • DOI

      10.1371/journal.pone.0205644

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of integrating conjugative elements in Helicobacter pylori: a review2018

    • Author(s)
      Waskito Langgeng Agung、Yih-Wu Jeng、Yamaoka Yoshio
    • Journal Title

      Journal of Biomedical Science

      Volume: 25 Issue: 1 Pages: 86-86

    • DOI

      10.1186/s12929-018-0489-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicobacter pylori Infection and Related Gastrointestinal Diseases in Southeast Asian Countries: An Expert Opinion Survey2018

    • Author(s)
      Quach Duc Trong、Vilaichone Ratha-korn、Vu Khien Van、Yamaoka Yoshio、Sugano Kentaro、Mahachai Varocha
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 19 Issue: 12 Pages: 3565-3569

    • DOI

      10.31557/apjcp.2018.19.12.3565

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area2018

    • Author(s)
      Gantuya Boldbaatar、Oyuntsetseg Khasag、Bolor Dashdorj、Erdene-Ochir Yansan、Sanduijav Ruvjir、Davaadorj Duger、Tserentogtokh Tegshee、Uchida Tomohisa、Yamaoka Yoshio
    • Journal Title

      Gastric Cancer

      Volume: 22 Issue: 1 Pages: 104-112

    • DOI

      10.1007/s10120-018-0844-8

    • NAID

      40021775217

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice2018

    • Author(s)
      Gendo Y、Matsumoto T、Kamiyama N、Saechue B、Fukuda C、Dewayani A、Hidano S、Noguchi K、Sonoda A、Ozaki T、Sachi N、Hirose H、Ozaka S、Eshita Y、Mizukami K、Okimoto T、Kodama M、Yoshimatsu T、Nishida H、Daa T、Yamaoka Y、Murakami K、Kobayashi T
    • Journal Title

      Inflammatory Intestinal Diseases

      Volume: 3 Issue: 3 Pages: 145-154

    • DOI

      10.1159/000495462

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study2018

    • Author(s)
      Binh Tran、Tuan Vo、Dung Ho、Tung Pham、Tri Tran、Thuan Ngo、Tam Le、Nam Bui、Giang Do、Hoan Phan、Uchida Tomohisa、Trang Tran、Khien Vu、Yamaoka Yoshio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 3 Pages: 708-708

    • DOI

      10.3390/ijms19030708

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Helicobacter pylori Infection in Asia: Remembrance of Things Past?2018

    • Author(s)
      Sugano Kentaro、Hiroi Shinzo、Yamaoka Yoshio
    • Journal Title

      Gastroenterology

      Volume: 154 Issue: 1 Pages: 257-258

    • DOI

      10.1053/j.gastro.2017.08.074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing Helicobacter pylori cagA in Myanmar2018

    • Author(s)
      Myint Thein、Miftahussurur Muhammad、Vilaichone Ratha-korn、Ni New、Aye Than Than、Subsomwong Phawinee、Uchida Tomohisa、Mahachai Varocha、Yamaoka Yoshio
    • Journal Title

      Gut and Liver

      Volume: 12 Issue: 1 Pages: 51-57

    • DOI

      10.5009/gnl17053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 海外Helicobacter pylori疫学調査:-立案,調査からデータ解析に至るまで-. 第18回 スリランカでの疫学調査2018

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 22 Pages: 6-14

    • NAID

      40021473985

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pylori bab characterization in clinical isolates from Bhutan, Myanmar, Nepal and Bangladesh.2017

    • Author(s)
      Ansari S, Kabamba ET, Shrestha PK, Aftab H, Myint T, Tshering L, Sharma RP, Ni N, Aye TT, Subsomwong P, Uchida T, Ratanachu-Ek T, Vilaichone RK, Mahachai V, Matsumoto T, Akada J, Yamaoka Y.
    • Journal Title

      PLoS One.

      Volume: 6 Issue: 11 Pages: 11-23

    • DOI

      10.1371/journal.pone.0187225

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence, risk factors, and virulence genes of Helicobacter pylori among dyspeptic patients in two different gastric cancer risk regions of Thailand2017

    • Author(s)
      Subsomwong Phawinee、Miftahussurur Muhammad、Uchida Tomohisa、Vilaichone Ratha-korn、Ratanachu-ek Thawee、Mahachai Varocha、Yamaoka Yoshio
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 10 Pages: 0187113-0187113

    • DOI

      10.1371/journal.pone.0187113

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nepalese Helicobacter pylori Genotypes Reflects a Geographical Diversity than a True Virulence Factor2017

    • Author(s)
      Rabi Prakash Sharma, Muhammad Miftahussurur, Pradeep Krishna Shrestha,Phawinee Subsomwong, Tomohisa Uchida, Yoshio Yamaoka
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 18 Pages: 2637-2641

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicobacter pylori virulence genes of minor ethnic groups in North Thailand2017

    • Author(s)
      Subsomwong Phawinee、Miftahussurur Muhammad、Vilaichone Ratha-korn、Ratanachu-ek Thawee、Suzuki Rumiko、Akada Junko、Uchida Tomohisa、Mahachai Varocha、Yamaoka Yoshio
    • Journal Title

      Gut Pathogens

      Volume: 9 Issue: 1 Pages: 56-60

    • DOI

      10.1186/s13099-017-0205-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advanced non-cardia gastric cancer and Helicobacter pylori infection in Vietnam2017

    • Author(s)
      Binh Tran Thanh、Tuan Vo Phuoc、Dung Ho Dang Quy、Tung Pham Huu、Tri Tran Dinh、Thuan Ngo Phuong Minh、Khien Vu Van、Hoan Phan Quoc、Suzuki Rumiko、Uchida Tomohisa、Trang Tran Thi Huyen、Yamaoka Yoshio
    • Journal Title

      Gut Pathogens

      Volume: 9 Issue: 1

    • DOI

      10.1186/s13099-017-0195-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two populations of less-virulent Helicobacter pylori genotypes in Bangladesh2017

    • Author(s)
      Aftab Hafeza、Miftahussurur Muhammad、Subsomwong Phawinee、Ahmed Faruque、Khan A. K. Azad、Matsumoto Takashi、Suzuki Rumiko、Yamaoka Yoshio
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 8 Pages: 1-17

    • DOI

      10.1371/journal.pone.0182947

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Primary antibiotic resistance in Helicobacter pylori in the Asia-Pacific region: a systematic review and meta-analysis2017

    • Author(s)
      Kuo Yu-Ting、Liou Jyh-Ming、El-Omar Emad M、Wu Jeng-Yih、Leow Alex Hwong Ruey、Goh Khean Lee、Das Rajashree、Lu Hong、Lin Jaw-Town、Tu Yu-Kang、Yamaoka Yoshio、Wu Ming-Shiang
    • Journal Title

      Lancet Gastroenterology and Hepatology

      Volume: 2 Issue: 10 Pages: 707-715

    • DOI

      10.1016/s2468-1253(17)30219-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Helicobacter pylori management in ASEAN: The Bangkok consensus report2017

    • Author(s)
      Mahachai V、Vilaichone R、Pittayanon R、(23 authors)、Yamaoka Yoshio、Fock KM、Goh KL、Sugano K、Graham D
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 33 Issue: 1 Pages: 37-56

    • DOI

      10.1111/jgh.13911

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interleukin-17C in Human Helicobacter pylori Gastritis2017

    • Author(s)
      Tanaka Shingo、Nagashima Hiroyuki、Cruz Modesto、Uchida Tomohisa、Uotani Takahiro、Jim?nez Abreu Jos? A.、Mahachai Varocha、Vilaichone Ratha-korn、Ratanachu-ek Thawee、Tshering Lotay、Graham David Y.、Yamaoka Yoshio
    • Journal Title

      Infection and Immunity

      Volume: 85 Issue: 10

    • DOI

      10.1128/iai.00389-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Helicobacter pylori BabA in adaptation for gastric colonization2017

    • Author(s)
      Ansari Shamshul、Yamaoka Yoshio
    • Journal Title

      World Journal of Gastroenterology

      Volume: 23 Issue: 23 Pages: 4158-4158

    • DOI

      10.3748/wjg.v23.i23.4158

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Gastric Cancer Risk and Serum Helicobacter pylori Antibody Titers2017

    • Author(s)
      Shuto Mitsutaka、Fujioka Toshio、Matsunari Osamu、Okamoto Kazuhisa、Mizukami Kazuhiro、Okimoto Tadayoshi、Kodama Masaaki、Takigami Shigeru、Seguchi Chuichi、Nonaka Yoshihito、Sato Ryugo、Yamaoka Yoshio、Murakami Kazunari
    • Journal Title

      Gastroenterol Res Pract.

      Volume: 2017 Pages: 1-6

    • DOI

      10.1155/2017/1286198

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter, Hygiene, Atopy, and Asthma2017

    • Author(s)
      Miftahussurur Muhammad、Nusi Iswan A.、Graham David Y.、Yamaoka Yoshio
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 1034-1040

    • DOI

      10.3389/fmicb.2017.01034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gastric mucosal status in populations with a low prevalence of Helicobacter pylori in Indonesia2017

    • Author(s)
      Miftahussurur Muhammad、Nusi Iswan Abbas、Akil Fardah、Syam Ari Fahrial、Wibawa I. Dewa Nyoman、Rezkitha Yudith Annisa Ayu、Maimunah Ummi、Subsomwong Phawinee、Parewangi Muhammad Luthfi、Mariadi IK、Adi P、Uchida Tomohisa、Purbayu H、Sugihartono T、Waskito LA、Hidayati HB、Lusida MI、Yamaoka Yoshio
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: 0176203-0176203

    • DOI

      10.1371/journal.pone.0176203

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Survival of Helicobacter pylori in gastric acidic territory2017

    • Author(s)
      Ansari Shamshul、Yamaoka Yoshio
    • Journal Title

      Helicobacter

      Volume: 22 Issue: 4 Pages: 12386-12386

    • DOI

      10.1111/hel.12386

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 胃内細菌叢とHelicobacter pylori感染(特集 Helicobacter pylori感染とマイクロバイオーム)2017

    • Author(s)
      松本昂、山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 235-239

    • NAID

      40021239008

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pyloriから分かるヒトの足跡2017

    • Author(s)
      山岡吉生
    • Journal Title

      日本消化器病学会雑誌

      Volume: 59 Pages: 706-707

    • NAID

      130006776354

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ラテンアメリカにおけるHelicobacter pylori除菌による胃がん予防(特集 Helicobacter pylori除菌による胃がん予防の国際的潮流)2017

    • Author(s)
      田中信吾,山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 363-369

    • NAID

      40021312327

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pylori研究の最新レヴュー Helicobacter pyloriの感染ルートはここまで明らかになった2017

    • Author(s)
      赤田純子、手島理絵、山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 446-450

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pyloriのプロテオーム:ゲノミクスありてプロテオミクス2017

    • Author(s)
      赤田純子、松尾祐一、山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 491-496

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pylori 感染症 認定医スキルアップ講座Helicobacter pyloriの毒性の強さはどこで決まりますか2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 77-80

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 海外Helicobacter pylori疫学調査:-立案,調査からデータ解析に至るまで-. 第12回 モンゴルでの疫学調査-その1-2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 5-17

    • NAID

      40021102926

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 海外Helicobacter pylori疫学調査:-立案,調査からデータ解析に至るまで-. 第13回 モンゴルでの疫学調査-その2-2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 95-104

    • NAID

      40021174773

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 海外Helicobacter pylori疫学調査:-立案,調査からデータ解析に至るまで-. 第14回 モンゴルでの疫学調査-その3-2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 191-207

    • NAID

      40021238934

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 海外Helicobacter pylori疫学調査:-立案,調査からデータ解析に至るまで-. 第15回 モンゴルでの疫学調査-その4-2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21 Pages: 304-317

    • NAID

      40021312216

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Helicobacter pylori as an oncogenic pathogen, revisited2017

    • Author(s)
      Miftahussurur M, Yamaoka Y, Graham DY
    • Journal Title

      Expert Rev Mol Med

      Volume: 19(e4) Pages: 1-11

    • DOI

      10.1017/erm.2017.4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori Outer Membrane Protein-Related Pathogenesis.2017

    • Author(s)
      Matsuo Y, Kido Y, Yamaoka Y
    • Journal Title

      Toxins (Basel)

      Volume: 9(3) Issue: 3 Pages: 1-9

    • DOI

      10.3390/toxins9030101

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas.2017

    • Author(s)
      Thorell K, Yahara K, Berthenet E, Lawson DJ, Mikhail J, Kato I, Mendez A, Rizzato C, Bravo MM, Suzuki R, Yamaoka Y, Torres J, Sheppard SK, Falush D.
    • Journal Title

      PLoS Genet

      Volume: 13(2) Issue: 2 Pages: 1-21

    • DOI

      10.1371/journal.pgen.1006546

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High Fluoroquinolone Resistant Strains of Helicobacter pylori in the Golden triangle2017

    • Author(s)
      Vilaichone RK, Ratanachu ek T, Gamnarai P, Subsomwong P, Uchida T, Yamaoka Y, Mahachai V.
    • Journal Title

      Asian Pac J Cancer Prev.

      Volume: 18(2) Pages: 455-458

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody.2017

    • Author(s)
      Matsuo Y, Kido Y, Akada J, Shiota S, Binh TT, Trang TT, Dung HD, Tung PH, Tri TD, Thuan NP, Tam LQ, Nam BC, Khien VV, Yamaoka Y.
    • Journal Title

      World J Gastroenterol

      Volume: 23(1) Issue: 1 Pages: 48-59

    • DOI

      10.3748/wjg.v23.i1.48

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ヘリコバクター学の世界展開2017

    • Author(s)
      山岡吉生, 松久威史
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 18(2) Pages: 44-46

    • Related Report
      2016 Annual Research Report
  • [Journal Article] スキルアップ (14) Helicobacter pyloriの毒性の強さはどこで決まりますか?2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21(1) Pages: 77-80

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 第12回 モンゴルでの疫学調査 - その1 -2017

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 21(1) Pages: 5-17

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Helicovanter pylori VacA, acting through receptor tyrosine phosphatase is crucial for CagA phosphorylation in human duodenal carcinoma cell line AZ-521.2016

    • Author(s)
      Nakano, M., Yahiro, K., Yamazaki, E., Kurazono, H., Akada, J.K., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T. Moss, J. and Hirayama, T.
    • Journal Title

      Dis. Model Mech.

      Volume: 9 Issue: 12 Pages: 1473-1481

    • DOI

      10.1242/dmm.025361

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surveillance of Helicobacter pylori Antibiotic Susceptibility in Indonesia: Different Resistance Types among Regions and with Novel Genetic Mutations.2016

    • Author(s)
      Miftahussurur M, Syam AF, Nusi IA, Makmun D, Waskito LA, Zein LH, Akil F, Uwan WB, Simanjuntak D, Wibawa ID, Waleleng JB, Saudale AM, Yusuf F, Mustika S, Adi P, Maimunah U, Maulahela H, Rezkitha YA, Subsomwong P, Nasronudin, Rahardjo D, Suzuki R, Akada J, Yamaoka Y.
    • Journal Title

      PLoS One

      Volume: 11(12):e0166199 Issue: 12 Pages: 1-17

    • DOI

      10.1371/journal.pone.0166199

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differences in amino acid frequency in CagA and VacA sequences of <i>Helicobacter pylori</i> distinguish gastric cancer from gastric MALT lymphoma.2016

    • Author(s)
      Hashinaga M, Suzuki R, Akada J, Matsumoto T, Kido Y, Okimoto T, Kodama M, Murakami K, Yamaoka Y
    • Journal Title

      Gut Pathog.

      Volume: 8:54 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s13099-016-0137-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal.2016

    • Author(s)
      Miftahussurur M, Shrestha PK, Subsomwong P, Sharma RP, Yamaoka Y
    • Journal Title

      BMC Microbiol.

      Volume: 16(1):256 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12866-016-0873-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer.2016

    • Author(s)
      Rezkitha YA, Miftahussurur M, Nusi IA, Maimunah U, Adi P, Yamaoka Y
    • Journal Title

      Acta Med Indones.

      Volume: 48(4) Pages: 307-313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.2016

    • Author(s)
      Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N.
    • Journal Title

      BMC Microbiol.

      Volume: 16(1):201 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s12866-016-0820-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between vacA Types and Development of Gastroduodenal Diseases.2016

    • Author(s)
      Thi Huyen Trang T, Thanh Binh T, Yamaoka Y.
    • Journal Title

      Toxins (Basel)

      Volume: 8(6) pii:E182 Issue: 6 Pages: 1-10

    • DOI

      10.3390/toxins8060182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand.2016

    • Author(s)
      Vilaichone RK, Ratanachu-Ek T, Gamnarai P, Chaithongrat S, Uchida T, Yamaoka Y, Mahachai V.
    • Journal Title

      Am J Trop Med Hyg

      Volume: 94 Issue: 4 Pages: 717-720

    • DOI

      10.4269/ajtmh.15-0449

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance.2016

    • Author(s)
      Aftab H, Miftahussurur M, Subsomwong P, Ahmed F, Khan AK, Yamaoka Y
    • Journal Title

      J Infect Dev Ctries

      Volume: 10(3) Pages: 245-253

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered.2016

    • Author(s)
      Miftahussurur M, Yamaoka Y, Graham DY
    • Journal Title

      Translational Cancer Res

      Volume: 5(Suupl 3) Issue: S3 Pages: 557-560

    • DOI

      10.21037/tcr.2016.09.33

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Empiric H. pylori therapy-10 day concomitant, bismuth quadruple or 14-day triple therapy: none is best2016

    • Author(s)
      Yamaoka Y, Graham DY
    • Journal Title

      Translational Cancer Res

      Volume: 5(Suppl 7) Issue: S7 Pages: 1476-1478

    • DOI

      10.21037/tcr.2016.12.39

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 第7回 ベトナムでの疫学調査 - その1 -2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(2) Pages: 106-117

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 第8回 ベトナムでの疫学調査 - その2 -2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(3) Pages: 213-222

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 第9回 バングラデシュでの疫学調査2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(4) Pages: 309-319

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 第10回 タイでの疫学調査 - その1 -2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(5) Pages: 430-442

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 第11回 タイでの疫学調査 - その2 -2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(6) Pages: 552-560

    • Related Report
      2016 Annual Research Report
  • [Journal Article] H.pylori感染症におけるToll-like receptor10の役割2016

    • Author(s)
      永島裕之, 魚谷貴史, 鈴木留美子, 内田智久, David Graham, 山岡吉生
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 17(2) Pages: 20-24

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] わが国における薬剤耐性Helicobacter pyloriの現状 - 2013~2014年度耐性菌サーベイランスの集計報告 -2016

    • Author(s)
      橋永正彦, 沖本忠義, 兒玉雅明, 水上一弘, 小川竜, 岡本和久, 首藤充孝, 福田健介, 園田光, 福田昌英, 本田俊一郎, 山岡吉生, 村上和成
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 17(2) Pages: 20-24

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第22回 日本ヘリコバクター学会学術集会の開催にあたって2016

    • Author(s)
      山岡吉生
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 17(2) Pages: 4-4

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Helicobacter pylori のプロテオーム - ゲノミクスありてプロテオミクス -2016

    • Author(s)
      赤田純子, 松尾祐一, 山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(5) Pages: 491-496

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Helicobacter pylori から探る人類の旅2016

    • Author(s)
      鈴木留美子, 山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20(5) Pages: 465-470

    • Related Report
      2016 Annual Research Report
  • [Journal Article] H.pylori感染症におけるTLR10 SNPの感染率, 組織所見に与える影響2016

    • Author(s)
      永島裕之, 山岡吉生
    • Journal Title

      日本消化器病学会雑誌

      Volume: 113(Suppl 2) Pages: 713-713

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Helicobacter pylori virulence and gastric cancer pathogenesis: current knoeledge2019

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 27th Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research and the 16th Japan-Korea Joint Symposium on Helicobacter Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A potential biomarker panel to distinguish gastric cancer from duodenal ulcer: results from GWAS in East Asian-type Helicobacter pylori2019

    • Author(s)
      Vo Phuoc Tuan, Kouji Yahara, Yoshio Yamaoka
    • Organizer
      The 27th Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research and the 16th Japan-Korea Joint Symposium on Helicobacter Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gastritis: Past, current and future treatment2019

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      World Class Professor Program in Indonesia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] H. pylori-related pathogenesis of diffuse-type gastric cancer2018

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 2nd Seoul international Symposium on Helicobacter
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori eradication and Gastric cancer prevention2018

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 2018 International Forum of Helicobacter pylori, Gastrointestinal Microbiota and the Associated diseases
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Updated information about the pathogenesis of Helicobacter pylori infection2018

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 8th Shanghai International Conference of Gastroenterology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-Helicobacter pylori microbiome in gastric carcinogenesis2018

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Asian Pacific Digestive Week(APDW 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori: Challenging the present and future2018

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Makassar Gastroenterology Hepatology Update 2018 (MAGEHAP2018) & Gastroenterology-Hepatology Update; Surabaya-Denpasar-Malang-Makassar 14 (SUDEMMA14) Joint conference.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 胃のマイクロバイオームに関する検討2018

    • Author(s)
      山岡吉生
    • Organizer
      平成30年度(第50回)九州微生物研究会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiology of Helicobacter pylori2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Peradeniya University Research Forum
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Virulence factors of Helicobacter pylori2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Renji-Nanfang Symposium on Helicobacter pylori and microbiota in health and disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Expanding horizon in molecular epidemiology of infectious diseases2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Airlangga University Research Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Japan: Gastritis: concept in evolution2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Asian Pacific Digestive Week 2017 (Healthy Stomach Initiative)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori and inflammation driven gastric cancer2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Asian Pacific Digestive Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stomach microbiome, results from 7 Asian countries2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXXth International Workshop on Helicobacter & Microbiota in Inflammation and Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori research in Asia2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      University of Malaysia Sabah Medical Research Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Gut microbiome and diseases2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      7th Mongolian Digestive Disease Week
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of Helicobacter pylori study and its future prospect2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      7th Mongolian Digestive Disease Week
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of antibiotics resistance for Helicobacter pylori in the Dominican Republic2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XIII Congreso Internacional de Investigacion Cientifica
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The epidemiology of Helicobacter pylori2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Muhammadiyah Surabaya University Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Update Management on Helicobacter pylori2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Denpasar Update in Gastroentero-Hepatology Meeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Education system in Japan2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Muhammadiyah Surabaya University Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Recent updates on basic research of H. pylori in Japan2017

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      14th Japan-Korea Joint Symposium on Helicobacter Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ピロリ菌と人類の長い付き合い2017

    • Author(s)
      山岡吉生
    • Organizer
      第15回日本予防医学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pyloriから分かるヒトの足跡2017

    • Author(s)
      山岡吉生
    • Organizer
      第93回日本消化器内視鏡学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori LPSはTLR2/TLR10に認識される2016

    • Author(s)
      永島裕之、山岡吉生、横田伸一
    • Organizer
      第 22 回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      鹿児島大学 郡元キャンパス(鹿児島県鹿児島市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘリコバクター・ピロリと人類の移動の歴史2016

    • Author(s)
      山岡吉生
    • Organizer
      第55回日本臨床細胞学会
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Epidemiology and disease association of H. pylori2016

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Asian Pacific Digestive Week(APDW) 2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Validation of serum markers of precancerous condition in Mongolia, where burdens high gastric cancer2016

    • Author(s)
      Boldbaatar G, Tegshee T, Khasag O, Duger D, Adiyasuren B, Uchida T, Subsomwong P, Matsuhisa T, Tsogt-Ochir B, Yamaoka Y.
    • Organizer
      Asian Pacific Digestive Week (APDW) 2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel East Asian-type CagA antibody ELISA can detect H. pylori CagA antibody with higher sensitivity than commercial available CagA ELISA2016

    • Author(s)
      Matsuo Y, Kido Y, Akada J, Shiota S, Binh TT, Trang TTH, Dung HDQ, Tung PH, Tri TD, Thuan NPM, Tam LQ, Nam BC, Khien VV, Yamaoka Y
    • Organizer
      Asian Pacific Digestive Week (APDW) 2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Different ethnics had different virulence genotypes of H. pylori in North Thailand2016

    • Author(s)
      Subsomwong P., Miftahussurur M., Vilaichone RK., Ratanachu-ek T., Suzuki R., Uchida T., Mahachai V., Yamaoka Y
    • Organizer
      Asian Pacific Digestive Week (APDW) 2016
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘリコバクター・ピロリのヒトとの共進化から紐解く共生から病原性へのパラダイムシフト2016

    • Author(s)
      山岡吉生
    • Organizer
      第31回日本微生物生態学会
    • Place of Presentation
      横須賀市文化会館(神奈川県横須賀市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Histopathological characteristic of Helicobacter pylori infected gastric mucosa in Asia2016

    • Author(s)
      Uchida T, Miftahussurur M,Ratha-Korn V, Thawee R, Mahachai V, Yamaoka Y
    • Organizer
      XXIXth International Workshop on Helicobacter and Microbiome in inflammation and Cancer.
    • Place of Presentation
      マーゲブルク(ドイツ)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utility of gastro-endoscopy for subjects with serum H. pylori antibody (Hp-IgG) titer equal or more than 3.0 U/mL-Study of endoscopic findings for titers between 3.0 and 9.9 U/mL (so-called “Grayzone”).2016

    • Author(s)
      Shuto M, Murakami K, Matsunari O, Okamoto K, Mizukami K, Okimoto T, Kodama M, Nonaka Y, Takigami S, Yamaoka Y, Fujioka T
    • Organizer
      XXIXth International Workshop on Helicobacter and Microbiome in inflammation and Cancer.
    • Place of Presentation
      マーゲブルク(ドイツ)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changing prevalence of Helicobacter pylori infection at a tertiary center in Austria2016

    • Author(s)
      Kamogawa Y, Uchida T, Beer A, Biliglier C, Schoneger-Heneke M, Trible B, Steininger C, Taruner M, Yamaoka Y, Dolak W
    • Organizer
      XXIXth International Workshop on Helicobacter and Microbiome in inflammation and Cancer.
    • Place of Presentation
      マーゲブルク(ドイツ)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コロンブス後の南米におけるピロリ菌・mtDNA・ Y2016

    • Author(s)
      鈴木留美子, 小野孝明, 塩田星児, 山岡吉生
    • Organizer
      日本進化学会第18回大会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都目黒区)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] GI complication of H. pylori infection2016

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      33rd World Congress of Internal Medicine
    • Place of Presentation
      バリ島(インドネシア)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori virulence and gastric cancer pathogenesis2016

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Singapore Gastric Cancer Consortium; 9th Annual Scientific Program
    • Place of Presentation
      シンガポール(シンガポール)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 現地に出かけてこその疫学研究2016

    • Author(s)
      山岡吉生
    • Organizer
      第22回日本ヘリコバクター学会
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Virulence factors and highly increasing antibiotics resistance of Helicobacter pylori in Vietnam2016

    • Author(s)
      Dung HD, Binh TT, Tri TD, Tung NL, Long T, Phuong TNN, Murakami K, Fujioka T, Moriyama M, Uchida T, Yamaoka Y
    • Organizer
      22nd annual meeting of the Japanese society for Helicobacter Research
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of Helicobacter pylori infection and gastroduodenal diseases in minor ethnic groups in Vietnam2016

    • Author(s)
      Khien VV, Trang HT, Binh TT, Dung HDQ, Nam BC, Tung PH, Tri TD, Thuan NPM, Hoan PQ, Yamaoka Y
    • Organizer
      22nd annual meeting of the Japanese society for Helicobacter Research
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human migration patterns in Asia revealed by H. pylori2016

    • Author(s)
      Suzuki R, Matsumoto T, Akada J, Matsunari O, Shiota S, Binh TT, Trang HT, Miftahussurur M, Subsomwong P, Yamaoka Y
    • Organizer
      22nd annual meeting of the Japanese society for Helicobacter Research
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter pylori感染による胃粘膜でのIL-17Cの発現について2016

    • Author(s)
      田中信吾、永島裕之、魚谷貴洋、Graham DY, 山岡吉生
    • Organizer
      第22回日本ヘリコバクター学会
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Helicobacter pylori感染症におけるToll-like receptor 10 polymorphimが与える感染率、組織的所見の影響2016

    • Author(s)
      永島裕之、鈴木留美子、山岡吉生
    • Organizer
      第22回日本ヘリコバクター学会
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] H. pylori virulence genes of Minor ethnic groups in North Thailand2016

    • Author(s)
      Subsomwong P., Miftahussurur M., Vilaichone RK., Ratanachu-ek T., Suzuki R., Uchida T., Mahachai V., Yamaoka Y
    • Organizer
      Digestive Disease Week (DDW) 2016
    • Place of Presentation
      サンディエゴ(アメリカ合衆国)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The trends of primary antibiotic resistance of Helicobacter pylori in Asia: A systemic review2016

    • Author(s)
      Liou JY, Kuo YK, Wu JY, Yamaoka Y. Wu MS.
    • Organizer
      Digestive Disease Week (DDW) 2016
    • Place of Presentation
      サンディエゴ(アメリカ合衆国)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter pylori Virulence and Gastric Cancer Pathogenesis: Population-based strategies for H. pylori-associated disease management: a Japanese perspective2016

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      National H. pylori Conference and Northeast Digestive Diseases Forum
    • Place of Presentation
      長春(中国)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Helicobacter pylori virulence and gastric cancer pathogenesis2016

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Digestive Disease Research Seminar; University of Vienna
    • Place of Presentation
      ウィーン(オーストリア)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヘリコバクター・ピロリの分子疫学的検討2016

    • Author(s)
      山岡吉生
    • Organizer
      第53回日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A novel East Asian-type CagA ELISA can evaluate the activity of chronic gastric inflammation in East Asian country2016

    • Author(s)
      Matsuo Y, Kido Y, Binh TT, Akada J, Yamaoka Y
    • Organizer
      13th Korea-Japan Joint Symposium on Helicobacter infection
    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] Microbiota: Current Research and Emerging Trends2019

    • Author(s)
      Vo Phuoc Tuan, Boldbaatar Gantuya, Takashi Matsumoto and Yoshio Yamaoka
    • Total Pages
      24
    • Publisher
      Caister Academic Press
    • Related Report
      2018 Annual Research Report
  • [Book] 病原菌の今日的意味 改正5版2018

    • Author(s)
      山岡 吉生
    • Publisher
      医薬ジャーナル社
    • Related Report
      2017 Annual Research Report
  • [Book] Helicobacter pylori2016

    • Author(s)
      Miftahussurur M, Yamaoka Y
    • Total Pages
      267
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] Helicobacter pylori Research: from Bench to Bedside2016

    • Author(s)
      Miftahussurur M, Yamaoka
    • Total Pages
      613
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Remarks] 大分大学医学部環境・予防医学講座

    • URL

      http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 大分大学国際教育研究推進機構

    • URL

      http://in-gear.med.oita-u.ac.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ペプチド及びその利用2018

    • Inventor(s)
      赤田純子、山岡吉生、村上和成、塩田星児
    • Industrial Property Rights Holder
      赤田純子、山岡吉生、村上和成、塩田星児
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] 「アフリカにおけるピロリ菌感染」国際セミナー:ルワンダおよびケニア共和国にて開催2018

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] 13th Korea-Japan Joint Symposium on Helicobacter infection2016

    • Place of Presentation
      別府ビーコンプラザ(大分県別府市)
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-05-20  

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