Analysis of microbiota that regulates influenza virus-specific adaptive immune responses
| Project/Area Number |
16H05193
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
MORIYAMA Miyu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | インフルエンザウイルス / 腸内細菌 / ワクチン / 腸内細菌叢 / 感染防御 |
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| Outline of Final Research Achievements |
Although half of the world’s population could face severe food crisis as a result of global warming by the end of this century, the effects of environmental temperature and host nutritional status in host defense to viral infection in vivo are less clear. Here, we demonstrated that exposure of mice to the high ambient temperature of 36 °C reduced their food intake and impaired adaptive immune responses to influenza virus infection. In addition, we found that administration of glucose or dietary short-chain fatty acids restored influenza virus-specific adaptive immune responses in high heat-exposed mice. Our results imply possible public health problems and concerns that outside temperature and host nutritional status may be critical determinants of viral pathogenesis or vaccine efficacy.
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| Academic Significance and Societal Importance of the Research Achievements |
以上の成果は、外気温がウイルス特異的な免疫応答の誘導に影響を与えることを示した世界で初めての例であり、腸内細菌叢がインフルエンザウイルス特異的な免疫応答に役立つ理由を解明した極めて重要な知見である。また地球温暖化や食糧危機、過度なダイエットが米国で認可されている弱毒生インフルエンザワクチンや、我が国で臨床試験段階にある経鼻投与型インフルエンザワクチンの効果を低下させる可能性を示唆するものであり、これらのことを正しく理解し、対策を講じるにはさらなる研究が必要である。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019
Author(s)
Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake, K.
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Journal Title
International immunology.
Volume: 31
Issue: 3
Pages: 167-173
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
Author(s)
Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
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Journal Title
Cell Host Microbe.
Volume: 23
Issue: 2
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017
Author(s)
Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 1592-1592
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017
Author(s)
Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
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Journal Title
J Clin Invest.
Volume: 127
Issue: 10
Pages: 3784-3795
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 小児科臨床2017
Author(s)
森山美優、一戸猛志
Total Pages
8
Publisher
日本小児医事出版社
Related Report
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[Book] 実験医学2016
Author(s)
森山美優、一戸猛志
Total Pages
8
Publisher
羊土社
Related Report
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