| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
T cells develop in the thymus, where various stromal cells including thymic epithelial cells regulate development and repertoire selection of immature T cells. Here, using a series of genetically modified mice, we studied the developmental mechanism and function of thymic epithelial cells. Our results showed that membrane-bound RANKL expressed in immature T cells is required for the development of medullary thymic epithelial cells. We also found that a PSMB11 gene polymorphism that is frequently found in the Japanese population impairs the function of cortical thymic epithelial cells and alters T cell repertoire in mice. In addition, we identified stromal factors and signaling proteins that determine the fate of distinct subsets of gamma/delta T cells in the thymus.
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