| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
The study results showed that (1) the expression of browning-inhibitor gene LR11 was induced before differentiation to mature adipocytes, suggesting the induction to white adipocytes through its specific inhibition for browning, (2) beige adipocytes existed in the human body, which show the different sensitivity from other fat against the reduction therapy, and (3) among patients with diabetes and/or obesity, the changes in circulating soluble LR11 levels were not associated with those in body weights, but clearly with the degrees of accompanied diseases. These cell-biological and laboratory research results revealed that circulating sLR11 reflects pathological alteration in adipocytes, and that sLR11 is potentially a novel marker for “activated adipocytes”.
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