• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of robust proton beam scanning treatment technology considering target heterogeneity and movement

Research Project

Project/Area Number 16H05235
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionHokkaido University

Principal Investigator

Umegaki Kikuo  北海道大学, 工学研究院, 特任教授 (40643193)

Co-Investigator(Kenkyū-buntansha) 宮本 直樹  北海道大学, 工学研究院, 准教授 (00552879)
高尾 聖心  北海道大学, 大学病院, 助教 (10614216)
清水 伸一  北海道大学, 医学研究院, 教授 (50463724)
松浦 妙子  北海道大学, 工学研究院, 准教授 (90590266)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords粒子線治療学 / 粒子線治療計画 / 動体追跡粒子線治療 / 医学物理学 / 粒子線治療 / 放射線治療計画
Outline of Final Research Achievements

We have proposed a new approach of treatment plan optimization method considering the probability distribution of dose error caused by the various uncertainties in proton beam therapy. The three-dimensional dose distribution is optimized to irradiate the target tumor while sparing the normal tissue by controlling the dose for each spot with intensity modulation. We have evaluated probabilistic dose errors caused by variation of individual device performance, patient positioning error, target tumor movement under respiration, etc.. The dose error considering the anisotropy unique to the proton beam is also clarified. Beyond the conventional treatment plan concept of contouring the tumor shape and providing a uniform margin, we have constructed a robust optimization method considering the probability distribution of dose error. The method was evaluated and demonstrated using the actual proton beam therapy system.

Academic Significance and Societal Importance of the Research Achievements

本研究では、将来の放射線治療の切り札として期待されているスキャニング方式の粒子線治療において、新たに確率/統計的手法を用いて位置決め誤差や呼吸等による標的の移動誤差による線量分布誤差を評価し、最適な治療計画を策定する指針を提示することを試みた。学術的には、線量誤差の確率分布を考慮したロバストな照射パラメータの最適化やトレードオフスタディ方法を考案し、陽子線治療センターで実践した。その結果、従来の治療計画の枠組みを越えた、照射プロセス全体のロバストな最適化が可能になった。今後も検証と実績評価を経て臨床現場に適用していく予定である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (82 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (19 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 19 results,  Open Access: 18 results,  Acknowledgement Compliant: 1 results) Presentation (55 results) (of which Int'l Joint Research: 30 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] Stanford University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Stanford University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Stanford University(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Dynamic gating window technique for the reduction of dosimetric error in respiratory-gated spot-scanning particle therapy: An initial phantom study using patient tumor trajectory data2020

    • Author(s)
      Naoki Miyamoto, Kouhei Yokokawa, Seishin Takao, Taeko Matsuura, Sodai Tanaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 1 Issue: 4 Pages: 1-9

    • DOI

      10.1002/acm2.12832

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in LET‐based biological doses between IMPT optimization techniques: Robust and PTV‐based optimizations2020

    • Author(s)
      Hirayama Shusuke、Matsuura Taeko、Yasuda Koichi、Takao Seishin、Fujii Takaaki、Miyamoto Naoki、Umegaki Kikuo、Shimizu Shinichi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: - Issue: 4 Pages: 1-9

    • DOI

      10.1002/acm2.12844

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical and biological impacts of collimator-scattered protons in spot-scanning proton therapy2019

    • Author(s)
      Ueno Koki、Matsuura Taeko、Hirayama Shusuke、Takao Seishin、Ueda Hideaki、Matsuo Yuto、Yoshimura Takaaki、Umegaki Kikuo
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 7 Pages: 48-57

    • DOI

      10.1002/acm2.12653

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new SOBP-formation method by superposing specially shaped Bragg curves formed by a mini-ridge filter for spot scanning in proton beam therapy2019

    • Author(s)
      Yokokawa K, Furusaka M, Matsuura T, Hirayama S, Umegaki K
    • Journal Title

      Physica Medica

      Volume: 67 Pages: 70-76

    • DOI

      10.1016/j.ejmp.2019.10.036

    • NAID

      120006937033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of treatment process time for real‐time‐image gated‐spot‐scanning proton‐beam therapy (RGPT) system2019

    • Author(s)
      Yoshimura Takaaki、Shimizu Shinichi、Hashimoto Takayuki、Nishioka Kentaro、Katoh Norio、Inoue Tetsuya、Taguchi Hiroshi、Yasuda Koichi、Matsuura Taeko、Takao Seishin、Tamura Masaya、Ito Yoichi M.、Matsuo Yuto、Tamura Hiroshi、Horita Kenji、Umegaki Kikuo、Shirato Hiroki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 2 Pages: 38-49

    • DOI

      10.1002/acm2.12804

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Literature Review of Proton Beam Therapy for Prostate Cancer in Japan2019

    • Author(s)
      Hoshina R M, Matsuura T, Umegaki K, Shimizu S
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 1 Pages: 48-48

    • DOI

      10.3390/jcm8010048

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study2019

    • Author(s)
      T. Takayanagi, T. Uesaka, M. Kitaoka, MB.Unlu, K.Umegaki, H. Shirato, L. Xing, T. Matsuura
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 4011-4011

    • DOI

      10.1038/s41598-019-38889-w

    • NAID

      120006626576

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An analytical dose-averaged LET calculation algorithm considering the off-axis LET enhancement by secondary protons for spot-scanning proton therapy.2018

    • Author(s)
      Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto R, Umegaki K, Shirato H.
    • Journal Title

      Med Phys.

      Volume: 45 Issue: 7 Pages: 3404-3416

    • DOI

      10.1002/mp.12991

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of Energy Absorption by Clustered Gold Nanoparticles2018

    • Author(s)
      Kwon J, Sutherland K, Makarova A, Matsuura T, Hashimoto T, Peng H, Toshito T, Umegaki K, Shirato H, Shimizu S
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 429 Pages: 34-41

    • DOI

      10.1016/j.nimb.2018.05.033

    • NAID

      120006878347

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Motion management in particle therapy2018

    • Author(s)
      Mori S, Knopf A C, Umegaki K
    • Journal Title

      Medical Physics

      Volume: 45 Issue: 11

    • DOI

      10.1002/mp.12679

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Theoretical analysis of angular distribution of scattering in nozzle components using a response-function method for proton spot-scanning therapy2018

    • Author(s)
      H. Ueda, M. Furusaka, T. Matsuura, S. Hirayama and K. Umegaki
    • Journal Title

      Physics in medicine and biology

      Volume: 63 Issue: 3 Pages: 35005-35005

    • DOI

      10.1088/1361-6560/aaa15a

    • NAID

      120006401473

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of external beam radiotherapy approaches for precise and accurate cancer treatment2018

    • Author(s)
      H. Shirato, Q-T. Le, K. Kobashi, A. Prayongrat, S. Takao, S. Shimizu, A. Giaccia, L. Xing and K. Umegaki
    • Journal Title

      Journal of Radiation Research

      Volume: 59 Issue: suppl_1 Pages: i2-i10

    • DOI

      10.1093/jrr/rrx092

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Present developments in reaching an international consensus for a model-based approach to particle beam therapy2018

    • Author(s)
      Prayongrat Anussara、Umegaki Kikuo、van der Schaaf Arjen、Koong Albert C、Lin Steven H、Whitaker Thomas、McNutt Todd、Matsufuji Naruhiro、Graves Edward、Mizuta Masahiro、Ogawa Kazuhiko、Date Hiroyuki、Moriwaki Kensuke、Ito Yoichi M、Kobashi Keiji、Dekura Yasuhiro、Shimizu Shinichi、Shirato Hiroki
    • Journal Title

      Journal of Radiation Research

      Volume: 59 Issue: suppl_1 Pages: i72-i76

    • DOI

      10.1093/jrr/rry008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic Malignancies on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee2017

    • Author(s)
      J. Y. Chang, X. Zhang, A. Knopf, H. Li, S. Mori, L. Dong, H-M. Lu, W. Liu, S. N. Badiyan, S. Both, A.Meijers, L. Lin, S. Flampouri, Z.Li, K. Umegaki, C. B. SimoneII and X. R. Zhu
    • Journal Title

      International Journal of Radiation Oncology, Biology, Physics

      Volume: 99 Issue: 1 Pages: 41-50

    • DOI

      10.1016/j.ijrobp.2017.05.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate2017

    • Author(s)
      Y. Fujii, T. Matsuura, S. Takao, Y. Matsuzaki, T. Fujii, N. Miyamoto, K. Umegaki, K. Nishioka, S. Shimizu and H. Shirato
    • Journal Title

      Journal of Radiation Research

      Volume: 58 Issue: 4 Pages: 591-597

    • DOI

      10.1093/jrr/rrx020

    • NAID

      120006346118

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Compact Synchrotron for Proton Beam Therapy2017

    • Author(s)
      F. Ebina, M. Umezawa, H. Nishiguchi, T. Aoki, K. Hiramoto, K.Matsuda, K. Umegaki and M. Furusaka
    • Journal Title

      Electronics and Communications in Japan

      Volume: 100 Issue: 8 Pages: 312-318

    • DOI

      10.1002/ecj.11972

    • NAID

      210000167888

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study.2017

    • Author(s)
      Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 97(1) Issue: 1 Pages: 173-181

    • DOI

      10.1016/j.ijrobp.2016.09.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique.2016

    • Author(s)
      Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M, Nihongi H, Shimizu S, Shirato H, Umegaki K
    • Journal Title

      Phys Med.

      Volume: 32(7) Issue: 7 Pages: 932-937

    • DOI

      10.1016/j.ejmp.2016.06.002

    • NAID

      120006313432

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT).2016

    • Author(s)
      Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T, Matsuzaki Y, Umegaki K, Shirato H, Shimizu S
    • Journal Title

      Phys Med.

      Volume: 32(9) Issue: 9 Pages: 1098-1102

    • DOI

      10.1016/j.ejmp.2016.08.007

    • NAID

      120005972937

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Development of a system to support intra-fractional clinical decision for real-time image-gated proton therapy; (1) Automatic actual-dose calculation system2019

    • Author(s)
      Hirayama S, Matsuura T, Kobashi K, Koyano H, Fuji Ti, Takao S, Miyamoto N, Umegaki K, Shirato H, Shimizu S,
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dependence of the Sub-Lethal Damage Repair Rate on LET in Proton Irradiation : An Initial Study2019

    • Author(s)
      Kasamatsu K, Hosoda M, Nam J-M, Yasui H, Tanaka S, Hirayama S, Miyamoto N, Umegaki K, Shirato H, Matsuura T,
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Image quality evaluation for four-dimensional cone-beam CT reconstruction using orthgonal X-ray imaging system on a gantry for proton beam therapy2019

    • Author(s)
      Otsuka Y, Ueda H, Shimizu S, Umegaki K, Miyamoto N, Takao S,
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prostate position deviation during real-time-image gated spot-scanning proton therapy (RGPT) for prostate cancer2018

    • Author(s)
      Tamura H, Shimizu S, Nishioka K, Hashimoto T, Yoshimura T, Matsuo Y, Matsuura T, Takao S, Umegaki K, Shirato H
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] A study on the influence of changing the motion recognition rate on the dose accuracy of spot-scanning proton therapy2018

    • Author(s)
      Sodeta T, Matsuura T, Takao S, Hirayama S, Kanehira, T, Miyamoto N, Shimizu S, Umegaki K, Shirato H
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of the DVH prediction method considering dose distribution in proton therapy2018

    • Author(s)
      Hiyama Y, Takao S, Matsuura T, Hirayama S, Shimizu S, Shirato H, Umegaki K
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] An investigation of biological impact caused by using a collimator in pencil beam scanning proton therapy2018

    • Author(s)
      Ueno K, Matsuura T, Takao S, Hirayama S, Ueda H, Yoshimura T, Matsuo Y, Umegaki K
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of an analytical dose-averaged LET calculation method using a dual-LET-kernel model for spot-scanning proton therapy2018

    • Author(s)
      Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto R, Umegaki K, Shirato H
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Time-dependent weighted reconstruction method with insufficient projection data for mobile target2018

    • Author(s)
      Motoi S, Tomioka S, Umegaki K, Miyamoto N
    • Organizer
      115th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Yokohama, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Time Saving Daily QA Measurement Tool for Spot scanning system2018

    • Author(s)
      Yamada T, Takayanagi T, Takao S, Matsuura T, Hirayama S, Fujii T, Umegaki K
    • Organizer
      Particle Therapy Co-Operative Group (PTCOG) 57th Annual Conference, Cincinnati, USA (2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of analytical dose-averaged LET calculation algorithm for spot-scanning proton therapy2018

    • Author(s)
      Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Shimizu S, Fujimoto R, Umegaki K, Shirato H
    • Organizer
      Particle Therapy Co-Operative Group (PTCOG) 57th Annual Conference, Cincinnati, USA (2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Prediction Method for Dose-Volume Histogram of Organ at Risks for Treatment Planning in Proton Beam Therapy2018

    • Author(s)
      Hiyama Y, Takao S, Matsuura T, Hirayama S, Fujii T, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 60th Annual Meeting & Exhibition, Nashville, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-Time Volumetric Image Generation with CT Image Deformation Driven by Displacement of Internal Fiducial Markers2018

    • Author(s)
      Miyamoto N, Matsumoto N, Suzuki R, Takao S, Matsuura T, Fujii T, Hirayama S, Tomioka S, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 60th Annual Meeting & Exhibition, Nashville, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Study On the Influence of Changing the Motion Recognition Rate On the Dose Accuracy of Spot-Scanning Proton Therapy2018

    • Author(s)
      Sodeta T, Matsuura T, Takao S, Hirayama S, Kanehira T, Miyamoto N, Nishioka K, Kato N, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 60th Annual Meeting & Exhibition, Nashville, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Investigation of Biological Impact Caused by Edge-Scattered Protons in Pencil Beam Scanning Proton Therapy2018

    • Author(s)
      Ueno K, Matsuura T, Takao S, Hirayama S, Ueda H, Matsuo Y, Yoshimura T, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 60th Annual Meeting & Exhibition, Nashville, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-Time Volumetric Image Generation with CT Image Deformation Driven by Displacement of Internal Fiducial Markers2018

    • Author(s)
      Miyamoto N, Matsumoto N, Suzuki R, Takao S, Matsuura T, Fujii T, Hirayama S, Tomioka S, Shimizu S, Umegaki K, Shirato H
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] 4D-CBCT technique with fiducial marker-position to reconstruct a volumetric image just before the treatment proton beam delivery in RGPT2018

    • Author(s)
      Fujii T, Takao S, Shimizu S, Matsuura T, Miyamoto N, Hirayama S, Umegaki K, Shirato H
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lateral profile validation procedure utilizing simplified Monte Carlo calculation based on log data for patient specific QA of proton beam therapy2018

    • Author(s)
      Yamada T, Takayanagi T, Fujimoto R, Takao S, Kobashi K, Shimizu S, Umegaki K, Shirato H
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] A study of checking method for Water-Equivalent Thickness change using CBCT in Proton Therapy2018

    • Author(s)
      Unno S, Fujii T, Ueda H, Fujita Y, Takao S, Umegaki K
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaluation of Dosimetric Error for Real-Time Motion Tracking Irradiation for Scanning Directions in Proton Beam Therapy2018

    • Author(s)
      Ishida K, Miyamoto N, Yokokawa K, Umegaki K
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of interactive image registration method between planning CT and CBCT for proton therapy2018

    • Author(s)
      Fujita Y, Takao S, Ueda H, Fujii T, Unno S, Yasuda K, Shimizu S, Umegaki K
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clinical feasibility of target tumor localization algorithm using multiple fiducial markers for Real-time Tumor-tracking Proton Therapy2018

    • Author(s)
      Arai Y, Miyamoto N, Ueda H, Umegaki K
    • Organizer
      116th Scientific Meeting of JSMP (Japanese Society of Medical Physics), Morioka, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] Big Data Analysis of Treatment Process Time for the Real-time-image Gated-spot-scanning Proton-beam Therapy (RGPT) System2018

    • Author(s)
      Yoshimura T, Shimizu S, Hashimoto T, Katoh N, Inoue T, Nishioka K, Matsuura T, Takao S, Tamumra M, Tamura H, Horita K, Umegaki K, Shirato H
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology (ASTRO), San Antonio, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intensity-modulated Proton Therapy with Dose Painting based on Hypoxia Imaging for Nasopharyngeal Cancer2018

    • Author(s)
      Yasuda K, Takao S, Matsuo Y, Yoshimura T, Tamura M, Minatogawa H, Dekura Y, Matsuura T, Onimaru R, Shiga T, Shimizu S, Umegaki K, Shirato H
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology (ASTRO), San Antonio, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy2018

    • Author(s)
      Shimizu S, Yoshimura T, Katoh N, Inoue T, Hashimoto T, Nishioka K, Takao S, Matsuura T, Miyamoto N, Ito M. Y, Umegaki K, Shirato H
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology (ASTRO), San Antonio, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time saving lateral profile validation procedure utilizing simplified Monte Carlo calculation for patient specific QA of proton beam therapy2017

    • Author(s)
      T. Yamada, T. Takayanagi, T. Matsuura, S. Takao, T. Yoshimura, S. Hirayama, T. Fujii, K. Umegaki
    • Organizer
      The 113th Scientific meeting the Japan Society of Medical Physics
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis software to evaluate deviation of water-equivalent thickness along proton beam path between Plan CT and CBCT for proton therapy2017

    • Author(s)
      T. Fujii, T. Matsuura, S. Takao, N. Miyamoto, S. Hirayama, K. Umegaki, S. Shimizu, T. Umezawa, R. Baba, H. Shirato
    • Organizer
      The 113th Scientific meeting the Japan Society of Medical Physics
    • Related Report
      2017 Annual Research Report
  • [Presentation] The retrospective interplay effect evaluation for real-time image-gated proton therapy using the fiducial marker motion and treatment machine log2017

    • Author(s)
      S. Hirayama, T. Matsuura, H. Koyano, S. Takao, T. Fujii, N. Miyamoto, S. Shimizu, Y. Fujii, T. Yamada, H. Nihongi, T. Umezawa, R. Fujimoto, K. Umegaki, H. Shirato
    • Organizer
      The 113th Scientific meeting the Japan Society of Medical Physics
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of Water-Equivalent-Thickness (WET) deviation between Plan CT and Re-plan CT for prostate cancer in Spot-Scanning Proton-beam Therapy2017

    • Author(s)
      T. Fujii, T. Matsuura, S. Takao, N. Miyamoto, S. Hirayama, K. Umegaki, S. Shimizu, T. Umekawa, H. Shirato
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Time Saving Daily QA Measurement Tool for Spot Scanning Proton Therapy System2017

    • Author(s)
      T. Yamada, T. Takayanagi, S. Takao, T. Matsuura, S. Hirayama, T. Fujii, K. Umegaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the sensitivity to variable RBE considering LET dependence for the robust opti- mization and the PTV-based optimization2017

    • Author(s)
      S. Hirayama, T. Matsuura, H. Ueda, H. Koyano, S. Takao, T. Fujii, N. Miyamoto, S. Shimizu, Y. Fujii, R. Fujimoto, K. Umegaki, H. Shirato
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers2017

    • Author(s)
      N. Miyamoto, R. Suzuki, S. Takao, T. Matsuura, S. Hirayama, T. Fujii, S. Tomioka, S. Shimizu, K. Umegaki, H. Shirato
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Target tumor localization algorithm using multiple fiducial markers for Real-time Tu- mor-tracking Radiation Therapy2017

    • Author(s)
      Y. Arai, N. Miyamoto, H. Ueda, H. Nakagawa, K. Umegaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Method for reducing depth dose error using a statistical respiratory motion model with beam angle optimization in proton beam therapy2017

    • Author(s)
      H. Nakagawa, N. Miyamoto, H. Ueda, K. Yokokawa, Y. Arai, S. Hirayama, K. Umegaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An evaluation of Water-Equivalent path Length Change along proton beam paths in Real-time Tumor-tracking Proton Therapy2017

    • Author(s)
      S. Unno, T. Fujii, H. Ueda, S. Takao, T. Ano, K. Umegaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Amplitude-Based 4D reconstruction with ML-EM method for on-board Cone Beam CT2017

    • Author(s)
      T. Ano, S. Takao, H. Ueda, T. Fujii, S. Unno, K. Umegaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of An Image Registration Method Using Beam Path-Weighted Mutual Information for Patient Setup in Proton Beam Therapy2017

    • Author(s)
      S Takao, S Kawamura , H Ueda , T Matsuura , T Fujii , S Hirayama , S Shimizu , H Shirato , K Umegaki
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Analytical Approach for Calculating the Dose-Averaged LET in Spot-Scanning Proton Therapy with An Input Derived From a Monte Carlo Simulation2017

    • Author(s)
      S Hirayama, T Matsuura , H Ueda , H Koyano , S Takao , T Fujii , Y Fujii , R Fujimoto , S Shimizu , K Umegaki , H Shirato
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Monoscopic X-Ray Imaging for Real-Time Three-Dimensional Target Localization Using Multiple Internal Fiducial Markers2017

    • Author(s)
      N Miyamoto, R Suzuki , S Takao , T Matsuura , T Fujii , S Hirayama , H Koyano , S Shimizu , K Umegaki , H Shirato
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A New SOBP-Formation Method by Superposing Specially Designed Composite Bragg Curves (CBCs) for Spot Scanning Proton Beam Therapy2017

    • Author(s)
      K Yokokawa, K Umegaki , T Matsuura , S Hirayama , M Furusaka
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a System for Evaluating the Actual Dose Distribution in Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance2017

    • Author(s)
      T Matsuura, S Hirayama , H Koyano , S Takao , T Fujii , T Yamada , Y Fujii , H Nihongi , S Shimizu , K Umegaki , H Shirato
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New Analysis Method of Proton Beam Profile Broadenings in Spot-Scanning Proton Nozzle Using Response Function of Angular Distribution2017

    • Author(s)
      H Ueda, T Matsuura , S Hirayama , M Furusaka , K Umegaki
    • Organizer
      AAPM(The American Association of Physicists in Medicine) 59th Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Durations and Dose Rates for Treatment of Moving Liver Tumors Using Real-Time Image Gated Spot Scanning Proton Beam Therapy2016

    • Author(s)
      Shimizu S, Katoh N, Hashimoto T, Nishioka K, Yoshimura T, Takao S, Matsuura T, Miyamoto N, Umegaki K, Shirato H
    • Organizer
      ASTRO 2016 58th Annual Meeting
    • Place of Presentation
      Boston Convention and Exhibition Center
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility Study of Using Dual-Energy Cone Beam Computed Tomography (DE-CBCT) in Proton Therapy Treatment Planning2016

    • Author(s)
      Peng H, Kanehira T, Takao S, Matsuura T, Umegaki K, Shirato H, Xing L
    • Organizer
      ASTRO 2016 58th Annual Meeting
    • Place of Presentation
      Boston Convention and Exhibition Center
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 陽子線スポットスキャニング治療における治療計画モンテカルロ検証システムの開発2016

    • Author(s)
      長田真由子, 上田英明, 藤井祐介, 松崎有華, 平山嵩祐, 梅垣菊男
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 陽子線治療における計画CTとコーンビームCT画像の三次元位置合わせプログラムの開発2016

    • Author(s)
      川村翔太郎, 上田英明, 中里慧二, 高尾聖心, 藤井孝明, 梅垣菊男
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 陽子線治療における呼吸性移動を考慮した空間位置位相別4次元コーンビームCT画像再構成法の開発2016

    • Author(s)
      阿野知史, 上田英明, 高尾聖心, 藤井孝明, 川村翔太郎, 梅垣菊男
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動体追跡陽子線治療における線量分布評価のための腫瘍の呼吸性移動のモデリング2016

    • Author(s)
      中川晴夫, 宮本直樹, 上田 英明, 横川航平, 松崎有華, 長田真由子, 梅垣菊男
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 体内マーカ3次元軌跡の解析による呼吸位相評価を利用した動体追跡放射線治療の患者位置決め/ゲート照射の効率化2016

    • Author(s)
      宮本直樹, 鈴木隆介, 高尾聖心, 松浦妙子, 松崎有華, 藤井孝明, 富岡智, 清水 伸一, 梅垣菊男, 白土博樹
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動体追跡研究及び4DCBCT 研究向け画像解析プラットフォームの開発2016

    • Author(s)
      藤井孝明, 高尾聖心, 宮本直樹, 松浦妙子, 松崎有華, 平山嵩祐, 清水伸一, 梅垣菊男, 白土博樹
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Software Development for 4D-CBCT Research of Real-Time-Image Gated Spot Scanning Proton Therapy2016

    • Author(s)
      Fujii T, Matsuura T, Takao S, Miyamoto N, Matsuzaki Y, Fujii Y, Umegaki K, Shimizu S, Shirato H
    • Organizer
      AAPM 2016 58th Annual meeting and Exhibition
    • Place of Presentation
      WALTER E. WASHINGTON CONVENTION CENTER, Washington DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] No Increase in Biological Effectiveness Through Collimator Scattered Low Energy Protons2016

    • Author(s)
      Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Maeda K, Ueda H, Koyano H, Umegaki K, Shirato H
    • Organizer
      AAPM 2016 58th Annual meeting and Exhibition
    • Place of Presentation
      WALTER E. WASHINGTON CONVENTION CENTER, Washington DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dosimetric Comparison of Spot-Scanning Proton Therapy Techniques for Liver Tumors Close to the Skin Surface2016

    • Author(s)
      Takao S, Matsuura T, Matsuzaki Y, Fujii Y, Fujii T, Katoh N, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 2016 58th Annual meeting and Exhibition
    • Place of Presentation
      WALTER E. WASHINGTON CONVENTION CENTER, Washington DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simulation Study of Real-Time-Image Gating On Spot Scanning Proton Therapy for Lung Tumors2016

    • Author(s)
      Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
    • Organizer
      AAPM 2016 58th Annual meeting and Exhibition
    • Place of Presentation
      WALTER E. WASHINGTON CONVENTION CENTER, Washington DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-Time Visualization of Discrete Spot Scanning Proton Therapy Beam for Quality Assurance2016

    • Author(s)
      Matsuzaki Y, Jenkins C, Yang Y, Yoshimura T, Fujii Y, Umegaki K, Xing L
    • Organizer
      AAPM 2016 58th Annual meeting and Exhibition
    • Place of Presentation
      WALTER E. WASHINGTON CONVENTION CENTER, Washington DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 北海道大学大学院工学研究院量子理工学部門量子ビーム応用医工学研究室

    • URL

      http://labs.eng.hokudai.ac.jp/labo/qsre/QSciEngjp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] http://labs.eng.hokudai.ac.jp/labo/qsre/QSciEngjp/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 粒子線治療システム2018

    • Inventor(s)
      梅垣菊男、藤井祐介、安藤竜弥、他4名
    • Industrial Property Rights Holder
      梅垣菊男、藤井祐介、安藤竜弥、他4名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-086846
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 粒子線照射システムおよび照射計画装置2018

    • Inventor(s)
      梅垣菊男、藤井祐介、藤本林太郎、宮本直樹、平山嵩祐、清水伸一
    • Industrial Property Rights Holder
      梅垣菊男、藤井祐介、藤本林太郎、宮本直樹、平山嵩祐、清水伸一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-028532
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線治療装置2017

    • Inventor(s)
      藤井孝明、高尾聖心、宮本直樹、松浦妙子、梅垣菊男
    • Industrial Property Rights Holder
      藤井孝明、高尾聖心、宮本直樹、松浦妙子、梅垣菊男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-047982
    • Filing Date
      2017-03-14
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-05-20  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi