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A cohort study in relation to lifestyle factors responsible for improvement of cancer patient survival and quality of life

Research Project

Project/Area Number 16H05240
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionTohoku University

Principal Investigator

YUKO MINAMI  東北大学, 医学系研究科, 名誉教授 (60239316)

Co-Investigator(Kenkyū-buntansha) 宮下 穣  東北大学, 大学病院, 講師 (60710788)
金村 政輝  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん疫学・予防研究部, 部長 (80418615)
鈴木 昭彦  東北大学, 医学系研究科, 准教授 (60375045)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん / コホート研究 / 予後 / 生活習慣 / 喫煙 / 飲酒 / 食事要因
Outline of Final Research Achievements

We clarified the associations between lifestyles at the time of diagnosis and survival among patients with major cancer using a prospective patient cohort study. In addition, we prepared a new project aiming to promote quality of life (QOL) among the patients. The cohort study found a positive association between alcohol drinking and the risk of death among patients with stomach cancer and an inverse association among those with breast cancer. Smoking was associated with an increased risk of death among patients with cancer of colon, prostate or lung (adenocarcinoma). In the analysis of dietary factors, intake of soybean products was associated with a decreased risk of death among patients with stomach cancer. Seaweed intake was associated with a decreased risk of death among patients with colon or rectal cancer. In future, further studies focusing on QOL are required to accumulate useful information for cancer patients.

Academic Significance and Societal Importance of the Research Achievements

これまでのがんの疫学研究はがんの罹患リスク要因解明を主たる目標としてきたが、本研究は主要がん患者を対象として診断時の生活習慣と生命予後との関連を明らかにした。予後要因に関する知見は日本・海外ともに少なく、喫煙・飲酒・食事要因などのがんのリスク要因が生命予後にも影響を与えることを明らかにした本研究は、がん疫学の新たな方向性を示している。今回の研究成果を契機に、今後さらに他の生活習慣要因や生活の質(QOL)に関する研究を進め、がん患者自身のセルフケア能力の向上や家族支援にも役立つような生活支援プログラムの開発を進めていきたいと考えている。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (6 results)

  • [Journal Article] Reproductive history and breast cancer survival: a prospective patient cohort study in Japan2019

    • Author(s)
      Minami Yuko、Nishino Yoshikazu、Kawai Masaaki、Tada Hiroshi、Kanemura Seiki、Miyashita Minoru、Ishida Takanori、Kakugawa Yoichiro
    • Journal Title

      Breast Cancer

      Volume: - Issue: 6 Pages: 687-702

    • DOI

      10.1007/s12282-019-00972-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study2019

    • Author(s)
      Minami Y, Kanemura S, Kawai M, Nishino Y, Tada H, Miyashita M, Ishida T, Kakugawa Y
    • Journal Title

      PLoS One

      Volume: 14(11) Issue: 11 Pages: e0224797-e0224797

    • DOI

      10.1371/journal.pone.0224797

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women2019

    • Author(s)
      Yoshida K, Takizawa Y, Nishino Y, Takahashi S, Kanemura S, Omori J, Kurosawa H, Maemondo M, Minami Y.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 247 Issue: 2 Pages: 99-110

    • DOI

      10.1620/tjem.247.99

    • NAID

      130007601733

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of cigarette smoking and alcohol drinking with stomach cancer survival: A prospective patient cohort study in Japan2018

    • Author(s)
      Minami Yuko、Kanemura Seiki、Oikawa Tomoyuki、Suzuki Shinichi、Hasegawa Yasuhiro、Miura Koh、Nishino Yoshikazu、Kakugawa Yoichiro、Fujiya Tsuneaki
    • Journal Title

      International Journal of Cancer

      Volume: - Issue: 5 Pages: 1072-1085

    • DOI

      10.1002/ijc.31408

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study2018

    • Author(s)
      Takizawa Y, Kawai M, Kakugawa Y, Nishino Y, Ohuchi N, Minami Y.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 244 Issue: 1 Pages: 63-73

    • DOI

      10.1620/tjem.244.63

    • NAID

      130006316035

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium2018

    • Author(s)
      Liu Y, Shu XO, Wen W, Saito E, Rahman MS, Tsugane S, Tamakoshi A, Xiang YB, Yuan JM, Gao YT, Tsuji I, Kanemura S, Nagata C, Shin MH, Pan WH, Koh WP, Sawada N, Cai H, Li HL, Tomata Y, Sugawara Y, Wada K, Ahn YO, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W
    • Journal Title

      Int J Epidemiol

      Volume: - Issue: 3 Pages: 771-779

    • DOI

      10.1093/ije/dyy024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] アルコール摂取と乳がんの予後との関連2019

    • Author(s)
      角川陽一郎、河合賢朗、金村政輝、南 優子
    • Organizer
      第27回日本乳癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 初経年齢、最終産年齢と乳がんの予後との関連:患者コホート研究2018

    • Author(s)
      角川陽一郎,河合賢朗,金村政輝,南 優子
    • Organizer
      第26回日本乳癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 全国がん登録を基盤とした記述疫学研究「日本版SEER」を実現するために2018

    • Author(s)
      金村政輝,伊藤秀美,大木いずみ,井上真奈美,柴田亜希子
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 全国のがん診療連携拠点病院における院内がん登録の現状分析-実施体制と実績との関連2017

    • Author(s)
      金村政輝
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] すべての病院で相対生存率の計算ができるために-期待生存率の計算ツールの開発-2016

    • Author(s)
      金村政輝
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん家族歴と組織型別肺がん罹患リスクに関する症例対照研究2016

    • Author(s)
      吉田 薫、瀧澤洋子、前門戸 任、金村政輝、南 優子
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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