Maternal and fetal prognosis and NCD risk stratification in relation to time course record during pregnancy.

• Project/Area Number: 16H05243
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: METOKI Hirohito 東北医科薬科大学, 医学部, 教授 (20580377)
• Co-Investigator(Kenkyū-buntansha): 村上 義孝 東邦大学, 医学部, 教授 (90305855)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 疫学 / 出生コホート / ライフコース疫学 / 妊娠高血圧症候群 / 生活習慣病 / 長期予後 / 家庭血圧 / 複数回測定 / 出生体重

Outline of Final Research Achievements

Blood pressure during early pregnancy, kidney function, alcohol consumption, smoking, and environmental tobacco smoking was associated with higher maternal and fetal risks. When we followed offspring’s weight and height for eight years, groups with higher maternal blood pressure showed smaller weight and height. Further analysis is needed to distinguish which effect is stronger; blood pressure level or later incidence of hypertension during pregnancy. White coat effect observed in pregnant women may be influenced by stress for antenatal checkups.

Academic Significance and Societal Importance of the Research Achievements

妊娠初期の血圧レベルや腎機能、飲酒、喫煙とその変化など、妊娠初期から中期にかけて測定される項目とその変化が、その後の妊娠高血圧症候群や出生体重に及ぼす影響が明らかとなった。これらの所見は、様々な交絡要因で補正後も有意であり、学術的意義は高い。また、妊婦のみならず、次世代に及ぼす健康影響であることから、社会的意義は大きい。

Research Products

• [Int'l Joint Research] Bristol University(英国)
• [Int'l Joint Research] Groningen University/Erasmus University(オランダ)
• [Int'l Joint Research] National Institute for Health and Welf/University of Turku(Finland)
• [Int'l Joint Research] Boston University(米国)
• [Int'l Joint Research] University of Leuven(Belgium)
• [Int'l Joint Research] Hospital Italiano de Buenos Aires(Argentina)
• [Int'l Joint Research] Sotiria Hospital(Greece)
• [Int'l Joint Research] National Institute for Health and Welf/University of Turku, Finland(Finland)
• [Int'l Joint Research] Boston University(米国)
• [Int'l Joint Research] University of Leuven(Belgium)
• [Int'l Joint Research] Hospital Italiano de Buenos Aires(Argentina)
• [Int'l Joint Research] Sotiria Hospital(Greece)
• [Int'l Joint Research]
• [Journal Article] Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy (2019)
  • Author(s): Sugawara J, Ochi D, Yamashita R, Yamauchi T, Saigusa D, Wagata M, Obara T, Ishikuro M, Tsunemoto Y, 18名略, Hiyama S, Nagasaki M
  • Journal Title: BMJ Open Volume: 9(2) Issue: 2 Pages: e025939-e025939
  • DOI: 10.1136/bmjopen-2018-025939
  • Peer Reviewed / Open Access
• [Journal Article] Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study (2019)
  • Author(s): Tanaka Kosuke、Nishigori Hidekazu、Watanabe Zen、Iwama Noriyuki、Satoh Michihiro、Murakami Takahisa、Hamada Hirotaka、Hoshiai Tetsuro、Saito Masatoshi、Mizuno Satoshi、Sakurai Kasumi、Ishikuro Mami、Obara Taku、Tatsuta Nozomi、Fujiwara Ikuma、Yaegashi Nobuo、Metoki Hirohito
  • Journal Title: Hypertension Research Volume: 4 Issue: 4 Pages: 558-566
  • DOI: 10.1038/s41440-019-0206-x
  • Peer Reviewed / Open Access
• [Journal Article] Stroke risk due to partial white-coat or masked hypertension based on the ACC/AHA guideline's blood pressure threshold: the Ohasama study. (2019)
  • Author(s): Satoh M, Asayama K, Murakami T, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Hypertension Research Volume: 42 Issue: 1 Pages: 120-122
  • DOI: 10.1038/s41440-018-0133-2
  • Peer Reviewed
• [Journal Article] N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years ― The Ohasama Study ― (2018)
  • Author(s): Satoh Michihiro、Murakami Takahisa、Asayama Kei、Hirose Takuo、Kikuya Masahiro、Inoue Ryusuke、Tsubota-Utsugi Megumi、Murakami Keiko、Matsuda Ayako、Hara Azusa、Obara Taku、Kawasaki Ryo、Nomura Kyoko、Metoki Hirohito、Node Koichi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Circulation Journal Volume: 82 Issue: 8 Pages: 2055-2062
  • DOI: 10.1253/circj.CJ-17-1227
  • NAID: 130007418933
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-07-25
  • Peer Reviewed
• [Journal Article] Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study (2018)
  • Author(s): Iwama Noriyuki、Metoki Hirohito、Nishigori Hidekazu、Mizuno Satoshi、Takahashi Fumiaki、Tanaka Kosuke、Watanabe Zen、Saito Masatoshi、Sakurai Kasumi、Ishikuro Mami、Obara Taku、Tatsuta Nozomi、Nishijima Ichiko、Sugiyama Takashi、Fujiwara Ikuma、Kuriyama Shinichi、Arima Takahiro、Nakai Kunihiko、Yaegashi Nobuo
  • Journal Title: Hypertension Research Volume: 42 Issue: 1 Pages: 85-94
  • DOI: 10.1038/s41440-018-0124-3
  • Peer Reviewed
• [Journal Article] Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study (2018)
  • Author(s): Ishikuro Mami、Obara Taku、Osanai Tamae、Yamanaka Chizuru、Sato Yuki、Mizuno Satoshi、Miyashita Masako、Kikuya Masahiro、Sakurai Kasumi、Hozawa Atsushi、Tomita Hiroaki、Taki Yasuyuki、Nagami Fuji、Metoki Hirohito、Kuriyama Shinichi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 246 Issue: 2 Pages: 97-105
  • DOI: 10.1620/tjem.246.97
  • NAID: 130007499816
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Association between tooth loss and cognitive impairment in community-dwelling older Japanese adults: a 4-year prospective cohort study from the Ohasama study (2018)
  • Author(s): Saito Sho、Ohi Takashi、Murakami Takahisa、Komiyama Takamasa、Miyoshi Yoshitada、Endo Kosei、Satoh Michihiro、Asayama Kei、Inoue Ryusuke、Kikuya Masahiro、Metoki Hirohito、Imai Yutaka、Ohkubo Takayoshi、Hattori Yoshinori
  • Journal Title: BMC Oral Health Volume: 18 Issue: 1 Pages: 1-8
  • DOI: 10.1186/s12903-018-0602-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Blood pressure changes during twin pregnancies (2018)
  • Author(s): Iwama Noriyuki、Metoki Hirohito、Nishigori Hidekazu、Mizuno Satoshi、Takahashi Fumiaki、Tanaka Kosuke、Watanabe Zen、Saito Masatoshi、Sakurai Kasumi、Ishikuro Mami、Obara Taku、Tatsuta Nozomi、Nishijima Ichiko、Sugiyama Takashi、Fujiwara Ikuma、Kuriyama Shinichi、Arima Takahiro、Nakai Kunihiko、Yaegashi Nobuo
  • Journal Title: Journal of Hypertension Volume: - Issue: 1 Pages: 1-1
  • DOI: 10.1097/hjh.0000000000001846
  • Peer Reviewed
• [Journal Article] Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study. (2018)
  • Author(s): Satoh M, Asayama K, Kikuya M, Inoue R, Tsubota-Utsugi M, Obara T, Murakami K, Matsuda A, Murakami T, Nomura K, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Clin Exp Hypertens Volume: 40 Issue: 1 Pages: 1-7
  • DOI: 10.1080/10641963.2016.1259324
  • Peer Reviewed
• [Journal Article] Accumulation of evidence regarding home blood pressure during pregnancy is necessary. (2017)
  • Author(s): Metoki H, Satoh M, Murakami T.
  • Journal Title: Hypertens Res. Volume: 40 Issue: 7 Pages: 635-636
  • DOI: 10.1038/hr.2017.53
  • Peer Reviewed
• [Journal Article] Home blood pressure predicts stroke incidence among older adults with impaired physical function: the Ohasama study. (2017)
  • Author(s): Murakami K, Asayama K, Satoh M, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: J Hypertens. Volume: 35 Issue: 12 Pages: 2395-2401
  • DOI: 10.1097/hjh.0000000000001473
  • Peer Reviewed
• [Journal Article] Monitoring and evaluation of out-of-office blood pressure during pregnancy (2017)
  • Author(s): Metoki H, Iwama N, Ishikuro M, Satoh M, Murakami T, Nishigori H.
  • Journal Title: Hypertens Res. Volume: 40 Issue: 2 Pages: 107-109
  • DOI: 10.1038/hr.2016.112
  • Peer Reviewed
• [Journal Article] Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study. (2016)
  • Author(s): Murakami K, Metoki H, Satoh M, Asayama K, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Neuroepidemiology. Volume: 47 Pages: 109-116
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study. (2016)
  • Author(s): Satoh M, Inoue R, Tada H, Hosaka M, Metoki H, Asayama K, Murakami T, Mano N, Ohkubo T, Yagihashi K, Hoshi K, Suzuki M, Imai Y.
  • Journal Title: J Hypertens. Volume: 34 Issue: 8 Pages: 1578-1585
  • DOI: 10.1097/hjh.0000000000000976
  • Peer Reviewed
• [Presentation] Casual and home blood pressures measuring for epidemiological study among pregnant women: The TMM BirThree Cohort Study (2018)
  • Author(s): Metoki H,et al.
  • Organizer: 国際妊娠高血圧学会
  • Int'l Joint Research
• [Presentation] 妊娠高血圧症候群と周辺疾患を考える 妊娠高血圧症候群診断の基礎となる正しい血圧測定について (2018)
  • Author(s): 目時 弘仁
  • Organizer: 母性衛生学会
  • Invited
• [Presentation] 妊娠初期の家庭血圧・妊婦健診時血圧の組み合わせと妊娠血圧症候群発症リスク (2018)
  • Author(s): 目時弘仁ら
  • Organizer: 第30回血圧管理研究会
• [Presentation] Risk of developing HDP by combination of home BP at early pregnancy and BP at pregnancy medical examination. (2018)
  • Author(s): Sasaki S, Metoki H, et al.
  • Organizer: 第71回日本産婦人科学会
• [Presentation] 妊婦の推定糸球体ろ過量と妊娠高血圧症候群の関連：BOSHI研究 (2018)
  • Author(s): 菊地ひかり、目時弘仁ら
  • Organizer: 第8回臨床高血圧フォーラム
• [Presentation] ライフコース疫学における経時測定データ取扱上の問題点 (2017)
  • Author(s): 目時 弘仁、佐藤 倫広、村上 任尚
  • Organizer: 2017年度日本計量生物学会年会
  • Place of Presentation: 中央大学後楽園キャンパス（東京都文京区）
  • Year and Date: 2017-03-16
• [Presentation] ライフコース疫学における経時測定データの解析手法 (2017)
  • Author(s): 大庭 真梨、村上 義孝
  • Organizer: 2017年度日本計量生物学会年会
  • Place of Presentation: 中央大学後楽園キャンパス（東京都文京区）
  • Year and Date: 2017-03-16
• [Presentation] 受動喫煙と妊娠期間中の血圧推移：BOSHI研究 (2017)
  • Author(s): 目時弘仁、佐藤倫広、村上任尚、田中宏典、石黒真美、小原拓、八重樫伸生、星和彦、今井潤、大久保孝義
  • Organizer: 日本アルコール・アディクション医学会
• [Presentation] 妊娠高血圧症候群に関する疫学研究 (2017)
  • Author(s): 目時弘仁
  • Organizer: 第38回日本妊娠高血圧学会
• [Presentation] 妊娠期間中の体重推移が出生体重に及ぼす影響:周辺構造モデルを用いた検討(BOSHI研究) (2017)
  • Author(s): 大庭真梨、村上義孝、佐藤倫広、村上任尚、石黒真美、小原拓、星和彦、今井潤、大久保孝義、目時弘仁
  • Organizer: 日本疫学会
• [Presentation] 我が国におけるDOHaD疫学研究の取り組みと今後の展望 (2017)
  • Author(s): 目時弘仁
  • Organizer: 日本衛生学会
• [Presentation] Study design and future perspective of a birth and three generation cohort study in Japan: The TMM BirThree Cohort Study (2017)
  • Author(s): Metoki H, Ishikuro M, Obara T,Kikuya M, Sato Y, Miyashita M, Yamanaka C, Mizuno S,Nagai N, Matsubara H, Hozawa A, Tsuji I, Nagami F, Kure S, Yaegashi N, Kuriyama S
  • Organizer: 国際DOHaD学会
  • Int'l Joint Research
• [Presentation] 三世代コホート調査の内容と目的、進捗状況について (2016)
  • Author(s): 目時弘仁
  • Organizer: 第61回日本新生児成育医学会・学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-12-01
• [Presentation] Morning and Evening Home Blood Pressure among Pregnant Women: the BOSHI Study (2016)
  • Author(s): Metoki H, Satoh M, Murakami T, et al.
  • Organizer: 国際妊娠高血圧学会
  • Place of Presentation: サンパウロ市（ブラジル）
  • Year and Date: 2016-10-23
  • Int'l Joint Research
• [Presentation] The TMM BirThree Cohort Study: World-first genome cohort study design of birth and three generation (2016)
  • Author(s): M Ishikuro, H Metoki, T Obara, et al.
  • Organizer: 米国人類遺伝学会
  • Place of Presentation: バンクーバー市（カナダ）
  • Year and Date: 2016-10-18
  • Int'l Joint Research
• [Presentation] さまざまな集団における高血圧の疫学ー妊娠中の高血圧ー (2016)
  • Author(s): 目時弘仁、佐藤倫広、村上任尚ら
  • Organizer: 日本高血圧学会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-09-30
• [Book] Preeclampsia (2018)
  • Author(s): Saito Shigeru et al.
  • Total Pages: 290
  • Publisher: Springer
  • ISBN: 9789811058912
• [Remarks] http://www.tohoku-mpu.ac.jp/laboratory/PHHE/
• [Remarks] 東北医科薬科大学医学部 衛生学・公衆衛生学教室
  • URL: http://www.tohoku-mpu.ac.jp/laboratory/PHHE/