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Prediction of the genetic and epigenetic risks associated with lifestyle-related diseases in the population-based confirmatory factor analysis

Research Project

Project/Area Number 16H05250
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionAichi Gakuin University

Principal Investigator

Yokota Mitsuhiro  愛知学院大学, 歯学部, 教授 (50201851)

Co-Investigator(Kenkyū-buntansha) 中杤 昌弘  名古屋大学, 医学部附属病院, 病院講師 (10559983)
市原 佐保子  自治医科大学, 医学部, 教授 (20378326)
松原 達昭  愛知学院大学, 歯学部, 教授 (30209598)
成瀬 桂子  愛知学院大学, 歯学部, 准教授 (30387576)
山本 健  久留米大学, 医学部, 教授 (60274528)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords生活習慣病 / 心筋梗塞 / 糖尿病 / 高血圧症 / 肥満 / 喫煙 / 遺伝子多型解析 / GWAS / GWAS / EWAS / ゲノム疫学 / エピゲノム / 罹患同胞対連鎖解析 / ゲノムワイドDNAメチル化 / ゲノムワイドDNAメチル化解析
Outline of Final Research Achievements

The discovery of genetic risk factors for many common diseases in the past couple of years has been enormously exciting. But we are still in the early stages of this revolution. We know that most diseases like diabetes are highly heritable, with, on average, about 50 percent of the risk attributable to genetics. Yet our genetic analysis has so far discovered less than 10 percent of that hereditary component.
Therefore, the identification of new epigenomic variations as well as new genomic variations that are associated with lifestyle-related diseases including coronary artery diseases(CADs), type 2 diabetes mellitus, and hypertension have to be made future efforts.

Academic Significance and Societal Importance of the Research Achievements

陽性的中率などの信頼性のある指標を得るためには、縦断研究によって、検証することが必須である。
我々は、信頼性の高い大規模症例―対照研究(横断研究)を実施するための研究基盤を確立し、また、縦断研究コホートとして、健康管理体制の確立した企業従業員コホート(NGK Study,NCT00408824)および、北名古屋市民コホート(北名古屋ゲノム疫学研究:KING Study,NCT00262691)を構築した。エピゲノム情報と生活習慣病リスク因子との関連や新規バイオマーカーを検索し、心筋梗塞をはじめとした生活習慣病の包括的リスク判定アルゴリズムの構築と検証的前向き研究を始める。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals2019

    • Author(s)
      Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, et al.
    • Journal Title

      Commun Biol.

      Volume: 2 Issue: 1 Pages: 115-115

    • DOI

      10.1038/s42003-019-0339-0

    • NAID

      120006937615

    • URL

      https://pure.teikyo.jp/en/publications/d2b1a87f-6b8d-4bb5-a753-843e5cd6647d

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interethnic analyses of blood pressure loci in populations of East Asian and European descent2018

    • Author(s)
      Takeuchi F, Kohara K, et al.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 5052-5052

    • DOI

      10.1038/s41467-018-07345-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.2017

    • Author(s)
      Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M.
    • Journal Title

      Clin. Epigenetics

      Volume: 9 Issue: 1 Pages: 54-54

    • DOI

      10.1186/s13148-017-0353-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease2017

    • Author(s)
      Nomura A, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Rader DJ, Kathiresan S, et al.
    • Journal Title

      Circ Res.

      Volume: 121 Issue: 1 Pages: 81

    • DOI

      10.1161/circresaha.117.311145

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease2017

    • Author(s)
      Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada K. H, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 4 Pages: e0175649-e0175649

    • DOI

      10.1371/journal.pone.0175649

    • NAID

      120006534994

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Characterising private and shared signatures of positive selection in 37 Asian populations2017

    • Author(s)
      Liu X, Yokota M (36人中21番目)
    • Journal Title

      European Journal of Human Genetics

      Volume: 25 Issue: 4 Pages: 499

    • DOI

      10.1038/ejhg.2016.181

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference2016

    • Author(s)
      W. Wen (他75名, 山本55番目)
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 17958-17958

    • DOI

      10.1038/srep17958

    • NAID

      120005822753

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Association analysis among myocardial infarction, cardiovascular disease-related single nucleotide polymorphisms, and DNA methylation sites utilizing the cluster analysis2017

    • Author(s)
      Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Tatsuaki Matsubara, Mitsuhiro Yokota
    • Organizer
      IFCS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenome-wide association study for myocardial infarction identified a DNA methylation site on the loci related to atrial fibrillation and ischemic stroke2016

    • Author(s)
      Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Tatsuaki Matsubara, Mitsuhiro Yokota
    • Organizer
      ASHG 2016
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the association between DNA methylation sites and cardiovascular disease-related single nucleotide polymorphisms in the Japanese population2016

    • Author(s)
      Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Tatsuaki Matsubara, Mitsuhiro Yokota
    • Organizer
      日本計算機統計学会 30周年記念
    • Place of Presentation
      シアトル, USA
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Epigenetic ageとChronological ageの差分値は非致死性心筋梗塞と関連しない2016

    • Author(s)
      中杤昌弘, 市原佐保子, 山本健, 松原達昭, 横田充弘
    • Organizer
      第22回国際個別化医療学会
    • Place of Presentation
      大崎ブライトコアホール(東京、品川区)
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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