Development of risk scores for cardiovascular events and serious diseases among workers

• Project/Area Number: 16H05251
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: MIZOUE TETSUYA 国立研究開発法人国立国際医療研究センター, その他部局等, 臨床研究センター部長 (60269074)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 労働者 / リスク予測 / 心血管疾患 / 重大疾病 / 糖尿病 / 重大疾患 / 長期病休 / 死亡 / コホート研究 / 社会医学 / 勤労者 / リスクスコア

Outline of Final Research Achievements

Long-term sick leave and death are serious consequence of disease for workers. We develeped risk prediction models for the following health outcomes using data of a large cohort study among workers (J-ECOH Study). 1) cardiovascular disease, 2) serious composite outcome including long-term sick leave lasting 30 days or more and death, and 3) type 2 diabetes. Area under the curve shows that these models have moderate to high predictive ability. These risk prediction tools can aid workers to change behaviors for prevention and contribute to efficient and effective input of health care resourse by identifying a high risk populaiton.

Academic Significance and Societal Importance of the Research Achievements

勤労者のデータに基づいて開発した心血管疾患リスクスコアとしては日本で初めてである。多大な労働損失を伴う「重大疾病群」（長期病休と在職死亡）のリスクを健康診断データを用いて予測する世界で初めての試みである。糖尿病のリスクを予測する日本人向けの高精度のツールである。これらは生活習慣改善の動機付けを支援するツールとして活用できる。ハイリスク者を絞り込むで、事業所で行う保健指導の効率化に寄与する。

Research Products

• [Journal Article] Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men (2020)
  • Author(s): Xiang M, Hu H, Imai T, Nishihara A, Sasaki N, Ogasawara T, Hori A, Nakagawa T, Yamamoto S, Honda T, Okazaki H, Uehara A, Yamamoto M, Miyamoto T, Kochi T, Eguchi M, Murakami T, Shimizu M, Tomita K, Nagahama S, Nanri A, Konishi M, Akter S, Kuwahara K, Kashino I, Yamaguchi M, Kabe I, Mizoue T, Kunugita N, Dohi S
  • Journal Title: Journal of Occupational Health Volume: 62 Issue: 1 Pages: n/a
  • DOI: 10.1002/1348-9585.12098
  • NAID: 130007803125
  • ISSN: 1341-9145, 1348-9585
  • Year and Date: 2020-01-20
  • Peer Reviewed / Open Access
• [Journal Article] BMI and Medically Certified Long-Term Sickness Absence Among Japanese Employees (2020)
  • Author(s): Endo M, Inoue Y, Kuwahara K, Nishiura C, Hori A, Ogasawara T, Yamaguchi M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Imai T, Nishihara A, Miyamoto T, Sasaki N, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Nagahama S, Tomita K, Kunugita N, Tanigawa T, Konishi M, Nanri A, Kabe I, Mizoue T, Dohi S
  • Journal Title: Obesity (Silver Spring） Volume: 28 Issue: 2 Pages: 437-444
  • DOI: 10.1002/oby.22703
  • Peer Reviewed / Open Access
• [Journal Article] Smoking and Long-Term Sick Leave in a Japanese Working Population: Findings of the Japan Epidemiology Collaboration on Occupational Health Study (2019)
  • Author(s): Hori A, Inoue Y, Kuwahara K, Kunugita N, Akter S, Nishiura C, Kinugawa C, Endo M, Ogasawara T, Nagahama S, Miyamoto T, Tomita K, Yamamoto M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Imai T, Nishihara A, Sasaki N, Uehara A, Murakami T, Shimizu M, Eguchi M, Kochi T, Konishi M, Kashino I, Yamaguchi M, et al.
  • Journal Title: Nicotine Tob Res Volume: - Issue: 1 Pages: 135-142
  • DOI: 10.1093/ntr/ntz204
  • Peer Reviewed / Open Access
• [Journal Article] Smoking, Smoking Cessation, and Risk of Mortality in a Japanese Working Population ― Japan Epidemiology Collaboration on Occupational Health Study ― (2018)
  • Author(s): Akter S, Nakagawa T, Honda T, Yamamoto S, Kuwahara K, Okazaki H, Hu H, Imai T, Nishihara A, Miyamoto T, Sasaki N, Ogasawara T, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Hori A, Nagahama S, Tomita K, Konishi M, Kashino I, Nanri A, Kabe I, Mizoue T, Kunugita N, Dohi S
  • Journal Title: Circulation Journal Volume: 82 Issue: 12 Pages: 3005-3012
  • DOI: 10.1253/circj.CJ-18-0404
  • NAID: 130007521296
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-11-24
  • Peer Reviewed / Open Access
• [Journal Article] Prediabetes and cardiovascular disease risk: A nested case-control study (2018)
  • Author(s): Hu H, Mizoue T, Sasaki N, Ogasawara T, Tomita K, Nagahama S, Hori A, Nishihara A, Imai T, Yamamoto M, Eguchi M, Kochi T, Miyamoto T, Honda T, Nakagawa T, Yamamoto S, Okazaki H, Uehara A, Shimizu M, Murakami T, Kuwahara K, Nanri A, Konishi M, Kabe I, Dohi S
  • Journal Title: Atherosclerosis Volume: 278 Pages: 1-6
  • DOI: 10.1016/j.atherosclerosis.2018.09.004
  • Peer Reviewed
• [Journal Article] Development and validation of risk models to predict the 7-year risk of type 2 diabetes: The Japan Epidemiology Collaboration on Occupational Health Study. (2018)
  • Author(s): Hu H, Nakagawa T, Yamamoto S, Honda T, Okazaki H, Uehara A, Yamamoto M, Miyamoto T, Kochi T, Eguchi M, Murakami T, Shimizu M, Tomita K, Nagahama S, Imai T, Nishihara A, Sasaki N, Ogasawara T, Hori A, Nanri A, Akter S, Kuwahara K, Kashino I, Kabe I, Mizoue T, Sone T, Dohi S
  • Journal Title: J Diabetes Investig Volume: 印刷中 Issue: 5 Pages: 1052-1059
  • DOI: 10.1111/jdi.12809
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic Syndrome Over 4 Years Before the Onset of Cardiovascular Disease ― Nested Case-Control Study ― (2018)
  • Author(s): Hu H, Nakagawa T, Honda T, Yamamoto S, Nanri A, Konishi M, Okazaki H, Kuwahara K, Hori A, Nishiura C, Kashino I, Imai T, Nishihara A, Akter S, Miyamoto T, Sasaki N, Ogasawara T, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Nagahama S, Tomita K, Kabe I, Mizoue T, Sone T, Dohi S
  • Journal Title: Circulation Journal Volume: 82 Issue: 2 Pages: 430-436
  • DOI: 10.1253/circj.CJ-17-0513
  • NAID: 130006321868
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Remarks] J-ECOHスタディ業績
  • URL: http://www.schoolhealth.jp/deih/gyosekitop-J-ECOH.html