| Project/Area Number |
16H05252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Kokubo Yoshihiro 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Keywords | 潜在性心不全 / リスクスコア / 追跡研究 / 地域住民 / BNP / 生活習慣 / 危険因子 / 血清脂質 / 血圧値 / 血漿Na利尿ペプチド / 心房細動 / コホート研究 / 脳性ナトリウム利尿ペプチド / 疫学 / 予防医学 / 心不全 / リスクスコアー / ナトリウム利尿ペプチド |
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| Outline of Final Research Achievements |
Despite the global heart failure (HF) pandemic, there are few population-based prospective studies on HF in non-Westerners. We prospectively followed-up 2,809 Suita Study subjects for new incident Latent HF. LHF was defined as BNP≧100pg/mL or HF medication. Each subject's health status and BNP were checked in biannual medical examinations, and all subjects completed annual questionnaires. Cox proportional hazard model was used for incident LHF. In 18134 person-years of follow-up, 335 incident LHF events occurred. We developed a scoring system for each risk factor as follows: 0/3/6/9 points for participants in their 40-50/60/70/80s, respectively; 3 points for atrial fibrillation; 2 points for cardiac murmur, CHD, ischemic stroke, or systolic hypertensive with non-HDLC≧140mg/dL and for systolic prehypertensive with low non-HDLC; 3 points for sHT with low non-HDLC; and 1 point for a GFR <45 mL/min/1.73m2 and for excessive drinker (C-statistic 0.727, 95% CI: 0.699-0.755).
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| Academic Significance and Societal Importance of the Research Achievements |
心不全患者が今後増えてパンデミックになると言われるも、地域住民を対象とした疫学研究がほとんどない。今回潜在性心不全の罹患リスクを求め、10年後の潜在性心不全の予測確率を初めて求めることが可能となる。潜在性心不全のリスクスコアを作成することで、健診や日常外来程度の項目で予測が可能となる。
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