The risk score for making a potential heart failure in a Japanese general urban population
| Project/Area Number |
16H05252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Kokubo Yoshihiro 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Keywords | 潜在性心不全 / リスクスコア / 追跡研究 / 地域住民 / BNP / 生活習慣 / 危険因子 / 血清脂質 / 血圧値 / 血漿Na利尿ペプチド / 心房細動 / コホート研究 / 脳性ナトリウム利尿ペプチド / 疫学 / 予防医学 / 心不全 / リスクスコアー / ナトリウム利尿ペプチド |
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| Outline of Final Research Achievements |
Despite the global heart failure (HF) pandemic, there are few population-based prospective studies on HF in non-Westerners. We prospectively followed-up 2,809 Suita Study subjects for new incident Latent HF. LHF was defined as BNP≧100pg/mL or HF medication. Each subject's health status and BNP were checked in biannual medical examinations, and all subjects completed annual questionnaires. Cox proportional hazard model was used for incident LHF. In 18134 person-years of follow-up, 335 incident LHF events occurred. We developed a scoring system for each risk factor as follows: 0/3/6/9 points for participants in their 40-50/60/70/80s, respectively; 3 points for atrial fibrillation; 2 points for cardiac murmur, CHD, ischemic stroke, or systolic hypertensive with non-HDLC≧140mg/dL and for systolic prehypertensive with low non-HDLC; 3 points for sHT with low non-HDLC; and 1 point for a GFR <45 mL/min/1.73m2 and for excessive drinker (C-statistic 0.727, 95% CI: 0.699-0.755).
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| Academic Significance and Societal Importance of the Research Achievements |
心不全患者が今後増えてパンデミックになると言われるも、地域住民を対象とした疫学研究がほとんどない。今回潜在性心不全の罹患リスクを求め、10年後の潜在性心不全の予測確率を初めて求めることが可能となる。潜在性心不全のリスクスコアを作成することで、健診や日常外来程度の項目で予測が可能となる。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population: The Suita Study.2019
Author(s)
Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, Takegami M, Nishimura K, Nakai M, Kiyoshige E, Hosoda K, Okamura T, Miyamoto Y.
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Journal Title
Journal of the American Heart Association
Volume: 8
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Change in QRS morphology as a marker of spontaneous elimination in verapamil-sensitive idiopathic left ventricular tachycardia.2018
Author(s)
Kawakami H, Aiba T, Ishibashi K, Nakajima I, Wada M, Kamakura T, Inoue Y, Miyamoto K, Okamura H, Nagase S, Noda T, Kokubo Y, Miyamoto Y, Yasuda S, Kamakura S, Kusano K.
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Journal Title
J Cardiovasc Electrophysiol
Volume: 29
Issue: 3
Pages: 446-455
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Diabetes and lifetime risk of coronary heart disease.2017
Author(s)
Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
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Journal Title
Prim Care Diabetes
Volume: 11
Issue: 5
Pages: 461-466
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease2016
Author(s)
Chowdhury Turin T, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
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Journal Title
Hypertens Res
Volume: ２３
Issue: 7
Pages: 548-51
DOI
Related Report
Peer Reviewed
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[Presentation] A Risk Score for Incident Atrial Fibrillation in General Cohort Studies in Japan: a Collaborative Meta-analysis.2017
Author(s)
Kokubo Y, Imao H, Hata J, Murakoshi N, Aizawa Y, Iso H, Ninomiya T, Nakamura F, Miyamoto Y, Aonuma K, Okamura T, Tomita H, Okumura K.
Organizer
Symposium, the 81th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Kanazawa
Year and Date
2017-03-17
Related Report
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[Presentation] The Development of a Risk Score for Incident Atrial Fibrillation in Japanese General Population Cohorts: a Collaborative Meta-analysis.2016
Author(s)
Kokubo Y, Imao H, Hata J, Murakoshi N, Aizawa Y, Iso H, Ninomiya T, Nakamura F, Miyamoto Y, Aonuma K, Okamura T, Tomita H, Okumura K.
Organizer
Scientific Session 2016, American Heart Association.
Place of Presentation
New Orleans, Louisiana, U.S.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Nishimura K, Takegami M, Kusano K, Miyamoto Y.2016
Author(s)
Systolic Blood Pressure and Lifestyle Contributes to the Development of a Risk Score for Incident Atrial Fibrillation in the Japanese General Population: The Suita Study
Organizer
Council on Hypertension 2016 Scientific Sessions of the American Heart Association
Place of Presentation
Orlando, Florida, USA
Year and Date
2016-09-14
Related Report
Int'l Joint Research
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