The impact of alveolar macrophage death by fine particle on allergic inflammation
Project/Area Number |
16H05256
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene and public health
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Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition (2017-2018) Osaka University (2016) |
Principal Investigator |
Kuroda Etsushi 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, 上級研究員 (10299604)
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Co-Investigator(Kenkyū-buntansha) |
森本 泰夫 産業医科大学, 産業生態科学研究所, 教授 (30258628)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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Keywords | 微粒子 / アレルギー性炎症 / IgE / 肺胞マクロファージ / 細胞死 / DAMP / iBALT / IL-1 / IL-1alpha / 微細粒子 / アレルギー / 三次リンパ節 |
Outline of Final Research Achievements |
Recently, the number of patients with allergic diseases have increased in the developed countries. Several reports have described that particulates in the air function as adjuvant to enhance allergic immune responses. However, the underlying mechanisms by which particulates induce and exacerbate allergic inflammation are still unclear. In this study, we found that inhaled particulates that induce allergic inflammation stimulate alveolar macrophages to induce cell death. Interleukin-1alpha (IL-1a) is released as one of dead cell factors and plays an important role for the induction of ectopic lymphoid tissue and IgE secretion in the lungs, suggesting that dead cell derived factors might be involved in allergic inflammation in the lungs.
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Academic Significance and Societal Importance of the Research Achievements |
PM2.5をはじめとする大気中の微粒子がアレルギー性炎症の発症と増悪に関与することは疫学的解析からも明らかにされているが、微粒子がどのように免疫細胞を活性化し、そのような機序でアレルギー性炎症を誘導するのかについては未だ明らかにされていない。本研究では微粒子が引き起こす細胞死とその結果生じる死細胞因子がIgEをはじめとしたアレルギー性炎症のメディエータの誘導に重要であることを明らかにした。微粒子によるアレルギー性炎症発症のメカニズムの一端を明らかにしたことにより、このようなタイプのアレルギー性炎症に対する予防法や治療法への応用が期待される。
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection.2018
Author(s)
Fujiwara S., Hoshizaki M., Ichida Y., Lex D., Kuroda E., Ishii KJ., Magi S., Okada M., Takao H., Gando M., Imai H., Hara R., Herzog H., Yoshimura A., Okamura H., Penninger JM., Slutsky AS., Uhlig S., Kuba K., and Imai Y.
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Journal Title
Nature Microbiology
Volume: 4(2)
Issue: 2
Pages: 258-268
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice.2018
Author(s)
Nagatake T, Suzuki H, Hirata S, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J.
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Journal Title
Int Immunol
Volume: 30
Issue: 10
Pages: 471-481
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Plasmodium products persist in the bone marrow and promote chronic bone loss2017
Author(s)
Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin JW, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C.
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Journal Title
Science Immunology
Volume: 2
Issue: 12
Pages: 2-2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.2016
Author(s)
Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
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Journal Title
Immunity.
Volume: 45(6)
Issue: 6
Pages: 1299-1310
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation.2016
Author(s)
Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Oyabu T, Myojo T, Kawai K, Yatera K, Shimada M, Kubo M, Yamamoto K, Kitajima S, Kuroda E, Kawaguchi K, Sasaki T.
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Journal Title
Int J Mol Sci.
Volume: 17
Issue: 8
Pages: 1241-1241
DOI
Related Report
Peer Reviewed
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[Journal Article] Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells.2016
Author(s)
Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ.
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Journal Title
Oncotarget
Volume: 7
Issue: 31
Pages: 48860-48869
DOI
Related Report
Peer Reviewed
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[Journal Article] RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.2016
Author(s)
Hayashi M, Aoshi T, Ozasa K, Kusakabe T, Momota M, Haseda Y, Kobari S, Kuroda E, Kobiyama K, Coban C, Ishii KJ.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 29165-29165
DOI
Related Report
Peer Reviewed
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