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Health and medical measures as well as investigations in Akita prefecture, the forgotten Japanese heaviest cadmium-polluted area

Research Project

Project/Area Number 16H05261
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene and public health
Research InstitutionKitasato University

Principal Investigator

Horiguchi Hyogo  北里大学, 医学部, 教授 (90254002)

Co-Investigator(Kenkyū-buntansha) 中嶋 克行  女子栄養大学, 付置研究所, 客員教授 (10444051)
姫野 誠一郎  徳島文理大学, 薬学部, 教授 (20181117)
松川 岳久  順天堂大学, 医学部, 助教 (60453586)
小松田 敦  秋田大学, 医学系研究科, 准教授 (70272044)
千葉 百子  順天堂大学, 医学部, 客員教授 (80095819)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywordsカドミウム / 腎尿細管機能障害 / 米 / 秋田県 / イタイイタイ病 / 湛水管理 / 腎尿細管障害 / 農家 / ヒ素 / 腎障害 / 衛生 / 環境 / 社会医学
Outline of Final Research Achievements

In cadmium (Cd)-polluted areas in Akita prefecture, health examinations for local residents in each hamlet and hospital-based screening for Cd nephropathy for patients with renal dysfunction were prosecuted. The residents in many hamlets, most of them were farmers who had consumed self-harvested rice, showed high Cd accumulation in bodies even today. Although the adverse effects of Cd on renal tubular function were not clearly recognized on the whole, there were some aged patients with Cd nephropathy. Through hospital-based screening, a patient with Cd nephropathy who was suspected to suffer from itai-itai disease was detected. These results indicate the potential existence of such patients in the Cd-polluted areas in Akita prefecture, suggesting that it is necessary to observe for Cd effects of the residents continuously.

Academic Significance and Societal Importance of the Research Achievements

本研究により、環境省から公表されている農用地土壌汚染対策地域からCd汚染地域である可能性が高いにも拘らずCdに係る住民健康調査がほとんど実施されて来なかった秋田県の当該地域の実態を初めて明らかにし、患者に対しては適切な医療を提供するための道を開くことができた。また、当該地域で広く実施されている米中Cd濃度を軽減するための湛水管理は安全で有効であることも示すことができた。そして、これらの結果は当該地域の農業従事者が今後も適切に湛水管理を実施することへの動機付けになり、さらには一般国民への安全な米の供給にもつながると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan2019

    • Author(s)
      Sasaki Toru、Horiguchi Hyogo、Arakawa Akira、Oguma Etsuko、Komatsuda Atsushi、Sawada Kenichi、Murata Katsuyuki、Yokoyama Kazuhito、Matsukawa Takehisa、Chiba Momoko、Omori Yuki、Kamikomaki Norihiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 24 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s12199-019-0762-3

    • NAID

      210000130325

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] カドミウム汚染地域住民におけるメタロチオネイン産生能と腎尿細管機能障害との関係2019

    • Author(s)
      堀口兵剛、小熊悦子、大森由紀、中嶋克行、齋藤秀俊、小平司、横山和仁、千葉百子、松川岳久、小松田敦、村田勝敬、内田正美
    • Organizer
      第89回日本衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 湛水管理実施下の秋田県カドミウム汚染地域における米作農家への健康影響及び米中カドミウムとヒ素濃度の現状、シンポジウム「食品中の重金属類の人体蓄積と健康影響 Up-To-Date」2018

    • Author(s)
      堀口兵剛
    • Organizer
      フォーラム2018 衛生薬学・環境トキシコロジー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食品からのカドミウム曝露の健康リスクについての再検討2018

    • Author(s)
      堀口兵剛
    • Organizer
      第16回 食品安全フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] カドミウム毒性研究のこれまでの知見と今後の意義、シンポジウム1「メタルバイオサイエンス研究の最前線と展望」2017

    • Author(s)
      堀口兵剛
    • Organizer
      メタルバイオサイエンス研究会2017
    • Related Report
      2017 Annual Research Report
  • [Book] Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation. In Himeno S and Aoshima K. (Ed.), Cadmium Toxicity. Springer.2019

    • Author(s)
      Aoshima K and Horiguchi H
    • Total Pages
      7
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Book] Cadmium exposure and its effects on the health status of rice farmers in Akita prefecture. In Himeno S and Aoshima K. (Ed.), Cadmium Toxicity. Springer.2019

    • Author(s)
      Horiguchi H
    • Total Pages
      8
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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