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Significance of cardiovascular risk factors among recent older Japanese aged 75 years or over.

Research Project

Project/Area Number 16H05263
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene and public health
Research InstitutionTeikyo University

Principal Investigator

Ohkubo Takayoshi  帝京大学, 医学部, 教授 (60344652)

Co-Investigator(Kenkyū-buntansha) 大橋 靖雄  中央大学, 理工学部, 教授 (00134461)
原田 亜紀子  中央大学, 理工学部, 助教 (00451774)
上島 弘嗣  滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
淺山 敬  帝京大学, 医学部, 准教授 (80431518)
北村 明彦  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80450922)
山田 美智子  公益財団法人放射線影響研究所, 広島臨床研究部, 主任研究員 (90359456)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords高齢者保健 / 脳卒中 / 心筋梗塞 / 心房細動
Outline of Final Research Achievements

The Japan Arteriosclerosis Longitudinal Study (JALS) is a large-scale study for statistical integration of individual data obtained from 33 cardiovascular cohort studies conducted in all parts of Japan. Using the JALS data, we examined the association between major cardiovascular risk factors and mortality/morbidity from cardiovascular diseases including stroke and myocardial infarction by gender and age categories (middle-aged, young-old and old-old). We revealed several significant factors and established risk prediction models by each group. We further conducted detailed analysis on the impact of atrial fibrillation on stroke and their subtypes in the old population.

Academic Significance and Societal Importance of the Research Achievements

全国規模のコホート研究によるリスクスコア作成、高齢者の危険因子の同定により、本研究成果は国内の循環器疾患関連のガイドライン・施策策定に貢献するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Absolute risk score for stroke, myocardial infarction, and all cardiovascular disease: Japan Arteriosclerosis Longitudinal Study2019

    • Author(s)
      Akiko Harada, Hirotsugu Ueshima, Yuki Kinoshita, Katsuyuki Miura, Takayoshi Ohkubo, Kei Asayama, Yasuo Ohashi
    • Journal Title

      Hypertension research

      Volume: 42 Issue: 4 Pages: 567

    • DOI

      10.1038/s41440-019-0220-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of diastolic blood pressure threshold for the young population: TheJapan Arteriosclerosis Longitudinal Study (JALS)2019

    • Author(s)
      Asayama K, Kinoshita Y, Watanabe S, Ohkubo T, Ando T, Harada A, Ohashi Y, Ueshima H, Imai Y; Japan Arteriosclerosis Longitudinal Study (JALS) group.
    • Journal Title

      Journal of Hypertension

      Volume: 37 Issue: 3 Pages: 652

    • DOI

      10.1097/hjh.0000000000002025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者における心房細動と脳梗塞・脳出血発症との関連: 日本動脈硬化縦断研究2018

    • Author(s)
      大久保 孝義、日本動脈硬化縦断研究
    • Journal Title

      日本老年医学会雑誌

      Volume: 55 Pages: 125-126

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Blood pressure, heart rate, and double product in a pooled cohort: The Japan Arteriosclerosis Longitudinal Study2017

    • Author(s)
      Asayama K, Hozawa A, Taguri M, Ohkubo T, Tabara Y, Suzuki K, Ando T, Harada A, Ohashi Y, Ueshima H, Toyoshima H, Imai Y.
    • Journal Title

      Journal of Hypertension

      Volume: 35 Issue: 9 Pages: 1808

    • DOI

      10.1097/hjh.0000000000001399

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高齢者における心房細動と脳梗塞・脳出血発症との関連: 日本動脈硬化縦断研究2018

    • Author(s)
      大久保 孝義
    • Organizer
      第60回日本老年医学会学術集会 2018年6月 京都
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多施設共同コホート研究における病型、部位別の脳卒中発症率: 日本動脈硬化縦断研究2017

    • Author(s)
      The Japan Arteriosclerosis Longitudinal Study Group(代表発表者:鈴木一夫)
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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