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Epidemiologic Study on Post-marketing Pharmaceuticals among the Elderly by Administrative Data

Research Project

Project/Area Number 16H05266
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical and hospital managemen
Research InstitutionKyushu University

Principal Investigator

Babazono Akira  九州大学, 医学研究院, 教授 (90228685)

Co-Investigator(Kenkyū-buntansha) 西 巧  福岡県保健環境研究所, その他部局等, 主任技師 (20760739)
松尾 龍  九州大学, 医学研究院, 助教 (60744589)
鴨打 正浩  九州大学, 医学研究院, 教授 (80346783)
藤田 貴子  九州大学, 医学研究院, 助教 (00822511)
今任 拓也  国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官 (20368989)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords病院管理学 / 電子レセプト / 市販後薬剤疫学研究 / 病院・医療管理学 / 医療管理学
Outline of Final Research Achievements

The objective of this study was to evaluate the effect of nonbenzodiazepine hypnotics on the risk of hip fracture. We conducted a population based case-crossover study on elderlies aged 65 year or older with hip fracture in Fukuoka Japan during fy2012-fy2014 (n=13,769). We defined case event as hospitalization for hip fracture. For each generic name, exposure in hazard period (30-day period prior to case event) was compared to those in two control periods set at 90 days and 150 day prior to case event. Subgroup analyses for comorbidities were also conducted. Nonbenzodiazepine hypnotic has significant association with increased risk of hip fracture(OR 1.45 [95%CI 1.22-1.71]). Eszopiclone and Zolpidem also increased the risk of hip fracture (OR 1.69 [95%CI 1.03-2.78], OR 1.41 [95%CI 1.17-1.71 ] respectively). In Japan, nonbenzodiazepine hypnotics, zolpidem and eszopiclone could increase the risk of hip fracture.

Academic Significance and Societal Importance of the Research Achievements

わが国は急速に高齢化が進んでおり、薬剤服用中の高齢患者数も増加の一途をたどっている。わが国でも長期的な有害事象の検討がなされたうえで、「ポストマーケティングサーベイランス:市販後薬剤疫学調査研究」に基づいた薬剤処方がなされるべきであると考えられるが、わが国では高齢者に対する市販後薬剤投与による有害事象の研究はほとんどなされていない。今回、市販後薬剤疫学調査研究によって、比較的安全とされた非ベンゾ系の入眠導入剤が、骨折のリスクを上昇させたことを明らかにすることによって、薬剤による有害事象のリスクの減少をもたらすための研究の方法を提示することができたと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (21 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association between dipeptidyl peptidase-4 inhibitors and urinary tract infection in elderly patients: a retrospective cohort study2018

    • Author(s)
      Imatoh T, Nishi T, Yasui M, Maeda T, Sai, Saito Y, Une H, Babazono A
    • Journal Title

      Pharmacoepidemiology

      Volume: 27 Issue: 8 Pages: 931-939

    • DOI

      10.1002/pds.4560

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surveillance of first-generation H1-antihistamine use for older patients with dementia in Japan: a retrospective cohort study2018

    • Author(s)
      Maeda T, Babazono A, Nishi T, Yasui M, Harano Y
    • Journal Title

      Curr Gerontol Geriatr Res

      Volume: 10 Pages: 1-6

    • DOI

      10.1155/2018/3406210

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of S-1 monotherapy for older patients with unresectable pancreatic cancer: A retrospective cohort study2018

    • Author(s)
      Harano Y, Babazono A, Fujita T, Jiang P
    • Journal Title

      J Geriatr Oncol

      Volume: 18 Issue: 3 Pages: 30152-8

    • DOI

      10.1016/j.jgo.2018.09.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Effectiveness of Anesthetic Technique among Older Patients after Hip Fracture Surgery: A Propensity Score-Matched Cohort Study Using Claims Data2018

    • Author(s)
      Nishi T, Maeda T, MD, Imatoh T, Babazono A
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 17 Pages: 1-7

    • DOI

      10.1093/intqhc/mzy233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Between Financial Incentives for Regional Care Coordination and Health Care Resource Utilization Among Older Patients after Femoral Neck Fracture Surgery2017

    • Author(s)
      Nishi T, Maeda T, Babazono A
    • Journal Title

      Popul Health Manag

      Volume: 無 Issue: 4 Pages: 331-334

    • DOI

      10.1089/pop.2017.0100

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of financial incentives for inter-provider care coordination on health-care resource utilization among elderly acute stroke patients.2017

    • Author(s)
      Takumi Nishi, Toshiki Maeda, Akira Babazono
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 印刷中 Issue: 4 Pages: 1-9

    • DOI

      10.1093/intqhc/mzx053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 精神科救急医療の効果に関する研究2017

    • Author(s)
      豊田史郎、馬場園明
    • Journal Title

      医療福祉経営マーケティング研究

      Volume: 12 Pages: 1-5

    • NAID

      40021844570

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of diabetes with pharmacotherapy for breast cancer on care resource use2016

    • Author(s)
      Maeda T, Babazono A, Nishhi T, Miyazaki H, Tamaki K, Fujii M.
    • Journal Title

      J Cancer Res Ther

      Volume: 12 Issue: 2 Pages: 876-880

    • DOI

      10.4103/0973-1482.172119

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Helicobacter pylori一次除菌療法におけるカリウム競合型アシッドブロッカー:ボノプラザンの費用効果分析2019

    • Author(s)
      西巧、馬場園明、前田俊樹、今任拓也
    • Organizer
      日本経済学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 後発品の普及推進が医療経済に与える影響の検討2018

    • Author(s)
      原野由美、馬場園明、姜鵬、藤田貴子
    • Organizer
      第78日本公衆衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 専門職によるがん疼痛緩和指導と終末期の積極的治療との関連2018

    • Author(s)
      西巧、前田俊樹、西巧
    • Organizer
      第56回日本医療病院管理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therepeutic interchangeの効果に関する集団ベース研究2018

    • Author(s)
      原野由美、馬場園明、姜鵬、藤田貴子
    • Organizer
      第56回日本医療病院管理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 特定養護老人ホーム入居者に対する抗菌薬処方状況と関連有害事象のリスク評価2018

    • Author(s)
      西巧、前田俊樹 、今任拓也、馬場園 明
    • Organizer
      第28回日本疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 後期高齢被保険者への後発品処方に関する要因分析2018

    • Author(s)
      原野由美、姜鵬、藤田貴子、馬場園明
    • Organizer
      第19回日本健康支援学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] レセプトデータを用いた後期高齢者におけるDPP4阻害薬と尿路感染症発症との関連に関する後ろ向きコホート研究2017

    • Author(s)
      今任拓也、西巧、安井みどり、前田俊樹、齋藤嘉朗、畝博、馬場園明
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      甲府
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of Dual Antiplatelet Therapy On The Elderly2017

    • Author(s)
      Yumi Harano, Midori Yasui and Akira Babazono
    • Organizer
      The 21th IAGG World Congress of Gerontology and Geriatrics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レセプトデータを用いた大腿骨頸部骨折術後の後期高齢者における医療・介護費推計と増加要因の検討2017

    • Author(s)
      西巧、前田俊樹、馬場園明
    • Organizer
      第76回日本医療病院管理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 虚血性心疾患を有する高齢者の抗うつ薬服薬アドヒアランスと死亡率に関する研究2016

    • Author(s)
      村田典子、姜鵬、原野由美、藤田貴子、安井みどり、前田俊樹、西巧、馬場園明
    • Organizer
      第54回日本医療・病院管理学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 後期高齢者における睡眠薬の重複処方実態と決定因子の探索2016

    • Author(s)
      安井みどり、村田典子、姜鵬、原野由美、藤田貴子、前田俊樹、西巧、馬場園明
    • Organizer
      第54回日本医療・病院管理学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 安井みどり、村田典子、姜鵬、原野由美、藤田貴子、前田俊樹、西巧、馬場園明、高齢者における非ベンゾジアゼピン系睡眠薬が大腿骨頸部骨折による入院に与える影響2016

    • Author(s)
      安井みどり、村田典子、姜鵬、原野由美、藤田貴子、前田俊樹、西巧、馬場園明
    • Organizer
      第75回日本公衆衛生学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 福岡県後期高齢者医療制度の被保険者における抗認知症薬の使用実態に関する研究2016

    • Author(s)
      小武家優子、安井みどり、馬場園明
    • Organizer
      第75回日本公衆衛生学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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