| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
BDNF plays an important role in expression of higher brain functions such as learning and memory. Lower brain BDNF level is thought to be associated with dementia including Alzheimer's disease. Here we constructed a novel screening assay to identify neuronal BDNF expression, and found a series of active agents from traditional medicines. Furthermore, one of them increased hippocampal BDNF levels in mice and enhanced hippocampus-dependent learning and memory. Taken together, our novel screening assay is beneficial for identifying candidates of anti-dementia drugs.
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