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Antigen processing in intestinal epithelial cells

Research Project

Project/Area Number 16H05286
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAGAISHI Takashi  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)

Co-Investigator(Kenkyū-buntansha) 中村 哲也  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (70265809)
渡辺 守  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
Research Collaborator ONIZAWA Michio  
SUZUKI Masahiro  
WATABE Taro  
TSUGAWA Naoya  
YAMADA Daiki  
KOJIMA Yudai  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords炎症性腸疾患 / 粘膜免疫 / 抗原提示
Outline of Final Research Achievements

IBD is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines and other mediators. Understanding the mechanisms of lymphocyte regulation is therefore of significant importance to dysregulated mucosal inflammation such as IBD. Genome-wide association studies in the analysis of IBD have identified genetic risk foci. Several studies have especially revealed the important roles of antigen presentation-related genes in IBD, including the major histocompatibility complex class I and II. In this regards, we have observed that the expressions of these molecules in several cell types such as hematopoietic cells and epithelial cells were modulated by the up-regulated pro-inflammatory cytokines in vivo. Defining the mechanisms of antigen presentation will lead to a significant understanding of the manner in which manipulation of this function may provide insights into novel therapeutic methods for the treatment of IBD.

Academic Significance and Societal Importance of the Research Achievements

腸管の免疫調節機構が未だ不明確であることは、炎症性腸疾患(IBD)治療法開発を困難にしている。本研究の特徴は腸管免疫調節機構に関する研究を展開してきた申請者らが、正常腸上皮細胞の初代培養技術を応用したことで、IBDの病態理解に留まらず、これまで実現し得なかった「生理的粘膜免疫応答」の機能解析に向けた技術基盤樹立という免疫学的インパクト、さらにはIBDにおける腸管粘膜傷害に対するその特異的な免疫調節異常を標的とした新規細胞治療、分子治療開発へ向けた理論、技術基盤の創出に発展するものと期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (59 results)

All 2019 2018 2017 2016

All Journal Article (12 results) (of which Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (43 results) (of which Int'l Joint Research: 28 results,  Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Indolent T cell lymphoproliferative disorder with villous atrophy in small intestinediagnosed by single-balloon enteroscopy.2019

    • Author(s)
      Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Clin J Gastroenterol.

      Volume: in press Issue: 5 Pages: 434-440

    • DOI

      10.1007/s12328-019-00971-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 免疫グロブリンAによる腸内細菌叢調節と腸管粘膜防御の再検証.2018

    • Author(s)
      津川直也、永石宇司、渡辺 守
    • Journal Title

      消化器と免疫 News letter

      Volume: 18 Pages: 1-1

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 腸管粘膜の新たな免疫調節機構-炎症性腸疾患から学ぶこと.2018

    • Author(s)
      永石宇司
    • Journal Title

      日大医学雑誌

      Volume: 77 Pages: 197-200

    • NAID

      130007418064

    • Related Report
      2018 Annual Research Report
  • [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model.2018

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 496 Issue: 2 Pages: 367-373

    • DOI

      10.1016/j.bbrc.2018.01.053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MKL1 expressed in macrophages contributes to the development of murine colitis.2017

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 13650-13650

    • DOI

      10.1038/s41598-017-13629-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1.2017

    • Author(s)
      Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
    • Journal Title

      Autophagy.

      Volume: 22 Issue: 2 Pages: 1-43

    • DOI

      10.1080/15548627.2017.1407889

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-7による腸管粘膜の免疫調節と大腸炎.2017

    • Author(s)
      永石宇司、渡辺 守
    • Journal Title

      医学のあゆみ.

      Volume: 261 Pages: 1083-1087

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 消化管病変の免疫応答制御に向けた新たな戦略.2017

    • Author(s)
      永石宇司
    • Journal Title

      消化器と免疫 News letter.

      Volume: 18 Pages: 2-3

    • Related Report
      2017 Annual Research Report
  • [Journal Article] クローン病感受性遺伝子 ”TNFAIP3・XIAP遺伝子”.2017

    • Author(s)
      鬼沢道夫、永石宇司、浅川剛人、南舘 愛、渡辺 守
    • Journal Title

      臨床免疫・アレルギー科.

      Volume: 68 Pages: 351-356

    • Related Report
      2017 Annual Research Report
  • [Journal Article] HADHA, the alpha subunit of the mitochondrial trifunctional protein,is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.2017

    • Author(s)
      Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 484 Issue: 3 Pages: 636-641

    • DOI

      10.1016/j.bbrc.2017.01.159

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease.2016

    • Author(s)
      Ohtsuka K, Takenaka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagaishi T, Watanabe M.
    • Journal Title

      Intest Res.

      Volume: 14 Issue: 2 Pages: 120-126

    • DOI

      10.5217/ir.2016.14.2.120

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.2016

    • Author(s)
      Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Memoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 36780-36780

    • DOI

      10.1038/srep36780

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 慢性大腸炎モデルにおけるAPL発現の解析.2019

    • Author(s)
      山田大貴、永石宇司、小島裕大、渡部太郎、津川直也、細谷明徳、Jose, Nisha、鈴木雅博、鬼沢道夫、渡辺 守.
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] APL expression is downregulated in an animal model of chronic colitis.2019

    • Author(s)
      Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      European Crohn’s and Colitis Organization 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] intra-vital imagingによる実験腸炎モデル回盲部免疫応答の解析.2018

    • Author(s)
      渡部太郎、永石宇司、細谷明徳、Jose, Nisha、津川直也、小島裕大、安達貴弘、渡辺 守.
    • Organizer
      第104回日本消化器病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analysis of ileocecal immune response in an animal model of colitis using intra-vital imaging.2018

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      Digestive Disease Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to the development of colitis.2018

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
    • Organizer
      Digestive Disease Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of cecal immune response in a murine model of colitis using intravital imaging.2018

    • Author(s)
      Takashi Nagaishi, Taro Watabe, Tsugawa, Yudai Kojima, Nisha Jose, Daiki Yamada, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      Federation of Clinical Immunology Societies 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to DSS-induced colitis.2018

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
    • Organizer
      Federation of Clinical Immunology Societies 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overexpression of MKL1 in Macrophages leads to the development of murine colitis.2018

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
    • Organizer
      Mucosal Immunology Course and Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] B cell-mediated ileocecal immune response is activated in the early phase of colitis development.2018

    • Author(s)
      Yudai Kojima, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Daiki Yamada, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      United European Gastroenterology Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mice overexpressing MKL1 in macrophages experience fulminant colitis.2018

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
    • Organizer
      United European Gastroenterology Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体イメージングを用いた炎症性腸疾患モデルにおける回盲部免疫応答の観察.2018

    • Author(s)
      小島裕大、永石宇司、 渡部太郎、津川直也、Jose Nisha、山田大貴、安達貴弘、 渡辺 守.
    • Organizer
      第46回日本臨床免疫学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5D intravital imagingによるIBDモデルにおける回盲部免疫応答の観察.2018

    • Author(s)
      津川直也、永石宇司、渡部太郎、Jose Nisha、小島裕大、山田大貴、安達貴弘、渡辺 守.
    • Organizer
      第9回日本炎症性腸疾患学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Downregulated APL expression in T cells in the setting of chronic colitis.2018

    • Author(s)
      Yudai Kojima, Takashi Nagaishi, Taro Watabe, Daiki Yamada, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgAによる腸内細菌叢制御と腸管粘膜防御の検証.2018

    • Author(s)
      津川直也、永石宇司、渡部太郎、細谷明徳、Jose, Nisha、小島裕大、安達貴弘、渡辺 守
    • Organizer
      第14回日本消化管学会総会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A.2018

    • Author(s)
      Takashi Nagaishi, Naoya Tsugawa, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      The 11th International Gastrointestinal Consensus Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体イメージングを用いた実験腸炎モデルにおける回盲部免疫応答の解析.2017

    • Author(s)
      渡部太郎、永石宇司、Jose, Nisha、東海有沙、細谷明徳、小島裕大、安達貴弘、渡辺守.
    • Organizer
      免疫学・病態生化学領域合同シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] IgAの欠損は回腸粘膜特異的な炎症を誘発する.2017

    • Author(s)
      渡部太郎、永石宇司、Jose, Nisha、東海有沙、細谷明徳、小島裕大、安達貴弘、渡辺守.
    • Organizer
      第13回日本消化管学会総会学術集会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgA欠損による回腸粘膜傷害の誘発.2017

    • Author(s)
      渡部太郎、永石宇司、Jose Nisha、東海有沙、細谷明徳、小島裕大、安達貴弘、渡辺守
    • Organizer
      第103回日本消化器病学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 潰瘍性大腸炎モデルマウスにおけるMAIT細胞の関与.2017

    • Author(s)
      亀井將人、千葉麻子、永石宇司、芳賀慶一、三宅幸子
    • Organizer
      第103回日本消化器病学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum.2017

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      Digestive Disease Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgA deficiency induces spontaneous inflammation in the ileum.2017

    • Author(s)
      Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      Federation of Clinical Immunology Societies 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Verification of immunoglobulin A protection of intestinal mucosa from microflora.2017

    • Author(s)
      Akinori Hosoya, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      The 5th Annual Meeting of Asian Organization of Crohn’s & Colitis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deficiency of IgA induces microflora alteration and ileal inflammation.2017

    • Author(s)
      Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      International Congress of Mucosal Immunology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体イメージングを応用したIBDモデルにおける腸管粘膜免疫応答の解析.2017

    • Author(s)
      永石宇司、渡部太郎、細谷明徳、Jose, Nisha、津川直也、小島裕大、安達貴弘、渡辺守
    • Organizer
      第45回日本臨床免疫学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 回腸粘膜における防御機構としてのIgAの重要性.2017

    • Author(s)
      渡部太郎、永石宇司、津川直也、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守
    • Organizer
      第45回日本臨床免疫学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 免疫グロブリンAによる腸内細菌叢調節と腸管粘膜防御の再検証.2017

    • Author(s)
      津川直也、永石宇司、渡部太郎、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守
    • Organizer
      第54回日本消化器免疫学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IgA欠損による腸内細菌叢制御の破綻と回腸粘膜傷害の誘発.2017

    • Author(s)
      渡部太郎、永石宇司、津川直也、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守
    • Organizer
      第55回日本小腸学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性腸疾患の病態形成におけるMKL1の役割.2017

    • Author(s)
      安健博、永石宇司、渡部太郎、成瀬妙子、渡辺守、木村彰方
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Verification of immunoglobulin A regulation of microflora and protection of intestinal mucosa.2017

    • Author(s)
      Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Takahiro Adachi, Richard S. Blumberg, Mamoru Watanabe
    • Organizer
      United European Gastroenterology Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MAIT cells exacerbate the disease course of oxazolone-induced colitis.2017

    • Author(s)
      Asako Chiba, Takashi Nagaishi, Sachiko Miyake
    • Organizer
      CD1-MR1 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging.2017

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Verification of immunoglobulin A regulation of mucosal microflora and homeostasis.2017

    • Author(s)
      Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MAIT cells exacerbate the disease course of oxazolone colitis.2017

    • Author(s)
      Asako Chiba, Masato Kamei, Takashi Nagaishi, Keiichi Haga, Sachiko Miyake
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CRISPR/Cas9-mediated mutations in mouse IgA locus and its characterization.2016

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Jose Nisha, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      Okinawa Convention Center (沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CD66a regulation of BCR signaling in the activated B cells.2016

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Arisa Tokai, Nisha Jose, Akinori Hosoya, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      Asian Pacific Digestive Disease 2016
    • Place of Presentation
      Kobe Convention Center (兵庫県神戸市)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Type 2 TNF receptor signaling in colonic epithelia may be involved in the development of colitis-associated carcinogenesis.2016

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Masahiro Suzuki, Motomi Yamazaki, Michio Onizawa, Nisha Jose, Arisa Tokai, Akinori Hosoya, Yudai Kojima, Mamoru Watanabe.
    • Organizer
      Asian Pacific Digestive Disease 2016
    • Place of Presentation
      Kobe Convention Center (兵庫県神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CEACAM1 regulation of BCR signaling in the activated B cells.2016

    • Author(s)
      Akinori Hosoya, Takashi Nagaishi, Arisa Tokai, Taro Watabe, Nisha Jose, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      United European Gastroenterology Week 2016
    • Place of Presentation
      Austria Center Vienna, Vienna (Austria)
    • Year and Date
      2016-10-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CEACAM1によるB細胞受容体シグナルの抑制.2016

    • Author(s)
      東海有沙、永石宇司、渡部太郎、Jose, Nisha、細谷明徳、小島裕大、渡辺守.
    • Organizer
      第44回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] BCR signaling in the activated B cells may be regulated by CEACAM1.2016

    • Author(s)
      Takashi Nagaishi, Arisa Tokai, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      Mucosal Immunology Course and Symposium 2016
    • Place of Presentation
      Westin Harbour Castle Hotel, Toronto (Canada)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BCR signaling in the activated B cells may be regulated by CD66a.2016

    • Author(s)
      Taro Watabe, Takashi Nagaishi, Arisa Tokai, Akinori Hosoya, Nisha Jose, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      The 4th Annual Meeting of AOCC
    • Place of Presentation
      Kyoto International Convention Center (京都府京都市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activated B cell receptor signaling may be regulated by CEACAM1.2016

    • Author(s)
      Arisa Tokai, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Michio Onizawa, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      Federation of Clinical Immunology Societies 2016
    • Place of Presentation
      Seaport Hotel & World Trade Center, Boston (U.S.A.)
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CEACAM1 may regulate BCR signaling in the activated B cells.2016

    • Author(s)
      Arisa Tokai, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego Convention Center, San Diego (U.S.A.)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体イメージングを用いたIBDモデルにおける回盲部免疫応答の解析2016

    • Author(s)
      渡部太郎、永石宇司、Jose Nisha、東海有沙、細谷明徳、安達貴弘、渡辺守.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
  • [Book] Crohn’s Disease and Ulcerative Colitis: from Epidemiology and Immunology to a Rational Diagnostic and Therapeutic Approach2017

    • Author(s)
      Nagaishi T and Watanabe M
    • Publisher
      Springer, New York
    • ISBN
      9783319337012
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2018

    • Inventor(s)
      永石宇司、渡辺守、久場敬司
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2017

    • Inventor(s)
      永石宇司、渡辺守、久場敬司
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2016

    • Inventor(s)
      永石宇司、渡辺守、久場敬司
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-234062
    • Filing Date
      2016-12-01
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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