Effects of a novel oral iron chelator on refractory digestive system cancers

• Project/Area Number: 16H05287
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yamaguchi University
• Principal Investigator: 山崎 隆弘 山口大学, 大学院医学系研究科, 教授 (00304478)
• Co-Investigator(Kenkyū-buntansha): 藤澤 浩一 山口大学, 大学院医学系研究科, 助教 (00448284) ; 高見 太郎 山口大学, 大学院医学系研究科, 講師 (60511251) ; 佐伯 一成 山口大学, 医学部附属病院, 助教 (60634756) ; 山本 直樹 山口大学, 大学教育機構, 准教授 (90448283)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 肝細胞癌 / 膵癌 / 鉄キレート剤 / deferasirox / deferoxamine / 癌

Outline of Annual Research Achievements

肝細胞癌での鉄キレート剤の検討：6名の進行肝癌患者に対して経口鉄キレート剤(deferasirox,DFX)治療のパイロットスタディを施行したが、全例腎機能障害のため、高容量投与に至らず、1例SD (stable disease)、4例PD(progressive disease)[１例は評価不能]の結果であり、DFXの臨床応用は困難と考え、肝癌に対してはdeferoxamine (DFO)動注が鉄キレート剤の臨床応用には適していると判断した。さらに、DFO耐性株の解析を検討し、解糖系の遺伝子発現増加、解糖系に関わる代謝産物の増加ならびにミトコンドリア抑制を確認し、鉄キレート剤耐性機序の関連が示唆された。DFO投与により解糖系優位の代謝に変化することで蓄積する乳酸の排泄抑制効果を調べたところ、一部の癌細胞増殖に対して乳酸排泄抑制薬とDFOとの相乗的併用効果が認められた。
膵癌でのDFXの検討：塩酸ゲムシタビン(GEM)とDFX併用により、DFX単剤より有意な増殖抑制効果を認め、DFXがRibnucleotide reductae(RR)を阻害する効果により、GEM耐性からプロテクトしていることを解明した 。また、膵癌細胞株(BxPC3、Panc-1、HPAFⅡ)を用いて浸潤・転移能を評価する目的でScratch assay、Boyden chamber assayを施行した。Scratch assayではcontrol群に比べ、DFX投与群で有意な浸潤能の低下を認めた。Boyden chamber assayでも同様にDFX投与群で有意な遊走能低下を認めた。そして、G-LISAでCdc42、Rac1の発現を検討したところ、DFX投与群で有意に発現低下を認めた。DFXはCdc42、Rac1の発現を低下させることで、癌細胞の浸潤・転移を抑制している可能性が示唆された。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Liver stiffness measured by transient elastography as predictor of prognoses following portosystemic shunt occlusion (2019)
  • Author(s): Ishikawa T, Sasaki R, Nishimura T, Matsuda T, Maeda M, Iwamoto T, Saeki I, Hidaka I, Takami T, Sakaida I.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 34(1) Pages: 215-223
  • DOI: 10.1111/jgh.14410
  • Peer Reviewed / Open Access
• [Journal Article] Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells. (2019)
  • Author(s): Takami T, Tani K, Taura Y, Sakaida I.
  • Journal Title: Methods Mol Biol. Volume: 1905 Pages: 201-209
  • DOI: 10.1007/978-1-4939-8961-4_18
  • Peer Reviewed
• [Journal Article] Usefulness of adult medaka fish as a model for the evaluation of alcoholic fatty liver. (2019)
  • Author(s): Fujisawa K, Takami T, Nagatomo T, Fukui Y, Hoshida H, Saeki I, Matsumoto T, Hidaka I, Yamamoto N, Sakaida I.
  • Journal Title: Alcohol Volume: 77 Pages: 147-154
  • DOI: 10.1016/j.alcohol.2019.01.005
  • Peer Reviewed / Open Access
• [Journal Article] Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model (2019)
  • Author(s): Nishimura T, Takami T, Sasaki R, Aibe Y, Matsuda T, Fujisawa K, Matsumoto T, Yamamoto N, Tani K, Taura Y, Sakaida I.
  • Journal Title: PLOS ONE Volume: 14(1) Pages: 210588-210596
  • DOI: 10.1371/journal.pone.0210588
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the Effects of Cultured Bone Marrow Mesenchymal Stem Cell Infusion on Hepatocarcinogenesis in Hepatocarcinogenic Mice With Liver Cirrhosis. (2019)
  • Author(s): Matsuura K, Takami T, Maeda M, Hisanaga T, Fujisawa K, Saeki I, Matsumoto T, Hidaka I, Yamamoto N, Sakaida I.
  • Journal Title: Transplant Proc. Volume: 51(3) Pages: 925-935
  • DOI: 10.1016/j.transproceed.2019.03.011
  • Peer Reviewed
• [Journal Article] EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions. (2019)
  • Author(s): Sasaki Sho、Nishikawa Jun、Sakai Kohei、Iizasa Hisashi、Yoshiyama Hironori、Yanagihara Masashi、Shuto Takuya、Shimokuri Kanami、Kanda Teru、Suehiro Yutaka、Yamasaki Takahiro、Sakaida Isao
  • Journal Title: Gastric Cancer. Volume: 21 Pages: 486-496
  • DOI: 10.1007/s10120-018-0880-4
  • NAID: 40021884057
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of CapeOX plus Cetuximab Treatment as a First-Line Therapy for Patients with Extended RAS/BRAF/PIK3CA Wild-Type Advanced or Metastatic Colorectal Cancer. (2018)
  • Author(s): Iwamoto S, Maeda H, Hazama S, Oba K, Okayama N, Suehiro Y, Yamasaki T, Suzuki N, Nagano H, Sakamoto J, Mishima H, Nagata N
  • Journal Title: Journal of Cancer Volume: 9(22) Pages: 4092-4098
  • DOI: 10.7150/jca.26840
  • Peer Reviewed / Open Access
• [Journal Article] TROY is a promising prognostic biomarker in patients with colorectal cancer. (2018)
  • Author(s): Nishioka Mitsuaki、Suehiro Yutaka、Sakai Kouhei、Matsumoto Toshihiko、Okayama Naoko、Mizuno Hidekazu、Ueno Koji、Suzuki Nobuaki、Hashimoto Shinichi、Takami Taro、Hazama Shoichi、Nagano Hiroaki、Sakaida Isao、Yamasaki Takahiro
  • Journal Title: Oncology letters Volume: 15 Pages: 5989-5994
  • DOI: 10.3892/ol.2018.8079
  • Peer Reviewed / Open Access
• [Journal Article] Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population. (2018)
  • Author(s): Yamaoka Yuko、Suehiro Yutaka、Hashimoto Shinichi、Hoshida Tomomi、Fujimoto Michiyo、Watanabe Michiya、Imanaga Daiki、Sakai Kouhei、Matsumoto Toshihiko、Nishioka Mitsuaki、Takami Taro、Suzuki Nobuaki、Hazama Shoichi、Nagano Hiroaki、Sakaida Isao、Yamasaki Takahiro
  • Journal Title: Journal of gastroenterology Volume: 53 Pages: 517-524
  • DOI: 10.1007/s00535-017-1382-6
  • Peer Reviewed
• [Journal Article] Clinical Importance of Epstein-Barr Virus-Associated Gastric Cancer. (2018)
  • Author(s): Nishikawa Jun、Iizasa Hisashi、Yoshiyama Hironori、Shimokuri Kanami、Kobayashi Yuki、Sasaki Sho、Nakamura Munetaka、Yanai Hideo、Sakai Kohei、Suehiro Yutaka、Yamasaki Takahiro、Sakaida Isao
  • Journal Title: Cancers (Basel). Volume: 10 Pages: 167-167
  • DOI: 10.3390/cancers10060167
  • Peer Reviewed / Open Access
• [Journal Article] Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo (2018)
  • Author(s): Shinoda S, Kaino S, Amano S, Harima H, Matsumoto T, Fujisawa K, Takami T, Yamamoto N, Yamasaki T, Sakaida I.
  • Journal Title: Oncotarget Volume: 9(47) Pages: 25421-25428
  • DOI: 10.18632/oncotarget.25421
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of Metabolomic Changes in Mesenchymal Stem Cells on Treatment with Desferrioxamine as a Hypoxia Mimetic Compared with Hypoxic Conditions (2018)
  • Author(s): Fujisawa K, Takami T, Okada S, Hara K, Matsumoto T, Yamamoto N, Yamasaki T, Sakaida I.
  • Journal Title: STEM CELLS Volume: 印刷中 Pages: 1226-1236
  • DOI: 10.1002/stem.2826
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells (2018)
  • Author(s): Fujisawa K, Hara K, Takami T, Okada S, Matsumoto T, Yamamoto N, Sakaida I.
  • Journal Title: Stem Cell Research & Therapy Volume: 9(1) Pages: 13287-13297
  • DOI: 10.1186/s13287-018-0825-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment strategies for advanced hepatocellular carcinoma: Sorafenib vs hepatic arterial infusion chemotherapy (2018)
  • Author(s): Saeki I, Yamasaki T, Maeda M, Hisanaga T, Iwamoto T, Fujisawa K, Matsumoto T, Hidaka I, Marumoto Y, Ishikawa T, Yamamoto N, Suehiro Y, Takami T, Sakaida I.
  • Journal Title: World Journal of Hepatology Volume: 10(9) Pages: 571-584
  • DOI: 10.4254/wjh.v10.i9.571
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No Muscle Depletion with High Visceral Fat as a Novel Beneficial Biomarker of Sorafenib for Hepatocellular Carcinoma (2018)
  • Author(s): Saeki I, Yamasaki T, Maeda M, Kawano R, Hisanaga T, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Sakaida I.
  • Journal Title: Liver Cancer Volume: 7(4) Pages: 359-371
  • DOI: 10.1159/000487858
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of tolvaptan non-responders and outcomes of tolvaptan treatment of ascites (2018)
  • Author(s): Iwamoto T, Maeda M, Saeki I, Hidaka I, Tajima K, Ishikawa T, Takami T, Sakaida I.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: -
  • DOI: 10.1111/jgh.14524
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of patients with hepatic encephalopathy and those with gastric varices before and after balloon-occluded retrograde transvenous obliteration (2018)
  • Author(s): Ishikawa T, Sasaki R, Nishimura T, Matsuda T, Maeda M, Iwamoto T, Saeki I, Hidaka I, Takami T, Sakaida I.
  • Journal Title: Hepatology Research Volume: 48(12) Pages: 1020-1030
  • DOI: 10.1111/hepr.13199
  • Peer Reviewed
• [Journal Article] Outcomes following liver resection for multinodular Barcelona Clinic Liver Cancer-B hepatocellular carcinoma. (2018)
  • Author(s): Matsukuma Satoshi、Sakamoto Kazuhiko、Tokuhisa Yoshihiro、Tokumitsu Yukio、Matsui Hiroto、Kanekiyo Shinsuke、Tomochika Shinobu、Iida Michihisa、Suzuki Nobuaki、Takeda Shigeru、Ueno Tomio、Wada Hiroshi、Kobayashi Shogo、Saeki Issei、Eguchi Hidetoshi、Sakon Masato、Sakaida Isao、Nagano Hiroaki
  • Journal Title: Oncol Lett. Volume: 16(5) Pages: 6383-6392
  • DOI: 10.3892/ol.2018.9420
  • Peer Reviewed / Open Access
• [Journal Article] 目で見る肝癌 まれな画像所見を呈した巨大肝細胞癌の一例 (2018)
  • Author(s): 佐伯 一成, 山﨑 隆弘, 前田 雅喜, 田邉 昌寛, 徳久 善弘, 星井 嘉信, 永野 浩昭, 坂井田 功
  • Journal Title: The liver cancer journal Volume: 10(1) Pages: 5-11
  • NAID: 40021633578
• [Journal Article] サルコペニアと肝細胞癌治療選択 (2018)
  • Author(s): 佐伯一成, 山崎隆弘, 坂井田功
  • Journal Title: 肝胆膵 Volume: 77(4) Pages: 811-816
• [Journal Article] Evaluation of the "assessment for continuous treatment with hepatic arterial infusion chemotherapy" scoring system in patients with advanced hepatocellular carcinoma. (2018)
  • Author(s): Saeki I, Yamasaki T, Maeda M, Hisanaga T, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Sakaida I.
  • Journal Title: Hepatol Res. Volume: 48(3)
  • DOI: 10.1111/hepr.12932
  • Peer Reviewed
• [Journal Article] Hemobilia immediately after transcatheter arterial chemoembolization using drug-eluting beads for hepatocellular carcinoma with intrahepatic bile duct invasion. (2018)
  • Author(s): Nishi M, Saeki I, Yamasaki T, Maeda M, Hisanaga T, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Sakaida I.
  • Journal Title: Hepatol Res. Volume: 48(4) Pages: 329-332
  • DOI: 10.1111/hepr.12995
  • Peer Reviewed
• [Journal Article] Highly sensitive faecal DNA testing of TWIST1 methylation in combination with faecal immunochemical test for haemoglobin is a promising marker for detection of colorectal neoplasia. (2018)
  • Author(s): Suehiro Y, Zhang Y, Hashimoto S, Takami T, Higaki S, Shindo Y, Suzuki N,
  • Journal Title: Ann Clin Biochem. Volume: - Pages: 59-68
  • DOI: 10.1177/0004563217691064
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Blood free-circulating DNA testing by highly sensitive methylation assay to diagnose colorectal neoplasias. (2018)
  • Author(s): Suehiro Y, Hashimoto S, Higaki S, Fujii I, Suzuki C, Hoshida T, Matsumoto T, Yamaoka Y, Takami T, Sakaida I, Yamasaki T.
  • Journal Title: Oncotarget. Volume: 9(24) Pages: 16974-16987
  • DOI: 10.18632/oncotarget.24768
  • Peer Reviewed / Open Access
• [Journal Article] III. 肝癌の治療 動注化学療法 (2018)
  • Author(s): 山﨑隆弘, 佐伯一成, 松本俊彦, 高見太郎, 坂井田 功
  • Journal Title: 日本臨床 Volume: 76(2) Pages: 240-246
• [Journal Article] The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer (2017)
  • Author(s): Nishikawa J, Iizasa H, Yoshiyama H, Nakamura M, Saito M, Sasaki S, Shimokuri K, Yanagihara M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I.
  • Journal Title: International Journal of Molecular Sciences Volume: 18(8) Pages: 1606-1606
  • DOI: 10.3390/ijms18081606
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver. (2017)
  • Author(s): Fujisawa K, Takami T, Matsuzaki A, Matsumoto T, Yamamoto N, Terai S, Sakaida I.
  • Journal Title: Sci Rep Volume: 7(1) Pages: 2749-2749
  • DOI: 10.1038/s41598-017-02924-5
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of tolvaptan monotherapy and low-dose furosemide/tolvaptan combination therapy for hepatoprotection and diuresis in a rat cirrhotic model (2017)
  • Author(s): Tanabe N, Takami T, Fujisawa K, Matsumoto T, Yamamoto N, Sakaida I.
  • Journal Title: J. Clin. Biochem. Nutr. Volume: 61(1) Issue: 1 Pages: 53-59
  • DOI: 10.3164/jcbn.16-122
  • NAID: 130006847656
  • Peer Reviewed / Open Access
• [Journal Article] Protective Effect of Daikenchuto on Dextran Sulfate Sodium-Induced Colitis in Mice. (2017)
  • Author(s): Takaharu Matsunaga, Shinichi Hashimoto, Naoki Yamamoto, Ryo Kawasato, Tomohiro Shirasawa, Atsushi Goto, Koichi Fujisawa, Taro Takami, Takeshi Okamoto, Jun Nishikawa, and Isao Sakaida
  • Journal Title: Gastroenterol Res Pract. Volume: 1298263 Pages: 1298263-1298263
  • DOI: 10.1155/2017/1298263
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluating effects of L-carnitine on human bone marrow derived mesenchymal stem cells. (2017)
  • Author(s): Fujisawa K, Takami T (Corresponding), Fukui Y, Quintanilha LF, Matsumoto T, Yamamoto N, Sakaida I.
  • Journal Title: Cell Tissue Res. Volume: 368(2) Pages: 301-310
  • DOI: 10.1007/s00441-017-2569-0
  • Peer Reviewed / Open Access
• [Journal Article] Plasma Glucose Level Is Predictive of Serum Ammonia Level After Retrograde Occlusion of Portosystemic Shunts. (2017)
  • Author(s): Ishikawa T, Aibe Y, Matsuda T, Iwamoto T, Takami T, Sakaida I
  • Journal Title: AJR Am J Roentgenol. Volume: 209
  • DOI: 10.2214/ajr.16.17307
  • Peer Reviewed
• [Journal Article] A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow derived cells. (2017)
  • Author(s): Matsuda T, Takami T, Sasaki R, Nishimura T, Aibe Y, Paredes BD, Quintanilha LF, Matsumoto T, Ishikawa T, Yamamoto N, Tani K, Terai S, Taura Y, Sakaida I.
  • Journal Title: Hepatology communications. Volume: 1 Pages: 691-703
  • DOI: 10.1002/hep4.1071
  • Peer Reviewed / Open Access
• [Journal Article] Profiling of the circadian metabolome in thioacetamide-induced liver cirrhosis in mice. (2017)
  • Author(s): Fujisawa K, Takami T, Matsumoto T, Yamamoto N, Sakaida I.
  • Journal Title: Hepatol Commun. Volume: 1(7) Pages: 704-718
  • DOI: 10.1002/hep4.1075
  • Peer Reviewed / Open Access
• [Journal Article] Age-specific serum anti-Mullerian hormone concentration in Japanese women and its usefulness as a predictor of the ovarian response (2017)
  • Author(s): Asada Y, Morimoto Y, Nakaoka Y, Yamasaki T, Suehiro Y, Sugimoto H, Yoshida M, Irahara M.
  • Journal Title: Reproductive Medicine and Biology Volume: 16(4) Pages: 364-373
  • DOI: 10.1002/rmb2.12055
  • Peer Reviewed / Open Access
• [Journal Article] 動注化学療法の新たな工夫－deferoxamineの効果－ (2017)
  • Author(s): 山﨑隆弘, 佐伯一成, 藤澤浩一, 松本俊彦, 末廣 寛, 山本直樹, 高見太郎, 坂井田 功
  • Journal Title: 肝胆膵 Volume: 75(2) Pages: 374-382
• [Journal Article] 肝硬変患者に対する肝疾患専門医療機関の早期介入の有用性 (2017)
  • Author(s): 久永拓郎、山﨑隆弘、前田雅喜、岩本拓也、佐伯一成、松本俊彦、日高 勲、丸本芳雄、石川 剛、高見太郎、坂井田 功
  • Journal Title: 山口医学 Volume: 66(3)
  • Peer Reviewed
• [Journal Article] Highly sensitive stool DNA testing ofFusobacterium nucleatumas a marker for detection of colorectal tumours in a Japanese population (2017)
  • Author(s): Suehiro Y, Sakai K, Nishioka M, Hashimoto S, Takami T, Higaki S, Shindo Y, Hazama S, Oka M, Nagano H, Sakaida I, Yamasaki T.
  • Journal Title: Annals of Clinical Biochemistry Volume: April 28 Pages: 86-91
  • DOI: 10.1177/0004563216643970
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in Epstein-Barr virus-associated gastric cancer. (2017)
  • Author(s): Nakamura M, Nishikawa J, Saito M, Sakai K, Sasaki S, Hashimoto S, Okamoto T, Suehiro Y, Yamasaki T, Sakaida I.
  • Journal Title: J Med Virol. Volume: 89（3） Pages: 508-17
  • DOI: 10.1002/jmv.24634
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical characteristics and prognosis of non-B non-C hepatocellular carcinoma patients with modest alcohol consumption. (2016)
  • Author(s): Urata Y, Yamasaki T, Saeki I, Iwai S, Kitahara M, Sawai Y, Tanaka K, Aoki T, Iwadou S, Fujita N, Nakayama Y, Maeshiro T, Takami T, Sakaida I.
  • Journal Title: Hepatol Res. Volume: - Pages: 434-42
  • DOI: 10.1111/hepr.12572
  • Peer Reviewed / Open Access
• [Journal Article] Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4 (2016)
  • Author(s): Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, Yamaguchi K, Owada Y, Nishina H, Noma T, Sakaida I.
  • Journal Title: J. Exp. Clin. Cancer Res. Volume: - Pages: 0322-0324
  • DOI: 10.1186/s13046-016-0322-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib (2016)
  • Author(s): Yamamoto N, Yamasaki T, Takami T, Uchida K, Fujisawa K, Matsumoto T, Saeki I, Terai S, Sakaida I.
  • Journal Title: J. Clin. Biochem. Nutr. Volume: 58（3） Issue: 3 Pages: 202-209
  • DOI: 10.3164/jcbn.15-127
  • NAID: 130005149374
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function. (2016)
  • Author(s): Takami T, Yamasaki T, Saeki I, Matsumoto M, Suehiro Y, Sakaida I.
  • Journal Title: World J Gastroenterol. Volume: 22（32） Pages: 7252-63
  • DOI: 10.3748/wjg.v22.i32.7252
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo. (2016)
  • Author(s): Harima H, Kaino S, Takami T, Shinoda S, Matsumoto T, Fujisawa K, Yamamoto N, Yamasaki T, Sakaida I.
  • Journal Title: BMC Cancer Volume: 16 Pages: 2744-2749
  • DOI: 10.1186/s12885-016-2744-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma (2016)
  • Author(s): Saeki I, Yamamoto N, Yamasaki T(corresponding author), Takami T, Maeda M, Fujisawa K, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Uchida k, Tani K, Sakaida I
  • Journal Title: World J Gastroenterol. Volume: 22(40) Pages: 8967-77
  • DOI: 10.3748/wjg.v22.i40.8967
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of the Effect of Tolvaptan on the Prognosis of Cirrhosis. (2016)
  • Author(s): Iwamoto T, Maeda M, Hisanaga T, Saeki I, Fujisawa K, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Sakaida I.
  • Journal Title: Intern Med. Volume: 55(20) Pages: 2911-16
  • NAID: 130005430015
  • Peer Reviewed / Open Access
• [Presentation] 超音波検査による仮想NAS(NASH activity score) (2018)
  • Author(s): 佐伯一成, 福井悠美, 日高勲, 高見太郎, 坂井田功, 山崎隆弘
  • Organizer: 日本超音波医学会第91回学術集会
• [Presentation] 門脈圧亢進症症例に対する部分脾動脈塞栓術の効果と門脈血流速の変化との関係性の検討 (2018)
  • Author(s): 福井悠美, 佐伯一成, 日高勲, 高見太郎, 山崎隆弘, 坂井田功
  • Organizer: 日本超音波医学会第91回学術集会
• [Presentation] 当院における肝硬変の実態と経時的変化の検討 (2018)
  • Author(s): 久永拓郎, 高見太郎, 前田雅喜, 岩本拓也, 佐伯一成, 松本俊彦, 日高勲, 丸本芳雄, 石川剛, 山崎隆弘, 坂井田功
  • Organizer: 第54回日本肝臓学会総会
• [Presentation] 肝癌診療におけるサルコペニア評価の問題点 (2018)
  • Author(s): 佐伯一成, 山崎隆弘, 坂井田功
  • Organizer: 第54回日本肝臓学会総会
• [Presentation] miR142‐3pによる肝線維化抑制効果の検討 (2018)
  • Author(s): 松本俊彦, 仁志麻衣子, 藤澤浩一, 高見太郎, 山本直樹, 山崎隆弘, 坂井田功
  • Organizer: 第54回日本肝臓学会総会
• [Presentation] 当院における免疫チェックポイント阻害薬関連有害事象マネジメント連携の構築 (2018)
  • Author(s): 吉野 茂文, 武田 茂, 鈴木 伸明, 飯田 通久, 徳久 善弘, 兼清 信介, 硲 彰一, 上野 富雄, 山崎 隆弘, 永野 浩昭
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] デジタルPCRを用いた血清メチル化DNA検査による大腸腫瘍スクリーニング (2018)
  • Author(s): 末廣寛, 橋本真一, 山崎隆弘
  • Organizer: 第60回日本消化器病学会大会(JDDW)
• [Presentation] 超音波検査を用いた仮想SAF systemによるNASH診断 (2018)
  • Author(s): 佐伯一成, 日高勲, 岡本健志, 山崎隆弘, 坂井田功
  • Organizer: 第39回日本肥満学会
• [Presentation] ソラフェニブ治療後の進行肝癌におけるレゴラフェニブの位置づけーPD時期に着目してー (2018)
  • Author(s): 佐伯一成、山﨑隆弘、前田雅喜、坂井田 功
  • Organizer: 第18回日本肝がん分子標的治療研究会
• [Presentation] 進行肝細胞癌に対してソラフェニブが一旦中止となるも、その後再開しレゴラフェニブを導入し奏功した1例 (2018)
  • Author(s): 前田雅喜、佐伯一成、高見太郎、山﨑隆弘、坂井田 功
  • Organizer: 第18回日本肝がん分子標的治療研究会
• [Presentation] 体組成評価及びACTHスコアによる進行肝癌治療アルゴリズム：肝動注とソラフェニブ治療との棲み分け (2018)
  • Author(s): 佐伯一成、前田雅喜、高見太郎、山﨑隆弘、坂井田 功
  • Organizer: 第54回日本肝癌研究会
• [Presentation] 肝細胞癌に対するTACE治療の早期治療効果方法の検討 (2018)
  • Author(s): 前田雅喜、佐伯一成、高見太郎、山﨑隆弘、坂井田 功
  • Organizer: 第54回日本肝癌研究会
• [Presentation] ステージ0大腸がん検出率向上を可能とする便DNA検査 (2018)
  • Author(s): 末廣 寛、松本俊彦、橋本真一、坂井田 功、山﨑隆弘
  • Organizer: 第109回日本消化器病学会中国支部例会
• [Presentation] Impact of body composition in patients with advanced hepatocellular carcinoma: sorafenib versus hepatic arterial infusion chemotherapy (2018)
  • Author(s): Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Taro Takami, Isao Sakaida
  • Organizer: 12th ILCA Annual Conference
• [Presentation] Multicenter study assesing complications of radiofrequency ablation for hepatocellular carcinoma: An analysis of 10,855 patients between 2011 and 2015 (2017)
  • Author(s): Takahiro Yamasak, Issei Saeki, Masaki Maeda, Takami Taro, Isao Sakaida
  • Organizer: 11th ILCA Annual Conference
  • Int'l Joint Research
• [Presentation] Non-sarcopenia with high visceral fat area as a favorable prognostic factor in patients with advanced hepatocellular carcinoma treated with sorafenib (2017)
  • Author(s): Issei Saeki, TakahiroYamasaki, MasakiMaeda, Taro Takami, and Isao Sakaida
  • Organizer: 11th ILCA Annual Conference
  • Int'l Joint Research
• [Presentation] 大腸腫瘍バイオマーカーとしてのFusobacterium nucleatum測定の有用性 (2017)
  • Author(s): 末廣 寛、橋本真一、山﨑隆弘
  • Organizer: 第103回 日本消化器病学会総会
• [Presentation] 次世代型経口鉄キレート剤デフェラシロクスとゲムシタビンを併用した新規膵癌治療の基礎的研究 (2017)
  • Author(s): 篠田祟平、戒能聖治、天野彰吾、安田真弓、仙譽学、松本俊彦、藤澤浩一、高見太郎、山本直樹、山﨑隆弘、坂井田功
  • Organizer: 第103回 日本消化器病学会総会
• [Presentation] 肝硬変患者に対する肝疾患専門医療機関の早期介入の有用性 (2017)
  • Author(s): 久永拓郎、山﨑隆弘、前田雅喜、岩本拓也、佐伯一成、松本俊彦、日高 勲、丸本芳雄、石川 剛、高見太郎、坂井田 功
  • Organizer: 第53回 日本肝臓学会総会
• [Presentation] 進行肝癌の治療戦略決定においてサルコペニアと内臓脂肪評価が有用である (2017)
  • Author(s): 佐伯一成、前田雅喜、岩本拓也、日高 勲、石川 剛、高見太郎、山﨑隆弘、坂井田 功
  • Organizer: 第53回 日本肝臓学会総会
• [Presentation] "Iron chelator therapy for Hepatocellular Carcinoma 肝がんに対する鉄キレート剤治療 " (2017)
  • Author(s): Takahiro Yamasaki, Issei Saeki, Isao Sakaida
  • Organizer: 第15回日本臨床腫瘍学会学術集会
• [Presentation] 体組成評価は、進行肝癌に対する肝動注とソラフェニブ治療の棲み分けを可能とする (2017)
  • Author(s): 佐伯一成、山﨑隆弘、坂井田功
  • Organizer: 第21回 日本肝臓学会大会
• [Presentation] メチル化TWIST1をターゲットとした便DNA検査による大腸腫瘍スクリーニング (2017)
  • Author(s): 末廣 寛、橋本真一、山﨑隆弘
  • Organizer: 第59回 日本消化器病学会大会
• [Presentation] 体組成評価及びACTHスコアによる進行肝癌治療アルゴリズムの提唱 (2017)
  • Author(s): 佐伯一成、山﨑隆弘、坂井田功
  • Organizer: 第42回 日本肝臓学会西部会
• [Presentation] 進行肝癌に対するソラフェニブ治療は内臓脂肪評価が蓄積した非サルコペニア症例が有効である (2017)
  • Author(s): 佐伯一成、前田雅喜、高見太郎、山﨑隆弘、坂井田功
  • Organizer: 第108回 日本消化器病学会中国支部例会
• [Presentation] 肝がん治療up to date (2017)
  • Author(s): 山﨑隆弘
  • Organizer: 日本消化器病学会中国支部例会 第26回教育講演会
  • Invited
• [Presentation] 進行肝癌の治療戦略においてCT検査によるサルコペニア評価が有用である (2017)
  • Author(s): 佐伯一成、山﨑隆弘、坂井田功
  • Organizer: 第53回 日本肝癌研究会
• [Presentation] DAA治療後のHCC発症抑制効果の検討とSVR後発癌の特徴 (2017)
  • Author(s): 日高勲、佐伯一成、前田雅喜、山﨑隆弘、坂井田功
  • Organizer: 第53回 日本肝癌研究会
• [Presentation] 多施設研究による肝癌ラジオ波焼灼療法の合併症：2010年から2015年までの10,855症例での解析 (2017)
  • Author(s): 前田雅喜、佐伯一成、山﨑隆弘、坂井田功
  • Organizer: 第53回 日本肝癌研究会
• [Presentation] 肝内胆管浸潤を伴う肝細胞癌に対してDEB-TACEを行った後に胆道出血を来した一例 (2017)
  • Author(s): 仁志麻衣子、佐伯一成、前田雅喜、日高勲、高見太郎、山﨑隆弘、坂井田功
  • Organizer: 第53回 日本肝癌研究会
• [Presentation] 進行肝癌治療ストラテジー：肝動注からソラフェニブ治療へのConversionは有用である (2017)
  • Author(s): 佐伯一成、前田雅喜、高見太郎、山﨑隆弘、坂井田功
  • Organizer: 第16回日本肝がん分子標的治療研究会
• [Presentation] 経口鉄キレート剤とゲムシタビン併用による新たな膵癌治療の基礎的検討 (2016)
  • Author(s): 篠田崇平、高見太郎、山﨑隆弘、坂井田 功.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市（パシフィコ横浜）
  • Year and Date: 2016-10-06
• [Presentation] Usefulness of ACTH (Assessment for Continuous Treatment with Hepatic arterial infusion chemotherapy) score in patients with advanced hepatocellular carcinoma. (2016)
  • Author(s): Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida.
  • Organizer: The 12th JSH single topic conference.
  • Place of Presentation: 石川兼金沢市（ホテル日航金沢）
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] Effects of iron chelator, deferasirox, on hepatocellular carcinoma in basic and clinical studies. (2016)
  • Author(s): Issei Saeki, Takahiro Yamasaki, Naoki Yamamoto, Koichi Fujisawa, Toshihiko Matsumoto, Taro Takami, Isao Sakaida.
  • Organizer: 10th ILCA Annual Conference
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-09-09
  • Int'l Joint Research
• [Presentation] Evaluation of ACTH (Assessment for Continuous Treatment with Hepatic arterial infusion chemotherapy) score in patients with advanced hepatocellular carcinoma. (2016)
  • Author(s): Takahiro Yamasaki, Issei Saeki, Masaki Maeda, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida.
  • Organizer: 10th ILCA Annual Conference
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-09-09
  • Int'l Joint Research
• [Presentation] ACTH(Assessment for Continuous Treatment with HAIC)スコアは動注化学療法の早期評価に有効である (2016)
  • Author(s): 佐伯一成、前田雅喜、日高 勲、高見太郎、山﨑隆弘、坂井田 功.
  • Organizer: 第52回日本肝癌研究会
  • Place of Presentation: 東京都港区（虎ノ門ヒルズフォーラム）
  • Year and Date: 2016-07-01
• [Presentation] 進行肝細胞癌に対する経口鉄キレート剤の治療戦略 (2016)
  • Author(s): 佐伯一成、山本直樹、坂井田 功.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: 千葉県千葉市（ホテルニューオータニ幕張）
  • Year and Date: 2016-05-19
• [Remarks] 山口大学大学院医学系研究科 臨床検査・腫瘍学講座
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~jnaka/kouza/
• [Remarks] 山口大学大学院医学系研究科 消化器内科学講座
  • URL: https://www.ichinai-yamaguchi.jp/
• [Remarks] 山口大学大学院医学系研究科 消化器内科学講座
  • URL: http://www.ichinai-yamaguchi.jp/
• [Remarks] 山口大学大学院医学系研究科 臨床検査・腫瘍学講座ホームページ
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~jnaka/kouza
• [Patent(Industrial Property Rights)] がんの診断用バイオマーカー (2018)
  • Inventor(s): 末廣寛, 山﨑隆弘, 星田朋美
  • Industrial Property Rights Holder: 国立大学法人 山口大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-139564
  • Filing Date: 2018
  • Application Year: 2018
• [Patent(Industrial Property Rights)] 前癌病変又は癌の有無の予測を補助する方法 (2017)
  • Inventor(s): 末廣 寛、山﨑隆弘、星田朋美
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-242407
  • Filing Date: 2017
  • Application Year: 2017
• [Funded Workshop] 10th ILCA Annual Conference (2016)
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-09-09