Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies

• Project/Area Number: 16H05291
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: SUZUKI HIDEKAZU 慶應義塾大学, 医学部(信濃町), 教授 (70255454)
• Co-Investigator(Kenkyū-buntansha): 津川 仁 慶應義塾大学, 医学部(信濃町), 講師 (30468483) ; 土居 信英 慶應義塾大学, 理工学部(矢上), 教授 (50327673)
• Research Collaborator: SAYA Hideyuki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 癌幹細胞 / H. pylori / オートファジー / CD44v9 / CAPZA1 / 一本鎖抗 / 膜透過促進ペプチド / CagA / ペプチド / がん幹細胞 / CD44 / 低分子抗体 / 膜透過性ペプチド / 酸化ストレス / 抗体 / autophagy / MnSOD

Outline of Final Research Achievements

Although autophagy expression in H. pylori-infected cells is responsible for oncogenic CagA degradation and suppresses tumorigenesis, CD44v9-expressing cancer stem-like cells do not evoke autophagy and intracellular CagA accumulates. LAMP1-dependent autophagosome formation is also essential for CagA degrading autophagy, and we showed that CAPZA1 would bind to LRP1-ICD in the nucleus and inhibit LAMP1 expression, and when CAPZA1 is loaded on CAPZA1 overexpressing cells, CD44v9 expression was enhanced. In order to target CD44v9 and a large amount of CAPZA1 translocated to the nucleus, it was possible to release from intracellular foreign body degradation by combining TAT with human Syncytin 1-derived membrane-penetrating peptide S19. A large amount of protein was purified by fusing the created anti-CD44v9 single-chain antibody and a human-derived membrane-penetrating peptide, and CD44v9-positive cell selective cellular uptake was confirmed.

Academic Significance and Societal Importance of the Research Achievements

癌幹細胞標的療法は治療抵抗性癌を根本的に克服する革新的癌治療戦略として大いに期待される。これまで、癌幹細胞の発生起源は明確にされていなかったが、代表者らは、最近、CAPZA1過剰発現細胞が癌幹細胞の前駆責任細胞であることを報告した(Autophagy 2019)。そこで、本研究では、CAPZA1を標的し、胃癌幹細胞の発生を抑制し、かつ治療する技術を開発した。これまでの癌幹細胞を標的する癌治療戦略では、常に、分子標的マテリアルの開発に難航してきたが、本研究では、独自のmRNAディスプレイ法や膜透過促進ペプチドを駆使することでCAPZA1を標的するマテリアルを開発しえた。

Research Products

• [Journal Article] CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy (2019)
  • Author(s): Tsugawa H., Mori H., Matsuzaki J., Sato A., Saito Y., Imoto M., Suematsu M., Suzuki H.
  • Journal Title: Autophagy Volume: 15 Issue: 2 Pages: 242-258
  • DOI: 10.1080/15548627.2018.1515530
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma. (2019)
  • Author(s): Matsuzaki, J., Suzuki, H.*, Shimoda, M., Mori, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Iwao, Y., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: 7 Issue: 2 Pages: 250-260
  • DOI: 10.1177/2050640618817689
  • Peer Reviewed
• [Journal Article] Burden of impaired sleep quality on work productivity in functional dyspepsia (2018)
  • Author(s): Matsuzaki, J., Suzuki, H.*, Togawa, K., Yamane, T., Mori, H., Komori, T., Masaoka, T., Kanai, T. .
  • Journal Title: United European Gastroenterology Journal Volume: 6 Issue: 3 Pages: 398-406
  • DOI: 10.1177/2050640617726466
  • Peer Reviewed
• [Journal Article] Pethidine dose and female sex as risk factors for nausea after esophagogastroduodenoscopy (2018)
  • Author(s): Nishizawa, T., Suzuki, H., Arita, M., Kataoka, Y., Fukagawa, K., Ohki, D., Hata, K., Uraoka, T., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 63 Issue: 3 Pages: 230-232
  • DOI: 10.3164/jcbn.18-5
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Autotaxin and vascular endothelial growth factor receptor-2 and -3 are related to vascular development during the progression of chronic viral hepatitis C. (2018)
  • Author(s): Yokomori, H., Ando, W., Kaneko, F., Suzuki, H., Igarashi, K., Oda, M.
  • Journal Title: APMIS Volume: 126 Issue: 12 Pages: 913-921
  • DOI: 10.1111/apm.12904
  • Peer Reviewed
• [Journal Article] Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression. (2018)
  • Author(s): Miyoshi S, Tsugawa H, Matsuzaki J, Hirata K, Mori H, Saya H, Kanai T, Suzuki H.
  • Journal Title: Anticancer Research Volume: 38 Issue: 11 Pages: 6163-6170
  • DOI: 10.21873/anticanres.12969
  • Peer Reviewed
• [Journal Article] Pathophysiology of potassium-competitive acid blocker-refractory gastroesophageal reflux and the potential of potassium-competitive acid blocker test. (2018)
  • Author(s): Masaoka, T., Kameyama, H., Yamane, T., Yamamoto, Y., Takeuchi, H., Suzuki, H., Kitagawa, Y., Kanai, T.
  • Journal Title: J Neurogastroenterol Motil. Volume: 24 Issue: 4 Pages: 577-583
  • DOI: 10.5056/jnm18036
  • Peer Reviewed
• [Journal Article] Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity,atrophy,and age: A cross-sectional study. (2018)
  • Author(s): Toyoshima, O., Nishizawa, T., Sakitani, K., Yamakawa, T., Takahashi, Y., Yamauchi, N., Hata, K., Seto, Y., Koike, K., Watanabe, H., Suzuki, H.
  • Journal Title: World J. Gastroenterol. Volume: 24 Issue: 35 Pages: 4061-4068
  • DOI: 10.3748/wjg.v24.i35.4061
  • Peer Reviewed
• [Journal Article] Serum autotaxin concentrations reflect changes in liver stiffness and fibrosis after antiviral therapy in patients with chronic hepatitis C. (2018)
  • Author(s): Ando, W., Yokomori, H., Kaneko, F., Kaneko, M., Igarashi, K., Suzuki, H.*
  • Journal Title: Hepatology Communications Volume: 2 Issue: 9 Pages: 1111-1122
  • DOI: 10.1002/hep4.1230
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection in subjects negative for high titer serum antibody. (2018)
  • Author(s): Toyoshima, O., Nishizawa, T., Arita, M., Kataoka, Y., Sakitani, K., Yoshida, S., Yamashita, H., Hata, K., Watanabe, H., Suzuki, H.
  • Journal Title: World J. Gastroenterol Volume: 24 Issue: 13 Pages: 1419-1428
  • DOI: 10.3748/wjg.v24.i13.1419
  • Peer Reviewed / Open Access
• [Journal Article] Acquisition of double mutation in gyrA caused high resistance to sitafloxacin in Helicobacter pylori after unsuccessful eradication with sitafloxacin-containing regimens. (2018)
  • Author(s): Mori, H., Suzuki, H.*, Matsuzaki, J., Masaoka, T., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: 6 Issue: 3 Pages: 391-397
  • DOI: 10.1177/2050640617737215
  • Peer Reviewed
• [Journal Article] Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts. (2018)
  • Author(s): Tack, J., Corsetti, M., Camilleri, Mi., Quigley, A., Simren, M., Suzuki, H., Talley, N.J., Tornbloom, H., Van Oudenhove, L.
  • Journal Title: Gut Volume: 67 Issue: 8 Pages: 1425-1433
  • DOI: 10.1136/gutjnl-2016-312230
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New medical approach to functional dyspepsia, from core symposium 3, Japan Gastroenterological Association. (2018)
  • Author(s): Suzuki, H.
  • Journal Title: Digestion Volume: 97 Issue: 1 Pages: 6-12
  • DOI: 10.1159/000484029
  • Peer Reviewed / Open Access
• [Journal Article] World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treat. (2018)
  • Author(s): Suzuki, H., Mori, H.
  • Journal Title: J. Gastroenterol Volume: 53 Issue: 3 Pages: 354-361
  • DOI: 10.1007/s00535-017-1407-1
  • Peer Reviewed / Open Access
• [Journal Article] Propofol for Gastrointestinal Endoscopy (2018)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: United European Gastroenterol Journal Volume: 6 Issue: 6 Pages: 801-805
  • DOI: 10.1177/2050640618767594
  • Peer Reviewed / Open Access
• [Journal Article] Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying. (2017)
  • Author(s): Fukuhara S, Masaoka T, Nishimura S, Nakamura M, Matsuzaki J, Tsugawa H, Miyoshi S, Mori H, Kawase S, Shibata S, Okano H, Kanai T, Suzuki H.
  • Journal Title: Dig Dis Sci. Volume: 62 Issue: 12 Pages: 3359-3369
  • DOI: 10.1007/s10620-017-4820-7
  • Peer Reviewed / Open Access
• [Journal Article] Circulating microRNAs as potential biomarkers to detect transformation of Barrett’s oesophagus to oesophageal adenocarcinoma (2017)
  • Author(s): Matsuzaki J, Suzuki H
  • Journal Title: BMJ Open Gastroenterol Volume: 4 Issue: 1 Pages: e000160-e000160
  • DOI: 10.1136/bmjgast-2017-000160
  • Peer Reviewed / Open Access
• [Journal Article] Antibiotic resistance and gyrA mutation affect the efficacy of 10-day sitafloxacin-metronidazole-esomeprazole therapy for Helicobacter pylori in penicillin allergic patients. (2017)
  • Author(s): Mori, H., Suzuki, H., Matsuzaki, J., Masaoka, T., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: 5 Issue: 6 Pages: 796-804
  • DOI: 10.1177/2050640616688995
  • Peer Reviewed / Open Access
• [Journal Article] Effects of patient age and choice of antisecretory agent on success of eradication therapy for <i>Helicobacter pylori</i> infection (2017)
  • Author(s): Nishizawa, T., Suzuki, H., Fujimoto, A., Kinoshita, H., Yoshida, S., Isomura, Y., Toyoshima, A., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 60 Issue: 3 Pages: 208-210
  • DOI: 10.3164/jcbn.16-86
  • NAID: 130005632018
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Colonic dysmotility and morphological abnormality frequently detected in Japanese patients with irritable bowel syndrome. (2017)
  • Author(s): Mizukami, T., Sugimoto, S., Masaoka, T., Suzuki, H., Kanai, T.
  • Journal Title: Intest. Res. Volume: 15 Issue: 2 Pages: 236-243
  • DOI: 10.5217/ir.2017.15.2.236
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gender difference of gastric emptying in healthy volunteers and patients with functional dyspepsia. (2017)
  • Author(s): Mori, H., Suzuki, H., Matsuzaki, J., Taniguchi, K., Shimizu, T., Yamane, T., Masaoka, T., Kanai, T.
  • Journal Title: Digestion Volume: 95 Issue: 1 Pages: 72-78
  • DOI: 10.1159/000452359
  • Peer Reviewed
• [Journal Article] Asian Perspectives on Diagnostic and Therapeutic Strategies in Inflammatory Bowel Disease: Report and Analysis of a Survey with Questionnaires. (2017)
  • Author(s): Yoshida, A., Ueno, F., Morizane, T., Joh, T., Kamiya, T., Takahashi, S., Tokunaga, K., Iwakiri, R., Kinoshita, Y., Suzuki, H., Naito, Y., Uchiyama, K., Fukodo, S., Chan, F.K., Halm, K.B., Kachintorn, U., Fock, K.M., Rani, A.A., Syam, A.F., Sollano, J.D., Zhu, Q.
  • Journal Title: Digestion Volume: 95 Issue: 1 Pages: 79-88
  • DOI: 10.1159/000453007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence of gastric non-Helicobacter pylori-Helicobacters in Japanese patients with gastric disease (2017)
  • Author(s): Overby, A., Murayama, S. Y., Michimae, H., Suzuki, H., Suzuki, M., Serizawa, H., Tamura, R., Nakamura, S., Takahashi, S. and Nakamura, M.
  • Journal Title: Digestion Volume: 95 Issue: 1 Pages: 61-66
  • DOI: 10.1159/000452400
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dexmedetomidine vs propofol for gastrointestinal endoscopy: A meta-analysis. (2017)
  • Author(s): Nishizawa, T., Suzuki, H., Hosoe, N., Ogata, H., Kanai, T., Yahagi, N.
  • Journal Title: United European Gastroenterol Journal Volume: 5 Issue: 7 Pages: 1037-1045
  • DOI: 10.1177/2050640616688140
  • Peer Reviewed / Open Access
• [Journal Article] The Application of the Rome Ⅳ Criteria to Functional Esophagogastroduodenal Disorders in Asia. (2017)
  • Author(s): Suzuki, H.
  • Journal Title: J. Neurogastroenterol. Motil. Volume: 23 Issue: 3 Pages: 325-333
  • DOI: 10.5056/jnm17018
  • Peer Reviewed / Open Access
• [Journal Article] Effect of prophylactic clipping in colorectal endoscopic resection: A meta-analysis of randomized controlled studies. (2017)
  • Author(s): Nishizawa, T., Suzuki, H., Goto, O., Ogata, H., Kanai, T., Yahagi, N.
  • Journal Title: United European Gastroenterol Journal Volume: 5 Issue: 6 Pages: 859-867
  • DOI: 10.1177/2050640616687837
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori-Associated Upper Gastrointestinal Symptoms:FD or HpD? (2017)
  • Author(s): Suzuki, H.
  • Journal Title: Dig. Dis. Sci. Volume: Epub
  • Peer Reviewed
• [Journal Article] Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection. (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Sakitani, K., Yamashita, H., Yoshida, S., Hata, K., Kanazawa, T., Fujiwara, N., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 1 Pages: 32-36
  • DOI: 10.1177/2050640616642341
  • Peer Reviewed / Open Access
• [Journal Article] Helicovanter pylori VacA, acting through receptor tyrosine phosphatase is crucial for CagA phosphorylation in human duodenal carcinoma cell line AZ-521. (2016)
  • Author(s): Nakano, M., Yahiro, K., Yamazaki, E., Kurazono, H., Akada, J.K., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T. Moss, J. and Hirayama, T.
  • Journal Title: Dis. Model Mech. Volume: 9 Issue: 12 Pages: 1473-1481
  • DOI: 10.1242/dmm.025361
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i> (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Arano, T., Yoshida, S., Yamashita, H., Hata, K., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 59 Issue: 3 Pages: 226-230
  • DOI: 10.3164/jcbn.16-43
  • NAID: 130005268711
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients. (2016)
  • Author(s): Lee, S-Y., Masaoka, T., Han, H-S., Matsuzaki, J., Hong, M-J., Fukuhara, S., Choi, H-S, Suzuki, H.
  • Journal Title: Neurogastroenterol. Motil. Volume: 28 Issue: 9 Pages: 1401-1408
  • DOI: 10.1111/nmo.12841
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influence of regular exercise on gastric emptying in healthy men: a pilot study (2016)
  • Author(s): Matsuzaki, J., Suzuki, H.*, Masaoka, T., Tanaka, K., Mori, H., Kanai, T.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 59 Issue: 2 Pages: 130-133
  • DOI: 10.3164/jcbn.16-29
  • NAID: 130005262393
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] A simple scoring system to assess the need for an endoscopic intervention in suspected upper gastrointestinal bleeding: A prospective cohort study. (2016)
  • Author(s): Horibe, M., Kaneko, T., Yokogawa, N., Yokota, T., Okawa, O., Nakatani, Y., Ogura, Y., Matsuzaki, J., Iwasaki, E., Hosoe, N., Masaoka, T., Inadomi, J.M., Suzuki, H., Kanai, T., Namiki, S.
  • Journal Title: Dig. Liver Dis. Volume: 48 Issue: 10 Pages: 1180-6
  • DOI: 10.1016/j.dld.2016.07.009
  • Peer Reviewed
• [Journal Article] Endoscopic slip knot clip suturing method: An ex vivo feasibility study (with video). (2016)
  • Author(s): Nishizawa, T., Uraoka, T., Sagara, S., Suzuki, H., Akimoto, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 83 Issue: 2 Pages: 447-450
  • DOI: 10.1016/j.gie.2015.09.007
  • Peer Reviewed
• [Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia. (2016)
  • Author(s): Togawa, K., Matsuzaki, J., Kobayakawa, M., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 31 Issue: 2 Pages: 334-341
  • DOI: 10.1111/jgh.13074
  • Peer Reviewed / Open Access
• [Journal Article] Different pathophysiology of gastritis between East and West? An Asian perspective. (2016)
  • Author(s): Suzuki, H. *, Mori, H.
  • Journal Title: Inflamm. Intest. Dis. Volume: 1 Issue: 3 Pages: 123-128
  • DOI: 10.1159/000446301
  • Peer Reviewed
• [Journal Article] Gastroduodenal Disorders. (2016)
  • Author(s): Stanghellini, V., Chan, F. K-L, Hasler, W.L., Malangelada, J.R., Suzuki, H., Tack, J., Talley, N.J.
  • Journal Title: Gastroenterology Volume: 150 Issue: 6 Pages: 1380-1392
  • DOI: 10.1053/j.gastro.2016.02.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Profile of acotiamide in the treatment of functional dyspepsia. (2016)
  • Author(s): Ueda, M., Iwasaki, E., Suzuki H.
  • Journal Title: Clin. Exp. Gastroenterol. Volume: 9 Pages: 83-88
  • DOI: 10.2147/ceg.s72172
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2016)
  • Author(s): Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
  • Journal Title: Autophagy Volume: 12(1) Issue: 1 Pages: 1-222
  • DOI: 10.1080/15548627.2015.1100356
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia (2016)
  • Author(s): Matsushita M., Masaoka T., Suzuki H.
  • Journal Title: Neurogastroenterol Motil. Volume: 28 Issue: 5 Pages: 631-8
  • DOI: 10.1111/nmo.12756
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of carbon dioxide insufflation in balloon-assisted enteroscopy: A systematic review and meta-analysis (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Fujimoto, A., Ochiai, Y., Kanai, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 11-17
  • DOI: 10.1177/2050640615588024
  • Peer Reviewed / Open Access
• [Journal Article] Effects of preoperative proton pump inhibitor administration on bleeding after gastric endoscopic submucosal dissection: A systematic review and meta-analysis. (2016)
  • Author(s): Nishizawa, T., Suzuki, H.*, Akimoto, T., Maehata, T., Kanai, T., Morizane, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 5-10
  • DOI: 10.1177/2050640615588023
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of 10-day and 14-day triple therapy as a third-line and fourth-line regimen for Helicobacter pylori eradication: a pilot study. (2015)
  • Author(s): Mori, H., Suzuki, H.*, Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Nishizawa, T., Masaoka, T., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 3 Pages: 380-387
  • DOI: 10.1177/2050640615618043
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of 10-day Sitafloxacin-containing third-line rescue therapies for Helicobacter pylori strains containing the gyrA mutation (2015)
  • Author(s): Mori H., Suzuki H., Matsuzaki J., Tsugawa H., Fukuhara S., Miyoshi S., Hirata K., Seino T., Matsushita M., Masaoka T., Kanai T.
  • Journal Title: Helicobacter Volume: 27 Issue: 4 Pages: 286-94
  • DOI: 10.1111/hel.12286
  • Peer Reviewed / Open Access
• [Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction. (2015)
  • Author(s): Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
  • Journal Title: Digestive Endoscopy Volume: 27 Issue: 1 Pages: 572-81
  • DOI: 10.1159/000440741
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Timing of oral refeeding in acute pancreatitis: A systematic review and meta-analysis. (2015)
  • Author(s): Horibe, M., Nishizawa, T., Suzuki, H., Minami, K., Yahagi, N., Iwasaki, E., Kanai, K.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 6 Pages: 725-732
  • DOI: 10.1177/2050640615612368
  • Peer Reviewed / Open Access
• [Presentation] H. pylori eradication: past, present and future. (2018)
  • Author(s): Suzuki, H.
  • Organizer: APDW2018, Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] Nationwide eradication strategy for Helicobacter pylori infection in Japan. (2018)
  • Author(s): Suzuki, H.
  • Organizer: APDW2018, Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] Gender difference in gastrointestinal function and functional GI disorders. (2018)
  • Author(s): Suzuki, H.
  • Organizer: APDW2018, Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] The evolving landscape of H. pylori, Relation to gastric cancer. Sponsored seminar lecture. (2018)
  • Author(s): Suzuki, H.
  • Organizer: The International Sentinel Node Society Biennial Meeting 2018 (ISNS 2018) Tokyo, Japan
  • Int'l Joint Research / Invited
• [Presentation] Case Presentation and Q&A - Novel approaches for PPI refractory GERD. Plenary Session 11: Novel approaches for PPI refractory GERD. (2018)
  • Author(s): Suzuki, H.
  • Organizer: The International Society for Diseases of the Esophagus (ISDE) 2018. VIenna, Austria
  • Int'l Joint Research / Invited
• [Presentation] Refux hypersensitivity: a new entity? (2018)
  • Author(s): Suzuki, H.
  • Organizer: GUT 2018 (Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology) Penang, Malaysia
  • Invited
• [Presentation] The evolving landscape of Helicobacter pylori in Asia. (2018)
  • Author(s): Suzuki, H.
  • Organizer: GUT 2018 (Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology) Penang, Malaysia
  • Invited
• [Presentation] Recent Advance in the therapeutic strategy for acid-related diseases. (2018)
  • Author(s): Suzuki, H.
  • Organizer: 58th GAT (Gastrointestinal Association of Thailand) Midyear Annual Meeting 2018, Bangkok, Thailand
  • Invited
• [Presentation] Association between oxidative stress and gastric carcinogenesis in H. pylori-infected patients. (2018)
  • Author(s): Tsugawa, H., Kato, C., Mori, H., Suematsu, M., Suzuki, H.
  • Organizer: Summer School on Stress 2018, Osaka, Japan
  • Int'l Joint Research
• [Presentation] Role of stress on gastrointestinal function and diseases. (2018)
  • Author(s): Suzuki, H.
  • Organizer: Summer School on Stress 2018, Osaka, Japan
  • Int'l Joint Research / Invited
• [Presentation] Changes of characterization in gastric cancer cells via reactive oxygen species resistance. (2018)
  • Author(s): Mori, H., Tsugawa, H., Matsuzaki, J., Masaoka, T., Kanai, T., Suzuki, H.
  • Organizer: Summer School on Stress 2018, Osaka, Japan
  • Int'l Joint Research
• [Presentation] Expression of CAPZA1, a negative regulator of CagA-degrading autophagy, is enhanced by oxidative stress-induced histone acetylation in Helicobacter pylori-infected gastric mucosa: A possible risk for gastric carcinogenesis. Esophageal, Gastric & Duodenal Disorders (EGD) Section Distinguished Abstract Plenary. (2018)
  • Author(s): Kato, C., Tsugawa, H., Saito, Y., Suzuki, H.
  • Organizer: Digestive Disease Week 2018, Washington, DC, U.S.A.
  • Int'l Joint Research
• [Presentation] Ghrelin is a useful marker of gastric mucosal atrophy after Helicobacter pylori eradication: a prospective clinical study. (2018)
  • Author(s): Mori, H., Suzuki, H., Matsuzaki, J., Masaoka, T., Igarashi, K., Kanai, T.
  • Organizer: Digestive Disease Week 2018, Washington, DC, U.S.A.
  • Int'l Joint Research
• [Presentation] Specific prediction of duodenal tumor using demographic and endoscopic characteristics: an age and sex matched case control study. (2018)
  • Author(s): Suzuki, H., Matsuzaki, J., Shimoda, M., Mori, H., Fukuhara, S., Kanai, Y., Kanai, T.
  • Organizer: Digestive Disease Week 2018, Washington, DC, U.S.A.
  • Int'l Joint Research
• [Presentation] Case study 2: Bloating & Fullness. Understanding Bloating & Fullness (2018)
  • Author(s): Suzuki, H.
  • Organizer: SEAGMA&AGIFT 4th Scientific Meeting, Singapore
  • Int'l Joint Research / Invited
• [Presentation] Case study 1: Epigastric Pain. Helicobacter pylori gastritis. (2018)
  • Author(s): Suzuki, H.
  • Organizer: SEAGMA&AGIFT 4th Scientific Meeting, Singapore
  • Int'l Joint Research / Invited
• [Presentation] Clinical evidence of Kampo medicine for functional gastrointestinal disorders (FGIDs). (2018)
  • Author(s): Suzuki, H.
  • Organizer: SEAGMA&AGIFT 4th Scientific Meeting, Singapore
  • Int'l Joint Research / Invited
• [Presentation] Role of acid suppression in FD: PPI and PCAB. (2018)
  • Author(s): Suzuki, H.
  • Organizer: APNM2018, Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] 上部消化管のベストプラクティス (2018)
  • Author(s): 鈴木秀和
  • Organizer: 日本消化器病学会関東支部第348回例会
  • Invited
• [Presentation] 機能性ディスペプシア (2018)
  • Author(s): 鈴木秀和
  • Organizer: 日本消化器病学会関東支部 第32回教育講演会
  • Invited
• [Presentation] Rome IVにおける機能性ディスペプシア (2018)
  • Author(s): 鈴木秀和
  • Organizer: 第14回日本消化管学会総会学術集会
  • Invited
• [Presentation] 機能性ディスペプシアの新展開：Rome IVを踏まえて. コアシンポジウム3 機能性疾患「機能性ディスペプシアの新展開～機能性ディスペプシアの薬物治療～」 (2017)
  • Author(s): 鈴木秀和
  • Organizer: 第13回日本消化管学会総会学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2017-02-18
• [Presentation] ディスペプシア症状に対する六君子湯の有効性-病院と診療所の違いを中心に. コアシンポジウム3 機能性疾患「機能性ディスペプシアの新展開～機能性ディスペプシアの薬物治療～」 (2017)
  • Author(s): 松崎潤太郎、東川康嗣、鈴木秀和
  • Organizer: 第13回日本消化管学会総会学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2017-02-18
• [Presentation] Cultivation of research mind to endoscopists and development of endoscopic science (2017)
  • Author(s): Suzuki, H.
  • Organizer: The 93rd Congress of the Japan Gastroenterological Endoscopy Society
  • Int'l Joint Research / Invited
• [Presentation] Impact of functional dyspepsia and its concomitant symptoms on the loss of work productivity. (2017)
  • Author(s): Suzuki, H., Togawa, K., Matsuzaki, J.
  • Organizer: Digestive Disease Week 2017
  • Int'l Joint Research
• [Presentation] Innovation of the therapeutic strategy for acid-related diseases. (2017)
  • Author(s): Suzuki, H.
  • Organizer: Tokyo Live 2017
  • Int'l Joint Research / Invited
• [Presentation] 慢性便秘への新たなる診療アプローチ (2017)
  • Author(s): 鈴木秀和
  • Organizer: 第108回日本消化器病学会中国支部例会・第119回日本消化器内視鏡学会中国支部例会
  • Invited
• [Presentation] Rome Ⅳ時代の機能性ディスペプシア (2017)
  • Author(s): 鈴木秀和
  • Organizer: 日本消化器病学会北陸支部第38回教育講演会
  • Invited
• [Presentation] 酸関連疾患：超高齢社会への挑戦 (2017)
  • Author(s): 鈴木秀和
  • Organizer: 第20回日本高齢消化器病学会総会
  • Invited
• [Presentation] ポストグラデュエイトコース 上部消化管「機能性ディスペプシア」 (2017)
  • Author(s): 鈴木秀和
  • Organizer: 第103回日本消化器病学会総会
  • Invited
• [Presentation] Lecture: Rome IV criteria: Application for upper GI in Asia. Symposium “What’s new in Rome IV criteria” (2016)
  • Author(s): Suzuki, H.
  • Organizer: APDW2016
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2016-11-05
  • Int'l Joint Research / Invited
• [Presentation] Preview of Rome IV criteria and its implication in Asia. Symposium III “Motility Symposium” (2016)
  • Author(s): Suzuki, H.
  • Organizer: GIHep Singapore 2016
  • Place of Presentation: Singapore
  • Year and Date: 2016-07-03
  • Int'l Joint Research / Invited
• [Presentation] メインシンポジウム「がん研究者と疫学研究者のコミュニケーション」 臨床医からみたがん病態と予防疫学． (2016)
  • Author(s): 鈴木秀和
  • Organizer: 第23回 日本がん予防学会/第39回 日本がん疫学・分子疫学研究会総会
  • Place of Presentation: 名古屋大学大学院医学系研究科基礎医学研究棟（愛知県名古屋市）
  • Year and Date: 2016-07-01
  • Invited
• [Presentation] パネルディスカッション4 「新しい除菌薬を含めたこれからの除菌治療」 ： シタフロキサシンを含む除菌療法前後のシタフロキサシン最小発育阻止濃度の変動． (2016)
  • Author(s): 森英毅、正岡建洋、松崎潤太郎、津川仁、西澤俊宏、柏﨑有紀、山根剛、金井隆典、鈴木秀和
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 別府ビーコンプラザ（大分県別府市）
  • Year and Date: 2016-06-25
• [Presentation] パネルディスカッション1 「新ガイドライン2016の改正ポイント」 ： 新ガイドライン2016の改正ポイント「適応疾患」． (2016)
  • Author(s): 鈴木秀和
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 別府ビーコンプラザ（大分県別府市）
  • Year and Date: 2016-06-24
  • Invited
• [Presentation] パネルディスカッション2 「我が国における胃癌撲滅対策と課題」： 東京都内多施設共同調査による一次・二次除菌率の経年的変化―ボノプラザンは除菌率を如何に変えたか―． (2016)
  • Author(s): 森英毅、鈴木秀和、伊藤愼芳、浅岡大介、鈴木雅之、川村洋、川上浩平、榊信廣、嶋田裕慈、佐々木仁、栗原直人、小俣富美雄、徳永健吾、河合隆、高橋信一 東京HP研究会
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 別府ビーコンプラザ（大分県別府市）
  • Year and Date: 2016-06-24
• [Presentation] The presence of sleep disorders was independently associated with delayed gastric emptying, but not with the presence of functional dyspepsia. (2016)
  • Author(s): Yamane, T., Masaoka, T., Matsuzaki, J., Mori, H., Kashiwazaki, Y., Komori, T., Shimizu, T., Taniguchi, K., Suzuki, H., Kanai, T.
  • Organizer: Digestive Disease Week 2016
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] 特別発言. ワークショップ10：「機能性消化管障害の内視鏡診療」 (2016)
  • Author(s): 鈴木秀和
  • Organizer: 第91回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール（東京都港区）
  • Year and Date: 2016-05-13
  • Invited
• [Presentation] 膵型乳頭括約筋機能不全症に対するEST治療後の長期成績. ワークショップ10：「機能性消化管障害の内視鏡診療」. (2016)
  • Author(s): 岩崎栄典、山岸由幸、鈴木秀和
  • Organizer: 第91回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール（東京都港区）
  • Year and Date: 2016-05-13
• [Presentation] 食道pHインピーダンスモニタリングと高解像度食道内圧測定による酸分泌抑制療法への反応性の検討. パネルディスカッション5：「酸分泌抑制療法のパラダイムシフト」. (2016)
  • Author(s): 正岡建洋、鈴木秀和、金井隆典
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-22
• [Book] Bile Acids in Gastroenterology: Bile Acids and Esophageal Cancer (2017)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Total Pages: 209
  • Publisher: Springer Japan
  • ISBN: 9784431560609
• [Book] Bile Acids and Esophageal Cancer. Bile Acids in Gastroenterology (eds.) Susumu Tazuma, Hajime Takikawa, (2017)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Total Pages: 209
  • Publisher: Springer Japan
• [Book] Symptom generation. Helicobacter pylori (eds.) Hidekazu Suzuki, Robin Warren, Barry Marshall (2016)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Total Pages: 267
  • Publisher: Springer Japan
• [Book] Gastric Non-Helicobacter pylori Helicobacter: Its Significance in Human Gastric Diseases. Helicobacter pylori (eds.) Hidekazu Suzuki, Robin Warren, Barry Marshall (2016)
  • Author(s): Nakamura, M., Overby, A., Murayama, S-Y., Suzuki, H., Takahashi, T., Takahashi, S., Matsui, H.
  • Total Pages: 267
  • Publisher: Springer Japan
• [Book] Third-line eradication therapy. Helicobacter pylori (eds.) Hidekazu Suzuki, Robin Warren, Barry Marshall (2016)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Total Pages: 267
  • Publisher: Springer Japan
• [Book] Autophagy. Helicobacter pylori (eds.) Hidekazu Suzuki, Robin Warren, Barry Marshall (2016)
  • Author(s): Tsugawa, H., Suzuki, H.
  • Total Pages: 267
  • Publisher: Springer Japan