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Promotion of personalized medicine for lifestyle-related diseases by revealing bile acids, microbiota and cell signaling interaction

Research Project

Project/Area Number 16H05292
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

WATANABE Mitsuhiro  慶應義塾大学, 政策・メディア研究科(藤沢), 教授 (10450842)

Co-Investigator(Kenkyū-buntansha) 横山 葉子  慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 (10617244)
滝川 一  帝京大学, 医学部, 教授 (70197226)
松崎 靖司  東京医科大学, 医学部, 教授 (50209532)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords胆汁酸 / 腸内細菌 / 糖尿病 / 肥満 / 消化器 / 代謝
Outline of Final Research Achievements

In recent years, it has been clarified that bile acids not only promote digestion and absorption of lipids, but also regulate metabolism as signal molecules. Bile acids were administered to two strains of mice with different bile acids responsiveness, with and without antibiotics. Multi-omics analysis such as bile acids composition, DNA microarray, microbiota analysis were performed. In addition to the difference in bile acids, lipid and cholesterol metabolism due to genetic background, the change in bile acid composition metabolized by microbiota was different depending on the presence or absence of obesity / diabetes suppression effect by bile acid in two strain mice. It turned out that they interact and affect intricately.

Academic Significance and Societal Importance of the Research Achievements

2系統マウスを用いた研究はR.Khan らによって精力的に行われ、PKC-δなど糖尿病を誘発する原因遺伝子の同定が行われてきたが、根本的なメカニズム解明には至っていない。しかしながら、我々が見出した2 系統マウスにおける胆汁酸応答性による生活習慣病発症差異に加えて、胆汁酸代謝-腸内細菌-宿主遺伝的背景という新たな視点から本研究を推進することで、人の個人的発症差異が存在する生活習慣病誘発の根本的な原因を抽出することができ、全く新しいストラテジーに基づく個別化予防・治療法の提唱に結びつけることができると考えている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] スイス連邦工科大学ローザンヌ校(スイス)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 治療標的としての胆汁酸シグナル2017

    • Author(s)
      北村奈穂, 渡辺光博.
    • Journal Title

      実験医学

      Volume: 35 Pages: 258-265

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 胆汁酸代謝調節と糖尿病治療2017

    • Author(s)
      川島えり, 渡辺光博.
    • Journal Title

      プラクティス

      Volume: 34 Pages: 372-379

    • Related Report
      2017 Annual Research Report
  • [Presentation] Difference between two mice strains changes their bile acid composition, gut microbiota, and metabolic regulation system2018

    • Author(s)
      N.Kitamura, H.Taoka, T.Tanigaki, E.Kawashima, Y.Yokoyama, A.Nakamura, M. Watanabe
    • Organizer
      XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分子生物学胆汁酸研究の夜明けと今後の行先2017

    • Author(s)
      渡辺光博
    • Organizer
      第39回胆汁酸研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] あなたの健康寿命はもっとのばせる!2017

    • Author(s)
      渡辺光博
    • Total Pages
      223
    • Publisher
      日本文芸社
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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