Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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Outline of Final Research Achievements |
We investigated the role of elongation of long-chain fatty acid (LCFA) member 6 (Elovl6), a rate-limiting enzyme catalyzing the elongation of saturated and monounsaturated LCFA, in the regulation of phenotypic switching of VSMC.We demonstrate for the first time that dysregulation of Elovl6-driven LCFA metabolism induces phenotypic switching of VSMC via ROS production and AMPK/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression. The modulation of Elovl6-mediated cellular processes may provide an intriguing approach for tackling atherosclerosis and post-angioplasty restenosis.
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