| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
Heart failure pandemic has become an important medical and social burden world-wide. We previously showed that chronic inflammation initiated in obese visceral adipose tissue activates inflammation in distant tissues, such as the pancreas and heart, and promotes cardiovascular and metabolic disease. In this study we analyzed the mechanism that link the heart and kidneys in cardiorenal syndrome. We found that the heart-brain-kidney organ networks is crucial for proper response to cardiac stress. Dysfunction in this system impairs adaptation to cardiac stress, resulting in heart failure.
|
