Elucidation of organ crosstalk in cardiovascular disease
| Project/Area Number |
16H05295
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Chiba University |
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Principal Investigator |
Manabe Ichiro 千葉大学, 大学院医学研究院, 教授 (70359628)
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| Co-Investigator(Kenkyū-buntansha) |
藤生 克仁 東京大学, 医学部附属病院, 特任准教授 (30422306)
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| Research Collaborator |
MATSUMOTO sahohime
HASUMI eriko
KOJIMA toshiya
NAKAYAMA yukiteru
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 心不全 / マクロファージ / 臓器連関 / 自律神経 / 心腎連関 / 循環器・高血圧 / 生理学 / 生体分子 / 慢性炎症 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
Heart failure pandemic has become an important medical and social burden world-wide. We previously showed that chronic inflammation initiated in obese visceral adipose tissue activates inflammation in distant tissues, such as the pancreas and heart, and promotes cardiovascular and metabolic disease. In this study we analyzed the mechanism that link the heart and kidneys in cardiorenal syndrome. We found that the heart-brain-kidney organ networks is crucial for proper response to cardiac stress. Dysfunction in this system impairs adaptation to cardiac stress, resulting in heart failure.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化を背景に、複数臓器の病気を併発している患者が増えている。特に、心腎連関は心不全や慢性腎臓病の治療を難しいものとしている。本研究の成果は、心腎連関の全く新しいメカニズムを明らかにした。また、GM-CSFやAmphiregulin、β受容体等、薬等で介入可能な分子を多数同定した。これらの分子を始めとして、本研究によって同定されたメカニズムは、心腎連関や心不全の治療標的となることが期待できる。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication2017
Author(s)
Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
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Journal Title
Nature Medicine
Volume: 印刷中
Issue: 5
Pages: 611-622
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.2017
Author(s)
Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK.
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Journal Title
Cell Metab.
Volume: 25(2)
Issue: 2
Pages: 412-427
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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