| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
The sympathetic nervous system is a major mechanism of regulating cardiac function together with the Frank Starling mechanism. Catecholamine is a neurotramsmitter molecule of the sympathetic nervous system, and activates adenylyl cyclase to produce cAMP. This second messenger activates protein kinase A, however, recent studies have identified Epac as another target enzyme. Epac is directly activated by cAMP, and activaes Rap and other G protein-related molecules within the regulation of cellular function. In the current research project, we have compared the role of Epac with that of protein kinase A, and found its regulation within the cAMP network that regulates cardiac function and the development of heart failure.
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