Autonomic regulation of cardiac function

• Project/Area Number: 16H05300
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Yokohama City University
• Principal Investigator: Ishikawa Yoshihiro 横浜市立大学, 医学研究科, 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): 奥村 敏 鶴見大学, 歯学部, 教授 (60233475) ; 梅村 将就 横浜市立大学, 医学部, 助教 (50595353)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 循環器・高血圧 / 生理学 / 薬理学

Outline of Final Research Achievements

The sympathetic nervous system is a major mechanism of regulating cardiac function together with the Frank Starling mechanism. Catecholamine is a neurotramsmitter molecule of the sympathetic nervous system, and activates adenylyl cyclase to produce cAMP. This second messenger activates protein kinase A, however, recent studies have identified Epac as another target enzyme. Epac is directly activated by cAMP, and activaes Rap and other G protein-related molecules within the regulation of cellular function. In the current research project, we have compared the role of Epac with that of protein kinase A, and found its regulation within the cAMP network that regulates cardiac function and the development of heart failure.

Academic Significance and Societal Importance of the Research Achievements

交感神経は心機能制御の最大の生理メカニズムであり、この作用は様々な心疾患における診断や治療に応用されている。交感神経伝達物質であるカテコラミンは心機能亢進作用があり、交感神経遮断剤は心機能低下作用を持つ。いずれも細胞内の作用は、cAMP産生調節であり、下流のPKAの活性調節である。今回の我々の研究成果から、PKAのみならずEPACと呼ばれる新規因子が、心機能調節に重要であることが分かった。これは心機能の調節と心不全発症の観点から、将来の新規治療法の開発につながると考えられる。

Research Products

• [Journal Article] Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration (2019)
  • Author(s): Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa
  • Journal Title: The Journal of Physiological Sciences Volume: 69 Issue: 2 Pages: 175-184
  • DOI: 10.1007/s12576-018-0631-7
  • NAID: 40021818894
  • Peer Reviewed / Open Access
• [Journal Article] An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model (2019)
  • Author(s): Yasuda Shota、Goda Motohiko、Shibuya Taisuke、Uchida Keiji、Suzuki Shinichi、Noishiki Yasuharu、Yokoyama Utako、Ishikawa Yoshihiro、Masuda Munetaka
  • Journal Title: Artificial Organs Volume: 印刷中 Issue: 6 Pages: 577-583
  • DOI: 10.1111/aor.13399
  • Peer Reviewed / Open Access
• [Journal Article] Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus. (2019)
  • Author(s): Kemmotsu T, Yokoyama U, Saito J, Ito S2, Uozumi A, Nishimaki S, Iwasaki S, Seki K, Ito S1, Ishikawa Y.
  • Journal Title: Circ J. Volume: 83 Pages: 654-661
  • NAID: 130007604194
  • Peer Reviewed
• [Journal Article] Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1- (2019)
  • Author(s): Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y.
  • Journal Title: Circ J. Volume: 83 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Alternating magnetic field (AMF) enhances cytotoxicity of compound c. (2018)
  • Author(s): Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y.
  • Journal Title: Cancer Sci. Volume: 109 Issue: 11 Pages: 3483-3493
  • DOI: 10.1111/cas.13781
  • Peer Reviewed / Open Access
• [Journal Article] A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm. (2018)
  • Author(s): Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y.
  • Journal Title: Physiol Rep. Volume: 6 Issue: 18
  • DOI: 10.14814/phy2.13878
  • Peer Reviewed / Open Access
• [Journal Article] Treatment of oral cancer using magnetized paclitaxel (2018)
  • Author(s): Nakakaji Rina、Umemura Masanari、Mitsudo Kenji、Kim Jeong-Hwan、Hoshino Yujiro、Sato Itaru、Masuda Takatsugu、Yamamoto Masahiro、Kioi Mitomu、Koizumi Toshiyuki、Fujita Takayuki、Yokoyama Utako、Iida Masaki、Sato Motohiko、以下7名
  • Journal Title: Oncotarget Volume: 9 Issue: 21 Pages: 15591-15605
  • DOI: 10.18632/oncotarget.24570
  • Peer Reviewed / Open Access
• [Journal Article] Acute hyperthermia inhibits TGF-β1-induced cardiac fibroblast activation via uppression of Akt Signaling. (2018)
  • Author(s): Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 6277-6277
  • DOI: 10.1038/s41598-018-24749-6
  • Peer Reviewed / Open Access
• [Journal Article] Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus. (2018)
  • Author(s): Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, Ishikawa Y.
  • Journal Title: PLoS One Volume: 13(1) Issue: 1 Pages: e0190871-e0190871
  • DOI: 10.1371/journal.pone.0190871
  • Peer Reviewed / Open Access
• [Journal Article] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice (2018)
  • Author(s): Suita Kenji、Fujita Takayuki、Cai Wenqian、Hidaka Yuko、Jin Huiling、Prajapati Rajesh、Umemura Masanari、Yokoyama Utako、Sato Motohiko、Knollmann Bj?rn C.、Okumura Satoshi、Ishikawa Yoshihiro
  • Journal Title: Pfl?gers Archiv - European Journal of Physiology Volume: 未定 Issue: 6 Pages: 923-935
  • DOI: 10.1007/s00424-018-2121-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hydrostatic pressure suppressed fibrotic change via Akt/GSK-3 signaling in human cardiac fibroblasts. (2018)
  • Author(s): Tanaka R, Umemura M, Narikawa M, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
  • Journal Title: Physiol Rep. Volume: 6 Issue: 9 Pages: e13687-e13687
  • DOI: 10.14814/phy2.13687
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal (2018)
  • Author(s): Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, Ishikawa Y.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 315 Issue: 4 Pages: H1012-H1018
  • DOI: 10.1152/ajpheart.00329.2018
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor (2018)
  • Author(s): Umemura Masanari、Islam Md. Rafikul、Fukumura Hidenobu、Sato Itaru、Kawabata Yusuke、Matsuo Kousuke、Nakakaji Rina、Nagasako Akane、Ohtake Makoto、Takayuki Fujita、Yokoyama Utako、Nakayama Tomohiro、Eguchi Haruki、Ishikawa Yoshihiro
  • Journal Title: Cancer Science Volume: 110 Issue: 1 Pages: 356-365
  • DOI: 10.1111/cas.13851
  • Peer Reviewed / Open Access
• [Journal Article] Arterial graft with elastic layer structure grown from cells. (2017)
  • Author(s): Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, Ishikawa Y.
  • Journal Title: Sci Rep Volume: 1 Issue: 1 Pages: 140-140
  • DOI: 10.1038/s41598-017-00237-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. (2017)
  • Author(s): Huiling Jin, Takayuki Fujita, Meihua Jin, Reiko Kurotani, Iyuki Namekata, Shogo Hamaguchi, Yuko Hidaka, Wenqian Cai, Kenji Suita, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Rajesh Prajapati, Chen Liang, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Hikaru Tanaka, Satoshi Okumura, Yoshihiro Ishikawa.
  • Journal Title: J Mol Cell Cardiol. Volume: 108 Pages: 170-180
  • DOI: 10.1016/j.yjmcc.2017.05.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor (2017)
  • Author(s): Masukawa Daiki、Koga Motokazu、Sezaki Anna、Nakao Yuka、Kamikubo Yuji、Hashimoto Tatsuo、Okuyama-Oki Yuki、Aladeokin Aderemi Caleb、Nakamura Fumio、Yokoyama Utako、Wakui Hiromichi、Ichinose Hiroshi、Sakurai Takashi、Umemura Satoshi、Tamura Koichi、Ishikawa Yoshihiro、Goshima Yoshio
  • Journal Title: JCI Insight Volume: 2 Issue: 18 Pages: 1-16
  • DOI: 10.1172/jci.insight.90903
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity (2017)
  • Author(s): Umemura Masanari、Kim Jeong-Hwan、Aoyama Haruki、Hoshino Yujiro、Fukumura Hidenobu、Nakakaji Rina、Sato Itaru、Ohtake Makoto、Akimoto Taisuke、Narikawa Masatoshi、Tanaka Ryo、Fujita Takayuki、Yokoyama Utako、Taguri Masataka、Okumura Satoshi、Sato Motohiko、Eguchi Haruki、Ishikawa Yoshihiro
  • Journal Title: Journal of Pharmacological Sciences Volume: 134 Issue: 4 Pages: 203-210
  • DOI: 10.1016/j.jphs.2017.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons (2017)
  • Author(s): Ito Satoko、Yokoyama Utako、Saito Junichi、Sato Shinichi、Usuda Haruo、Watanabe Shimpei、Kitanishi Ryuta、Miura Yuichiro、Saito Masatoshi、Hanita Takushi、Matsuda Tadashi、Ishikawa Yoshihiro
  • Journal Title: The Journal of Physiological Sciences Volume: 67 Issue: 6 Pages: 723-729
  • DOI: 10.1007/s12576-017-0565-5
  • NAID: 40021363517
  • Peer Reviewed / Open Access
• [Journal Article] The role of Epac in the heart (2017)
  • Author(s): T. Fujita, M. Umemura, U. Yokoyama, S. Okumura, and Y. Ishikawa
  • Journal Title: Cellular and Molecular Life Sciences Volume: 74 Issue: 4 Pages: 591-606
  • DOI: 10.1007/s00018-016-2336-5
  • Peer Reviewed
• [Journal Article] Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform. (2017)
  • Author(s): Kim J-H, Eguchi H,Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai,YamamotoM, and Ishikawa YK,
  • Journal Title: NPG Asia Materials. Volume: 9 Issue: 3 Pages: e367-e367
  • DOI: 10.1038/am.2017.29
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. (2017)
  • Author(s): Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, Ishikawa Y.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 42783-42783
  • DOI: 10.1038/srep42783
  • Peer Reviewed / Open Access
• [Journal Article] Pathology and Molecular Mechanisms of Coarctation of the Aorta and its Association with the Ductus Arteriosus. (2017)
  • Author(s): Yokoyama U, Ichikawa Y, Minamisawa S, Ishikawa Y
  • Journal Title: J Physiol Sci. Volume: 67 Issue: 2 Pages: 259-270
  • DOI: 10.1007/s12576-016-0512-x
  • NAID: 40021113914
  • Peer Reviewed / Open Access
• [Journal Article] Epac activation inhibits IL-6-induced cardiac myocyte dysfunction. (2016)
  • Author(s): Jin H，Fujita T，Jin M，Kurotani R，Hidaka Y，Cai W，Suita K，Prajapati R，Liang C，Ohnuki Y，Mototani Y，Umemura M，Yokoyama U，Sato M，Okumura S，Ishikawa Y.
  • Journal Title: J Physiol Sci. Volume: 印刷中 Issue: 1 Pages: 77-87
  • DOI: 10.1007/s12576-016-0509-5
  • NAID: 40021443658
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Use of Three-dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery (2016)
  • Author(s): P. Chetprayoon, M. Matsusaki, U. Yokoyama, T. Tejima, Y. Ishikawa, M. Akashi
  • Journal Title: Angew. Chem. Int. Ed. Volume: 55 Issue: 14 Pages: 4461-4466
  • DOI: 10.1002/anie.201509752
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles (2016)
  • Author(s): Itaru Sato, Masanari Umemura, Kenji Mitsudo, Hidenobu Fukumura, Jeong-Hwan Kim, Yujiro Hoshino Hideyuki Nakashima, Mitomu Kioi, Rina Nakakaji, Motohiko Sato, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Hisashi Oshiro, Haruki Eguchi, Iwai Tohnai and Yoshihiro Ishikawa.
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 24629-24629
  • DOI: 10.1038/srep24629
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction． (2016)
  • Author(s): Cai W，Fujita T，Hidaka Y，Jin H，Suita K，Prajapati R，Liang C，Umemura M，Yokoyama U，Sato M，Okumura S，Ishikawa Y
  • Journal Title: Biochem Biophys Res Commun. Volume: 475 Issue: 1 Pages: 1-7
  • DOI: 10.1016/j.bbrc.2016.04.123
  • Peer Reviewed
• [Journal Article] Transient receptor potential cation 3 channel regulates melanoma proliferation and migration． (2016)
  • Author(s): Oda K，Umemura M，Nakakaji R，Tanaka R，Sato I，Nagasako A，Oyamada C，Baljinnyam E，Katsumata M，Xie L，Narikawa M，Yamaguchi Y，Akimoto T，Ohtake M，Fujita T，Yokoyama U，Iwatsubo K，Aihara M and Ishikawa Y
  • Journal Title: J Physiol Sci. Volume: 該当なし Issue: 4 Pages: 497-505
  • DOI: 10.1007/s12576-016-0480-1
  • NAID: 40021238419
  • Peer Reviewed / Open Access
• [Journal Article] Glutamate Promotes Contraction of the Rat Ductus Arteriosus (2016)
  • Author(s): S. Fujita, U. Yokoyama, R. Ishiwata, R. Aoki, K. Nagao, D. Masukawa, M. Umemura, T. Fujita, S. Iwasaki, S. Nishimaki, K. Seki, S. Ito, Y. Goshima, T. Asou, M. Masuda, and Y. Ishikawa
  • Journal Title: Circulation Journal Volume: 80 Issue: 11 Pages: 2388-2396
  • DOI: 10.1253/circj.CJ-16-0649
  • NAID: 130005433144
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy (2016)
  • Author(s): T. Nakamura, T. Fujita, M. Kishimura, K. Suita, Y. Hidaka, W. Cai, M. Umemura, U. Yokoyama, M. Uechi, and Y. Ishikawa
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2496-2505
  • DOI: 10.1253/circj.CJ-16-0736
  • NAID: 130005284971
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Role of phosphodiesterase 4 expression in the epac1 signaling-dependent skeletal muscle hypertrophic action of clenbuterol． (2016)
  • Author(s): Ohnuki Y，Umeki D，Mototani Y，Shiozawa K，Nariyama M，Ito A，Kawamura N，Yagisawa Y，Jin H，Cai W，Suita K，Saeki Y，Fujita T，Ishikawa Y，Okumura S.
  • Journal Title: Physiological reports. Volume: 4 Issue: 10 Pages: e12791-e12791
  • DOI: 10.14814/phy2.12791
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function. (2015)
  • Author(s): Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 310(1) Issue: 1 Pages: 92-103
  • DOI: 10.1152/ajpheart.00411.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Tissue-type plasminogen activator promotes intimal thickening formation of the ductus arteriosus． (2018)
  • Author(s): Saito J，Yokoyama U，Nicho N，Zheng YW，Ito S，Ito S，Taniguchi H，Asou T，Masuda M，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference．
  • Int'l Joint Research
• [Presentation] Antenatal administration of betamethasone promotes closure of the preterm ductus arteriosus via intimal thickening formation． (2018)
  • Author(s): Kemmotsu T，Yokoyama U，Azuma S，Saito J，Ito S，Uozumi A，Nishimaki S，Iwasaki S，Seki K，Ito S，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference.
  • Int'l Joint Research
• [Presentation] Prostaglandin E-EP4 signaling-mediated fibulin-1 integrates extracellular matrices to promote smooth muscle cell migration of the ductus arteriosus． (2018)
  • Author(s): Ito S，Yokoyama U，Saito J，Masuda M，Asou T，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference.
  • Int'l Joint Research
• [Presentation] Mechanoresponse to periodic hydrostatic pressure enables fabrication of human arterial graft． (2018)
  • Author(s): Saito J，Yokoyama U，Takayama T，Horade M，Ito H，Sugo Y，Kurasawa K，Ogawa M，Miyagi E，Kaneko M，Ishikawa Y.
  • Organizer: American Society for Matrix Biology Biennial Meeting 2018.
  • Int'l Joint Research
• [Presentation] 胎盤由来プロスタグランディンEはFibulin-1を介した動脈管リモデリングを促進する． (2018)
  • Author(s): 横山詩子，伊藤智子，石川義弘.
  • Organizer: 第50回日本結合組織学会学術大会.
• [Presentation] The role of Epac1 in the development of ventricular arrhythmia in mice． (2018)
  • Author(s): Prajapati R，Fujita T，Suita K，Nakamura T，Cai W，Hidaka Y，Okumura S，Ishikawa Y.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] 線維芽細胞と組織内圧からみた心臓障害修復過程の病態生理． (2018)
  • Author(s): 田中 遼，梅村将就，成川雅俊，石川義弘.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] Fibulin-1の動脈管内膜肥厚形成における役割． (2018)
  • Author(s): 中川路太一，横山詩子，伊藤智子，石川義弘.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] 母体ラットへのべタメタゾン投与が動脈管内膜肥厚に与える作用の検討 (2018)
  • Author(s): 釼持孝博，横山詩子，齋藤純一，伊藤智子，魚住 梓，岩崎志穂，西巻 滋，関 和男，伊藤秀一，石川義弘.
  • Organizer: 第63回日本新生児成育医学科医・学術集会.
• [Presentation] プロスタグランディンE受容体EP4シグナルは腹部大動脈瘤の増悪に関与する． (2018)
  • Author(s): 廣見太郎，横山詩子，Al M，竹内一郎，石川義弘.
  • Organizer: CCM輸液・栄養研究会.
• [Presentation] プロスタグランディンE-EP4シグナルによる大動脈瘤進行の分子機序. (2018)
  • Author(s): 横山詩子，廣見太郎，石川義弘.
  • Organizer: 心血管膜輸送研究会2018.
• [Presentation] 周期的加圧培養による移植可能な血管グラフトの作製． (2018)
  • Author(s): 齋藤純一，横山詩子，高山俊男，洞出光洋，伊藤弘明，須郷慶信，倉澤健太郎，宮城悦子，金子 真，石川義弘.
  • Organizer: 第17回日本心臓血管発生研究会.
• [Presentation] Molecular mechanisms of arterial duct closure via PGE2-EP4. (2018)
  • Author(s): Ishikawa Y.
  • Organizer: The 5th International Congress on Cardiac Problems in Pregnancy.
  • Int'l Joint Research
• [Presentation] Fabrication of scaffold-free human vascular graft by periodic hydrostatic pressurization. (2018)
  • Author(s): Yokoyama U, Saito J, Ito H, Tadokoro T, Taniguchi H, Kaneko M, .Ishikawa Y.
  • Organizer: The 95th Annual Meeting of the Physiological Society of Japan.
  • Int'l Joint Research
• [Presentation] Tissue-type plasminogen activator contributes to remodeling of the ductus arteriosus. (2018)
  • Author(s): Saito J, Yokoyama U, Ishikawa Y.
  • Organizer: The 95th Annual Meeting of the Physiological Society of Japan.
• [Presentation] 不整脈発症におけるEpac1の役割. The role of exchanged protein directly activated by cAMP. (2018)
  • Author(s): 藤田孝之, プラジャパティ ラジェシュ, 中村 隆, 蔡 文倩, 日高祐子, 吹田憲治, 奥村 敏, 石川義弘.
  • Organizer: 第95回日本生理学会大会.
• [Presentation] 新規化合物の探索・同定による生理調節機構の解析. (2018)
  • Author(s): Umemura M, Nakakaji R, Eguchi H, Ishikawa Y.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Epac1 deficiency inhibits bFGF-induced neointimal formation via diminished phosphorylation of GSK3. (2018)
  • Author(s): Kato Y, Yokoyama U, Fujita T, Kubota T, Ishikawa, Y.
  • Organizer: The 95th Annual Meeting of the Physiological Society of Japan.
• [Presentation] 心筋細胞の生存維持におけるTCTPの役割. (2017)
  • Author(s): 藤田 孝之，蔡 文倩，日高 祐子，金 慧玲，プラジャパティ ラジェッシュ，梁 宸，他
  • Organizer: 第94回日本生理学会大会.
  • Place of Presentation: アクトシティ浜松（愛知県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] The function of Transient Receptor Potential Canonical 3 (TRPC3) Channel in cell proliferation. (2017)
  • Author(s): Umemura M, Oda K, Ishikawa Y.
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: アクトシティ浜松（愛知県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] Human gene analysis identified tissue plasminogen activator as a mediator of disrupting the internal elastic lamina in the ductus arteriosus. (2017)
  • Author(s): Saito J, Yokoyama U, Ishikawa Y.
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: アクトシティ浜松（愛知県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] 心臓型アデニル酸シクラーゼの阻害は心機能. (2017)
  • Author(s): 吹田 憲治，藤田 孝之，奥村 敏，石川 義弘.
  • Organizer: 第94回日本生理学会大会.
  • Place of Presentation: アクトシティ浜松（愛知県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] An EP4 antagonist has inhibitory and therapeutic effects on mouse models of abdominal antagonist has inhibitory and therapeutic effects on mouse models of abdominal aortic aneurysm. (2017)
  • Author(s): Al Mamun, Yokoyama U, Ishiwata R, Isono O, Nagabukuro H, Ishikawa Y.
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: アクトシティ浜松（愛知県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] In vitro fabrication of functional arterial graft by supraphysiological hydrostatic pressurization. (2017)
  • Author(s): Yokoyama U, Saito J, Sakuma S, Arai F, Kaneko M, Ishikawa Y.
  • Organizer: The 81th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: 金沢県立音楽堂他（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] ON-CHIP CELL GYM. (2017)
  • Author(s): Horade M, Kaneko M, Tsai CHD, Ito H, Higashino N, Akai T, Yokoyama U, Ishikawa Y, Sakuma S, Arai F.
  • Organizer: The 30th IEEE International Conference on Micro Electro Mechanical Systems.
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2017-01-22
  • Int'l Joint Research
• [Presentation] EP4 Signal in Vascular Inflammation. (2017)
  • Author(s): Ishikawa Y.
  • Organizer: Ｉnternational Union of Physiological Sciences (IUPS2017)
  • Int'l Joint Research
• [Presentation] Fabrication of Implantable Human Arterial Graft by Periodic Hydrostatic Pressure． (2017)
  • Author(s): Saito J，Yokoyama U，Ito H，Tadokoro T，Sugo Y，Kurasawa K，Ogawa M，Miyagi E，Taniguchi H，Kaneko M，Ishikawa Y.
  • Organizer: The 8th TAKAO International symposium.
  • Int'l Joint Research
• [Presentation] Prostaglandin E-EP4-mediated fibulin-1 up-regulation plays a role in intimal thickening of the ductus arteriosus． (2017)
  • Author(s): Ito S， Yokoyama U， Saito J， Masuda M， Asou T， Ishikawa Y
  • Organizer: The 8th TAKAO International symposium.
  • Int'l Joint Research
• [Presentation] Antenatal Administration of Betamethasone Contributes to Intimal thickening of the Ductus Arteriosus． (2017)
  • Author(s): Kemmotsu T，Yokoyama U，Azuma S，Saito J，Ito S，Uozumi A，Iwasaki S，Nishimaki S， Ito S，Masuda M，Asou T，Ishikawa Y.
  • Organizer: The 8th TAKAO International symposium.
  • Int'l Joint Research
• [Presentation] 自律神経制御を運動療法にどう活用するか－心不全から宇宙旅行まで－ (2017)
  • Author(s): 石川義弘
  • Organizer: 第42回日本運動療法学会学術集会
  • Invited
• [Presentation] Fibulin-1 の動脈管内膜肥厚形成機序. (2017)
  • Author(s): 伊藤智子，齋藤純一，横山詩子，石川義弘.
  • Organizer: 第53回日本新生児成育医学会学術集会.
• [Presentation] 母体ラットへのベタメタゾン投与が動脈管閉鎖に与える作用の検討． (2017)
  • Author(s): 釼持孝博，横山詩子，齋藤純一，魚住 梓，岩崎志穂，西巻 滋，伊藤秀一，石川義弘.
  • Organizer: 第53回日本新生児成育医学会学術集会.
• [Presentation] 虚血による心筋細胞死におけるTCTPの役割について． (2017)
  • Author(s): 吉田裕紀，藤田孝之，日髙祐子，金 慧玲，蔡 文倩，中村 隆，Prajapati R，石川義弘.
  • Organizer: 第27回日本病態生理学会大会.
• [Presentation] Epac1 plays an important role in the development of atrial fibrillation in mice． (2017)
  • Author(s): Prajapati R, Fujita T，Nakamura T，Suita K，Cai W，Hidaka Y，Ishikawa Y.
  • Organizer: 第27回日本病態生理学会大会.
• [Presentation] Development of a combination cancer therapy with a novel magnetized anti-cancer drug and hyperthermia． (2017)
  • Author(s): Nakakaji R，Mitsudou K，Umemura M，Sato I，Ohtake M，Koizumi T，Ishikawa Y，Tohnai I.
  • Organizer: The 34th Annual Meeting of Japanese Society for Thermal Medicine.
• [Presentation] A development of oral cancer treatment with a novel intrinsic magnetized paclitaxel. (2017)
  • Author(s): Nakakaji R， Umemura M， Ohtake M， Kioi M， Eguchi H， Tohnai I， Ishikawa Y.
  • Organizer: The 76th Annual Meeting of the Japanese Cancer Association.
• [Presentation] 温熱刺激は、Akt/S6K経路を介して心臓線維芽細胞の活性化を抑制する. (2017)
  • Author(s): 成川雅俊，梅村将就，木村一雄，田村功一，石川義弘.
  • Organizer: 第65回日本心臓病学会
• [Presentation] β 受容体シグナルの分子メカニズムの新展開. (2017)
  • Author(s): 石川義弘
  • Organizer: 第40回日本高血圧学会
  • Invited
• [Presentation] 多胎妊娠では動脈管内膜肥厚が抑制される． (2017)
  • Author(s): 伊藤智子，横山詩子，齋藤純一，佐藤信一，臼田治夫，渡邊真平，北西龍太，三浦雄一郎， 埴田卓志，松田 直，石川義弘.
  • Organizer: 第62回日本新生児成育医学会学術集会.
• [Presentation] 静水圧による力学的負荷と心臓線維芽細胞に関する検討． (2017)
  • Author(s): 田中 遼，梅村将就，成川雅俊，石川義弘.
  • Organizer: 心血管膜輸送研究会2017
• [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma． (2016)
  • Author(s): Oda K，et al.
  • Organizer: 日本研究皮膚科学会，第41回年次学術大会・総会.
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-12-09
• [Presentation] Fibulin-1 は平滑筋細胞遊走を介して動脈管内膜肥厚を誘導する． (2016)
  • Author(s): 伊藤智子，横山詩子，益田宗孝，麻生俊英，石川義弘.
  • Organizer: 第61回日本新生児成育医学会学術集会.
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-12-01
• [Presentation] EP4 signaling in smooth muscle cells attracts inflammatory immune responses in the aorta. (2016)
  • Author(s): Ishiwata R, Yokoyama U, Ichikawa Y, Kurotaki D, Yasuda S, Goda M, Suzuki S, Masuda M, Tamura T, Ishikawa Y.
  • Organizer: The 89th Scientific Session, American Heart Association (AHA).
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Human Gene Profiling Reveals contribution of Tissue Plasminogen Activator to Intimal Thickening of the Ductus Arteriosus. (2016)
  • Author(s): Saito J, Yokoyama U, Masuda M, Asou T, Ishikawa Y.
  • Organizer: The 89th Scientific Session, American Heart Association (AHA)
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Fibulin-1 plays a role in smooth muscle cell migration and intimal thickening in the ductus arteriosus. (2016)
  • Author(s): Ito S, Yokoyama U, Yanai C, Masuda M, Asou T, Ishikawa Y.
  • Organizer: The 89th Scientific Session, American Heart Association (AHA).
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 組織型プラスミノーゲン活性化因子による動脈管内弾性板の分解． (2016)
  • Author(s): 齋藤純一, 横山詩子, 石川義弘
  • Organizer: 第15回日本心臓血管発生研究会.
  • Place of Presentation: 国立循環器病研究センター（大阪府吹田市）
  • Year and Date: 2016-10-14
• [Presentation] PGE2-EP4シグナルはfibulin-1を介して動脈管平滑筋遊走を促進する． (2016)
  • Author(s): 伊藤智子, 横山詩子, 石川義弘
  • Organizer: 第15回日本心臓血管発生研究会.
  • Place of Presentation: 国立循環器病研究センター（大阪府吹田市）
  • Year and Date: 2016-10-14
• [Presentation] Anticancer Nanomagnet-loaded Smart Nano-Ensembles for Magneto-Drug Delivery，MRI，and Hyperthermal Cancer Targeting． (2016)
  • Author(s): Kim JH，Eguchi H，Umemura M，Ishikawa Y.
  • Organizer: Asian Nano
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-10
  • Int'l Joint Research
• [Presentation] An application of a novel intrinsic magnetized paclitaxel for oral cancer. (2016)
  • Author(s): Nakakaji R, Umemura M, Ohtake M, Oda K, Kioi M, Eguchi H, Tohnai I, Ishikawa Y.
  • Organizer: 第75回日本癌学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 神経膠芽腫に対する有機磁性体化合物を用いた化学温熱同時療法． (2016)
  • Author(s): 大竹 誠、梅村 将就、秋本 大輔、江口 晴樹、石川 義弘、川原 信隆.
  • Organizer: 第75回日本脳神経外科学術集会総会.
  • Place of Presentation: 福岡国際会議場、福岡サンパレス、マリンメッセ福岡
  • Year and Date: 2016-09-29
• [Presentation] Exchange protein activated by cyclic AMP 1 (Epac1) promotes bFGF-induced arterial smooth muscle cell migration. (2016)
  • Author(s): Kato Y, Yokoyama U, Kubota T, Ishikawa Y.
  • Organizer: The 32nd World Congress of Biomedical Laboratory Science.
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Presentation] Functional arterial graft fabricated from pressurized cell-layers (2016)
  • Author(s): Ishikawa Y, Akimoto T, Saito J, Gonda Y, Sakuma S, Arai F, Kaneko M, Yokoyama U.
  • Organizer: European Society of Cardiology．
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] TCTP down-regulation-induced cardiac cell death through BNIP3 may be a pivotal mechanism of Doxorubicin-induced heart failure． (2016)
  • Author(s): Cai W，Fujita T，Hidaka Y，Jin H，Suita K，Hasegawa N，Kubota K，Liang C，Ishikawa Y.
  • Organizer: European Society of Cardiology．
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング． (2016)
  • Author(s): 齋藤純一，横山詩子，麻生俊英，石川義弘.
  • Organizer: 第52回日本周産期・新生児医学会学術集会.
  • Place of Presentation: 富山国際会議場(富山県富山市）
  • Year and Date: 2016-07-16
• [Presentation] In-vitro fabrication of scaffold-free arterial grafts by periodic hydrodynamic pressurization. (2016)
  • Author(s): Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Sakuma S, Kaneko M, Ishikawa Y.
  • Organizer: International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research.
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] 平滑筋細胞におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促す． (2016)
  • Author(s): 石渡 遼，横山詩子，市川泰弘，黒滝大翼，田村智彦，石川義弘.
  • Organizer: 第37回日本循環制御医学会総会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2016-07-07
• [Presentation] キソルビシン誘発心不全発症における，p53を介したtranslationally controlled tumor protein（TCTP）発現抑制の役割． (2016)
  • Author(s): 蔡 文倩，藤田孝之，日高祐子，金 慧玲，Rajesh Prajapati，梁 宸，石川義弘
  • Organizer: 第37回循環制御医学会総会.
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2016-07-07
• [Presentation] The role of Epac in the development of atrial fibrillation in mice． (2016)
  • Author(s): Rajesh Prajapati，藤田孝之，蔡 文倩，吹田憲治，長谷川希望，金 慧玲，梁 晨，日高祐子，石川義弘.
  • Organizer: 第37回日本循環制御医学会総会.
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2016-07-07
• [Presentation] 敗血症性心不全における心機能低下に対するEpac1の保護的役割． (2016)
  • Author(s): 金 慧玲，藤田孝之，金 美花，蔡 文倩，日高祐子，吹田憲治，Rajesh Prajapati，梁 晨，奥村 敏，石川義弘 .
  • Organizer: 第37回日本循環制御医学会総会.
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2016-07-07
• [Presentation] The behavior of cells during Cell Exercise. (2016)
  • Author(s): Higashino N, Kaneko M, Yokoyama U, Ishikawa Y.
  • Organizer: ROBOMECH2016
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-06-08
• [Book] ガイトン生理学 原著第13版 (2018)
  • Author(s): John E. Hall (著), 石川義弘 (翻訳), 岡村康司 (翻訳), 尾仲達史 (翻訳), 河野憲二 (翻訳)
  • Total Pages: 1100
  • Publisher: エルゼビア・ジャパン社
  • ISBN: 4860347749
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学 HP
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Remarks] http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Patent(Industrial Property Rights)] 電源装置及び磁界発生システム (2018)
  • Inventor(s): 石川義弘、梅村将就、秋本大輔、岸和人 他
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、株式会社リコー
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-099149
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 金属アセン錯体を含む薬剤送達システム (2018)
  • Inventor(s): 石川義弘、梅村将就、中鍛治里奈 他
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、慶應義塾大学、株式会社ＩＨＩ
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-233877
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 9-β-D-アラビノフラノシルヒポキサンチンによる不整脈治療. (2017)
  • Inventor(s): 藤田孝之、石川義弘、中村隆、奥村敏、吹田憲治
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] 磁性高分子ミセル (2016)
  • Inventor(s): J-H Kim, Ishikawa Y, Umemura M
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-06-24
• [Patent(Industrial Property Rights)] がん治療装置 (2016)
  • Inventor(s): 石川義弘、梅村将就、秋本大輔
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-228164
  • Filing Date: 2016-11-24