• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of cardiovascular regulation and multiple function of gastrointestinal peptides

Research Project

Project/Area Number 16H05306
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MIYAZATO Mikiya  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (50291183)

Co-Investigator(Kenkyū-buntansha) 日野 純  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40260351)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywordsペプチド / ニューロメジン / 自律神経 / 循環調節 / グレリン
Outline of Final Research Achievements

To clarify the cardiovascular regulation and multiple functions of gastrointestinal peptides, 1) we searched for the endogenous ligands of the orphan receptors expressed in the vagal nerve ganglion, 2) we identified a novel peptide, neuromadin U precursor-related peptide (NURP), from rat brain and small intestine, and analyzed its function, and 3) we generated endothelial cell-specific C-type natriuretic peptide (CNP) transgenic mice and analyzed their effect in high fat diet-induced obesity.

Academic Significance and Societal Importance of the Research Achievements

研究代表者の研究室では、生体内に存在する新たな生理活性ペプチドを同定し、その機能を解明することにより、未知の生体機能調節機構を明らかにすることをテーマとして研究を進めてきた。今回、NURPと命名した新規ペプチドの発見に成功し、生体内の新たな調節機構を提示することができた。また、既知ペプチドであるCNPによる肥満およびその関連疾患に対する治療標的としての可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (13 results)

All 2019 2018 2017 2016

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Ghrelin and the heart2019

    • Author(s)
      Tokudome T, Otani K, Miyazato M, Kangawa K
    • Journal Title

      Peptides

      Volume: 111 Pages: 42-46

    • DOI

      10.1016/j.peptides.2018.05.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis2018

    • Author(s)
      Bae Cho-Rong、Hino Jun、Hosoda Hiroshi、Miyazato Mikiya、Kangawa Kenji
    • Journal Title

      Life Sciences

      Volume: 209 Pages: 349-356

    • DOI

      10.1016/j.lfs.2018.08.031

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone Morphogenetic Protein (BMP)-3b Gene Depletion Causes High Mortality in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy2018

    • Author(s)
      Ogawa Yuko、Tsuji Masahiro、Tanaka Emi、Miyazato Mikiya、Hino Jun
    • Journal Title

      Frontiers in Neurology

      Volume: 9 Pages: 397-397

    • DOI

      10.3389/fneur.2018.00397

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet.2018

    • Author(s)
      Bae CR, Hino J, Hosoda H, Son C, Makino H, Tokudome T, Tomita T, Hosoda K, Miyazato M, Kangawa K.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2093-2093

    • DOI

      10.1038/s41598-018-20469-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of a human neuromedin U receptor 1-selective hexapeptide agonist with enhanced serum stability2017

    • Author(s)
      Takayama T, Mori K, Tanaka A, Nomura E, Sohma Y, Mori M, Taguchi A, Taniguchi A, Sakane T, Yamamoto A,& Minamino N, Miyazato M, Kangawa K, Hayashi Y
    • Journal Title

      J Med Chem

      Volume: 60 Pages: 5228-5234

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release2017

    • Author(s)
      Mori Kenji、Ida Takanori、Fudetani Mami、Mori Miwa、Kaiya Hiroyuki、Hino Jun、Nakahara Keiko、Murakami Noboru、Miyazato Mikiya、Kangawa Kenji
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-017-10319-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.2017

    • Author(s)
      Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 9807-9807

    • DOI

      10.1038/s41598-017-10240-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuromedin U precursor-related peptide (NURP) exerts neuromedin U-like sympathetic nerve action in the rat2017

    • Author(s)
      Ensho Takuya、Maruyama Keisuke、Mori Kenji、Miyazato Mikiya、Kangawa Kenji、Nakahara Keiko、Murakami Noboru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 492 Issue: 3 Pages: 412-418

    • DOI

      10.1016/j.bbrc.2017.08.084

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity.2017

    • Author(s)
      Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K
    • Journal Title

      Int J Obes

      Volume: 41 Issue: 4 Pages: 483-488

    • DOI

      10.1038/ijo.2017.15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice.2017

    • Author(s)
      Zenitani M, Nojiri T, Kimura T, Hosoda H, Miura K, Hino J, Nakahata K, Uehara S, Miyazato M, Oue T, Okuyama H, Kangawa K
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 79 Issue: 2 Pages: 363-368

    • DOI

      10.1007/s00280-016-3221-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice : ANP for pulmonary fibrosis.2017

    • Author(s)
      Okamoto A, Nojiri T, Konishi K, Tokudome T, Miura K, Hosoda H, Hino J, Miyazato M, Kyomoto Y, Asai K, Hirata K, Kangawa K
    • Journal Title

      Respir Res

      Volume: 18 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12931-016-0492-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effects of ghrelin on cisplatin-induced nephrotoxicity in mice.2016

    • Author(s)
      Nojiri T, Hosoda H, Kimura T, Tokudome T, Miura K, Takabatake H, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      Peptides

      Volume: 82 Pages: 85-91

    • DOI

      10.1016/j.peptides.2016.06.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia.2016

    • Author(s)
      Nojiri T, Hosoda H, Zenitani M, Tokudome T, Kimura T, Miura K, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 78 Issue: 1 Pages: 191-197

    • DOI

      10.1007/s00280-016-3075-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi