| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
In the current project, we found that the amounts of plasma growth differentiation factor 11 (GDF11) in the COPD patients were decreased compared to those of the healthy subjects as well as in the lungs. The amounts of plasma GDF11 were significantly correlated with the data of lung function. GDF11 was mainly expressed in the bronchial epithelial cells and lung fibroblasts. The expression of GDF11 in the lungs of COPD was significantly less than in those of healthy subjects. Administration of GDF11 was attenuated the elastase-induced cellular senescence and enlargement of airspace. Oxysterol was highly expressed in the lungs of COPD compared to healthy subjects. Oxysterol accelerated cellular senescence of the lung fibroblasts through nitrosative stress. Further, we found that the expression of CD169 in the COPD alveolar macrophages, which was involved in phagocytosis of bacteria was significantly attenuated compared to that in the control subjects.
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