New anti-inflammatory strategy for the pathogenesis of chronic obstructive pulmonary disease

• Project/Area Number: 16H05307
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Ichinose Masakazu 東北大学, 医学系研究科, 教授 (80223105)
• Research Collaborator: Sugiura Hisatosi ; Yamada Mitsuhiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 細胞老化 / 酸化型コレステロール / エピゲノム変化 / COPD / GDF11 / オキシステロール / エピゲノム / 活性硫黄分子種 / 成長因子 / 抗老化分子 / エピゲノム解析

Outline of Final Research Achievements

In the current project, we found that the amounts of plasma growth differentiation factor 11 (GDF11) in the COPD patients were decreased compared to those of the healthy subjects as well as in the lungs. The amounts of plasma GDF11 were significantly correlated with the data of lung function. GDF11 was mainly expressed in the bronchial epithelial cells and lung fibroblasts. The expression of GDF11 in the lungs of COPD was significantly less than in those of healthy subjects. Administration of GDF11 was attenuated the elastase-induced cellular senescence and enlargement of airspace. Oxysterol was highly expressed in the lungs of COPD compared to healthy subjects. Oxysterol accelerated cellular senescence of the lung fibroblasts through nitrosative stress. Further, we found that the expression of CD169 in the COPD alveolar macrophages, which was involved in phagocytosis of bacteria was significantly attenuated compared to that in the control subjects.

Academic Significance and Societal Importance of the Research Achievements

COPDにおける抗炎症治療の確立にはCOPDの病態をさらに解明する必要がある。我々は全身及び肺における抗老化因子GDF11の発現がCOPD患者において低下していることを明らかにした。さらにCOPD患者の肺および気道では酸化型コレステロールの発現が増強しており細胞老化に関与すること、COPDの肺胞マクロファージでは細菌貪食受容体の発現が低下していることを明らかにした。これらの知見は呼吸器領域のトップジャーナルに掲載されており、新規創薬の基礎研究となりうる重要な知見と考える。

Research Products

• [Journal Article] Relapsed Myasthenia Gravis after Nivolumab Treatment (2018)
  • Author(s): Mitsune Ayumi、Yanagisawa Satoru、Fukuhara Tatsuro、Miyauchi Eisaku、Morita Mami、Ono Manabu、Tojo Yutaka、Ichinose Masakazu
  • Journal Title: Internal Medicine Volume: 57 Issue: 13 Pages: 1893-1897
  • DOI: 10.2169/internalmedicine.9153-17
  • NAID: 130007387159
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease (2018)
  • Author(s): Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 13 Pages: 1333-1342
  • DOI: 10.2147/copd.s157035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxidative stress enhances the expression of IL-33 in human airway epithelial cells. (2018)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
  • Journal Title: Respir Res. Volume: 27 Issue: 1 Pages: 52-52
  • DOI: 10.1186/s12931-018-0752-9
  • Peer Reviewed / Open Access
• [Journal Article] Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised controlled trial. (2018)
  • Author(s): Ferguson GT, Rabe KF, Martinez FJ, Fabbri LM, Wang C, Ichinose M, Bourne E, Ballal S, Darken P, DeAngelis K, Aurivillius M, Dorinsky P, Reisner C
  • Journal Title: Lancet Respir Med. Volume: 6 Issue: 10 Pages: 747-758
  • DOI: 10.1016/s2213-2600(18)30327-8
  • Peer Reviewed
• [Journal Article] TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells (2018)
  • Author(s): Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M
  • Journal Title: Exp Physiol Volume: 103 Issue: 11 Pages: 1543-1559
  • DOI: 10.1113/ep087221
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. (2018)
  • Author(s): Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
  • Journal Title: ERJ open research Volume: 4 Issue: 1 Pages: 00071-2017
  • DOI: 10.1183/23120541.00071-2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The first case of multiple pulmonary granulomas with amyloid deposition in a dental technician; a rare manifestation as an occupational lung disease (2018)
  • Author(s): Hirano Taizou、Numakura Tadahisa、Moriyama Hiroshi、Saito Ryoko、Shishikura Yutaka、Shiihara Jun、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: BMC Pulmonary Medicine Volume: 18 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s12890-018-0654-0
  • Peer Reviewed / Open Access
• [Journal Article] Possible involvement of intrerleukin-18 in the pathology of hepatobiliary adverse effects related to treatment with ceritinib (2018)
  • Author(s): Hirano T, Koarai A , Ichikawa T, Sato T, Ohe T, Ichinose M
  • Journal Title: BMC Cancer. Volume: 18 Issue: 1 Pages: 995-995
  • DOI: 10.1186/s12885-018-4913-5
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity. (2018)
  • Author(s): Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K
  • Journal Title: Int J COPD Volume: 13 Pages: 1407-1419
  • DOI: 10.2147/copd.s166023
  • Peer Reviewed / Open Access
• [Journal Article] Tiotropium/olodaterol versus tiotropium in Japanese patients with COPD: results from the DYNAGITO study (2018)
  • Author(s): Ichinose Masakazu、Nishimura Masaharu、Akimoto Manabu、Kurotori Yasuhiro、Zhao Yihua、de la Hoz Alberto、Mishima Michiaki
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 13 Pages: 2147-2156
  • DOI: 10.2147/copd.s169941
  • Peer Reviewed / Open Access
• [Journal Article] Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease (2018)
  • Author(s): Kamata Satoshi、Fujino Naoya、Yamada Mitsuhiro、Grime Ken、Suzuki Satoshi、Ota Chiharu、Tando Yukiko、Okada Yoshinori、Sakurada Akira、Noda Masafumi、Matsuda Yasushi、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: Pharmacology Research & Perspectives Volume: 6 Issue: 3
  • DOI: 10.1002/prp2.405
  • Peer Reviewed / Open Access
• [Journal Article] Possible involvement of acetylcholine-mediated inflammation in airway diseases. (2018)
  • Author(s): Koarai A, Ichinose M
  • Journal Title: Allergol Int. Volume: 67 Pages: 460-466
  • Peer Reviewed
• [Journal Article] Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. (2018)
  • Author(s): Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose.
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle. Volume: 9(4) Issue: 4 Pages: 643653-643653
  • DOI: 10.1002/jcsm.12297
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Splenic tuberculosis (2018)
  • Author(s): Tojo Yutaka、Yanagisawa Satoru、Miyauchi Eisaku、Ichinose Masakazu
  • Journal Title: Int J Infect Dis Volume: 67 Pages: 41-42
  • DOI: 10.1016/j.ijid.2017.12.009
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5 (2018)
  • Author(s): Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose
  • Journal Title: OncoImmunology. Volume: 8(2) Issue: 2 Pages: 1543526-1543526
  • DOI: 10.1080/2162402x.2018.1543526
  • Peer Reviewed / Open Access
• [Journal Article] Definition and diagnosis of asthma-COPD overlap (ACO) (2018)
  • Author(s): Yanagisawa Satoru、Ichinose Masakazu
  • Journal Title: Allergology International Volume: 67 Issue: 2 Pages: 172-178
  • DOI: 10.1016/j.alit.2018.01.002
  • NAID: 130006721711
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnea syndrome. (2018)
  • Author(s): Yamada E, Himori H, Kunikata H, Omodaka K, Ogawa H, Ichinose M, Nakazawa T
  • Journal Title: Acta Ophthalmologica Volume: 印刷中 Issue: 4
  • DOI: 10.1111/aos.13693
  • Peer Reviewed / Open Access
• [Journal Article] The cholinergic anti-inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities (2018)
  • Author(s): Yamada Mitsuhiro、Ichinose Masakazu
  • Journal Title: Current opinion in pharmacology Volume: 40 Pages: 18-25
  • DOI: 10.1016/j.coph.2017.12.003
  • Peer Reviewed / Open Access
• [Journal Article] Right-to-left pulmonary shunt through arteriovenous malformation (2018)
  • Author(s): Yanagisawa Satoru、Mitsune Ayumi、Ichinose Masakazu
  • Journal Title: Medicina Clinica Volume: 151 Issue: 7 Pages: 297-297
  • DOI: 10.1016/j.medcli.2017.11.035
  • Peer Reviewed
• [Journal Article] COPD uncovered: a cross-sectional study to assess the socioeconomic burden of COPD in Japan. (2018)
  • Author(s): Igarashi A, Fukuchi Y, Hirata K, Ichinose M, Nagai A, Nishimura M, Yoshisue H, Ohara K, Gruenberger JB
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 13 Pages: 2629-2641
  • DOI: 10.2147/copd.s167476
  • Peer Reviewed / Open Access
• [Journal Article] 慢性閉塞性肺疾患（COPD）の先制医療 (2018)
  • Author(s): 一ノ瀬 正和
  • Journal Title: 診断と治療 Volume: 106 Pages: 84-89
• [Journal Article] Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease. (2017)
  • Author(s): Bai C, Ichinose M, Lee SH, Lee KH, Jöns O, Bothner U, Zhao Y, Buhl R
  • Journal Title: International Journal of COPD Volume: 12 Pages: 3329-3339
  • DOI: 10.2147/copd.s137719
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis. (2017)
  • Author(s): Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.
  • Journal Title: The Journal of biological chemistry Volume: 292 Issue: 44 Pages: 18098-18112
  • DOI: 10.1074/jbc.m117.808535
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia. (2017)
  • Author(s): Hirano T, Yamada M, Sato K, Murakami K, Tamai T, Mitsuhashi Y, Tamada T, Sugiura H, Sato N, Saito R, Tominaga J, Watanabe A, Ichinose M.
  • Journal Title: BMC Pulm Med Volume: 17 Issue: 1 Pages: 76-76
  • DOI: 10.1186/s12890-017-0419-1
  • Peer Reviewed / Open Access
• [Journal Article] Chronic Cholestasis with Dilation of Intrahepatic Bile Duct Related to Administration of Ceritinib (2017)
  • Author(s): Hirano Taizou、Yamada Mitsuhiro、Ichinose Masakazu
  • Journal Title: J Thorac Oncol. Volume: 12 Issue: 8 Pages: e123-e125
  • DOI: 10.1016/j.jtho.2017.04.006
  • Peer Reviewed
• [Journal Article] Long-term safety and efficacy of combined tiotropium and olodaterol in Japanese patients with chronic obstructive pulmonary disease (2017)
  • Author(s): Ichinose Masakazu、Kato Motokazu、Takizawa Ayako、Sakamoto Wataru、 Gronke Lars、Tetzlaff Kay、Fukuchi Yoshinosuke
  • Journal Title: Respir Investig. Volume: 55 Issue: 2 Pages: 121-129
  • DOI: 10.1016/j.resinv.2016.09.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Study Design of VESUTO?: Efficacy of Tiotropium/Olodaterol on Lung Hyperinflation, Exercise Capacity, and Physical Activity in Japanese Patients with Chronic Obstructive Pulmonary Disease (2017)
  • Author(s): Ichinose Masakazu、Minakata Yoshiaki、Motegi Takashi、Ueki Jun、Seki Tetsuo、Anzai Tatsuhiko、Takizawa Ayako、Gronke Lars、Hirata Kazuto
  • Journal Title: Adv Ther. Volume: 34 Issue: 7 Pages: 1622-1635
  • DOI: 10.1007/s12325-017-0554-3
  • Peer Reviewed
• [Journal Article] ASTHMA PREVENTION AND MANAGEMENT GUIDELINE 2015 (2017)
  • Author(s): Ichinose M
  • Journal Title: Japanese Journal of Allergology Volume: 66 Issue: 2 Pages: 77-81
  • DOI: 10.15036/arerugi.66.77
  • NAID: 130005466717
  • ISSN: 0021-4884, 1347-7935
• [Journal Article] Prevalence and characteristics of asthma-COPD overlap syndrome identified by a stepwise approach. (2017)
  • Author(s): Inoue H, Nagase T, Morita S, Yoshida A, Jinnai T, Ichinose M
  • Journal Title: International Journal of COPD Volume: 12 Pages: 1803-1810
  • DOI: 10.2147/copd.s133859
  • Peer Reviewed
• [Journal Article] Successful Osimertinib Rechallenge in a Patient with T790M-Mutant Non?Small Cell Lung Cancer after Osimertinib-Induced Interstitial Lung Disease (2017)
  • Author(s): Miyauchi Eisaku、Ichinose Masakazu、Inoue Akira
  • Journal Title: J Thorac Oncol. Volume: 12 Issue: 5 Pages: e59-e61
  • DOI: 10.1016/j.jtho.2017.01.027
  • Peer Reviewed
• [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease (2017)
  • Author(s): Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
  • Journal Title: Thorax Volume: 72 Issue: 12 Pages: 1074-1083
  • DOI: 10.1136/thoraxjnl-2016-209359
  • Peer Reviewed / Open Access
• [Journal Article] Sequential GM-CSF Inhalation after Whole Lung Lavage for Pulmonary Alveolar Proteinosis: A Report of Five Intractable Cases. (2017)
  • Author(s): Ohkouchi S, Akasaka K, Ichiwata T, Hisata S, Iijima H, Takada T, Tsukada H, Nakayama H, Machiya JI, Irokawa T, Ogawa H, Shibata Y, Ichinose M, Ebina M, Nukiwa T, Kurosawa H, Nakata K, Tazawa R
  • Journal Title: Ann Am Thorac Soc. Volume: 72 Issue: 8 Pages: 1074-1083
  • DOI: 10.1513/annalsats.201611-892bc
  • Peer Reviewed
• [Journal Article] Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease. (2017)
  • Author(s): Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, Tanaka R, Numakura T, Togo S, Sato K, Kyogoku Y, Hashimoto Y, Okazaki T, Tamada T, Kobayashi S, Yanai M, Miura M, Hoshikawa Y, Okada Y, Suzuki S, Ichinose M.
  • Journal Title: Thorax Volume: 2017 Issue: 10 Pages: 893-904
  • DOI: 10.1136/thoraxjnl-2016-209352
  • Peer Reviewed / Open Access
• [Journal Article] Coexisting COPD in elderly asthma with fixed airflow limitation: assessment by DLco %predicted and HRCT. (2017)
  • Author(s): Tamada T, Sugiura H, Takahashi T, Matsunaga K, Kimura K, Katsumata U, Ohta K, Ichinose M.
  • Journal Title: J Asthma Volume: 印刷中 Issue: 6 Pages: 1-9
  • DOI: 10.1080/02770903.2016.1247168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer. (2017)
  • Author(s): Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
  • Journal Title: Cancer Sci Volume: 印刷中 Issue: 6 Pages: 1263-1270
  • DOI: 10.1111/cas.13233
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Indacaterol/glycopyrronium versus salmeterol/fluticasone in Asian patients with COPD at a high risk of exacerbations: results from the FLAME study (2017)
  • Author(s): Wedzicha JA, Zhong N, Ichinose M, Humphries M, Fogel R, Thach C, Patalano F, Banerji D
  • Journal Title: International Journal of COPD Volume: 19 Pages: 339-349
  • DOI: 10.2147/copd.s125058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Necrobiotic Pulmonary Nodules of Rheumatoid Arthritis (2017)
  • Author(s): Yanagisawa Satoru、Inoue Chihiro、Ichinose Masakazu
  • Journal Title: Am J Med Sci. Volume: 354 Issue: 3 Pages: 329-329
  • DOI: 10.1016/j.amjms.2017.02.007
  • Peer Reviewed
• [Journal Article] Numb Chin Syndrome: An Ominous Sign of Lung Cancer (2017)
  • Author(s): Yanagisawa Satoru、Miyauchi Eisaku、Ichinose Masakazu
  • Journal Title: J Thorac Oncol. Volume: 12 Issue: 8 Pages: e114-e116
  • DOI: 10.1016/j.jtho.2017.03.014
  • Peer Reviewed
• [Journal Article] 特集 喘息とCOPDのオーバーラップ症候群－病態と治療 ACOSの疾患概念 (2017)
  • Author(s): 玉田 勉、一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 37 Pages: 17-21
• [Journal Article] 酸化ストレスと喘息の重症化 (2017)
  • Author(s): 杉浦 久敏、一ノ瀬 正和
  • Journal Title: アレルギー Volume: 66 Pages: 931-935
  • NAID: 130005975420
• [Journal Article] 自然崩壊型腫瘍崩壊症候群を合併した肺扁平上皮癌の1例 (2017)
  • Author(s): 板倉康司、平野泰三、宮内栄作、井上 彰、杉浦久敏、一ノ瀬正和
  • Journal Title: 日本呼吸器学会雑誌 Volume: 6 Pages: 200-204
  • Peer Reviewed
• [Journal Article] 好酸球性肺炎の像を呈した肺接合菌症の1例 (2017)
  • Author(s): 平野泰三、山田充啓、村上康司、佐藤 慶、玉井ときわ、高橋秀徳、岡崎達馬、杉浦久敏、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 1006-1011
  • NAID: 130006733547
  • Peer Reviewed
• [Journal Article] Precision Medicineのための難治性喘息の病態と治療 Ⅱ難治に関する因子 4.喫煙、COPD合併 (2017)
  • Author(s): 柳澤 悟、一ノ瀬正和
  • Journal Title: アレルギー・免疫 Volume: 24 Pages: 66-72
• [Journal Article] Japanese guidelines for adult asthma 2017 (2017)
  • Author(s): Ichinose M, Sugiura H, Nagase H, Yamaguchi M, Inoue H, Sagara H, Tamaoki J, Tohda Y, Munakata M, Yamauchi K, Ohta K; Japanese Society of Allergology.
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 163-189
  • DOI: 10.1016/j.alit.2016.12.005
  • NAID: 130005628173
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sequential GM-CSF inhalation after whole lung lavage for pulmonary alveolar proteinosis: a report of five intractable cases. (2017)
  • Author(s): Ohkouchi S, Akasaka K, Ichiwata T, Hisata S, Iijima H, Takada T, Tsukada H, Nakayama H, Machiya J, Irokawa T, Ogawa H, Shibata Y, Ichinose M, Ebina M, Nukiwa T, Kurosawa H, Nakata K, Tazawa R.
  • Journal Title: Ann Am Thorac Soc. Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Successful osimertinib rechallenge in a patient with T790M mutant non-small cell lung cancer after osimertinib-induced interstitial lung disease. (2017)
  • Author(s): Miyauchi E, Inoue A, Ichinose M.
  • Journal Title: J Thorac Oncol. Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Phase II study of modified carboplatin plus weekly nab-paclitaxel in elderly patients with non-small cell lung cancer: North Japan Lung Cancer Study Group Trial 1301. (2017)
  • Author(s): Miyauchi E, Inoue A, Ichinose M.
  • Journal Title: Oncologist Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease. (2016)
  • Author(s): Abe. K., H. Sugiura, Y. Hashimoto, T. Ichikawa, A. Koarai, M. Yamada, T. Numakura, K. Onodera, R. Tanaka, K. Sato, S. Yanagisawa, T. Okazaki, T. Tamada, T. Kikuchi and M. Ichinose.
  • Journal Title: Respir Res Volume: 17 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s12931-016-0322-y
  • Peer Reviewed / Open Access
• [Journal Article] 27-hydroxycholesterol accelerates cellular senescence in human lung resident cells. (2016)
  • Author(s): Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, Ichikawa T, Kikuchi T, Numakura T, Onodera K, Tanaka R, Sato K, Yanagisawa S, Okazaki T, Tamada T, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 310 Issue: 11 Pages: L1028-L1041
  • DOI: 10.1152/ajplung.00351.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. (2016)
  • Author(s): Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M.
  • Journal Title: Respir Res Volume: 17 Issue: 1 Pages: 110-110
  • DOI: 10.1186/s12931-016-0427-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium. (2016)
  • Author(s): Shishikura Y, Koarai A, Aizawa H, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguti T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Respir Res Volume: 17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of pseudo-achalasia with lung cancer: Case report and short literature review. (2016)
  • Author(s): Hirano T, Miyauchi E, Inoue A, Igusa R, Chiba S, Sakamoto K, Sugiura H, Kikuchi T, Ichinose M.
  • Journal Title: Respir Invest Volume: 54 Issue: 6 Pages: 494-499
  • DOI: 10.1016/j.resinv.2016.04.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevention of COPD exacerbation by lysozyme: a double-blind, randomized, placebo-controlled study. (2016)
  • Author(s): Fukuchi Y, Tatsumi K, Inoue H, Sakata Y, Shibata K, Miyagishi H, Marukawa Y, Ichinose M
  • Journal Title: Int J of COPD Volume: 11 Pages: 831-838
  • DOI: 10.2147/copd.s103105
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Continuing to confront COPD international patient survey: Ecomic impact of COPD in 12 countries. (2016)
  • Author(s): Foo J, Landis SH, Maskell J, Oh YM, van der Molen T, Han MK, Mannino DM, Ichinose M, Punekar Y.
  • Journal Title: PLoS One Volume: 11 Issue: 4 Pages: e0152618-e0152618
  • DOI: 10.1371/journal.pone.0152618
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of the need for nitric oxide measurement in patients with respiratory diseases. (2016)
  • Author(s): Ichinose M
  • Journal Title: Resp Investig Volume: 54 Issue: 3 Pages: 137-138
  • DOI: 10.1016/j.resinv.2016.03.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. (2016)
  • Author(s): Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M.
  • Journal Title: EMBO Mol Med. Volume: 8 Issue: 4 Pages: 422-436
  • DOI: 10.15252/emmm.201506154
  • NAID: 120006845618
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Health behaviors and their correlates among participants in the Continuing to Confront COPD International Patient Survey. (2016)
  • Author(s): Mullerova H, HLandis S, Aisanov Z, Davis KJ, Ichinose M, Mannino DM, Maskell J, Menezes AM, van der Molen T, Oh Y-M, Tabberer M.
  • Journal Title: Int J of COPD Volume: 11 Pages: 881-890
  • DOI: 10.2147/copd.s102280
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy. (2016)
  • Author(s): Numakura T, Tamada T, Nara M, Muramatsu S, Murakami K, Kikuchi T, Kobayashi M, Muroi M, Okazaki T, Takagi S, Eishi Y, Ichinose M.
  • Journal Title: BMC Pulm Med. Volume: 16 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s12890-016-0193-5
  • Peer Reviewed / Open Access
• [Journal Article] Walking Pattern in COPD Patients. (2016)
  • Author(s): Sakamoto Y, Sakamoto K, Minakata Y, Shiba S, Takeshi Nakamura T, Ichinose M, Tajima F.
  • Journal Title: Rehabili Nurs Volume: 41 Issue: 4 Pages: 211-217
  • DOI: 10.1002/rnj.209
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Improving Physical Activity Ensures the Long-Term Survival of Pneumonia Patients in a Super-Aged Society: A Retrospective Study in an Acute-Care Hospital in Japan (2016)
  • Author(s): Sato K, Okada S, Sugawara A, Tode N, Watanuki Z, Suzuki K, Ichinose M.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 238 Issue: 3 Pages: 237-245
  • DOI: 10.1620/tjem.238.237
  • NAID: 130005137589
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inflammatory responses in the initiation of lung repair and regeneration: their role in stimulating lung resident stem cells. (2016)
  • Author(s): Yamada M, Fujino N, Ichinose M
  • Journal Title: Inflammation and Regeneration Volume: 36
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 喘息予防・管理ガイドライン2015のポイント (2016)
  • Author(s): 一ノ瀬正和
  • Journal Title: 日本薬剤師会雑誌 Volume: 68 Pages: 13-27
• [Journal Article] 喘息とＣＯＰＤのオーバーラップの診断と治療の重要性 (2016)
  • Author(s): 一ノ瀬正和
  • Journal Title: 新薬と臨床 Volume: 65 Pages: 27-31
• [Journal Article] 喘息予防・管理ガイドライン2015－GINA2015との比較 (2016)
  • Author(s): 一ノ瀬正和
  • Journal Title: 日本臨床 Volume: 74 Pages: 1609-1614
• [Journal Article] 発熱、多関節痛を伴った急性サルコイドーシスの1例 (2016)
  • Author(s): 小野寺克洋、玉田 勉、村松聡士、村上康司、奈良正之、小松理世、小林 誠、山田充啓、杉浦久敏、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 540-546
  • NAID: 130005439474
• [Journal Article] ARDSを合併したChlamydophilia pneumoniae 感染症の1例 (2016)
  • Author(s): 突田容子、山田充啓、大江 崇、伊藤俊輔、小林 誠、玉井ときわ、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 2426-2431
• [Journal Article] バイオマーカーによるCOPD治療の展開 (2016)
  • Author(s): 小荒井晃, 一ノ瀬正和
  • Journal Title: The LUNG perspectives Volume: 24 Pages: 26-30
• [Presentation] 重症喘息の病態と治療 (2019)
  • Author(s): 一ノ瀬 正和
  • Organizer: 第1回日本アレルギー学会中国・四国支部地方会ランチョンセミナー1、広島、平成31年2月2日
  • Invited
• [Presentation] 胆管癌治療中に発症した慢性好酸球性肺炎の一例 (2019)
  • Author(s): 京極自彦、藤野直也、村松聡士、千葉茂樹、山田充啓、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第1回日本アレルギー学会東北地方会
• [Presentation] 好酸球増多を伴う重症喘息に対してmepolizumabが奏効した一例 (2019)
  • Author(s): 大江 崇、奥友洸二、山田充啓、東出直樹、村上康司、藤野直也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第1回日本アレルギー学会東北地方会
• [Presentation] 喘息とCOPDのオーバーラップ（ACO）における活性イオウ分子種と活性イオウ分子種産生酵素に関する検討 (2019)
  • Author(s): 京極自彦、杉浦久敏、市川朋宏、沼倉忠久、小荒井晃、山田充啓、藤野直也、田中里江、佐野寛仁、山中 駿、一ノ瀬正和
  • Organizer: 第108回日本呼吸器学会東北地方会
• [Presentation] 再発性多発軟骨炎に血管炎症症候群を合併した1例 (2019)
  • Author(s): 伊藤辰徳、三橋善哉、村上康司、佐藤輝幸、宍倉 裕、一ノ瀬正和
  • Organizer: 第108回日本呼吸器学会東北地方会
• [Presentation] Pathogenesis of COPD. (2018)
  • Author(s): Ichinose M
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research / Invited
• [Presentation] Efficacy of Tiotropium/Olodaterol on Lung Hyperinflation,Exercise Capacity, and Physical Activity in Japanese Patients with Chronic Obstructive Pulmonary Disease (VESUTO Study):A Randomized Crossover Trial. (2018)
  • Author(s): Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Production of Reactive Persulfide Species and Their Effects in the Lungs of Patients with COPD. (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Yanagisawa S, Koarai A, Ichinose M.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Oxidative Stress Enhances the Expression of IL-33 in Airway Epithelial Cells During Virus Infection. (2018)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Enhanced Nitrosative Stress in the Airways of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap. (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Ito S, Akaike T, Ichinose M.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Circulating ACE+ EMPs are a potential marker for evaluating pulmonary endothelial injury during ARDS (2018)
  • Author(s): Takei Y, Yamada M, Saito K, Kameyama Y, Sugiura H, Makiguchi T, Fujino N, Toyama H, Saito K, Ejima Y, Kawazoe Y, Kudo D, Kushimoto S, Yamauchi M, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Impact of eosinophil levels on lung function and exacerbation benefits with co-supension delivery technology budesonide/glycopyrronium/formoterol metered dose inhaler(BGF MDI) in COPD(KRONOS study subgroup analysis) (2018)
  • Author(s): Fabbri LM, Rabe KF, Martinez FJ, Ferguson GT, Wang C, Ichinose M, Bourne E, BallalS, Darken P, DeAngelis K, Aurivillius M, Dorinsky P, Reisner C.
  • Organizer: The 28th ERS International Congress
  • Int'l Joint Research
• [Presentation] 24-week study of triple fixed-dose combination budesonide/glycopyrronium/formoterol (BGF) MDI via co-suspension delivery technology vs glycopyrroniumu/formoterol(GFF)MDI,budesonide/formoterol(BFF)MDI and BFF inhalation powder in COPD (2018)
  • Author(s): Ferguson GT,Rabe KF,Martinez FJ,Fabbi LM,Wang C,Ichinose M,Bourne E,Ballal S,DeAngelis K,Aurivillius M,Dorinsky P.KRONOS
  • Organizer: The 28th ERS International Congress
  • Int'l Joint Research
• [Presentation] Production of reactive persulfide species in lungs of patients with COPD and their effects on lung resident cells (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Fujino N, Koarai A, Ichinose M
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] Production of reactive nitrogen species in asthma-chronic obstructive pulmonary disease overlap (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Akaike T,
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] COPDガイドラインの改訂と今後の行方 治療 (2018)
  • Author(s): 一ノ瀬 正和
  • Organizer: 第58回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 呼気一酸化窒素（NO）濃度の測定 update：NO測定ハンドブックを踏まえて． (2018)
  • Author(s): 一ノ瀬 正和
  • Organizer: 第58回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 重症喘息管理の現状と展望 (2018)
  • Author(s): 一ノ瀬 正和
  • Organizer: 第107回日本呼吸器学会東北地方会/第137回日本結核病学会東北支部会
  • Invited
• [Presentation] 新しいガイドラインに基づく気管支喘息の治療 (2018)
  • Author(s): 一ノ瀬 正和
  • Organizer: 日本内科学会第59回生涯教育講演会教育講演
  • Invited
• [Presentation] ヒト気道上皮細胞のIL-33発現に対する酸化ストレスの影響の検討 (2018)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、柳澤 悟、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、市川朋宏、藤野直也、一ノ瀬正和
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] ニトロ化ストレス、活性硫黄種に着目したCOPD合併喘息（ACO）の病態解明に関する検討 (2018)
  • Author(s): 京極自彦、杉浦久敏、沼倉忠久、市川朋宏、田中里江、小荒井晃、山田充啓、藤野直也、一ノ瀬正和
  • Organizer: 第67回日本アレルギー学会学術大会
• [Presentation] TLR7刺激による Sarco/Endoplasimic Reticulm Caicium ATPase（SERCA）作用更新についての検討 (2018)
  • Author(s): 蒲生俊一、玉田 勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演
• [Presentation] リンパ管を標的とした新規胸膜炎治療の検討 (2018)
  • Author(s): 小林 誠、岡崎達馬、突田容子、小松理世、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演
• [Presentation] 東北メディカルメガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析（中間報告） (2018)
  • Author(s): 山田充啓、杉浦久敏、布施昇男、寳澤 篤、高井貴子、土屋奈歩、光根 歩、栗山進一、山本雅之、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演
• [Presentation] EGFR変異遺伝子陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する (2018)
  • Author(s): 突田容子、藤野直也、宮内栄作、井上 彰、板倉康司、山田充啓、岡崎達馬、桜田 晃、杉浦久敏、岡田克典、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演
• [Presentation] COPDに対する気管支拡張薬が気道被覆液の質的特性に及ぼす影響の検討 (2018)
  • Author(s): 有竹秀美、玉田 勉、村上康司、蒲生俊一、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演
• [Presentation] Scedosporium apiospermumによるステント感染により喘息様の病態を呈した一例 (2018)
  • Author(s): 大江 崇、市川朋宏、平野泰三、佐藤輝幸、齋藤良太、佐々木優作、板倉康司、田中里江、奥友洸二、安藤正勝、小荒井晃、一ノ瀬正和
  • Organizer: 第41回日本呼吸器内視鏡学会学術集会
• [Presentation] 気道症状を初発症状とし、亜急性の経過を辿った再発性多発軟骨炎の一例 (2018)
  • Author(s): 齋藤良太、市川朋宏、大江 崇、平野泰三、佐藤輝幸、佐々木優作、奥友洸二、安藤正勝、板倉康司、田中里江、小荒井晃、一ノ瀬正和
  • Organizer: 第41回日本呼吸器内視鏡学会学術集会
• [Presentation] スケドスポリウム属によるステント腐生により喘息様症状を呈した1例 (2018)
  • Author(s): 大江 崇、小荒井晃、平野泰三、佐藤輝幸、市川朋宏、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第214回日本内科学会東北地方会
• [Presentation] Stevens-Johnson症候群による閉塞性肺気管支炎が疑われ、気管支鏡検査で水泡状の気道粘膜病変を認めた一例 (2018)
  • Author(s): 成田大輔、山田充啓、佐藤輝幸、市川朋宏、小林 誠、千葉茂樹、滝田克也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第107回日本呼吸器学会東北地方会/第137回日本結核病学会東北地方会
• [Presentation] 当科における重症喘息患者に対する抗IL-5抗体治療の現状 (2018)
  • Author(s): 奥友洸二、山田充啓、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第215回日本内科学会東北地方会
• [Presentation] The establishment and optimization of customized circulating tumor DNA cancer screening panel (2018)
  • Author(s): Siew-Kee Low, Shibayama T, Nagayama S, Miyauchi E , Kiyotani K, Kobayashi T, Ohno S, Ueno T, Ichinose M, Ueno M, Takahashi S, Nakamura Y
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] EGFR遺伝子変異陽性肺癌におけるT細胞受容体レパトア解析 (2018)
  • Author(s): 宮内栄作、松田達雄、Yu-wen Hsu、突田容子、一ノ瀬正和、桜田 晃、岡田克典、齊藤涼子、清谷一馬、中村祐輔
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] EGFR遺伝子変異陽性肺癌においてAXLキナーゼは免疫抑制分子を促進する (2018)
  • Author(s): 突田容子、宮内栄作、齊藤涼子、岡崎達馬、井上 彰、岡田克典、一ノ瀬正和
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Gaシンチグラフィーでnegative heart sign を認めた急性発症肺サルコイドーシスの1例 (2018)
  • Author(s): 鈴木 歩、平野泰三、玉田 勉、田中里江、藤野直也、齋藤良太、村上康司、杉浦久敏、一ノ瀬正和
  • Organizer: 第216回日本内科学会東北地方会
• [Presentation] 進行性の気管支の肥厚及び狭窄を認めた1例 (2018)
  • Author(s): 大江 崇、市川朋宏、冨永慶太、平野泰三、佐藤輝幸、小荒井晃、杉浦久敏、一ノ瀬正和
  • Organizer: 第213回日本内科学会東北地方会
• [Presentation] Pembrolizumab投与後に発症した難治性薬剤性腸炎の一例 (2018)
  • Author(s): 佐々木優作、山田充啓、藤野直也、小林 誠、東條 裕、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第106回日本呼吸器学会東北地方会/第136回日本結核病学会東北支部学会/第12回日本サルコイドーシス/肉芽腫性疾患学会東北支部会
• [Presentation] Decreased Levels of Plasma Growth Differentiation Factor 11 Are Associated with Physical Activity, Exercise Capacity and Systemic Inflammation in COPD (2017)
  • Author(s): Tanaka R, Sugiura H, Yamada M, Onodera K, Numakura T, Miura M, Takahashi T, Ichinose M
  • Organizer: 2017ATS International Conference
  • Int'l Joint Research
• [Presentation] Gene Expression Profiles in Isolated Lung Endothelial Cells in Chronic Obstructive Pulmonary Disease (2017)
  • Author(s): Tojo Y, Yamada M, Fujino N, Chiba S, Shibuya R, Koarai A, Sugiura H, Ogawa H, Ichinose M
  • Organizer: 2017ATS International Conference
  • Int'l Joint Research
• [Presentation] Upregulation of Ca2+-ATPase by TLR7 decreases electrolyte secretion from airway submucosal gland cells. (2017)
  • Author(s): Gamo S, Tamada T, Muramatsu S, Murakami K, Nara M, Sugiura H, Ichinose M
  • Organizer: 2017ATS International Conference
  • Int'l Joint Research
• [Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection. (2017)
  • Author(s): .Aizawa H, Koarai A, Shishikura Y, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguchi T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M
  • Organizer: 2017ATS International Conference
  • Int'l Joint Research
• [Presentation] ACE陽性EMPに着目した新規ARDSバイオマーカーの開発 (2017)
  • Author(s): 武井佑介、山田充啓、藤野直也、斎藤浩二、山内正憲、杉浦久敏、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会ミニシンポジウム
• [Presentation] COPD患者由来肺血管内皮細胞の単離と網羅的遺伝子発現解析． (2017)
  • Author(s): 東條 裕、山田充啓、藤野直也、千葉茂樹、渋谷里沙、杉浦久敏、小川浩正、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会ミニシンポジウム
• [Presentation] COPD患者の身体活動性、運動耐容能および全身性炎症におけるgrowth differentiation factor11(GDF11)の役割 (2017)
  • Author(s): 田中里江、杉浦久敏、山田充啓、小野寺克洋、三浦元彦、高橋識至、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会ミニシンポジウム
• [Presentation] COPD合併喘息（ACO）におけるニトロ化ストレスに関する検討 (2017)
  • Author(s): 京極自彦、杉浦久敏、沼倉忠久、伊藤俊輔、田中里江、小野寺克洋、小荒井晃、山田充啓、一ノ瀬正和
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 睡眠ポリグラフ検査と呼吸機能の関連性の検討 (2017)
  • Author(s): 東條 裕、室井美穂、小川浩正、一ノ瀬正和
  • Organizer: 第114回日本内科学会講演会
• [Presentation] COPDにおける老化抑制因子Growth differentiation factor11(GDF11)の関与に関する研究 (2017)
  • Author(s): 小野寺克洋、杉浦久敏、山田充啓、田中里江、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 誤嚥性肺炎はマイオカインを誘導し筋肉を委縮させる (2017)
  • Author(s): 小松理世、岡崎達馬、突田容子、小林 誠、二瓶真由美、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 客観的指標を用いたCOPD合併喘息の検討 (2017)
  • Author(s): 玉田 勉、杉浦久敏、高橋識至、松永和人、勝又宇一郎、木村啓二、大田 健、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] COPD患者における活性イオウ分子種（reactive sulfur species:RSS）の産生に関する検討 (2017)
  • Author(s): 沼倉忠久、杉浦久敏、赤池孝章、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ライノウイルス感染による粘液産生誘導に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] Efficacy of Three Doses of Co-SuspensionTM Delivery Technology Glycopyrronium(GP)MDI in Japanese Versus Western Patients with Moderate-to-Sever COPD (2017)
  • Author(s): Rabe KF, Hironori S, Fukushima Y, Nakatani Y, Ide Y, Sekino H, Ichinose M, Maes A, Darken P, Martin U, Orevillo C, Reisne C
  • Organizer: 第57回日本呼吸器学会学術講演会English Poster Discussion
• [Presentation] Axl Receptor Tyrosine Kinase Regulates Dying Cell-Triggered Proliferation of Airway Basal Cells and Is Involved Epithelial Remodeling of COPD. (2017)
  • Author(s): Fujino N, Fujimori T, Grabiec AM, Maciewicz RA, Onodera K, Numakura T, Yamada M, Sugiura H, Hussell T, Ichinose M
  • Organizer: 第57回日本呼吸器学会学術講演会English Poster Discussion
• [Presentation] TLR7リガンドによる気道分泌制御作用の細胞内機序について (2017)
  • Author(s): 蒲生俊一、玉田 勉、村松聡士、村上康司、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 新しい呼気陰圧不可機器の開発：閉塞性換気障害指標の検証 (2017)
  • Author(s): 小川浩正、黒澤 一、色川俊也、大河内眞也、田畑雅央、荒川梨津子、三浦絵美里、新國悦弘、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] サルコイドーシス診断に有用な因子の検討 (2017)
  • Author(s): 光根 歩、佐藤輝幸、柳澤 悟、突田容子、東條 裕、小野 学、宮内栄作、一ノ瀬正和
  • Organizer: 第40回日本呼吸器内視鏡学会学術集会
• [Presentation] ライノウイルス感染によるムチン産生に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] デノスマブによる顎骨壊死との鑑別を要したNumb Chin syndromeの1例 (2017)
  • Author(s): 宮内栄作、柳澤 悟、光根 歩、小野 学、東條 裕、一ノ瀬正和
  • Organizer: 第211回日本内科学会東北地方会
• [Presentation] セリチニブ投与に関連した肝内胆管拡張に伴う遷延性薬剤性胆汁うっ滞を発症した肺癌の1例 (2017)
  • Author(s): 山田充啓、平野泰三、佐野寛仁、村上康司、岡崎達馬、玉田 勉、杉浦久敏、藤井博司、一ノ瀬正和
  • Organizer: 第212回日本内科学会東北地方会
• [Presentation] 可逆性の肺高血圧症を呈した強皮症によるShrinking lung syndromeの一例 (2017)
  • Author(s): 山中 駿、東條 裕、佐々木優作、千葉茂樹、宮内栄作、玉井ときわ、玉田 勉、杉浦久敏、小川浩正、一ノ瀬正和
  • Organizer: 第105回日本呼吸器学会東北地方会、第135回日本結核病学会東北地方会
• [Presentation] Sunitinib improves tumor microenvironment and augments the T cell infiltration and effects of immunotherapy by DR-5. (2017)
  • Author(s): Tsukita Y, Okazaki T, Sato Y, Yagita H, Ichinose M
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 特徴的な腎病変と眼病変を有し、TINU症候群との鑑別が問題となった兄弟発症サルコイドーシスの１例 (2017)
  • Author(s): 有竹秀美、村上康司、玉田 勉、蒲生俊一、村松聡士、奈良正之、一ノ瀬正和
  • Organizer: 第37回日本サルコイドーシス/肉芽腫性疾患学会総会
• [Presentation] メタボロミクス解析を用いたサルコイドーシスの活動性予測バイオマーカーの探索 (2017)
  • Author(s): 蒲生俊一、玉田 勉、村上康司、三枝大輔、元池育子、有竹秀美、奈良正之、村松聡士、杉浦久敏、一ノ瀬正和
  • Organizer: 第37回日本サルコイドーシス/肉芽腫性疾患学会総会
• [Presentation] 当科サルコイドーシス患者の肺病変に対する外来全身ステロイド療法の実際 (2017)
  • Author(s): 村上康司、玉田 勉、奈良正之、村松聡士、蒲生俊一、有竹秀美、杉浦久敏、一ノ瀬正和
  • Organizer: 第37回日本サルコイドーシス/肉芽腫性疾患学会総会
• [Presentation] Study design of vesuto;sutudy to evaluate the efficacy of tiotropium+olodaterol vs tiotropium on lung hyperinflation, exercise capacity, and physical activity in Japanese COPD patients. (2016)
  • Author(s): Ichinose M, Minakata Y, Motegi T, Ueki J, Seki T, Anzai T, Takizawa A, Gronle L, Hirata K.
  • Organizer: APSR2016
  • Place of Presentation: Bangkok,Thai
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] COPD:病態理解から新規治療法開発へ (2016)
  • Author(s): 一ノ瀬正和
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 京都(国立京都国際会館）
  • Invited
• [Presentation] COPD治療 Update (2016)
  • Author(s): 一ノ瀬正和
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 京都（国立京都国際会館）
  • Invited
• [Presentation] COPD軽症～中等度にLAMA/LABAの使用は？ Conの立場から (2016)
  • Author(s): 一ノ瀬正和
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 京都（国立京都国際会館）
  • Invited
• [Presentation] 喘息とCOPDのoverlap症候群(ACOS: asthma-COPD overlap syndrome) (2016)
  • Author(s): 一ノ瀬正和
  • Organizer: 第113回日本内科学会学術講演会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Invited
• [Presentation] 酸化ストレスと喘息の重症化 (2016)
  • Author(s): 一ノ瀬正和
  • Organizer: 第65回日本アレルギー学会学術大会
  • Place of Presentation: 東京（東京国際フォーラム）
  • Invited
• [Book] Handb Exp Pharmacol (2017)
  • Author(s): Tamada T, Ichinose M
  • Total Pages: 13
  • Publisher: springer
• [Book] 内科外来診断navi (2017)
  • Author(s): 平野泰三、一ノ瀬正和
  • Total Pages: 2
  • Publisher: 中外医学社
• [Book] Pharmacology and Therapeutics of Asthma and COPD (2017)
  • Author(s): Tamada T, Ichinose M
  • Total Pages: 280
  • Publisher: Springer International Publishing