Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Outline of Final Research Achievements |
Double transgenic mice overexpressing soluble (pro)renin receptor and prorenin have been developed mating mice overexpressing soluble (pro)renin receptor and prorenin-overexpressing mice. In the mice, nephropathy is developed and progressed independently their blood pressure. Since soluble (pro)renin receptor is the N-terminal fragment of (pro)renin receptor and releases into the tissue and blood, where the soluble (pro)renin receptor binds prorenin to contribute with the development of nephropathy as a paracrine system. In the near future, new therapy targeting soluble (pro)renin receptor will be developed to inhibit the pathogenesis of chronic kidney diseases.
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