| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
On the study of mutant rats established by ENU mutagenesis, we found a lineage of diseased rats with developmental and epileptic encephalopathy-like epilepsy. Epileptic seizures occurred during a limited period of 4 to 6 weeks of age. The brain lesions were recovered spontaneously. The causative gene found in the rats is a missense mutation of a gene that regulates oxidative stress by redox reaction. Our results suggested that there may be a critical period when the oxidative stress becomes particularly high in the local region of the brain during the developmental process of the brain. Mutant rats may have reduced ability to properly suppress the oxidative stress due to its low function of antioxidant activity, resulting in damage of the brain.
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