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The present status of viral gastroenteritis in Japan and the vaccine development

Research Project

Project/Area Number 16H05360
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNihon University

Principal Investigator

USHIJIMA Hiroshi  日本大学, 医学部, 上席研究員 (10091068)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords胃腸炎ウイルス / 分子疫学 / 抗原抗体反応 / ワクチン評価 / ワクチン開発 / ウイルス / 胃腸炎 / ワクチンの有効性 / ワクチンの開発 / イムノクロマト法 / 環境 / ウイルス血症 / ワクチン / 下痢症ウイルス / 迅速診断 / 遺伝子解析 / 診断 / ワクチン有効性
Outline of Final Research Achievements

For 4 years, we examined the epidemic and mutative types of 17 diarrheal viruses by multiplex RT-PCR in about 1600 diarrhea in children and environmental water in Japan. Outbreaks of G8 and G9 genotypes not included in the rotavirus (RV) vaccine were observed. Norovirus (NoV) recognized GII.4_Sydney, followed by GII.2 and GII.6. Rare viruses were also detected.
The RV vaccine prevented severe infection but did not prevent infection, and RV infection surpassed NoV infection in 2018/2019. The efficacy was verified by immunochromatography together with RT-PCR. Antigenemia and uremia were commonly observed in non-vaccinated persons due to RV infection. Simultaneous subcutaneous inoculation of RV and NoV was attempted in mice. The high antibody titer persisted with the second inoculation.

Academic Significance and Societal Importance of the Research Achievements

途上国でウイルス性胃腸炎は小児死亡の大きな原因である。先進国では、死亡は少ないが集団感染が多発している。近年、遺伝子や抗原・抗体検出診断がなされる。現在、直接ウイルスに有効な治療法はない。一方、ロタウイルス胃腸炎に対しワクチンがある。どのような胃腸炎ウイルスの流行があるかは公衆衛生学的に重要である。わが国のロタウイルスワクチンの有効性を検証することは2020年10月からの定期接種化の重要な情報となる。胃腸炎ウイルスを網羅的に調べることは不顕性感染、非病原性のウイルスの存在を見ることになる。ロタウイルスとノロウイルス(中空粒子)の同時皮下接種は下痢症ウイルスの次世代ワクチンの候補ともなりうる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (117 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (10 results) Journal Article (46 results) (of which Int'l Joint Research: 42 results,  Peer Reviewed: 45 results,  Open Access: 8 results,  Acknowledgement Compliant: 10 results) Presentation (51 results) (of which Int'l Joint Research: 20 results,  Invited: 1 results) Book (5 results) Remarks (5 results)

  • [Int'l Joint Research] Chiang Mai University/Mahidol University(タイ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] HCM Univ of Medicine and Pharmacy(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Univ of Dakka/Jahangirnagar University(バングラデシュ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Univ of Pittsburg(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Chiang Mai University/Mahidol University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] HCM Univ of Medicine and Pharmacy(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Univ of Dakka/Jahangirnagar University(バングラデシュ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Chiang Mai University(Thailand)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] HCM Univ of Medicine and Pharmacy(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Dakka/Jahangirnagar University(Bangladesh)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Comparative evaluation of sensitivity and specificity of immunochromatography kit for the rapid detection of norovirus and rotavirus in Bangladesh.2020

    • Author(s)
      Shaha M , Sifat SF , Mamun MA, Billah MB, Sharif N, Nobel NU , Talukder AA, Nomura A , Ushijima H, Dey SK
    • Journal Title

      F1000Research

      Volume: 8 Pages: 183-183

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genteic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010-20182020

    • Author(s)
      Kumthip K, Khamrin P, Ushijima H, Chen L, Li S, Maneekarn N
    • Journal Title

      Peer J

      Volume: 8 Pages: e8520-e8520

    • DOI

      10.7717/peerj.8520

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reverse Genetics System for a Human Group A Rotavirus.2020

    • Author(s)
      Kawagishi T, Nurdin J, Onishi M, Nouda R, Kanai Y, Tajima T, Ushijima H, Kobayashi T
    • Journal Title

      J Virol

      Volume: 94 Issue: 2

    • DOI

      10.1128/jvi.00963-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of Immunochromatographic Tests for Detection of a Wide Variety of Group A Rotavirus Genotypes and Adenovirus2019

    • Author(s)
      Khamrin Pattara、Kumthip Kattareeya、Thongprachum Aksara、Okitsu Shoko、Maneekarn Niwat、Hayakawa Satoshi、Ushijima Hiroshi
    • Journal Title

      Clinical Laboratory

      Volume: 65 Issue: 12/2019 Pages: 2289-2293

    • DOI

      10.7754/clin.lab.2019.190415

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diagnosis of Acute Gastroenteritis with Immunochromatography and Effectiveness of Rotavirus Vaccine in a Japanese Clinic.2019

    • Author(s)
      Kawata K, Hikita T, Takanashi S, Hikita H, Ogita K, Okitsu S, Hoque SA, Phan T G, Ushijima H.
    • Journal Title

      Access Microbiol.

      Volume: acmi.0.000085. Issue: 3

    • DOI

      10.1099/acmi.0.000085

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular detection of enteric viruses in the stool samples of children without diarrhea in Bangladesh.2019

    • Author(s)
      Okitsu S, Khamrin P, Takanashi S, Thongprachum A, Hoque SA, Takeuchi H, Khan MA, Hasan SMT, Iwata T, Shimizu H, Jimba M, Hayakawa S, Maneekarn N, Ushijima H.
    • Journal Title

      Infect Genet Evol

      Volume: 77 Pages: 104055-104055

    • DOI

      10.1016/j.meegid.2019.104055

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diversity of human parechovirus in infants and children with acute gastroenteritis in Japan during 2014?20162019

    • Author(s)
      Pham Ngan Thi Kim、Thongprachum Aksara、Shimizu Yuko、Trinh Quang Duy、Okitsu Shoko、Komine-Aizawa Shihoko、Shimizu Hiroyuki、Hayakawa Satoshi、Ushijima Hiroshi
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 75 Pages: 104001-104001

    • DOI

      10.1016/j.meegid.2019.104001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of mutations in the VP7 gene of vaccine-derived strains shed by monovalent rotavirus vaccine recipients.2019

    • Author(s)
      Kaneko M, Takanashi S, Inoue M, Sakiyama H, Okitsu S, Mizuguchi M, Ushijima H
    • Journal Title

      Access Microbiology

      Volume: acmi.0.000033 Issue: 8

    • DOI

      10.1099/acmi.0.000033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determining effectiveness of rotavirus vaccine by immunochromatography and reverse transcriptase polymerase chain reaction: A comparison.2019

    • Author(s)
      Hoque SA, Iizuka I, Kobayashi M, Takanashi S, Anwar KS, Islam MT, Hoque SA, Khamrin P, Okitsu S, Hayakawa S, Ushijima H.
    • Journal Title

      Vaccine

      Volume: 39 Issue: 39 Pages: 5886-5890

    • DOI

      10.1016/j.vaccine.2019.07.091

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enteric and non-enteric adenoviruses associated with acute gastroenteritis in pediatric patients in Thailand, 2011 to 20172019

    • Author(s)
      Kumthip K, Khamrin P, Ushijima H, Maneekarn N
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 8 Pages: e0220263-e0220263

    • DOI

      10.1371/journal.pone.0220263

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular epidemiology and genetic diversity of human parechoviruses in children hospitalized with acute diarrhea in Thailand during 2011-20162019

    • Author(s)
      Malasao Rungnapa、Khamrin Pattara、Kumthip Kattareeya、Ushijima Hiroshi、Maneekarn Niwat
    • Journal Title

      Archives of Virology

      Volume: 164 Issue: 7 Pages: 1743-1752

    • DOI

      10.1007/s00705-019-04249-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Occurrence of noroviruses in recycled water and sewage sludge: emergence of recombinant norovirus strains.2019

    • Author(s)
      Kittigul L, Rupprom K, Che-Arsae M1, Pombubpa K, Thongprachum A, Hayakawa S, Ushijima H
    • Journal Title

      J Appl Microbiol

      Volume: 126 Issue: 4 Pages: 1290-1301

    • DOI

      10.1111/jam.14201

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alarming Situation of Spreading Enteric Viruses Through Sewage Water in Dhaka City: Molecular Epidemiological Evidences.2019

    • Author(s)
      Ariful Hoque SA, Thongprachum A, Takanashi S, Mostafa SM, Saito H, Anwar KS, Nomura A, Hoque A, Begum R, Sultana UN, Hossain T, Khamrin P, Okitsu S, Hayakawa S, Ushijima H
    • Journal Title

      Food Environ Virol

      Volume: 11 Issue: 1 Pages: 65-75

    • DOI

      10.1007/s12560-018-09363-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Distribution of norovirus and sapovirus genotypes with emergence of NoV GII.P16/GII.2 recombinant strains in Chiang Mai, Thailand2019

    • Author(s)
      Supadej K, Khamrin P, Kumthip K, Malasao R, Chaimongkol N, Saito M, Oshitani H, Ushijima H, Maneekarn N
    • Journal Title

      J Med Virol

      Volume: 91 Issue: 2 Pages: 215-224

    • DOI

      10.1002/jmv.25261

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular epidemiology and characterization of porcine adenoviruses in pigs with diarrhea in Thailand2019

    • Author(s)
      Kumthip K, Khamrin P, Kongkaew A, Vachirachewin R, Malasao R, Ushijima H, Maneekarn N.
    • Journal Title

      Infect Genet Evol

      Volume: 67 Pages: 73-77

    • DOI

      10.1016/j.meegid.2018.10.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of nineteen enteric viruses in raw sewage in Japan2018

    • Author(s)
      Thongprachum Aksara、Fujimoto Tsuguto、Takanashi Sayaka、Saito Hiroyuki、Okitsu Shoko、Shimizu Hiroyuki、Khamrin Pattara、Maneekarn Niwat、Hayakawa Satoshi、Ushijima Hiroshi
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 63 Pages: 17-23

    • DOI

      10.1016/j.meegid.2018.05.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular detection and genetic characterization of Salivirus in environmental water in Thailand2018

    • Author(s)
      Badru S, Khamrin P, Kumthip K, Yodmeeklin A, Surajinda S, Supadej K, Sirilert S, Malasao R, Okitsu S, Ushijima H, Maneekarn N
    • Journal Title

      Infect Genet Evol

      Volume: 65 Pages: 352-356

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Increasing predominance of G8P[8] species A rotaviruses in children admitted to hospital with acute gastroenteritis in Thailand from2010 to ;2013.2018

    • Author(s)
      Yodmeeklin A, Khamrin P,· Kattareeya Kumthip K, · Rungnapa Malasao R, ·Ukarapol N, Ushijima H, Maneekarn N
    • Journal Title

      Arch Virol

      Volume: 163 Issue: 8 Pages: 2165-2178

    • DOI

      10.1007/s00705-018-3848-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Letter to the Editor:Our response to the letter to the editor.2018

    • Author(s)
      Hoque SA, Islam MT, Kobayashi M, Takanashi S, Anwar KS, Watanabe T, Khamrin P, Okitsu S, Hayakawa S, Ushijima H
    • Journal Title

      Vaccine36

      Volume: 36 Issue: 34 Pages: 50110-50111

    • DOI

      10.1016/j.vaccine.2018.05.004

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Detection and molecular characterization of two rare G8P[14] and G3P[3] rotavirus strains collected from children with acute gastroenteritis in Japan2018

    • Author(s)
      Okitsu S, Hikita T, Thongprachum A, Khamrin P, Takanashi S, Hayakawa S, Maneekarn N, Ushijima H
    • Journal Title

      Infect Genet Evol

      Volume: - Pages: 95-108

    • DOI

      10.1016/j.meegid.2018.04.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intra-genogroup recombination in the complete genome sequence of human Sapovirus 1 circulating in Bangladesh2018

    • Author(s)
      Dey SK, Sumiya MK, Shaha M, Haque R, Okitsu S, Ushijima H
    • Journal Title

      Genome Announcements

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection and genetic characterization of porcine astroviruses in piglets with and without diarrhea in Thailand2018

    • Author(s)
      Kumthip K, Khamrin P, Saikruang W, Kongkaew A, Vachirachewin R, Ushijima H
    • Journal Title

      Arch Virol

      Volume: - Issue: 7 Pages: 1823-1829

    • DOI

      10.1007/s00705-018-3806-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular epidemiology of rotavirus gastroenteritis in Japan during 2014-2015: Characterization of re-emerging G2P[4] after rotavirus vaccine introduction2018

    • Author(s)
      Khandoker Nusrat、Thongprachum Aksara、Takanashi Sayaka、Okitsu Shoko、Nishimura Shuichi、Kikuta Hideaki、Yamamoto Atsuko、Sugita Kumiko、Baba Tsuneyoshi、Kobayashi Masaaki、Hayakawa Satoshi、Mizuguchi Masashi、Ushijima Hiroshi
    • Journal Title

      Journal of Medical Virology

      Volume: 印刷中 Issue: 6 Pages: 1040-1046

    • DOI

      10.1002/jmv.25067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014?20162018

    • Author(s)
      Ngan Thi Kim Pham、Aksara Thongprachum、Quang Duy Trinh、Shoko Okitsu、Shihoko Komine-Aizawa、Hiroyuki Shimizu、Satoshi Hayakawa、Hiroshi Ushijima
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 61 Pages: 16-19

    • DOI

      10.1016/j.meegid.2018.03.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of rotavirus vaccination on an emerging G8P[8] rotavirus strain causing an outbreak in central Japan2018

    • Author(s)
      Hoque SA, Kobayashi M, Takanashi S, Anwar KS, Watanabe T, Khamrin P, Okitsu S, Hayakawa S, Ushijima H
    • Journal Title

      Vaccine

      Volume: 36 Issue: 1 Pages: 43-49

    • DOI

      10.1016/j.vaccine.2017.11.056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative Evaluation of Norovirus Infection in Children with Acute Gastroenteritis by Rapid Immunochromatographic Test, RT-PCR and Real-time RT-PCR.2017

    • Author(s)
      Kumthip K, Khamrin P, Saikruang W, Supadej K, Ushijima H, Maneekarn N.
    • Journal Title

      J Trop Pediatr

      Volume: 印刷中 Issue: 6 Pages: 468-475

    • DOI

      10.1093/tropej/fmx014

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multiple enterovirus genotypes circulating in children hospitalized with acute gastroenteritis in Thailand2017

    • Author(s)
      Kumthip K, Khamrin P, Ushijima H, Maneekarn N
    • Journal Title

      Infect Genet Evol

      Volume: 55 Pages: 324-331

    • DOI

      10.1016/j.meegid.2017.10.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of vaccine-derived rotavirus strains in children with acute gastroenteritis in Japan, 2012-20152017

    • Author(s)
      Kaneko Mei、Takanashi Sayaka、Thongprachum Aksara、Hanaoka Nozomu、Fujimoto Tsuguto、Nagasawa Koo、Kimura Hirokazu、Okitsu Shoko、Mizuguchi Masashi、Ushijima Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 9 Pages: e0184067-e0184067

    • DOI

      10.1371/journal.pone.0184067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A 3-Month-Old Child with Acute Gastroenteritis with Enterovirus D68 Detected from Stool Specimen2017

    • Author(s)
      Pham NTK, Thongprachum A, Baba T, Okitsu S, Trinh QD, Komine-Aizawa, S Shimizu H, Hayakawa S, Ushijima H
    • Journal Title

      Clin Lab

      Volume: 63 Issue: 07+08/2017 Pages: 1269-1272

    • DOI

      10.7754/clin.lab.2017.170219

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Noroviruses and sapoviruses associated with acute gastroenteritis in pediatric patients in Thailand: increased detection of recombinant norovirus GII.P16/GII.13 strains2017

    • Author(s)
      Khamrin P, Kumthip K, Supadej K, Thongprachum A, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N
    • Journal Title

      Arch Virol

      Volume: 162 Issue: 11 Pages: 3371-3380

    • DOI

      10.1007/s00705-017-3501-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular Epidemiological Traits of Group A Rotaviruses in Japanese Children During Transitional Period of Rotavirus Vaccine Implementation, 2011 - 2014.2017

    • Author(s)
      Takanashi S, Thongprachum A, Okitsu S, Nishimura S, Kobayashi M, Kikuta H, Yamamoto A, Sugita K, Baba T, Hayakawa S, Mizuguchi M, Ushijima H
    • Journal Title

      Clinical Laboratory

      Volume: 63 Issue: 05+06/2017 Pages: 961-970

    • DOI

      10.7754/clin.lab.2017.161216

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection and molecular characterization of porcine kobuvirus in piglets in 2009-2013 in northern Thailand2017

    • Author(s)
      Chuchaona W, Khamrin P, Yodmeeklin A, Kongkaew A, Vachirachewin R, Kumthip K, Ushijima H, Maneekarn N
    • Journal Title

      Trop Anim Health Prod

      Volume: 49 Issue: 5 Pages: 1077-1080

    • DOI

      10.1007/s11250-017-1298-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wide variety of recombinant strains of norovirus GII in pediatric patients hospitalized with acute gastroenteritis in Thailand during 2005 to 20152017

    • Author(s)
      Supadej K, Khamrin P, Kumthip K, Kochjan P, Yodmeeklin A, Ushijima H, Maneekarn N
    • Journal Title

      Infect Genet Evol

      Volume: 52 Pages: 44-51

    • DOI

      10.1016/j.meegid.2017.04.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-20162017

    • Author(s)
      Thongprachum A, Okitsu S, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H
    • Journal Title

      Infect Genet Evol

      Volume: 51 Pages: 86-88

    • DOI

      10.1016/j.meegid.2017.03.020

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular epidemiological traits of group A rotaviruses in Japanese children during transitional period of rotavirus vaccine implementation, 2011-20142017

    • Author(s)
      Takanashi S, Thongprachum A, Okitsu S, Nishimura S, Kobayashi M, Kikuta H, Yamamoto A, Sugita K, Baba T, Hayakawa S, Mizuguchi M, Ushijima H
    • Journal Title

      Clin Lab

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of Immunochromatographic Tests and a New Enzyme Immunoassay for Detection of a Novel GII.17 Norovirus in Stool Samples2017

    • Author(s)
      Ushijima H, Thongprachum A, Khamrin P, Takanashi S, Okitsu S, Maneekarn N, Hayakawa S.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 70 Issue: 3 Pages: 326-328

    • DOI

      10.7883/yoken.JJID.2016.413

    • NAID

      130005671844

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multiplex RT-PCR for rapid detection of viruses commonly causing diarrhea in pediatric patients2017

    • Author(s)
      Thongprachum A, Khamrin P, Thi Kim Pham N, Takanashi S, Okitsu S, Shimizu H, Maneekarn N, Hayakawa S, Ushijima H
    • Journal Title

      J Med Virol

      Volume: 89 Issue: 5 Pages: 818-824

    • DOI

      10.1002/jmv.24711

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multiplex PCR for the detection of 10 viruses causing encephalitis/encephalopathy and its application to clinical samples collected from Japanese children with suspected viral encephalitis/encephalopathy.2017

    • Author(s)
      Pham NT, Ushijima H, Thongprachum A, Trinh QD, Khamrin P, Arakawa C, Ishii W, Okitsu S, Komine-Aizawa S, Hayakawa S
    • Journal Title

      Clin Lab

      Volume: 63 Issue: 01/2017 Pages: 91-100

    • DOI

      10.7754/clin.lab.2016.160630

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immune responses against norovirus GII.4 virus-like particles in mice2016

    • Author(s)
      Ushijima H, Machida S, Nomura A, Khamrin P, Tran DN, Nomura H, Hayakawa S
    • Journal Title

      Acta Virol

      Volume: 60 Pages: 339-346

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detection and haracterization of Aichi virus 1 in pediatric patients with diarrhea in Thailand2016

    • Author(s)
      Chuchaona W, Khamrin P, Yodmeeklin A, Kumthip K, Saikruang W, Thongprachum A, Okitsu S, Ushijima H, Maneekarn N
    • Journal Title

      J Med Virol

      Volume: 89 Issue: 2 Pages: 234-238

    • DOI

      10.1002/jmv.24630

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Analysis of complete genome sequences of G9P[19] rotavirus strains from human and piglet with diarrhea provides evidence for whole-genome interspecies transmission of nonreassorted porcine rotavirus.2016

    • Author(s)
      Yodmeeklin A, Khamrin P, Chuchaona W, Kumthip K, Kongkaew A, Vachirachewin R, Okitsu S, Ushijima H, Maneekarn N
    • Journal Title

      Infect Genet Evol

      Volume: 47 Pages: 99-108

    • DOI

      10.1016/j.meegid.2016.11.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Great genetic diversity of rotaviruses detected in piglets with diarrhea in Thailand2016

    • Author(s)
      Yodmeeklin A, Khamrin P, Chuchaona W, Saikruang W, Kongkaew A, Vachirachewin R, Kumthip K, Okitsu S, Ushijima H, Maneekarn N
    • Journal Title

      Arch Virol

      Volume: 161 Issue: 10 Pages: 2843-2849

    • DOI

      10.1007/s00705-016-2976-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Complete genome analysis of a rare G12P[6] rotavirus isolated in Thailand in 2012 reveals a prototype strain of DS-1-like constellation2016

    • Author(s)
      Saikruang W, Khamrin P, Malasao R, Kumthip K, Ushijima H Maneekarn N
    • Journal Title

      Virus Res

      Volume: 224 Pages: 38-45

    • DOI

      10.1016/j.virusres.2016.08.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular characterization of norovirus GII.17 detectd in Healthy adult, intussusception patient, and acute gastroenteritis children in Thailand2016

    • Author(s)
      Khamrin P, Kumthip K, Yodmeeklin A, Supadeu K, Ukarapol N, Thongprachum A, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N
    • Journal Title

      Infect, Genet, Evol

      Volume: 44 Pages: 330-333

    • DOI

      10.1016/j.meegid.2016.07.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The virucidal effects against murine norovirus and feline calicivirus F4 as surrogates for human norovirus by the different additive concentrations of ethanol-based sanitizers2016

    • Author(s)
      Akasaka T, Shimizu-Onda Y, Hayakawa S, Ushijima H
    • Journal Title

      J Infect Chemother.

      Volume: 22 Issue: 3 Pages: 191-3

    • DOI

      10.1016/j.jiac.2015.09.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epidemiology of gastroenteritis viruses in Japan: Prevalence, seasonality, and outbreak 20162016

    • Author(s)
      Thongprachum A, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H.
    • Journal Title

      J Med Virol.

      Volume: 83 Issue: 4 Pages: 551-70

    • DOI

      10.1002/jmv.24387

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Genetic recombination and diversity of sapovirus in hospitalized children with acute gastroenteritis in Thailand2019

    • Author(s)
      Kumthip K, Khamrin P, Ushijima H, Maneekarn N
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic diversity of norovirus genogroup I, II, IV and sapovirus in environmental water in Thailand2019

    • Author(s)
      Khamrin P, Kumthip K, Okitsu S, Ushijima H, Maneekarn N
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular epidemiology of norovirus and sapovirus in pediatric patient2019

    • Author(s)
      Maneekarn N, Khamrin P, Kumtip K, Okitsu S, Ushijima H
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of gastroenteritis viruses in environmental rain water and dust.2019

    • Author(s)
      Ushijima H, Kawata K, Okuda T, Hoque A, Nomura A, Yuk Shimizu-Onda Y, Okitsu S,, Khamrin P, Takanashi S, Pham NTK, Hayakawa S, Maneekarn N
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular detection of sapovirus in the children with acute gastroenteritis collected from one outpatient clinic in Japan, 2014 to 20172019

    • Author(s)
      Okitsu S, Khamrin P, Hikita T, Takanashi S, Hayakawa S, Maneekarn N, Ushijima H
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Larg -scale genomics of human noroviruses reveal coexistence of viral populations evolving under recombination constraints: Summary of a multinational collaboration study2019

    • Author(s)
      Gabriel I. Parra, Kentaro Tohma, Cara Lepore, Magaly Martinez, Juan I. Degiuseppe, Pattara Khamrin, Mayuko Saito, Holger Mayta, Amy Nwaba, Lauren A. Ford-Siltz, Maria E. Galeano, Mirko Zimic, Juan A. Stupka, Robert H Gilman, Niwat Maneekarn, Hiroshi Ushijima, Kim Y. Green
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of sensitivity and specificity of immunochromatography (IC) methods for detection of norovirusassociated acute gastroenteritis in Bangladesh2019

    • Author(s)
      Dey SK, Sharif N, Takanashi S, Ushijima H
    • Organizer
      The 7th International Calicivirus Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long Term Survey of Viral Gstroenteritis in Children and Evaluation of Rotavirus Vaccine in Japan2019

    • Author(s)
      Ushijima H
    • Organizer
      Gut-Brain Axis and Child Health (Symposium)(北京大学)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Antigenicity of simian and human reassortant rotaviruses generated by reverse genetics2018

    • Author(s)
      Yuta Kanai, Takahiro Kawagishi, Misa Onishi, Pannacha Pimfhun, Ryotaro Nouda, Jeffery Nurdin, Keiichiro Nomura, Hiroshi Ushijima and Takeshi Kobayashi.
    • Organizer
      13th International dsRNA virus symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Further study of detection of enteric viruses in raw sewage in Japan2018

    • Author(s)
      Thongprachum A, Nomura A, Takanashi S, Fujimoto T, Okitsu S, Hayakawa S, Ushijima H.
    • Organizer
      he 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular detection of diarrheal viruses in the stool samples of children without diarrhea in Bangladesh.2018

    • Author(s)
      Okitsu S, Takanashi S, Thongprachum A, Hoque AS, Takeuchi H, Khan AM, IwataT, Shimizu H, Jimba M, Hayakawa S, Ushijima H.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Infection of classic, MLB and VA astroviruses in pediatric patients with acute gastroenteritis in Thailand.2018

    • Author(s)
      Kumthip K, Khamrin P, Surajinda S, Ushijima H, Maneekarn N.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plattform for rotavirus vaccine development using plasmid-based reverse genetics.2018

    • Author(s)
      Kanai Y, Kawagishi T, Onishi M, Pimfhun P, Nouda R, Nurdin J, Nomura K, Ushijima H, Kobayashi T.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 静岡におけるG8P[8]ロタウイルス株流行時のロタウイルスワクチンの効果2018

    • Author(s)
      Hoque A, 小林正明、高梨さやか、西村光司、沖津祥子、牛島廣治
    • Organizer
      第121回日本小児科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A群ロタウイルスの地域別における検出状況と遺伝子解析2018

    • Author(s)
      西村光司、小林正明、西村修一、杉田久美子、馬場常嘉、菊田英明、山本あつ子、疋田敏之、中山栄一、高梨さやか、沖津祥子、牛島廣治、高橋昌里
    • Organizer
      第121回日本小児科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2015-2017年の急性胃腸炎患児におけるロタウイルスワクチン株の検出と解析2018

    • Author(s)
      高梨さやか、Thongprachum A、金子明依、横田幸恵、河本聡志、谷口幸喜、沖津祥子、早川智、水口雅、牛島廣治
    • Organizer
      第14回日本小児消化管感染症研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2009~2017年のサポウイルスの地域別の検出状況と遺伝子解析2018

    • Author(s)
      西村光司、Thongprachum A、沖津祥子、早川智、高橋昌里、牛島廣治
    • Organizer
      第14回日本小児消化管感染症研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rotarix接種児の便から検出されたワクチン株VP7遺伝子の変異2017

    • Author(s)
      金子 明依、高梨 さやか、沖津 祥子、牛島 廣治
    • Organizer
      第58回日本臨床ウイルス学会
    • Place of Presentation
      長崎大学医学部(坂本キャンパス)記念講堂・良順会館(長崎県・長崎市)
    • Year and Date
      2017-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小児科領域のノロウイルス感染症の近年の傾向と診断法に対する考察2017

    • Author(s)
      Thongprachum A, 沖津祥子、早川智、牛島廣治
    • Organizer
      第91回日本感染症学会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2017-04-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 2016年冬のノロウイルス感染症の分子疫学(第1報)2017

    • Author(s)
      Thongprachum A、西村修一、小林正明、杉田久美子、中山栄一、菊田英明、馬場常嘉、山本あつ子、疋田敏之、高梨さやか、沖津祥子、早川智、牛島廣治
    • Organizer
      第13回日本小児消化管感染症研究会
    • Place of Presentation
      大阪大学中之島センター 佐治敬三メモリアルホール(大阪府・大阪市)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 最近のノロウイルス流行株に対するイムノクロマト方について2017

    • Author(s)
      牛島廣治、Thongprashum A、高梨さやか、沖津祥子、早川智
    • Organizer
      第13回日本小児消化管感染症研究会
    • Place of Presentation
      大阪大学中之島センター 佐治敬三メモリアルホール(大阪府・大阪市)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rotarix接種児の便から検出されたワクチン株VP7遺伝子の変異2017

    • Author(s)
      金子明依、高梨さやか、井上茉南、崎山弘、沖津祥子、牛島廣治、水口雅
    • Organizer
      第13回日本小児消化管感染症研究会
    • Place of Presentation
      大阪大学中之島センター 佐治敬三メモリアルホール(大阪府・大阪市)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Norovirus GII.2 and its novel recombination in children with gastroenteritis in 2016 and 20172017

    • Author(s)
      Thongprachum A, Hoque A, Khamrin P, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular epidemiology of rotavirus detected in a pediatric outpatient clinic in Gunma Prefecture, 2015-20162017

    • Author(s)
      Okitsu S, Thongprachum A, Khamrin P, Hikita T, Takanashi S, Hayakawa S, Ushijima H
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epidemiology of gastroenteritis viruses circulating in Japanese pediatric patients2017

    • Author(s)
      Thongprachum A, 沖津祥子、早川智、牛島廣治
    • Organizer
      第91回日本感染症学会・学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 急性胃腸炎患児におけるロタウイルスワクチン株の検出と解析2017

    • Author(s)
      高梨さやか、Aksara Thongprachum、金子明依、横田幸恵、沖津祥子、早川智、水口雅、牛島廣治
    • Organizer
      第49回日本小児感染症学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2016/2017年のロタウイルス、ノロウイルス胃腸炎の分子疫学研究2017

    • Author(s)
      Ariful Hoque、小林正明、西村修一、杉田久美子、馬場常嘉、菊田英明、山本あつ子、疋田敏之、中山栄一、Aksara Thongprachum、Pattara Khamrin、西村光司、恩田優子、高梨さやか、沖津祥子、早川智、牛島廣治
    • Organizer
      第49回日本小児感染症学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下水から下痢症関連ウイルスの検出-特にロタウイルス、ノロウイルスについて2017

    • Author(s)
      牛島廣治、Aksara Thongprachum、高梨さやか、Pattara Khamrin、清水優子、沖津祥子、早川智
    • Organizer
      第49回日本小児感染症学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 東京都東北部のロタウイルス感染症による入院増加とGP遺伝子型の解析2017

    • Author(s)
      1宮下英将、Pattara Khamrin、根岸沖津祥子、佐藤恭弘、飯塚雄俊、早川智、田島剛、牛島廣治
    • Organizer
      第49回日本小児感染症学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rotarix接種児の便から検出されたワクチン株VP7遺伝子の変異2017

    • Author(s)
      金子明依、高梨さやか、沖津祥子、牛島廣治
    • Organizer
      第58回日本臨床ウイルス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児急性胃腸炎の発症に対するロタウイルスワクチン導入による影響2017

    • Author(s)
      横田幸恵、高梨さやか、Thongprachuma A、金子明依、大澤麻記、沖津祥子、早川智、水口雅、牛島廣治
    • Organizer
      第120回日本小児科学会・学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 児科領域のノロウイルス感染症の近年の傾向と診断法に対する考察2017

    • Author(s)
      Thongprachum A, 沖津祥子、早川智、牛島廣治
    • Organizer
      第91回日本感染症学会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epidemiology of gastroenteritis viruses circulating in Japanese Pediatric patients2017

    • Author(s)
      Thongprachum A, 沖津 祥子、早川智、牛島廣治
    • Organizer
      第91回日本感染症学会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] An immunochromatographic test for rapid and simultaneous detection of norovirus and rotavirus in fecal specimens2017

    • Author(s)
      Lucero Neyra Agarie, Yuko Nanba, Hiroshi Nomura, Hideki Kohno, Hiroshi Ushijima
    • Organizer
      6th Pacific Congress on Marine Science and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] First report of salivirus (family of Picornaviridae) in gastroenteritis children in Japan2016

    • Author(s)
      Thongprachum A, Pham TKN, Takanashi S, Kikuta H, Yamamoto A, Kobayashi M, Sugita K, Nishimura S, Baba T, Nakayama E, Okitsu S, Hayakawa S, Ushijima H
    • Organizer
      第48回日本小児感染症学会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] ロタウイルスワクチン株に起因する急性胃腸炎の実態調査2016

    • Author(s)
      金子明依、高梨さやか、Thongprachum A、菊田英明、山本あつ子、小林正明、杉田久美子、西村修一、馬場常嘉、井上茉南、花岡希、藤本嗣人、沖津祥子、早川智、水口 雅、牛島廣治
    • Organizer
      第48回日本小児感染症学会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Group A Rotavirus in Children with Acute Gastroenteritis in Japan: A Molecular Epidemiological Study.2016

    • Author(s)
      Khandoker N, Thonprachum A, Takanashi S, Okitsu S, Hayakawa S, Mizuguchi M, Ushijima H.
    • Organizer
      第48回日本小児感染症学会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 2014年から2015年の一小児科外来における急性胃腸炎原因ウイルスの検索2016

    • Author(s)
      沖津祥子、疋田敏之、Thongprachum A、高梨さやか、早川智、牛島廣治
    • Organizer
      第48回日本小児感染症学会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] A varity of virus commonly causing diarrhea detected in untreated sewage2016

    • Author(s)
      Thongprachum A, Fujimoto T, Takanashi S, OKitsu S, Hayakawa S, Ushijima H
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular characterization of rotavirus detected in a pediatric clinic in Gunma Prefecture, 2014-20152016

    • Author(s)
      Okitsu S, Thongprachum A, Hikita T, Takanashi S, Hayakawa S, Ushijima H
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 米を用いたノロウイルスワクチンの開発(第1報)2016

    • Author(s)
      Lucero NA, Nakamura Y, Nomura A, Thongprachum A, Okitsu S, Ushijima H
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Genotype diversities of norovirus and sapovirus associated with acute gastroenteritis in pediatric patients in Thailand, 2012-20142016

    • Author(s)
      Maneekarn N, Khamrin P, Kumthip K, Yodmeeklin A, Supadej K, Okitsu S, Ushijima H
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Hyatt Reagency Savannah(USA・Georgia,Savannah)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Epidemiology of Sapovirus Infection in Children with Acute Gastroenteritis from one Clinic, Japan2016

    • Author(s)
      Okitsu S, Thongprachum A, Khamrin P, Takanashi S, Hikita T, Hayakawa S, Maneekarn N, Ushijima H
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Hyatt Reagency Savannah(USA・Georgia, Savannah)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of norovirus GII.17 in a Healthy Adult Intussusception patient, and Acute Gastroenteritis Children in Thailand2016

    • Author(s)
      Khamrin P, Kumthip K, Yodmeeklin A, Supadej K, Ukarapol N, Thongprachum A, Okitsu S, Ushijima H, Maneekarn N
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Hyatt Reagency Savannah(USA・Georgia, Savannah)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Changes of Norovirus GII.4 variants Associated with the Binding Patterns to Human Blood Group Substances2016

    • Author(s)
      Thongprachum A, Yazawa S, Okitsu S, Takanashi S, Hayakawa S, Ushijima H
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Hyatt Reagency Savannah(USA・Georgia, Savannah)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immune response against different genotypes of noroviruses in two adults with the recurrent Infection2016

    • Author(s)
      Ushijima H, Saito H, Shimizu Y, Sato H, Thongprachum A, Khamrin P, Okitsu S, Takanashi S, Maneekarn N, Hayakawa S
    • Organizer
      The 6th International Calicivirus Conference
    • Place of Presentation
      Reagency Savannah, Savannah(USA・Georgia, Savannah)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] he gastroenteritis viruses circulating in Japanese pediatric patients.2016

    • Author(s)
      Ushijima H, Thongprachum A, Khamrin P, Okitsu S, Takanashi S, Maneekarn N, Hayakawa S
    • Organizer
      The 11th Japan-China International Conference of Virology
    • Place of Presentation
      Kotohiki-so( Japan・Kagawa,Kan-onji)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] わが国小児のノロウイルスGII.17胃腸炎の流行について2016

    • Author(s)
      Thongprachum A, 沖津祥子、高梨さやか、早川智、牛島廣治
    • Organizer
      第57回日本臨床ウイルス学会
    • Place of Presentation
      磐梯熱海温泉 ホテル華の湯(福島県・磐梯)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular epidemiology of group A rotavirus in children with acute gastroenteritis2016

    • Author(s)
      Khandoker N、 Thongprachum A、 高梨さやか、沖津祥子、早川智、牛島廣治
    • Organizer
      第57回日本臨床ウイルス学会
    • Place of Presentation
      磐梯熱海温泉 ホテル華の湯(福島県・磐梯)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ピコルナウイルスと胃腸炎、脳炎・脳症について-最近経験した臨床例の分子疫学を中心に-2016

    • Author(s)
      牛島廣治、Thongprachum A、Pham Thi Kim Ngan、沖津祥子、早川智、清水博之
    • Organizer
      第57回日本臨床ウイルス学会
    • Place of Presentation
      磐梯熱海温泉 ホテル華の湯(福島県・磐梯)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ロタウイルスワクチン様株に起因する急性胃腸炎の実態調査2016

    • Author(s)
      金子明依、高梨さやか、Thongprachum A、井上茉南、沖津祥子、早川智、水口雅、牛島廣治
    • Organizer
      第119回日本小児科学会学術集会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Book] Handbook of Foodborne Diseases2018

    • Author(s)
      Okitsu S, Khamrin P, Maneekarn N, Ushijima H.
    • Total Pages
      1191
    • Publisher
      CRC Press
    • Related Report
      2018 Annual Research Report
  • [Book] ウイルス検査法2018

    • Author(s)
      沖津祥子、牛島廣治
    • Total Pages
      382
    • Publisher
      春恒社
    • Related Report
      2018 Annual Research Report
  • [Book] 感染症専門医テキスト 第I部 解説編(改訂第2版)2017

    • Author(s)
      牛島廣治 (分担執筆者) 日本感染症学会編
    • Total Pages
      1279
    • Publisher
      南江堂
    • ISBN
      9784524261567
    • Related Report
      2017 Annual Research Report
  • [Book] Chapter 11. Immunochromatographic tests for rapid diagnosis of noroviruses.The Novovirus: Features, detection, and prevention of foodborne disease.2016

    • Author(s)
      Ushijima H, Thongprachum A, Okitsu S, Khamrin P.
    • Total Pages
      241
    • Publisher
      Academic Press, London
    • Related Report
      2016 Annual Research Report
  • [Book] Emerging foodborne pathogenic kobuvirus, picobirnavirus, and torovirus. Foodborne Viral Pathogens2016

    • Author(s)
      Khamrin P, Maneekarn N, Okitsu S, Ushijima H
    • Total Pages
      280
    • Publisher
      CRC press, London
    • Related Report
      2016 Annual Research Report
  • [Remarks] 日本大学医学部 医局・教室紹介 病態病理学系 微生物学分野 研究業績

    • URL

      http://www.nihon-u.med-microbe.jp/publications.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] Pub Med (Ushijima HiroshiまたはUshijima h)

    • URL

      https://www.ncbi.nlm.nih.gov/pubmed/?term=ushijima+h

    • Related Report
      2019 Annual Research Report
  • [Remarks] 日本大学医学部 医局・教室紹介 病態病理学分野 研究業績

    • URL

      http://www.nihon-u.med-microbe.jp/publications.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/read0046282

    • Related Report
      2018 Annual Research Report
  • [Remarks] 日本大学医学部 医局・教室紹介 病態病理学系微生物学分野 研究業績

    • URL

      http://www.nihon-u.med-microbe.jp/publications.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-08-19  

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