| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Functional and structural defects in neuronal synapses are thought to underlie the pathophysiology of autism spectrum disorders (ASD). While more than 50 % of ASD patients suffer from sleep disturbance, relationship between circadian rhythm and ASD etiology is largely unknown. In this study, we focused on 3 circadian clock genes, TIMELESS, NR1D1 and PER3, whose gene abnormalities have been reported in ASD individuals. By the use of mouse models produced by "comprehensive in vivo/in vitro analytical battery" we constructed, we analyzed pathophysiological significance of gene abnormalities of TIMELESS, NR1D1 and PER3 in ASD.
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