Research Project
Grant-in-Aid for Scientific Research (B)
In the 3 year study, we clarified that mesenchymal blood cells (MBCs) accumulated into the injured skin to differentiate into the epidermal and follicular keratinocytes, melanocytes, dermal fibroblasts, and peripheral nerves, in which the TGF-b secreting abnormal myelin formation was suppressed not to induce scar formation. Moreover, MBC was shown to be originated from ectomesenchyme, which generate by delamination of neural crest epithelia, indicating developmental identity of the MBCs for regenerating ectodermal epithelia. HMGB1 peptide induced increase of the ectodermal MBCs, suggesting future therapeutic activity of the peptide to regulate cutaneous homeostasis in various skin diseases.
学術的には、これまで詳細が知られていなかった末梢血間葉系細胞の存在意義が初めて明らかとなり、またその発生学的起源が外胚葉であることが明らかとなったことが大きな学術的進展である。社会的には、HMGB1ペプチドが外胚葉性末梢血間葉系細胞を血中に動員する活性を持つことが明らかとなったことあら、壊死を伴う種々の難治性皮膚疾患において、非瘢痕性機能的組織再生を誘導する医薬開発の根拠がえられたことが創薬の実現という点において極めて社会的意義が高い。
All 2019 2018 2017 2016
All Journal Article (5 results) (of which Peer Reviewed: 5 results, Open Access: 5 results) Presentation (30 results) (of which Int'l Joint Research: 7 results, Invited: 30 results)
Biochemical and Biophysical Research Communications
Volume: pii: S0006-291X(19) Issue: 2 Pages: 30410-3
10.1016/j.bbrc.2019.03.033
PloS one
Volume: 13 Issue: 12 Pages: 1-15
10.1371/journal.pone.0202838
Sci. Rep.
Volume: 8 Issue: 1 Pages: 17765-17765
10.1038/s41598-018-36057-0
Geriatr Gerontol Int.
Volume: 17 Issue: 11 Pages: 2150-2156
10.1111/ggi.13051
Stem Cells and Development
Volume: 25(22): Issue: 22 Pages: 1721-1732
10.1089/scd.2016.0067
